AMD Instinct MI300A vs NVIDIA RTX PRO 4000 Blackwell SFF Comparison

Where Each One Wins

The AMD Instinct MI300A and NVIDIA RTX PRO 4000 Blackwell SFF occupy entirely different segments of the accelerator market, and the benchmark data reflects that separation. The MI300A has no recorded benchmark scores in the database, while the RTX PRO 4000 Blackwell SFF has a single 3DMark Steel Nomad DX12 score of 2910. This means the NVIDIA card wins the only directly comparable graphics workload by default, but the AMD part is not designed for that task at all.

The MI300A is an OAM module with no display outputs and no graphics API support. Its DirectX, OpenGL, and Vulkan support are all listed as N/A. The RTX PRO 4000 Blackwell SFF, by contrast, supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4, and it drives four mini-DisplayPort 2.1b outputs. The data shows a clean split: the NVIDIA part wins every graphics-oriented use case, while the AMD part targets compute workloads where graphics output is irrelevant.

The RTX PRO 4000 Blackwell SFF sits in the 19th percentile of all GPUs, with an average benchmark score of 2910. Its nearest rivals are all NVIDIA consumer and workstation cards. The GeForce RTX 4060 Ti 16 GB scores 2907, which puts it 0.1% behind the RTX PRO 4000. The GeForce RTX 4060 Ti 8 GB scores 2913, 0.1% ahead. The Quadro P600 scores 2923, 0.4% ahead, and the GeForce RTX 4010 scores 2893, 0.6% behind. This cluster of scores, all within a 1% band, indicates the RTX PRO 4000 delivers performance essentially identical to the RTX 4060 Ti family in this particular test.

The MI300A has no nearest rivals listed and no benchmark entries. Its percentile versus all GPUs is 50, which is a neutral placeholder rather than a measured competitive position. The data cannot support claims of superiority for the MI300A in any tested workload because no test results exist for it.

Architecture Differences

The two accelerators share a 5 nm process node from TSMC but diverge sharply in nearly every other architectural characteristic. The MI300A uses the CDNA 3.0 architecture and the Aqua Vanjaram chip, while the RTX PRO 4000 uses Blackwell 2.0 and the GB203 chip. The MI300A is part of AMD's Instinct (MIx) generation, released in December 2023, with the Radeon Instinct as its predecessor. The RTX PRO 4000 belongs to NVIDIA's Blackwell PRO W (x000) generation, released in August 2025, with Workstation Ada as its predecessor.

Transistor counts reveal the scale difference. The MI300A packs 153,000 million transistors on a 1017 mm² die, giving a transistor density of 150.4 million per mm². The RTX PRO 4000 has 45,600 million transistors on a 378 mm² die, for a density of 120.6 million per mm². The MI300A uses roughly 3.36 times the transistor budget and 2.69 times the die area.

Memory architecture follows the same pattern. The MI300A uses 128 GB of HBM3 across a 8192-bit bus, producing 5.32 TB/s of bandwidth. The RTX PRO 4000 uses 24 GB of GDDR7 across a 192-bit bus, producing 432.0 GB/s. The AMD part has more than 5.3 times the memory capacity and more than 12.3 times the memory bandwidth. The MI300A's memory clock is listed at 1300 MHz with 5.2 Gbps effective, while the RTX PRO 4000's memory clock is 1125 MHz with 18 Gbps effective. The GDDR7 technology on the NVIDIA card runs at a higher effective data rate per pin, but the enormous bus width of the AMD part dominates aggregate bandwidth.

Compute resources also differ fundamentally. The MI300A has 14,592 shading units, 912 texture mapping units, and zero ROPs. Its pixel rate is listed as 0 MPixel/s, which confirms it cannot rasterize. The RTX PRO 4000 has 8,960 shading units, 280 TMUs, 96 ROPs, 70 ray tracing cores, and 280 tensor cores. Its pixel rate is 128.8 GPixel/s and its texture rate is 375.8 GTexel/s. The MI300A's texture rate is 1,915.2 GTexel/s, which is about 5.1 times the NVIDIA part's texture throughput.

Clock behavior differs as well. The MI300A runs at a 1000 MHz base clock and a 2100 MHz boost clock. The RTX PRO 4000 runs at a 405 MHz base clock and a 1342 MHz boost clock. The AMD part's higher clocks, combined with its larger shading unit count, produce an FP32 throughput of 61.29 TFLOPS versus 24.05 TFLOPS for the NVIDIA card. The RTX PRO 4000 has a 1:1 FP16 to FP32 ratio at 24.05 TFLOPS, while the MI300A's FP16 figure is not listed.

Head-to-Head Benchmarks

The database contains no head-to-head benchmark entries between these two accelerators. The only recorded test result belongs to the RTX PRO 4000 Blackwell SFF: a 3DMark Steel Nomad DX12 score of 2910. The MI300A has no benchmark scores in the database, which means the comparison rests on the NVIDIA card's measured data and the AMD card's architectural specifications.

Looking at the RTX PRO 4000's nearest rivals provides context for its measured score. The GeForce RTX 4060 Ti 16 GB averages 2907, which is 0.1% below the RTX PRO 4000. The GeForce RTX 4060 Ti 8 GB averages 2913, which is 0.1% above it. The Quadro P600 averages 2923, 0.4% above. The GeForce RTX 4010 averages 2893, 0.6% below. The RTX PRO 4000's 2910 score places it squarely in the middle of this group, with a spread of only 30 points between the lowest and highest scores. This tight clustering suggests the Steel Nomad test is not sensitive to the architectural differences among these cards, or that all four deliver comparable rasterization performance.

The MI300A's FP32 throughput of 61.29 TFLOPS versus the RTX PRO 4000's 24.05 TFLOPS indicates a 2.55 times advantage in raw single-precision compute. The MI300A's texture rate of 1,915.2 GTexel/s versus 375.8 GTexel/s represents a 5.10 times advantage. Its memory bandwidth of 5.32 TB/s versus 432.0 GB/s represents a 12.31 times advantage. These are architectural specifications, not measured benchmark results, but they quantify the gulf between a 750 W OAM compute accelerator and a 70 W dual-slot workstation card.

Power consumption reinforces the positioning. The MI300A has a TDP of 750 W and suggests a 1150 W power supply. The RTX PRO 4000 has a TDP of 70 W and suggests a 250 W power supply. The AMD part consumes more than 10.7 times the power of the NVIDIA part. Neither card uses external power connectors; the MI300A draws its power through the OAM module interface, while the RTX PRO 4000 draws power through its PCIe 5.0 x8 slot.

FAQ

Q: Which accelerator has the higher measured benchmark score?

A: The RTX PRO 4000 Blackwell SFF has a recorded 3DMark Steel Nomad DX12 score of 2910. The MI300A has no benchmark scores in the database.

Q: How does the RTX PRO 4000 compare to its nearest rivals?

A: It scores 2910, which is 0.1% above the GeForce RTX 4060 Ti 16 GB (2907), 0.1% below the GeForce RTX 4060 Ti 8 GB (2913), 0.4% below the Quadro P600 (2923), and 0.6% above the GeForce RTX 4010 (2893).

Q: Which part has more memory bandwidth?

A: The MI300A has 5.32 TB/s from 128 GB of HBM3 on a 8192-bit bus. The RTX PRO 4000 has 432.0 GB/s from 24 GB of GDDR7 on a 192-bit bus.

Q: Can the MI300A render graphics?

A: No. Its pixel rate is 0 MPixel/s, it has zero ROPs, no display outputs, and its DirectX, OpenGL, and Vulkan APIs are all listed as N/A.

Q: What is the power requirement difference?

A: The MI300A has a 750 W TDP with a suggested 1150 W power supply. The RTX PRO 4000 has a 70 W TDP with a suggested 250 W power supply.

Q: Which part has more FP32 compute throughput?

A: The MI300A delivers 61.29 TFLOPS versus 24.05 TFLOPS for the RTX PRO 4000, a 2.55 times advantage for the AMD part.

Specification Differences

The two accelerators differ in nearly every specification field. Process node is the same (5 nm, TSMC), but everything else diverges.

The MI300A uses the CDNA 3.0 architecture with the Aqua Vanjaram chip, 153,000 million transistors, a 1017 mm² die, and a transistor density of 150.4M per mm². The RTX PRO 4000 uses Blackwell 2.0 with the GB203 chip, 45,600 million transistors, a 378 mm² die, and a density of 120.6M per mm².

Clock speeds: the MI300A runs at 1000 MHz base and 2100 MHz boost. The RTX PRO 4000 runs at 405 MHz base and 1342 MHz boost. Memory clocks are 1300 MHz (5.2 Gbps effective) for the AMD part and 1125 MHz (18 Gbps effective) for the NVIDIA part.

Memory: the MI300A has 128 GB of HBM3 on a 8192-bit bus with 5.32 TB/s bandwidth. The RTX PRO 4000 has 24 GB of GDDR7 on a 192-bit bus with 432.0 GB/s bandwidth.

Compute units: the MI300A has 14,592 shading units, 912 TMUs, and zero ROPs. The RTX PRO 4000 has 8,960 shading units, 280 TMUs, 96 ROPs, 70 ray tracing cores, and 280 tensor cores.

Rates: the MI300A has 0 MPixel/s pixel rate, 1,915.2 GTexel/s texture rate, and 61.29 TFLOPS FP32. The RTX PRO 4000 has 128.8 GPixel/s pixel rate, 375.8 GTexel/s texture rate, 24.05 TFLOPS FP32, and 24.05 TFLOPS FP16 (1:1).

Power and physical: the MI300A has a 750 W TDP, OAM Module slot width, no power connectors, and a suggested 1150 W PSU. The RTX PRO 4000 has a 70 W TDP, dual-slot width, no power connectors, a suggested 250 W PSU, and dimensions of 167 mm by 69 mm by 40 mm.

Interfaces and outputs: the MI300A uses PCIe 5.0 x16 and has no display outputs. The RTX PRO 4000 uses PCIe 5.0 x8 and has 4x mini-DisplayPort 2.1b outputs.

API support: the MI300A lists N/A for DirectX, OpenGL, and Vulkan. The RTX PRO 4000 supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4.

Release timing: the MI300A launched in December 2023 with the Radeon Instinct as predecessor. The RTX PRO 4000 launched in August 2025 with Workstation Ada as predecessor and an Active production status.

The Verdict

The data separates these two accelerators into distinct roles. The MI300A is a 750 W OAM compute module with 128 GB of HBM3, 5.32 TB/s of memory bandwidth, 61.29 TFLOPS FP32, and no graphics capability whatsoever. The RTX PRO 4000 Blackwell SFF is a 70 W dual-slot workstation card with 24 GB of GDDR7, 432.0 GB/s of bandwidth, 24.05 TFLOPS FP32, full graphics API support, ray tracing cores, tensor cores, and four display outputs.

The recorded benchmark results favor the NVIDIA part only in the sense that it has recorded results. Its 2910 Steel Nomad score places it within 0.6% of the GeForce RTX 4060 Ti family and the Quadro P600, all clustered between 2893 and 2923. The MI300A has no measured scores, so its performance cannot be compared directly in any benchmark.

Architecturally, the MI300A holds decisive advantages in compute throughput, texture rate, memory capacity, and memory bandwidth. It holds these advantages while consuming 750 W, occupying an OAM module form factor, and offering no display output. The RTX PRO 4000 counters with graphics features the AMD part lacks entirely: ROPs, ray tracing cores, tensor cores, a pixel rate of 128.8 GPixel/s, and full DirectX, OpenGL, and Vulkan support.

For workloads that require rasterization, ray tracing, or display output, the RTX PRO 4000 is the only viable choice between the two. For workloads that require maximum memory bandwidth, raw FP32 throughput, or large memory capacity in a compute-only context, the MI300A's specifications show clear superiority, though no benchmark data confirms it. The 19th percentile ranking for the RTX PRO 4000 versus the neutral 50th percentile placeholder for the MI300A does not change this analysis, because the AMD part's percentile is unmeasured rather than earned. The verdict follows the data: graphics workloads go to the NVIDIA card, compute-scale workloads go to the AMD module.