AMD Radeon RX 7650 GRE vs NVIDIA Quadro M6000 Comparison

The Verdict

The AMD Radeon RX 7650 GRE is the decisive winner in this comparison, based on the benchmark data available. It holds a 1.4% average benchmark score advantage over the NVIDIA Quadro M6000, with the Quadro averaging 43,313 points versus the Radeon's 42,723 points. However, the head-to-head benchmark tells a far more dramatic story: in Geekbench OpenCL, the RX 7650 GRE scores 83,109 versus the Quadro M6000's 39,510, a 52.5% lead for the AMD card. The Quadro M6000 does edge the RX 7650 GRE in average score by 1.4%, but that single OpenCL result shows the generational gap clearly. For anyone choosing between these two today, the RX 7650 GRE is the obvious pick for compute-heavy workloads. The Quadro M6000 remains an end-of-life product with no active production status, while the RX 7650 GRE is actively produced. The Radeon also launches at 279 USD MSRP, though that figure should not be weighed as a purchasing factor here.

Architecture Differences

The architectural divide between these two GPUs is vast, representing nearly a decade of silicon evolution. The NVIDIA Quadro M6000 uses the GM200 chip on the Maxwell 2.0 architecture, built on a 28 nm process at TSMC. It packs 8,000 million transistors into a 601 mm² die, yielding a transistor density of 13.3M per mm². In contrast, the AMD Radeon RX 7650 GRE uses the Navi 33 chip with RDNA 3.0 architecture, built on a 6 nm process, also at TSMC. It contains 13,300 million transistors on a much smaller 204 mm² die, achieving a transistor density of 65.2M per mm² — nearly five times denser.

The memory subsystems differ fundamentally as well. The Quadro M6000 offers 12 GB of GDDR5 on a 384-bit bus, delivering 317.4 GB/s of bandwidth. The RX 7650 GRE has 8 GB of GDDR6 on a 128-bit bus, providing 288.0 GB/s. Despite the narrower bus, the newer GDDR6 memory runs at 18 Gbps effective versus 6.6 Gbps on the Quadro, closing the bandwidth gap. The shading core counts tell a nuanced story: the Quadro has 3,072 shading units, 192 TMUs, and 96 ROPs, while the RX 7650 GRE has 2,048 shading units, 128 TMUs, and 64 ROPs. However, the RX 7650 GRE adds 32 ray tracing cores, which the Maxwell-based Quadro lacks entirely.

Clock speeds and compute throughput show the generational leap. The Quadro M6000 runs at a 988 MHz base and 1,114 MHz boost, producing 6.844 TFLOPS of FP32 compute. The RX 7650 GRE runs at 1,720 MHz base, 2,350 MHz game clock, and 2,695 MHz boost, achieving 22.08 TFLOPS FP32 and 44.15 TFLOPS FP16 (2:1). The Radeon's pixel rate of 172.5 GPixel/s exceeds the Quadro's 106.9 GPixel/s, and its texture rate of 345.0 GTexel/s dwarfs the Quadro's 213.9 GTexel/s. Both cards are dual-slot with a single 8-pin power connector, but the Quadro draws 250 W TDP versus 165 W for the Radeon, with suggested PSU ratings of 600 W and 450 W respectively. The Quadro uses PCIe 3.0 x16, while the RX 7650 GRE uses PCIe 4.0 x8. Display outputs also differ: the Quadro offers 1x DVI and 4x DisplayPort 1.2, while the Radeon provides 1x HDMI 2.1a and 3x DisplayPort 2.1. Both support DirectX 12, OpenGL 4.6, and Vulkan 1.4, but the Radeon's DirectX 12 Ultimate (12_2) exceeds the Quadro's DirectX 12 (12_1).

Head-to-Head Benchmarks

The only direct head-to-head benchmark available is Geekbench OpenCL, and it is not close. The AMD Radeon RX 7650 GRE scores 83,109, while the NVIDIA Quadro M6000 scores 39,510. That represents a 52.5% advantage for the Radeon, a massive margin that underscores the architectural leap from Maxwell 2.0 to RDNA 3.0. The Quadro M6000's single benchmark win count is zero; the RX 7650 GRE claims the sole victory.

Looking at the broader benchmark landscape through the nearest rivals data, the two cards sit at nearly identical average scores. The Quadro M6000 averages 43,313, placing it 0.8% below the NVIDIA GeForce RTX 4090 Mobile (43,667) and 1.5% above the NVIDIA RTX A6000 (42,653). The RX 7650 GRE averages 42,723, which is 0.2% above the RTX A6000, 0.3% above the NVIDIA GeForce RTX 4070 SUPER (42,576), and 1.7% above the AMD Radeon Pro 580X (41,991). Both GPUs sit at the 84th percentile against all GPUs, indicating they occupy the same performance tier in aggregate — yet the OpenCL gap suggests the Radeon is substantially stronger in compute-specific tasks while the Quadro may hold its own in other unmeasured workloads.

FAQ

Q: Which GPU has the higher average benchmark score?

A: The NVIDIA Quadro M6000 has a slightly higher average benchmark score of 43,313, which is 1.4% above the AMD Radeon RX 7650 GRE's 42,723.

Q: How large is the performance difference in OpenCL compute?

A: The AMD Radeon RX 7650 GRE scores 83,109 in Geekbench OpenCL versus 39,510 for the NVIDIA Quadro M6000, giving the Radeon a 52.5% lead.

Q: Which card supports ray tracing?

A: Only the AMD Radeon RX 7650 GRE has ray tracing cores, with 32 RT cores. The NVIDIA Quadro M6000 has no RT cores at all.

Q: What are the memory capacities and types?

A: The NVIDIA Quadro M6000 has 12 GB of GDDR5 on a 384-bit bus with 317.4 GB/s bandwidth. The AMD Radeon RX 7650 GRE has 8 GB of GDDR6 on a 128-bit bus with 288.0 GB/s bandwidth.

Q: Which GPU is still in production?

A: The AMD Radeon RX 7650 GRE has an active production status, while the NVIDIA Quadro M6000 is end-of-life.

Q: How do the power requirements compare?

A: The NVIDIA Quadro M6000 has a 250 W TDP with a 600 W suggested PSU, while the AMD Radeon RX 7650 GRE has a 165 W TDP with a 450 W suggested PSU.

Where Each One Wins

The AMD Radeon RX 7650 GRE wins decisively in compute performance. The 52.5% lead in Geekbench OpenCL indicates that any workload leveraging OpenCL — such as general-purpose GPU computing, physics simulations, or data processing — will run dramatically faster on the Radeon. Its 22.08 TFLOPS FP32 throughput versus 6.844 TFLOPS on the Quadro reinforces this advantage. The Radeon also wins on architectural modernity: RDNA 3.0 with 32 RT cores enables ray-traced workloads that the Maxwell 2.0 Quadro cannot handle at all. The Radeon's higher pixel rate (172.5 GPixel/s vs 106.9 GPixel/s) and texture rate (345.0 GTexel/s vs 213.9 GTexel/s) suggest it will also excel in rasterization-heavy rendering tasks. Its active production status means ongoing availability and driver support. The Radeon also supports PCIe 4.0, which offers twice the bandwidth of the Quadro's PCIe 3.0 interface, and newer display outputs (HDMI 2.1a, DisplayPort 2.1 versus DVI and DisplayPort 1.2).

The NVIDIA Quadro M6000's wins are narrower but real. Its average benchmark score of 43,313 is 1.4% higher than the Radeon's 42,723, suggesting that in aggregate across all benchmark types — not just OpenCL — the Quadro holds a slight edge. It also offers more memory: 12 GB versus 8 GB, which matters for workloads that exceed 8 GB of VRAM. The Quadro's 384-bit memory bus provides 317.4 GB/s bandwidth versus 288.0 GB/s on the Radeon, a 9.3% advantage in raw memory bandwidth. For legacy compatibility, the Quadro's PCIe 3.0 x16 interface and DVI output may be preferable in older workstations. The Quadro also has more shading units (3,072 vs 2,048), TMUs (192 vs 128), and ROPs (96 vs 64), though these advantages are rendered moot by the Radeon's vastly higher clock speeds and per-clock efficiency.

Specification Differences

| Specification | NVIDIA Quadro M6000 | AMD Radeon RX 7650 GRE |

|---|---|---|

| Chip | GM200 | Navi 33 |

| Architecture | Maxwell 2.0 | RDNA 3.0 |

| Process Node | 28 nm | 6 nm |

| Transistors | 8,000 million | 13,300 million |

| Die Size | 601 mm² | 204 mm² |

| Transistor Density | 13.3M / mm² | 65.2M / mm² |

| Base Clock | 988 MHz | 1720 MHz |

| Boost Clock | 1114 MHz | 2695 MHz |

| Game Clock | N/A | 2350 MHz |

| Memory Size | 12 GB | 8 GB |

| Memory Type | GDDR5 | GDDR6 |

| Memory Bus Width | 384 bit | 128 bit |

| Memory Bandwidth | 317.4 GB/s | 288.0 GB/s |

| Shading Units | 3072 | 2048 |

| TMUs | 192 | 128 |

| ROPs | 96 | 64 |

| RT Cores | N/A | 32 |

| Pixel Rate | 106.9 GPixel/s | 172.5 GPixel/s |

| Texture Rate | 213.9 GTexel/s | 345.0 GTexel/s |

| FP32 | 6.844 TFLOPS | 22.08 TFLOPS |

| FP16 | N/A | 44.15 TFLOPS (2:1) |

| TDP | 250 W | 165 W |

| Suggested PSU | 600 W | 450 W |

| Bus Interface | PCIe 3.0 x16 | PCIe 4.0 x8 |

| Display Outputs | 1x DVI, 4x DisplayPort 1.2 | 1x HDMI 2.1a, 3x DisplayPort 2.1 |

| DirectX Support | 12 (12_1) | 12 Ultimate (12_2) |

| Production Status | End-of-life | Active |

| Release Date | 2015-03-20 | N/A |

| Predecessor | Quadro Kepler | Navi II |

| Successor | Quadro Pascal | Navi IV |