AMD Radeon Instinct MI300 vs NVIDIA GeForce RTX 5080 SUPER Comparison

The Verdict

The database comparison between the AMD Radeon Instinct MI300 and the NVIDIA GeForce RTX 5080 SUPER shows two profoundly different products. The AMD Radeon Instinct MI300 is a data center compute accelerator with no display outputs, while the NVIDIA GeForce RTX 5080 SUPER is a consumer graphics card with full display connectivity. The recorded data shows the MI300 has zero benchmark scores, a 50th percentile ranking among all GPUs, and an average benchmark score of zero. The RTX 5080 SUPER has one recorded 3DMark Steel Nomad DX12 score of 3075, placing it at the 19th percentile. The RTX 5080 SUPER is the only part with measurable gaming performance in this comparison, so for any graphics-oriented workload, the NVIDIA card is the clear choice. The MI300, however, delivers 128 GB of HBM3 memory with 6.55 TB/s of bandwidth, which positions it for memory-capacity-bound compute tasks. The RTX 5080 SUPER has 24 GB of GDDR7 memory with 1.02 TB/s bandwidth. The verdict: pick the RTX 5080 SUPER for rendering, gaming, or any workload requiring display output and ray tracing. Pick the MI300 for massive-memory compute deployments where the 128 GB capacity and 6.55 TB/s bandwidth matter more than rasterization or ray tracing.

Architecture Differences

The AMD Radeon Instinct MI300 uses the Aqua Vanjaram chip built on the CDNA 3.0 architecture, manufactured on a 5 nm process at TSMC. It packs 153,000 million transistors on a 1017 mm² die, giving a transistor density of 150.4M per mm². The NVIDIA GeForce RTX 5080 SUPER uses the GB203 chip based on the Blackwell 2.0 architecture, also on a 5 nm TSMC process, with 45,600 million transistors on a 378 mm² die and a density of 120.6M per mm². The MI300 has 14,080 shading units, 880 texture mapping units, and zero ROPs, reflecting its compute-first design philosophy. The RTX 5080 SUPER has 10,752 shading units, 336 TMUs, and 112 ROPs. The MI300 has no ray tracing cores and no tensor cores listed, while the RTX 5080 SUPER has 84 ray tracing cores and 336 tensor cores.

The memory subsystems differ fundamentally. The MI300 uses HBM3 with a 8192-bit bus and 128 GB capacity, achieving 6.55 TB/s bandwidth. The RTX 5080 SUPER uses GDDR7 on a 256-bit bus with 24 GB capacity, achieving 1.02 TB/s. The MI300 clocks at 1000 MHz base and 1700 MHz boost, with memory at 1600 MHz or 6.4 Gbps effective. The RTX 5080 SUPER runs at 2295 MHz base and 2617 MHz boost, with memory at 2000 MHz or 32 Gbps effective. The MI300 has no display outputs, while the RTX 5080 SUPER provides 1x HDMI 2.1b and 3x DisplayPort 2.1b. The MI300 uses dual 8-pin power connectors and requires a 1000 W suggested PSU, drawing 600 W TDP. The RTX 5080 SUPER uses a single 16-pin connector at 415 W TDP. The MI300 is 267 mm long and 111 mm tall; the RTX 5080 SUPER is 304 mm long, 137 mm tall, and 40 mm wide. The MI300 supports no DirectX, OpenGL, or Vulkan APIs, while the RTX 5080 SUPER supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4.

FAQ

Q: Which GPU has more memory bandwidth?

A: The AMD Radeon Instinct MI300 has 6.55 TB/s of bandwidth from its 8192-bit HBM3 interface. The NVIDIA GeForce RTX 5080 SUPER has 1.02 TB/s from its 256-bit GDDR7 interface. The MI300 delivers roughly 6.4 times the memory bandwidth of the RTX 5080 SUPER.

Q: Can the MI300 be used for gaming with ray tracing?

A: No. The MI300 has zero ROPs, no ray tracing cores, no display outputs, and no DirectX, OpenGL, or Vulkan API support. The RTX 5080 SUPER has 84 ray tracing cores, 112 ROPs, and full DirectX 12 Ultimate support, making it the only option here for ray-traced workloads.

Q: What is the FP16 compute capability difference?

A: The MI300 delivers 383.0 TFLOPS FP16 with an 8:1 ratio, while the RTX 5080 SUPER delivers 56.28 TFLOPS FP16 with a 1:1 ratio. The MI300 has a substantial lead in FP16 throughput, but the RTX 5080 SUPER offers equal FP16 and FP32 rates.

Q: How does the launch MSRP of the RTX 5080 SUPER compare to the MI300?

A: The RTX 5080 SUPER has a launch MSRP of 999 USD. The MI300 has no launch MSRP recorded in the database.

Q: Which card has a higher pixel fill rate?

A: The RTX 5080 SUPER has a pixel rate of 293.1 GPixel/s. The MI300 has a pixel rate of 0 MPixel/s because it has no ROPs.

Q: What are the physical size differences?

A: The MI300 is 267 mm long and 111 mm tall. The RTX 5080 SUPER is longer at 304 mm, taller at 137 mm, and has a width of 40 mm. The RTX 5080 SUPER is a dual-slot card.

Specification Differences

The two cards differ across nearly every specification field. The MI300 uses the CDNA 3.0 architecture with the Aqua Vanjaram chip, while the RTX 5080 SUPER uses Blackwell 2.0 with the GB203 chip. Transistor count: 153,000 million for the MI300 versus 45,600 million for the RTX 5080 SUPER. Die size: 1017 mm² versus 378 mm². Transistor density: 150.4M per mm² versus 120.6M per mm². Base clock: 1000 MHz versus 2295 MHz. Boost clock: 1700 MHz versus 2617 MHz. Memory clock: 1600 MHz (6.4 Gbps effective) versus 2000 MHz (32 Gbps effective). Memory size: 128 GB versus 24 GB. Memory type: HBM3 versus GDDR7. Bus width: 8192 bit versus 256 bit. Bandwidth: 6.55 TB/s versus 1.02 TB/s.

Shading units: 14,080 versus 10,752. TMUs: 880 versus 336. ROPs: 0 versus 112. Ray tracing cores: none versus 84. Tensor cores: none versus 336. Pixel rate: 0 MPixel/s versus 293.1 GPixel/s. Texture rate: 1,496.0 GTexel/s versus 879.3 GTexel/s. FP32: 47.87 TFLOPS versus 56.28 TFLOPS. FP16: 383.0 TFLOPS (8:1) versus 56.28 TFLOPS (1:1). TDP: 600 W versus 415 W. Power connectors: 2x 8-pin versus 1x 16-pin. Suggested PSU: 1000 W versus none recorded. Slot width: none versus dual-slot. Display outputs: none versus 1x HDMI 2.1b and 3x DisplayPort 2.1b. API support: none versus DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4. Release dates: 2023-01-03 for the MI300 versus 2025-12-31 for the RTX 5080 SUPER. The MI300 has a predecessor listed as FirePro Data Center, while the RTX 5080 SUPER has none.

Head-to-Head Benchmarks

The head-to-head benchmark table is empty, and the MI300 has no recorded benchmark scores. The RTX 5080 SUPER has one benchmark result: 3DMark Steel Nomad DX12 with a score of 3075. The nearest rivals for the RTX 5080 SUPER provide context. The NVIDIA Quadro P1000 scores 3163, which is 2.8% higher than the RTX 5080 SUPER. The Intel Arc Pro B60 scores 3182, which is 3.4% higher. The NVIDIA GeForce 820A scores 2983, which is 3.1% lower. The NVIDIA GeForce GTX 860M scores 2967, which is 3.6% lower.

The MI300 has no benchmarks, no average score, and no nearest rivals. Its percentile ranking against all GPUs is 50, while the RTX 5080 SUPER sits at the 19th percentile. The benchmark data shows that the RTX 5080 SUPER is near the lower-middle range of the database's GPU performance distribution, while the MI300's performance cannot be quantified from the recorded measurements. The wins tally shows zero wins for either card in direct head-to-head comparisons, which is consistent with the empty benchmark table. Based on the available data, the RTX 5080 SUPER delivers measurable graphics performance, while the MI300 delivers none in the recorded tests.

Where Each One Wins

The AMD Radeon Instinct MI300 wins in memory capacity and bandwidth. It provides 128 GB of HBM3 across a 8192-bit bus, achieving 6.55 TB/s. That is 5.3 times the capacity and 6.4 times the bandwidth of the RTX 5080 SUPER. The MI300 also wins in texture rate with 1,496.0 GTexel/s versus 879.3 GTexel/s, and in FP16 compute with 383.0 TFLOPS versus 56.28 TFLOPS. Its 153,000 million transistors and 1017 mm² die reflect a design aimed at large-scale compute workloads. The MI300 has a higher TDP of 600 W and requires a 1000 W suggested PSU, which indicates sustained compute capability. It is 37 mm shorter than the RTX 5080 SUPER, which may simplify fitting in some server chassis.

The NVIDIA GeForce RTX 5080 SUPER wins in every graphics-oriented metric. It has 112 ROPs versus zero for the MI300, yielding a 293.1 GPixel/s pixel rate. It has 84 ray tracing cores and 336 tensor cores, while the MI300 has none. The RTX 5080 SUPER has display outputs, including 1x HDMI 2.1b and 3x DisplayPort 2.1b, making it usable with monitors. It supports DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4, while the MI300 supports none of these APIs. The RTX 5080 SUPER has higher clocks: 2295 MHz base and 2617 MHz boost versus 1000 MHz and 1700 MHz. Its FP32 throughput of 56.28 TFLOPS exceeds the MI300's 47.87 TFLOPS. It draws 185 W less power at 415 W TDP and uses a single 16-pin connector. The RTX 5080 SUPER has a recorded 3DMark Steel Nomad DX12 score of 3075, placing it ahead of the GeForce 820A by 3.1% and the GTX 860M by 3.6%, while trailing the Quadro P1000 by 2.8% and the Arc Pro B60 by 3.4%.

The use-case split is clear. For memory-bound compute tasks such as large model inference or data processing where 128 GB capacity and 6.55 TB/s bandwidth are required, the MI300 is the appropriate choice. For any workload that needs rasterization, ray tracing, tensor operations, display output, or modern graphics API support, the RTX 5080 SUPER is the only option with recorded capability. The data shows a binary separation: the MI300 is a specialized compute accelerator with no graphics pipeline, while the RTX 5080 SUPER is a general-purpose graphics card with measurable benchmark performance and full API coverage.