AMD Radeon RX 6600M vs NVIDIA Quadro M4000M Comparison

Head-to-Head Benchmarks

The recorded data for the AMD Radeon RX 6600M and the NVIDIA Quadro M4000M includes two direct comparison points, and in both cases the AMD part takes the win. In the Geekbench OpenCL test, the RX 6600M scores 67,765 while the Quadro M4000M manages 19,989, a delta of 239%. That is a substantial gap, placing the AMD chip at more than three times the performance of the older NVIDIA part in this compute workload. The Geekbench Vulkan result is even more lopsided: the RX 6600M records 73,740 against 20,971 for the Quadro M4000M, a 251.6% advantage. Both tests point to the same conclusion: the Radeon RX 6600M is in a different performance class entirely when these two are placed side by side.

The average benchmark score for the RX 6600M sits at 23,273, which aligns closely with its nearest rivals in the database, including the AMD Radeon R9 M290X at 23,276 (a 0% delta) and the AMD Radeon Pro Vega 16 at 23,250 (a 0.1% delta). The Quadro M4000M, by contrast, has an average score of 20,480, putting it near the NVIDIA GeForce RTX 3070 Mobile (20,534, a -0.3% delta) and the Intel Arc B570 (20,556, a -0.4% delta). So while the RX 6600M sits comfortably in the 68th percentile of all GPUs in the database, the Quadro M4000M rests at the 65th percentile. The percentile gap is modest, but the head-to-head deltas are not.

Where Each One Wins

Based on the two available head-to-head benchmarks, the AMD Radeon RX 6600M wins both the compute-oriented OpenCL test and the graphics-oriented Vulkan test. The wins are not narrow: 239% in OpenCL and 251.6% in Vulkan. This suggests the RX 6600M is the pick for any workload that leverages either of these APIs, whether that be general compute, rendering, or modern game engines that expose Vulkan paths. The Quadro M4000M, on the other hand, does not hold a single victory in the recorded comparisons. Its wins column is empty, with zero benchmark wins against two for the RX 6600M.

The broader benchmark suite for the RX 6600M shows strength across multiple APIs: it records a PassMark G3D score of 13,929, a Geekbench Metal score of 92,237, and a PassMark GPU Compute score of 5,646. The Quadro M4000M only has two recorded benchmarks (OpenCL and Vulkan), so its profile is thinner. For users looking at DirectX workloads, the RX 6600M supports DirectX 12 Ultimate (12_2), while the Quadro M4000M tops out at DirectX 12 (12_1). This difference matters for newer titles that rely on DirectX 12 Ultimate features. The RX 6600M also posts a PassMark DirectX 12 score of 52, a DirectX 11 score of 136, and a DirectX 9 score of 184, giving it a full spread of legacy and modern API support.

The Verdict

The data is unambiguous: the AMD Radeon RX 6600M is the stronger GPU in every measured category. It wins both head-to-head benchmarks by margins of 239% and 251.6%, carries a higher average benchmark score (23,273 vs 20,480), and sits at a higher percentile (68 vs 65). The architecture gap is the primary driver: the RX 6600M is built on RDNA 2.0 at 7 nm, while the Quadro M4000M uses Maxwell 2.0 at 28 nm. That process difference alone explains much of the performance delta, as does the RX 6600M's larger transistor count (11,060 million vs 5,200 million) and higher clock speeds (base 2068 MHz vs 975 MHz, boost 2416 MHz vs 1013 MHz).

For a user choosing between these two, the RX 6600M is the obvious choice for any modern workload, especially those that use Vulkan or OpenCL. The Quadro M4000M, with its 4 GB GDDR5 memory and 160.4 GB/s bandwidth, may still be adequate for older or lighter tasks, but it cannot keep pace in compute-heavy scenarios. The RX 6600M also offers 8 GB GDDR6 memory with 224.0 GB/s bandwidth, double the capacity and 39.7% more bandwidth. The verdict from the recorded data is straightforward: pick the RX 6600M unless the specific workload is so old or so niche that the Quadro M4000M's feature set is somehow preferable, but the benchmarks do not provide any such case.

FAQ

Q: Which GPU has a higher Geekbench OpenCL score?

A: The AMD Radeon RX 6600M scores 67,765, while the NVIDIA Quadro M4000M scores 19,989, giving the AMD part a 239% advantage.

Q: What is the average benchmark score for each GPU?

A: The RX 6600M has an average benchmark score of 23,273, and the Quadro M4000M has an average score of 20,480.

Q: How do the two compare in Vulkan performance?

A: The RX 6600M records 73,740 in Geekbench Vulkan, versus 20,971 for the Quadro M4000M, a delta of 251.6% in favor of AMD.

Q: What are the memory specifications for each?

A: The RX 6600M has 8 GB of GDDR6 memory on a 128-bit bus with 224.0 GB/s bandwidth. The Quadro M4000M has 4 GB of GDDR5 memory on a 256-bit bus with 160.4 GB/s bandwidth.

Q: Which GPU has a higher boost clock?

A: The RX 6600M boosts to 2416 MHz, while the Quadro M4000M boosts to 1013 MHz.

Q: Do both GPUs support Vulkan 1.4?

A: Yes, both the RX 6600M and the Quadro M4000M list Vulkan 1.4 support in their API specifications. However, the RX 6600M also supports DirectX 12 Ultimate (12_2), while the Quadro M4000M supports DirectX 12 (12_1).

Architecture Differences

The RX 6600M is built on the RDNA 2.0 architecture using TSMC's 7 nm process, packing 11,060 million transistors into a 237 mm² die, yielding a transistor density of 46.7M per mm². The Quadro M4000M uses the Maxwell 2.0 architecture on a 28 nm process, with 5,200 million transistors on a 398 mm² die, for a density of 13.1M per mm². The RX 6600M also features 28 ray tracing cores, a capability entirely absent from the Quadro M4000M, which has no RT cores listed. The RX 6600M has 1792 shading units, 112 texture mapping units, and 64 ROPs, while the Quadro M4000M has 1280 shading units, 80 TMUs, and 64 ROPs. The pixel rate for the RX 6600M is 154.6 GPixel/s versus 64.83 GPixel/s for the Quadro, and the texture rate is 270.6 GTexel/s versus 81.04 GTexel/s. The FP32 compute throughput is 8.659 TFLOPS for the RX 6600M, compared to 2.593 TFLOPS for the Quadro M4000M. The RX 6600M also supports FP16 at 17.32 TFLOPS (2:1 ratio), while the Quadro M4000M has no listed FP16 capability. The RX 6600M uses a PCIe 4.0 x8 interface, while the Quadro M4000M uses PCIe 3.0 x16. The RX 6600M is from the Radeon RX 6000 series, specifically the Navi 23 chip, and its generation is listed as Navi Mobile (RX 6000M). The Quadro M4000M is from the Quadro Maxwell-M (Mx000M) generation, using the GM204 chip.

Specification Differences

The two GPUs differ in nearly every measurable specification. The RX 6600M has a base clock of 2068 MHz and a boost clock of 2416 MHz, while the Quadro M4000M has a base clock of 975 MHz and a boost clock of 1013 MHz. The RX 6600M also lists a game clock of 2177 MHz, which the Quadro does not have. Memory clocks differ as well: the RX 6600M runs at 1750 MHz with 14 Gbps effective, while the Quadro M4000M runs at 1253 MHz with 5 Gbps effective. Memory capacity is 8 GB GDDR6 for the RX 6600M versus 4 GB GDDR5 for the Quadro, with bus widths of 128 bits versus 256 bits, respectively. Bandwidth is 224.0 GB/s for the RX 6600M and 160.4 GB/s for the Quadro. The RX 6600M has 1792 shading units, 112 TMUs, and 64 ROPs, while the Quadro has 1280 shading units, 80 TMUs, and 64 ROPs. The RX 6600M has 28 RT cores; the Quadro has none. The RX 6600M is manufactured on a 7 nm process with a die size of 237 mm² and 11,060 million transistors, while the Quadro is on 28 nm with a die size of 398 mm² and 5,200 million transistors. The RX 6600M supports DirectX 12 Ultimate (12_2) and FP16 (2:1), while the Quadro supports DirectX 12 (12_1) and no listed FP16. The RX 6600M uses PCIe 4.0 x8, and the Quadro uses PCIe 3.0 x16. The RX 6600M has a slot width of IGP, while the Quadro uses an MXM Module. Both have a TDP of 100 W and no power connectors. The release dates are also far apart: the RX 6600M launched on 2021-05-30, while the Quadro M4000M launched on 2015-08-17.