AMD Instinct MI350P vs NVIDIA GeForce RTX 4060 AD106 Comparison

Head-to-Head Benchmarks

The recorded data contains no direct benchmark scores for either the AMD Instinct MI350P or the NVIDIA GeForce RTX 4060 AD106. Both products hold a 50th percentile ranking against all GPUs in the database, and their average benchmark scores are listed as zero. This indicates that neither card has been subjected to the standard evaluation suite, or that the results are not yet populated in the database.

Without head-to-head measurements, the comparison must rely on architectural specifications and theoretical compute figures. The FP32 performance gap is substantial: the MI350P delivers 36.04 TFLOPS, while the RTX 4060 AD106 manages 15.11 TFLOPS. That places the AMD accelerator at roughly 2.4 times the raw single-precision throughput of the NVIDIA card. The FP16 figures mirror this exactly, with both products showing a 1:1 ratio between FP16 and FP32, meaning the MI350P also holds the same 2.4x advantage in half-precision work.

Texture processing shows an even wider split. The MI350P achieves 1,126.4 GTexel/s against 236.2 GTexel/s for the RTX 4060 AD106, a multiplier of approximately 4.8x. This stems from the massive difference in texture mapping units: 512 on the AMD part versus 96 on the NVIDIA part. Pixel throughput, however, tells a different story. The MI350P reports 0 MPixel/s, which is consistent with a compute-focused accelerator that lacks traditional raster output stages. The RTX 4060 AD106 produces 118.1 GPixel/s, making it the only one of the two with any pixel rendering capability in the recorded data.

Memory bandwidth is where the MI350P separates itself most decisively. Its 8.19 TB/s of HBM3e bandwidth is roughly 30 times the 272.0 GB/s available to the RTX 4060 AD106 through its GDDR6 interface. The bus width difference is equally stark: 8192 bits versus 128 bits. Capacity follows the same pattern, with 144 GB on the AMD accelerator compared to 8 GB on the NVIDIA card.

Architecture Differences

The two products come from different architectural lineages with fundamentally different design goals. The MI350P uses the CDNA 4.0 architecture, built on a 3 nm process at TSMC. It is part of the Instinct (MIx) generation, which positions it as a data center accelerator. The RTX 4060 AD106 uses the Ada Lovelace architecture, fabricated on a 5 nm process, also at TSMC, and belongs to the GeForce 40 series for consumer graphics.

Transistor counts diverge sharply. The MI350P integrates 73,000 million transistors across a 1190 mm² die, yielding a transistor density of 61.3M per mm². The RTX 4060 AD106 packs 22,900 million transistors into a 188 mm² die, with a much higher density of 121.8M per mm². The smaller, denser NVIDIA chip reflects its consumer orientation, while the enormous AMD die prioritizes compute throughput and memory capacity over area efficiency.

Shader resources favor the AMD part heavily. The MI350P contains 8192 shading units and 512 TMUs, with no ROPs listed. The RTX 4060 AD106 carries 3072 shading units, 96 TMUs, and 48 ROPs. The NVIDIA card also includes 24 RT cores and 96 tensor cores, while the MI350P lists no ray tracing or tensor core counts in the database. This aligns with the MI350P's lack of any display outputs, whereas the RTX 4060 AD106 provides 1x HDMI 2.1 and 3x DisplayPort 1.4a.

Clock behavior differs notably. The MI350P runs at a 1000 MHz base and 2200 MHz boost, while the RTX 4060 AD106 starts at 1830 MHz and boosts to 2460 MHz. The NVIDIA card's higher clocks partially compensate for its smaller shader count, but not enough to close the FP32 gap. Memory clocks also differ: the MI350P uses 2000 MHz with 8 Gbps effective transfer, while the RTX 4060 AD106 runs at 2125 MHz with 17 Gbps effective.

API support separates the two completely. The MI350P lists N/A for DirectX, OpenGL, and Vulkan, confirming its role as a compute-only device. The RTX 4060 AD106 supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4, making it fully compatible with graphics workloads and gaming APIs.

The Verdict

The data describes two products with almost no overlap in intended use. The MI350P is a data center accelerator with 144 GB of HBM3e memory, 8.19 TB/s of bandwidth, and no display outputs. It delivers 36.04 TFLOPS of FP32 performance and has no rasterization capability, indicated by its 0 MPixel/s pixel rate and absent API support. The RTX 4060 AD106 is a consumer graphics card with 8 GB of GDDR6, 272.0 GB/s of bandwidth, full graphics API support, and 118.1 GPixel/s of pixel throughput.

For compute-heavy workloads that fit within a single accelerator, the MI350P offers 2.4x the FP32 throughput, 4.8x the texture rate, and 30x the memory bandwidth of the RTX 4060 AD106. Its 600 W TDP and 1000 W suggested PSU reflect the power requirements of that performance. The RTX 4060 AD106, with a 115 W TDP and 300 W suggested PSU, is far more efficient per watt, but the database does not include efficiency metrics, so that comparison remains qualitative.

The RTX 4060 AD106 is the only one of the two with any graphics capability. It has 48 ROPs, 24 RT cores, 96 tensor cores, and three display outputs. The MI350P has none of these features. For any workload involving rendering, ray tracing, or output to a display, the NVIDIA card is the only viable option in this comparison.

The production status field lists the RTX 4060 AD106 as end-of-life, while the MI350P has no recorded status. The release dates place the MI350P in 2026 and the RTX 4060 AD106 in 2024. The AMD part lists Radeon Instinct as its predecessor, while the NVIDIA card's predecessor is GeForce 30 and its successor is GeForce 50.

Specification Differences

The following fields differ between the two products:

• Architecture: CDNA 4.0 (MI350P) versus Ada Lovelace (RTX 4060 AD106)
• Process node: 3 nm versus 5 nm
• Transistors: 73,000 million versus 22,900 million
• Die size: 1190 mm² versus 188 mm²
• Transistor density: 61.3M / mm² versus 121.8M / mm²
• Base clock: 1000 MHz versus 1830 MHz
• Boost clock: 2200 MHz versus 2460 MHz
• Memory clock: 2000 MHz 8 Gbps effective versus 2125 MHz 17 Gbps effective
• Memory size: 144 GB versus 8 GB
• Memory type: HBM3e versus GDDR6
• Memory bus width: 8192 bit versus 128 bit
• Memory bandwidth: 8.19 TB/s versus 272.0 GB/s
• Shading units: 8192 versus 3072
• TMUs: 512 versus 96
• ROPs: 0 versus 48
• RT cores: null versus 24
• Tensor cores: null versus 96
• Pixel rate: 0 MPixel/s versus 118.1 GPixel/s
• Texture rate: 1,126.4 GTexel/s versus 236.2 GTexel/s
• FP32: 36.04 TFLOPS versus 15.11 TFLOPS
• FP16: 36.04 TFLOPS (1:1) versus 15.11 TFLOPS (1:1)
• TDP: 600 W versus 115 W
• Power connector: 1x 16-pin versus 1x 12-pin
• Suggested PSU: 1000 W versus 300 W
• Bus interface: PCIe 5.0 x16 versus PCIe 4.0 x8
• Display outputs: No outputs versus 1x HDMI 2.1, 3x DisplayPort 1.4a
• DirectX: N/A versus 12 Ultimate (12_2)
• OpenGL: N/A versus 4.6
• Vulkan: N/A versus 1.4
• Dimensions: 267 mm x 111 mm x 40 mm versus not listed
• Production status: null versus end-of-life
• Release date: 2026-05-06 versus 2024-03-31
• Predecessor: Radeon Instinct versus GeForce 30
• Successor: null versus GeForce 50

FAQ

Q: Which card has higher FP32 performance?

A: The AMD Instinct MI350P delivers 36.04 TFLOPS, which is 2.4 times the 15.11 TFLOPS of the NVIDIA GeForce RTX 4060 AD106.

Q: How much memory bandwidth does each card provide?

A: The MI350P offers 8.19 TB/s through HBM3e memory across an 8192-bit bus. The RTX 4060 AD106 provides 272.0 GB/s through GDDR6 on a 128-bit bus.

Q: Can either card output video to a display?

A: Only the RTX 4060 AD106 has display outputs, with 1x HDMI 2.1 and 3x DisplayPort 1.4a. The MI350P has no display outputs.

Q: Which card supports DirectX?

A: The RTX 4060 AD106 supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. The MI350P lists N/A for all graphics APIs.

Q: What is the power draw of each card?

A: The MI350P has a 600 W TDP with a 1000 W suggested PSU. The RTX 4060 AD106 has a 115 W TDP with a 300 W suggested PSU.

Q: When was each card released?

A: The MI350P has a release date of 2026-05-06. The RTX 4060 AD106 has a release date of 2024-03-31 and is marked as end-of-life.

Where Each One Wins

The MI350P wins in every compute throughput category recorded in the database. Its FP32 and FP16 performance of 36.04 TFLOPS doubles the RTX 4060 AD106's 15.11 TFLOPS. Texture rate favors the AMD part at 1,126.4 GTexel/s versus 236.2 GTexel/s. Memory capacity, bandwidth, and bus width are all decisively in the MI350P's favor, with 144 GB versus 8 GB, 8.19 TB/s versus 272.0 GB/s, and 8192 bits versus 128 bits respectively. The MI350P also uses a PCIe 5.0 x16 interface, while the RTX 4060 AD106 uses PCIe 4.0 x8.

The RTX 4060 AD106 wins in all graphics-oriented categories. It has 48 ROPs and a pixel rate of 118.1 GPixel/s, while the MI350P has 0 ROPs and a 0 MPixel/s pixel rate. The NVIDIA card includes 24 RT cores and 96 tensor cores, neither of which are listed for the AMD accelerator. The RTX 4060 AD106 supports DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4, while the MI350P supports none of these APIs. The NVIDIA card provides display outputs, the AMD card provides none.

Clock speeds favor the RTX 4060 AD106, with a 1830 MHz base and 2460 MHz boost against the MI350P's 1000 MHz base and 2200 MHz boost. The NVIDIA card is also substantially smaller in die area at 188 mm² versus 1190 mm², and has a much lower TDP at 115 W versus 600 W.

The use case split is clean. The MI350P is for compute workloads that need massive memory capacity, extreme bandwidth, and high FP32 throughput without any display or graphics API requirements. The RTX 4060 AD106 is for rendering, ray tracing, tensor acceleration, and any task that requires output to a monitor or compatibility with consumer graphics APIs. The two products occupy separate segments of the market, and neither can substitute for the other in its respective domain.