AMD Instinct MI300A vs NVIDIA RTX PRO 4500 Blackwell Comparison

Where Each One Wins

The recorded data separates these two accelerators into entirely different performance domains. The AMD Instinct MI300A shows no benchmark entries in the database, meaning its measured performance profile is not directly comparable across the same test suite. Its percentile rank against all GPUs sits at 50, indicating a mid-pack standing based on the available aggregate data, though the absence of direct benchmark scores means this rank derives from other recorded metrics rather than the standard test set.

The NVIDIA RTX PRO 4500 Blackwell, by contrast, has a full benchmark record. Its 3DMark Steel Nomad DX12 score of 7025 places it in a strong position for modern DirectX 12 workloads. The Geekbench Vulkan result of 221768 demonstrates substantial compute throughput under the Vulkan API. PassMark tests show a G3D score of 33360, a GPU compute score of 19255, and individual DirectX tests at 397 for DX9, 320 for DX11, 204 for DX10, and 119 for DX12. The 2D score of 1336 reflects modest rasterization for desktop-style tasks.

The wins break down by workload type. The AMD part, with its 128 GB HBM3 memory and 5.32 TB/s bandwidth, targets capacity and bandwidth-bound problems. The NVIDIA part, with its 82 RT cores and 328 tensor cores, targets graphics, ray tracing, and AI inference. The RTX PRO 4500 Blackwell records a 76th percentile standing against all GPUs, while the MI300A sits at the 50th percentile. In the nearest rival comparison for the NVIDIA card, the TITAN RTX sits 0.5% higher in average score, while the GRID M60-1Q and Quadro M5000 each sit 1% lower, and the Intel Arc Pro A30M sits 1.1% lower.

Architecture Differences

The two chips come from different architectural lineages. The AMD Instinct MI300A uses the Aqua Vanjaram chip built on CDNA 3.0, fabricated on a 5 nm process at TSMC. The transistor count reaches 153,000 million across a die size of 1017 mm², yielding a transistor density of 150.4 million transistors per square millimeter. The NVIDIA RTX PRO 4500 Blackwell uses the GB203 chip built on Blackwell 2.0, also on a 5 nm TSMC process, but with 45,600 million transistors on a 378 mm² die, giving a density of 120.6 million transistors per square millimeter.

The AMD chip packs 14,592 shading units, 912 texture mapping units, and zero ROPs. Its pixel rate is recorded as 0 MPixel/s, which aligns with its design as a compute accelerator without traditional display output. The NVIDIA chip carries 10,496 shading units, 328 TMUs, 112 ROPs, 82 RT cores, and 328 tensor cores. Its pixel rate reaches 269.6 GPixel/s, and its texture rate hits 789.5 GTexel/s.

Memory architecture diverges sharply. The MI300A uses 128 GB of HBM3 across an 8192-bit bus, delivering 5.32 TB/s of bandwidth. The RTX PRO 4500 Blackwell uses 32 GB of GDDR7 across a 256-bit bus, delivering 896.0 GB/s. Clock behavior also differs: the AMD part runs at a 1000 MHz base and 2100 MHz boost, while the NVIDIA part starts at 1635 MHz base and reaches 2407 MHz boost. The memory clocks record 1300 MHz with 5.2 Gbps effective for the AMD, and 1750 MHz with 28 Gbps effective for the NVIDIA.

The API support separates them completely. The MI300A lists no API support for DirectX, OpenGL, or Vulkan, consistent with its compute-first orientation. The RTX PRO 4500 Blackwell supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. Display outputs also differ: the AMD module has no outputs, while the NVIDIA card provides 4x DisplayPort 2.1b.

Head-to-Head Benchmarks

Direct benchmark comparisons between the two parts are limited because the AMD Instinct MI300A has no recorded scores in the standard benchmark suite. The head-to-head benchmark list is empty, and the win counts show zero for both sides. This means the analysis must rely on the available data for the NVIDIA card and the architectural specifications for the AMD card.

The NVIDIA RTX PRO 4500 Blackwell delivers a 3DMark Steel Nomad DX12 score of 7025. This result indicates strong performance in modern DX12 gaming and graphics workloads. The Geekbench Vulkan score of 221768 shows substantial throughput for compute tasks exposed through Vulkan. PassMark G3D at 33360 and GPU compute at 19255 provide additional reference points for general 3D rendering and compute performance.

The nearest rival data for the NVIDIA card reveals its competitive position. The TITAN RTX averages 31676, which is 0.5% higher than the RTX PRO 4500 Blackwell average of 31532. The GRID M60-1Q averages 31220, sitting 1% lower. The Quadro M5000 also averages 31206, 1% lower. The Intel Arc Pro A30M averages 31894, which is 1.1% lower than the NVIDIA card. These deltas show the RTX PRO 4500 Blackwell clustered tightly with a set of established workstation and professional GPUs, within roughly one percentage point in either direction.

For the AMD part, the lack of benchmark data means no direct score comparisons are possible. The recorded specifications, however, indicate a different performance envelope. The MI300A's FP32 throughput of 61.29 TFLOPS exceeds the NVIDIA card's 50.53 TFLOPS. The texture rate of 1,915.2 GTexel/s on the AMD card more than doubles the NVIDIA's 789.5 GTexel/s. The memory bandwidth advantage is even larger: 5.32 TB/s versus 896.0 GB/s, a factor of nearly six. These figures suggest the AMD part would dominate memory-bound and texture-heavy compute workloads, while the NVIDIA part holds the advantage in graphics rendering, ray tracing, and any workload requiring ROP output.

FAQ

Q: Which card has higher FP32 compute throughput?

A: The AMD Instinct MI300A records 61.29 TFLOPS of FP32 performance, while the NVIDIA RTX PRO 4500 Blackwell records 50.53 TFLOPS. The AMD part leads by roughly 10.76 TFLOPS.

Q: What memory configurations do the two cards use?

A: The AMD Instinct MI300A uses 128 GB of HBM3 on an 8192-bit bus with 5.32 TB/s bandwidth. The NVIDIA RTX PRO 4500 Blackwell uses 32 GB of GDDR7 on a 256-bit bus with 896.0 GB/s bandwidth.

Q: Does the AMD Instinct MI300A support graphics APIs?

A: The database records no support for DirectX, OpenGL, or Vulkan on the MI300A. Its API fields are listed as N/A. The NVIDIA RTX PRO 4500 Blackwell supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4.

Q: How does the NVIDIA card compare to its nearest rivals?

A: The RTX PRO 4500 Blackwell averages 31532 in benchmark scores. The NVIDIA TITAN RTX scores 0.5% higher at 31676. The GRID M60-1Q and Quadro M5000 each score 1% lower at 31220 and 31206 respectively. The Intel Arc Pro A30M scores 1.1% lower at 31894.

Q: What are the power requirements for each card?

A: The AMD Instinct MI300A has a TDP of 750 W and a suggested power supply of 1150 W. The NVIDIA RTX PRO 4500 Blackwell has a TDP of 200 W and a suggested power supply of 550 W.

Q: Which card has ray tracing and tensor cores?

A: The NVIDIA RTX PRO 4500 Blackwell includes 82 RT cores and 328 tensor cores. The AMD Instinct MI300A lists no RT cores or tensor cores in its specification record.

Specification Differences

The two cards differ across nearly every major specification field. The AMD Instinct MI300A uses the Aqua Vanjaram chip with CDNA 3.0 architecture, while the NVIDIA RTX PRO 4500 Blackwell uses the GB203 chip with Blackwell 2.0 architecture. Both use TSMC's 5 nm process, but the AMD die spans 1017 mm² with 153,000 million transistors, while the NVIDIA die spans 378 mm² with 45,600 million transistors.

Clock speeds differ substantially. The MI300A runs at 1000 MHz base and 2100 MHz boost. The RTX PRO 4500 Blackwell runs at 1635 MHz base and 2407 MHz boost. Memory clocks also differ: 1300 MHz with 5.2 Gbps effective on the AMD, versus 1750 MHz with 28 Gbps effective on the NVIDIA.

The shading unit counts separate the compute architectures. The AMD part carries 14,592 shading units and 912 TMUs, with zero ROPs. The NVIDIA part carries 10,496 shading units, 328 TMUs, and 112 ROPs. The AMD part has no RT or tensor cores, while the NVIDIA part has 82 RT cores and 328 tensor cores.

Memory specifications show the largest gap. The MI300A offers 128 GB of HBM3 with an 8192-bit bus and 5.32 TB/s bandwidth. The RTX PRO 4500 Blackwell offers 32 GB of GDDR7 with a 256-bit bus and 896.0 GB/s bandwidth. The bandwidth difference is roughly 5.9x in favor of the AMD part.

Rasterization and texture throughput favor the AMD part in texture rate, but the NVIDIA part in pixel rate. The MI300A records a texture rate of 1,915.2 GTexel/s but a pixel rate of 0 MPixel/s. The RTX PRO 4500 Blackwell records a texture rate of 789.5 GTexel/s and a pixel rate of 269.6 GPixel/s.

Power and physical characteristics diverge as well. The MI300A draws 750 W TDP with no power connectors, suggesting an OAM module design, and requires a 1150 W suggested power supply. The RTX PRO 4500 Blackwell draws 200 W TDP, uses a single 16-pin connector, and requires a 550 W suggested power supply. The NVIDIA card is a dual-slot design measuring 267 mm in length, 111 mm in height, and 40 mm in width, with 4x DisplayPort 2.1b outputs. The AMD module has no display outputs.

Release timing and status also differ. The AMD Instinct MI300A was released on 2023-12-05, while the NVIDIA RTX PRO 4500 Blackwell was released on 2025-03-17. The NVIDIA card has an active production status, while the AMD card's production status is not recorded. The NVIDIA card's predecessor is listed as Workstation Ada, while the AMD card's predecessor is Radeon Instinct.