AMD Radeon Pro 580 vs NVIDIA GeForce RTX 4080 Comparison

Where Each One Wins

The benchmark data splits these two cards into completely different performance tiers. The NVIDIA GeForce RTX 4080 wins every head-to-head comparison by a massive margin. In the two shared tests, Geekbench OpenCL and Geekbench Vulkan, the RTX 4080 takes both wins without contest. The AMD Radeon Pro 580 does not win a single comparative benchmark in the database.

For compute workloads measured through OpenCL, the RTX 4080 is the clear choice. Its score of 214,739 dwarfs the Radeon Pro 580's 38,457, a 458.4% advantage. This is not a close race; the RTX 4080 is in a different league entirely for general-purpose GPU compute.

For graphics APIs, the story repeats. In Geekbench Vulkan, the RTX 4080 scores 263,779 versus the Radeon Pro 580's 43,285. That is a 509.4% lead. Applications that leverage Vulkan for rendering or compute will see enormous performance gains on the NVIDIA card.

The Radeon Pro 580 does have one unique benchmark result: Geekbench Metal with a score of 39,213. However, the RTX 4080 has no Metal score in the database, so no direct comparison is possible for Apple's graphics API. This means the Radeon Pro 580 may still have relevance in macOS environments where Metal is the primary interface, but the data cannot confirm any performance relationship.

Looking at the broader database context, the RTX 4080 sits at the 86th percentile among all GPUs, while the Radeon Pro 580 sits at the 82nd percentile. These percentiles appear close, but the average benchmark scores tell a different story: the RTX 4080 averages 54,247 across all its tests, while the Radeon Pro 580 averages 40,318. The RTX 4080's average is roughly 34.5% higher, which is a substantial gap in overall capability.

FAQ

Q: Which card is faster in OpenCL compute?

A: The NVIDIA GeForce RTX 4080 is dramatically faster. It scores 214,739 in Geekbench OpenCL versus 38,457 for the AMD Radeon Pro 580, a 458.4% advantage.

Q: Does the Radeon Pro 580 win any benchmark against the RTX 4080?

A: No. In the head-to-head data, the RTX 4080 wins both shared tests (Geekbench OpenCL and Geekbench Vulkan). The Radeon Pro 580 has zero wins in direct comparisons.

Q: How do these cards compare in Vulkan performance?

A: The RTX 4080 leads by 509.4% in Geekbench Vulkan, scoring 263,779 versus the Radeon Pro 580's 43,285.

Q: Is the Radeon Pro 580 competitive in any API?

A: The Radeon Pro 580 has a Geekbench Metal score of 39,213, but the RTX 4080 has no Metal score recorded in the database. So no direct comparison exists for Metal.

Q: What are the average benchmark scores for each card?

A: The RTX 4080 has an average benchmark score of 54,247 across its tests. The Radeon Pro 580 averages 40,318 across its tests.

Q: How do these cards rank against all other GPUs?

A: The RTX 4080 sits at the 86th percentile, while the Radeon Pro 580 sits at the 82nd percentile among all GPUs in the database.

Head-to-Head Benchmarks

The recorded data shows only two shared benchmark tests between these cards, and both are landslide victories for the NVIDIA GeForce RTX 4080.

In Geekbench OpenCL, the RTX 4080 posts 214,739 points. The AMD Radeon Pro 580 manages 38,457 points. The delta is 458.4% in favor of NVIDIA. This test measures raw compute throughput across heterogeneous workloads, and the results indicate the RTX 4080 handles OpenCL compute tasks at roughly 5.6 times the speed of the Radeon Pro 580. For any professional workflow relying on OpenCL acceleration, this difference is decisive.

In Geekbench Vulkan, the gap widens further. The RTX 4080 scores 263,779, while the Radeon Pro 580 scores 43,285. The delta reaches 509.4%. Vulkan is a low-level graphics and compute API, and the RTX 4080's Ada Lovelace architecture clearly extracts far more performance from it. The Radeon Pro 580's older GCN 4.0 design cannot keep pace.

The RTX 4080's nearest rivals in the database include the NVIDIA GeForce RTX 4080 SUPER with an average score of 54,209 (a 0.1% difference), the AMD Radeon Pro W5700X at 54,828 (1.1% higher), and the AMD Radeon RX 6750 GRE 12 GB at 55,698 (2.6% higher). This places the RTX 4080 in a tightly contested band of high-end cards, where small percentage differences separate models.

The Radeon Pro 580's nearest rivals paint a different picture. The NVIDIA GeForce RTX 5070 averages 40,377 (0.1% higher), the AMD Radeon Pro WX 7100 averages 40,063 (0.6% lower), and the AMD Radeon Pro 5300 averages 40,870 (1.4% higher). The Radeon Pro 580 competes with mid-range and mobile workstation parts, not flagship desktop GPUs.

Specification Differences

The two cards differ in nearly every measurable specification. The NVIDIA GeForce RTX 4080 uses the AD103 chip with 45,900 million transistors on a 379 mm² die. The AMD Radeon Pro 580 uses the Ellesmere chip with 5,700 million transistors on a 232 mm² die. The RTX 4080 packs roughly 8 times more transistors into a die that is only 63% larger.

Clock speeds favor NVIDIA substantially. The RTX 4080 runs at a base clock of 2205 MHz and boosts to 2505 MHz. The Radeon Pro 580 bases at 1100 MHz and boosts to 1200 MHz. Memory clocks differ too: the RTX 4080 runs at 1400 MHz with 22.4 Gbps effective, while the Radeon Pro 580 runs at 1695 MHz with 6.8 Gbps effective.

Memory capacity and bandwidth are starkly different. The RTX 4080 has 16 GB of GDDR6X on a 256-bit bus, delivering 716.8 GB/s. The Radeon Pro 580 has 8 GB of GDDR5 on a 256-bit bus, delivering 217.0 GB/s. The RTX 4080 offers triple the bandwidth despite the same bus width.

Compute resources show a similar gap. The RTX 4080 has 9,728 shading units, 304 TMUs, and 112 ROPs. The Radeon Pro 580 has 2,304 shading units, 144 TMUs, and 32 ROPs. The RTX 4080 also includes 76 RT cores and 304 tensor cores; the Radeon Pro 580 has neither.

Power and physical specifications differ greatly. The RTX 4080 has a 320 W TDP, requires a triple-slot cooler, uses a 1x 16-pin power connector, and needs a 700 W suggested PSU. The Radeon Pro 580 has a 185 W TDP, is listed as an IGP (integrated graphics processor), uses no power connectors, and has no suggested PSU. The RTX 4080 measures 310 mm long, 140 mm tall, and 61 mm wide, while the Radeon Pro 580 has no recorded dimensions.

Architecture Differences

The architectural divide is generational. The NVIDIA GeForce RTX 4080 uses the Ada Lovelace architecture on a 5 nm process from TSMC. The AMD Radeon Pro 580 uses the GCN 4.0 architecture on a 14 nm process from GlobalFoundries. The process node difference alone explains much of the performance and efficiency gap.

Transistor density illustrates the manufacturing advantage. The RTX 4080 achieves 121.1 million transistors per mm², while the Radeon Pro 580 achieves 24.6 million per mm². That is nearly a 5x density advantage for NVIDIA, enabled by the smaller process node.

Feature support differs at the API level. The RTX 4080 supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. The Radeon Pro 580 supports DirectX 12 (12_0), OpenGL 4.6, and Vulkan 1.3. The RTX 4080 also includes dedicated ray tracing cores and tensor cores, which the Radeon Pro 580 lacks entirely.

The bus interface also differs. The RTX 4080 uses PCIe 4.0 x16, while the Radeon Pro 580 uses PCIe 3.0 x16. This doubles the available bandwidth for data transfer between the GPU and system.

Display outputs reflect their intended markets. The RTX 4080 offers 1x HDMI 2.1 and 3x DisplayPort 1.4a. The Radeon Pro 580's outputs are listed as "Portable Device Dependent," indicating it was designed for integrated use in portable systems, likely Apple Mac products given the "Radeon Pro Mac (500 Series)" generation label.

The Verdict

The data directs different buyers to different cards. For anyone needing maximum compute or graphics performance, the NVIDIA GeForce RTX 4080 is the only rational choice. It wins every shared benchmark by margins of 458% to 509%, has 16 GB of faster GDDR6X memory, and includes modern features like ray tracing and tensor cores. Its 86th percentile ranking and average score of 54,247 place it firmly in high-end territory.

The AMD Radeon Pro 580 serves a specific niche. Its only unique benchmark is Geekbench Metal, where it scores 39,213. The RTX 4080 has no Metal score in the database, so the Radeon Pro 580 remains the only option for Metal-based workflows in this comparison. Its 82nd percentile and average score of 40,318 show it is a capable mid-range part, but it cannot compete with the RTX 4080 in any shared workload.

The launch MSRP for the RTX 4080 is 1,199 USD. The Radeon Pro 580 has no recorded launch MSRP. Both cards are end-of-life in production status.

The RTX 4080 is the clear pick for PC builders, workstation users, or anyone running OpenCL or Vulkan workloads. The Radeon Pro 580 is only relevant in Mac or portable systems where Metal is the primary graphics API and where the IGP form factor is required. For all other purposes, the RTX 4080's performance advantages are so large that the comparison is not close. The recorded data leaves no ambiguity: the RTX 4080 dominates, and the Radeon Pro 580 fills a narrow compatibility role.