AMD Instinct MI300A vs NVIDIA RTX PRO 4000 Blackwell Comparison

The Verdict

The database contains no head-to-head benchmark scores between the AMD Instinct MI300A and the NVIDIA RTX PRO 4000 Blackwell, and the AMD part has no recorded benchmark results of its own. Its percentile rank of 50 against all GPUs is the only relative placement available, while the NVIDIA card sits at the 72nd percentile. The MI300A is a compute accelerator with no display outputs, no graphics API support, and a zero pixel rate; it is not a graphics card in any conventional sense. The RTX PRO 4000 Blackwell is a workstation GPU with full DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4 support, plus four DisplayPort outputs. For anyone building a workstation that must render, display, or run standard graphics workloads, the RTX PRO 4000 is the only viable choice from this data. For large-scale compute workloads that do not require graphics output, the MI300A offers substantially more memory and raw FP32 throughput, but no benchmark evidence exists in the database to confirm its performance level. The data supports picking the RTX PRO 4000 for interactive and graphics work, and the MI300A only for specialized compute deployments where its memory capacity and bandwidth are the deciding factors.

Where Each One Wins

The NVIDIA RTX PRO 4000 Blackwell wins in every recorded benchmark category because it is the only part with benchmark entries. Its PassMark G3D score of 28427 places it slightly below the AMD Radeon RX 6700 XT (27425, delta -1.1%), the NVIDIA GeForce RTX 4070 Mobile (27435, delta -1.1%), and the NVIDIA GeForce RTX 3090 (27565, delta -1.6%), while it beats the NVIDIA RTX A4000 (26683, delta 1.7%). The Geekbench Vulkan score of 194168 and the 3DMark Steel Nomad DX12 score of 4648 indicate solid graphics performance. The MI300A has no wins in any benchmark category because no benchmark scores exist for it. Its advantages are purely architectural: 128 GB of HBM3 memory versus 24 GB of GDDR7, a 8192-bit memory bus versus 192-bit, and 5.32 TB/s of memory bandwidth versus 672.0 GB/s. Those are not benchmark wins, but they define the use case split. The MI300A suits problems that need massive memory capacity and bandwidth, such as large model inference or simulation data sets. The RTX PRO 4000 suits every task that requires graphics output, API support, or a conventional workstation form factor.

Architecture Differences

The MI300A uses the Aqua Vanjaram chip on CDNA 3.0 architecture, built on a 5 nm TSMC process with 153,000 million transistors on a 1017 mm² die, giving a transistor density of 150.4M per mm². The RTX PRO 4000 Blackwell uses the GB203 chip on Blackwell 2.0 architecture, also on 5 nm TSMC, but with 45,600 million transistors on a 378 mm² die, for a density of 120.6M per mm². The MI300A has 14,592 shading units, 912 texture mapping units, and zero ROPs, which explains its 0 MPixel/s pixel rate. The RTX PRO 4000 has 8,960 shading units, 280 TMUs, 96 ROPs, 70 RT cores, and 280 tensor cores. The MI300A lists no RT or tensor core counts. Clock speeds differ: the MI300A runs at 1000 MHz base and 2100 MHz boost, while the RTX PRO 4000 runs at 1230 MHz base and 2055 MHz boost. Memory clocks are 1300 MHz (5.2 Gbps effective) for the MI300A versus 1750 MHz (28 Gbps effective) for the RTX PRO 4000. The MI300A has no display outputs and no graphics API support (DirectX, OpenGL, Vulkan all N/A). The RTX PRO 4000 has four DisplayPort 2.1b outputs and full API coverage. Power requirements differ sharply: the MI300A has a 750 W TDP with a suggested 1150 W PSU and no power connectors (OAM Module form factor), while the RTX PRO 4000 has a 140 W TDP with a single 16-pin connector and a suggested 300 W PSU. The MI300A uses PCIe 5.0 x16, as does the RTX PRO 4000. The MI300A ships as an OAM module, the RTX PRO 4000 as a single-slot card measuring 241 mm by 111 mm by 20 mm. Release dates are December 5, 2023 for the MI300A and March 17, 2025 for the RTX PRO 4000. The MI300A's predecessor is Radeon Instinct; the RTX PRO 4000's predecessor is Workstation Ada.

FAQ

Q: Which card has more memory bandwidth?

A: The AMD Instinct MI300A has 5.32 TB/s of bandwidth from its 128 GB HBM3 memory on an 8192-bit bus. The NVIDIA RTX PRO 4000 Blackwell has 672.0 GB/s from 24 GB GDDR7 on a 192-bit bus.

Q: Can the MI300A drive a display?

A: No. The MI300A has no display outputs and lists DirectX, OpenGL, and Vulkan as N/A. The RTX PRO 4000 has four DisplayPort 2.1b outputs and supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4.

Q: How do the transistor counts compare?

A: The MI300A has 153,000 million transistors on a 1017 mm² die, while the RTX PRO 4000 has 45,600 million transistors on a 378 mm² die. The MI300A's density is 150.4M per mm² versus 120.6M per mm² for the RTX PRO 4000.

Q: What is the form factor difference?

A: The MI300A is an OAM Module with no power connectors and a 750 W TDP, requiring a suggested 1150 W power supply. The RTX PRO 4000 is a single-slot card with one 16-pin connector, a 140 W TDP, and a suggested 300 W power supply.

Q: Which card has a higher boost clock?

A: The MI300A boosts to 2100 MHz, which is higher than the RTX PRO 4000's 2055 MHz boost. However, the RTX PRO 4000 has a higher base clock at 1230 MHz versus 1000 MHz for the MI300A.

Q: How does the RTX PRO 4000 compare to its nearest rivals?

A: Its PassMark G3D score of 28427 is 1.1% below the RX 6700 XT (27425), 1.1% below the RTX 4070 Mobile (27435), 1.6% below the RTX 3090 (27565), and 1.7% above the RTX A4000 (26683).

Head-to-Head Benchmarks

No head-to-head benchmark records exist in the database for these two products, so a direct score comparison is impossible. The only benchmark data available belongs to the NVIDIA RTX PRO 4000 Blackwell. Its 3DMark Steel Nomad DX12 score is 4648. Its Geekbench Vulkan score is 194168. PassMark results include 28427 in G3D, 14805 in GPU compute, 1265 in G2D, 354 in DirectX 9, 276 in DirectX 11, 173 in DirectX 10, and 97 in DirectX 12. The AMD Instinct MI300A has an average benchmark score of 0 and no entries in the benchmark list. Its percentile rank of 50 places it below the RTX PRO 4000's 72nd percentile, but this ranking is based on the MI300A's absence of recorded performance data rather than measured results. The MI300A's FP32 throughput is 61.29 TFLOPS versus 36.83 TFLOPS for the RTX PRO 4000, and its texture rate is 1,915.2 GTexel/s versus 575.4 GTexel/s. The RTX PRO 4000 has a pixel rate of 197.3 GPixel/s, while the MI300A has none. These are specification differences, not benchmark outcomes. The only conclusion the data supports is that the RTX PRO 4000 has measurable graphics and compute performance across standard benchmarks, while the MI300A has no such measurements. The MI300A's 5.32 TB/s memory bandwidth is 7.9 times the RTX PRO 4000's 672.0 GB/s, and its 128 GB memory capacity is more than five times the 24 GB on the NVIDIA card. Those margins are large, but without benchmark scores, they cannot be translated into performance deltas.

Specification Differences

| Specification | AMD Instinct MI300A | NVIDIA RTX PRO 4000 Blackwell |

|---|---|---|

| Architecture | CDNA 3.0 | Blackwell 2.0 |

| Process node | 5 nm | 5 nm |

| Foundry | TSMC | TSMC |

| Transistors | 153,000 million | 45,600 million |

| Die size | 1017 mm² | 378 mm² |

| Transistor density | 150.4M / mm² | 120.6M / mm² |

| Base clock | 1000 MHz | 1230 MHz |

| Boost clock | 2100 MHz | 2055 MHz |

| Memory clock | 1300 MHz 5.2 Gbps effective | 1750 MHz 28 Gbps effective |

| Memory size | 128 GB | 24 GB |

| Memory type | HBM3 | GDDR7 |

| Memory bus width | 8192 bit | 192 bit |

| Memory bandwidth | 5.32 TB/s | 672.0 GB/s |

| Shading units | 14592 | 8960 |

| TMUs | 912 | 280 |

| ROPs | 0 | 96 |

| RT cores | null | 70 |

| Tensor cores | null | 280 |

| Pixel rate | 0 MPixel/s | 197.3 GPixel/s |

| Texture rate | 1,915.2 GTexel/s | 575.4 GTexel/s |

| FP32 | 61.29 TFLOPS | 36.83 TFLOPS |

| FP16 | null | 36.83 TFLOPS (1:1) |

| TDP | 750 W | 140 W |

| Slot width | OAM Module | Single-slot |

| Power connectors | None | 1x 16-pin |

| Suggested PSU | 1150 W | 300 W |

| Bus interface | PCIe 5.0 x16 | PCIe 5.0 x16 |

| Display outputs | No outputs | 4x DisplayPort 2.1b |

| DirectX | N/A | 12 Ultimate (12_2) |

| OpenGL | N/A | 4.6 |

| Vulkan | N/A | 1.4 |

| Dimensions | N/A | 241 mm x 111 mm x 20 mm |

| Release date | 2023-12-05 | 2025-03-17 |

| Production status | null | Active |

| Predecessor | Radeon Instinct | Workstation Ada |

| Percentile vs all GPUs | 50 | 72 |

| Average benchmark score | 0 | 27135 |