AMD Instinct MI300A vs NVIDIA GeForce RTX 5080 Comparison

Head-to-Head Benchmarks

The database records no head-to-head benchmark entries for the AMD Instinct MI300A and NVIDIA GeForce RTX 5080, as the MI300A has no benchmark scores, an average score of zero, and sits at the 50th percentile among all GPUs. The RTX 5080, by contrast, has a full benchmark suite and an average score of 56,083, placing it at the 87th percentile. The MI300A is a compute accelerator without display outputs or a consumer benchmark suite in the database, so direct frame-by-frame comparisons are impossible. The only measurable comparison is architectural and theoretical, drawn from the specification sheets.

The RTX 5080 delivers 56.28 TFLOPS of FP32 compute, while the MI300A records 61.29 TFLOPS, a difference of roughly 9 percent in raw single-precision throughput. The MI300A leads in texture rate, posting 1,915.2 GTexel/s against the RTX 5080's 879.3 GTexel/s, a margin of more than double. The RTX 5080 counters with a pixel rate of 293.1 GPixel/s, while the MI300A lists 0 MPixel/s, reflecting its lack of a raster output stage. Memory bandwidth strongly favors the MI300A: 5.32 TB/s versus 960.0 GB/s, a factor of roughly 5.5. The RTX 5080 shows higher clock speeds, with a base of 2295 MHz and a boost of 2617 MHz, against the MI300A's 1000 MHz base and 2100 MHz boost. The MI300A's transistor count of 153,000 million dwarfs the RTX 5080's 45,600 million, and its die size of 1017 mm² compares to 378 mm².

Architecture Differences

The two parts target entirely different segments of the GPU market. The MI300A uses CDNA 3.0 architecture on the Aqua Vanjaram chip, built on a 5 nm process at TSMC with 153,000 million transistors on a 1017 mm² die, producing a transistor density of 150.4M per mm². The RTX 5080 uses Blackwell 2.0 architecture on the GB203 chip, also fabricated on 5 nm at TSMC, but with 45,600 million transistors on a 378 mm² die, for a density of 120.6M per mm². The MI300A belongs to the Instinct (MIx) generation, while the RTX 5080 is part of the GeForce 50 series.

Memory design separates the two fundamentally. The MI300A carries 128 GB of HBM3 across an 8192-bit bus, with a bandwidth of 5.32 TB/s and memory clocks at 1300 MHz (5.2 Gbps effective). The RTX 5080 uses 16 GB of GDDR7 on a 256-bit bus, achieving 960.0 GB/s at 1875 MHz (30 Gbps effective). The MI300A has no RT cores and no tensor cores listed, while the RTX 5080 includes 84 RT cores and 336 tensor cores. Shader organization differs: the MI300A has 14,592 shading units and 912 TMUs but zero ROPs, whereas the RTX 5080 has 10,752 shading units, 336 TMUs, and 112 ROPs. The MI300A's FP16 throughput is not recorded, while the RTX 5080 lists FP16 at 56.28 TFLOPS (1:1).

Power and physical specifications also diverge. The MI300A has a TDP of 750 W, a suggested PSU of 1150 W, no power connectors (as an OAM Module), and a slot width of OAM Module. The RTX 5080 draws 360 W, requires a 750 W suggested PSU, uses a single 16-pin connector, and occupies a dual-slot layout measuring 304 mm in length, 137 mm in height, and 40 mm in width. The MI300A has no display outputs and no API support for DirectX, OpenGL, or Vulkan, while the RTX 5080 supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4, with outputs of 1x HDMI 2.1b and 3x DisplayPort 2.1b. The MI300A was released on 2023-12-05, and the RTX 5080 on 2025-01-29. The MI300A's predecessor is Radeon Instinct, and the RTX 5080's predecessor is GeForce 40 with a successor of GeForce 60.

FAQ

Q: Which GPU has more FP32 compute performance?

A: The MI300A delivers 61.29 TFLOPS of FP32, which is about 9 percent higher than the RTX 5080's 56.28 TFLOPS.

Q: How do the memory subsystems compare?

A: The MI300A uses 128 GB of HBM3 on an 8192-bit bus with 5.32 TB/s bandwidth. The RTX 5080 uses 16 GB of GDDR7 on a 256-bit bus with 960.0 GB/s. The MI300A's bandwidth is roughly 5.5 times higher.

Q: Does the MI300A support DirectX or Vulkan?

A: No. The MI300A lists DirectX, OpenGL, and Vulkan all as N/A, and it has no display outputs. The RTX 5080 supports DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4.

Q: What is the RTX 5080's benchmark percentile?

A: The RTX 5080 sits at the 87th percentile among all GPUs with an average benchmark score of 56,083. The MI300A has no recorded benchmarks and sits at the 50th percentile with a score of zero.

Q: How do the power requirements differ?

A: The MI300A has a 750 W TDP and a suggested PSU of 1150 W. The RTX 5080 has a 360 W TDP and a suggested PSU of 750 W.

Q: Which GPUs are the RTX 5080's closest rivals?

A: The nearest rivals are the AMD Radeon 8060S with an average score of 55,757 (0.6 percent behind), the AMD Radeon RX 6750 GRE 12 GB at 55,698 (0.7 percent behind), the AMD Radeon Pro W5700X at 54,828 (2.3 percent behind), and the AMD Radeon RX 9070 GRE at 57,367 (2.2 percent ahead).

The Verdict

The data indicates two different tools. The MI300A is a compute-oriented accelerator with 128 GB of HBM3, 5.32 TB/s of bandwidth, 61.29 TFLOPS of FP32, and no display or graphics API support. It is designed for workloads that demand massive memory capacity and bandwidth, not for rendering frames. The RTX 5080 is a graphics card with 16 GB of GDDR7, 960.0 GB/s of bandwidth, 56.28 TFLOPS of FP32, full DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4 support, plus RT cores and tensor cores. It records an average benchmark score of 56,083 at the 87th percentile, while the MI300A has no benchmark presence in the database.

For rasterization, the RTX 5080 is the only candidate with a pixel rate (293.1 GPixel/s) and ROPs (112). For compute throughput and memory bandwidth, the MI300A leads in texture rate (1,915.2 GTexel/s versus 879.3 GTexel/s), FP32 (61.29 versus 56.28 TFLOPS), and bandwidth (5.32 TB/s versus 960.0 GB/s). The RTX 5080's nearest rivals are all AMD Radeon consumer cards within 2.3 percent of its average score, confirming its position in the graphics segment. The MI300A has no nearest rivals recorded and no benchmarks, so it cannot be ranked against the RTX 5080 numerically.

Specification Differences

| Field | AMD Instinct MI300A | NVIDIA GeForce RTX 5080 |

|---|---|---|

| Architecture | CDNA 3.0 | Blackwell 2.0 |

| Chip | Aqua Vanjaram | GB203 |

| Process Node | 5 nm | 5 nm |

| Transistors | 153,000 million | 45,600 million |

| Die Size | 1017 mm² | 378 mm² |

| Transistor Density | 150.4M / mm² | 120.6M / mm² |

| Base Clock | 1000 MHz | 2295 MHz |

| Boost Clock | 2100 MHz | 2617 MHz |

| Memory Clock | 1300 MHz 5.2 Gbps effective | 1875 MHz 30 Gbps effective |

| Memory Size | 128 GB | 16 GB |

| Memory Type | HBM3 | GDDR7 |

| Memory Bus Width | 8192 bit | 256 bit |

| Memory Bandwidth | 5.32 TB/s | 960.0 GB/s |

| Shading Units | 14592 | 10752 |

| TMUs | 912 | 336 |

| ROPs | 0 | 112 |

| RT Cores | Not listed | 84 |

| Tensor Cores | Not listed | 336 |

| Pixel Rate | 0 MPixel/s | 293.1 GPixel/s |

| Texture Rate | 1,915.2 GTexel/s | 879.3 GTexel/s |

| FP32 | 61.29 TFLOPS | 56.28 TFLOPS |

| FP16 | Not listed | 56.28 TFLOPS (1:1) |

| TDP | 750 W | 360 W |

| Slot Width | OAM Module | Dual-slot |

| Power Connectors | None | 1x 16-pin |

| Suggested PSU | 1150 W | 750 W |

| Bus Interface | PCIe 5.0 x16 | PCIe 5.0 x16 |

| Display Outputs | No outputs | 1x HDMI 2.1b, 3x DisplayPort 2.1b |

| DirectX | N/A | 12 Ultimate (12_2) |

| OpenGL | N/A | 4.6 |

| Vulkan | N/A | 1.4 |

| Dimensions | Not listed | 304 mm x 137 mm x 40 mm |

| Release Date | 2023-12-05 | 2025-01-29 |

| Predecessor | Radeon Instinct | GeForce 40 |

| Successor | Not listed | GeForce 60 |

Where Each One Wins

The MI300A wins on raw compute density and memory architecture. Its 61.29 TFLOPS of FP32 exceeds the RTX 5080 by about 9 percent. Its texture rate of 1,915.2 GTexel/s is more than double the RTX 5080's 879.3 GTexel/s. Its 128 GB of HBM3 on an 8192-bit bus delivers 5.32 TB/s, roughly 5.5 times the RTX 5080's bandwidth. These specifications point to workloads such as large-scale compute, data processing, and memory-bound operations where capacity and throughput matter more than graphics output. The MI300A also uses a larger die (1017 mm² versus 378 mm²) and more transistors (153,000 million versus 45,600 million), reflecting a design focused on massive parallel throughput.

The RTX 5080 wins on graphics features, clock speeds, efficiency, and ecosystem support. Its base clock of 2295 MHz and boost clock of 2617 MHz are more than double the MI300A's base clock of 1000 MHz. It includes 84 RT cores and 336 tensor cores, neither of which the MI300A lists. It has 112 ROPs and a pixel rate of 293.1 GPixel/s, while the MI300A has zero ROPs and zero pixel rate. The RTX 5080 supports DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4, plus HDMI 2.1b and DisplayPort 2.1b outputs, making it functional as a display adapter. Its TDP is 360 W versus 750 W, and its suggested PSU is 750 W versus 1150 W, so it fits in conventional desktop builds. The RTX 5080 also has a recorded benchmark suite with an average score of 56,083 and sits at the 87th percentile, while the MI300A has no benchmarks.

The launch MSRP for the RTX 5080 is 999 USD. The MI300A's launch MSRP is not recorded. The RTX 5080's nearest rivals, all within 2.3 percent of its average score, are consumer and workstation cards from AMD, placing it in a competitive graphics tier. The MI300A has no nearest rivals recorded, which reflects its absence from the benchmark database rather than a lack of competition in its market segment.