AMD Radeon Pro 5300 vs NVIDIA Quadro M6000 24 GB Comparison

Where Each One Wins

The benchmark data draws a clear line between these two professional GPUs. The NVIDIA Quadro M6000 24 GB wins both shared head-to-head tests, making it the outright performance leader in OpenCL and Vulkan workloads. Its average benchmark score of 43,262 places it in the 83rd percentile of all GPUs, while the AMD Radeon Pro 5300 sits just one percentile lower at 82, with an average score of 40,870.

The AMD card’s sole benchmark victory comes in a test the NVIDIA card does not participate in: Geekbench Metal. There, the Radeon Pro 5300 scores 48,070, a figure that exceeds its own OpenCL and Vulkan results by a wide margin. This suggests the AMD card is disproportionately strong in Apple’s Metal API, which is relevant given its "Radeon Pro Mac" generation label. For users tied to Metal-based applications, the Radeon Pro 5300 is clearly the more capable option, despite losing the cross-platform tests.

For general compute and cross-vendor workloads, the Quadro M6000 24 GB is the winner. Its OpenCL score of 40,098 beats the Radeon’s 38,747 by 3.5%, and its Vulkan score of 46,425 beats the Radeon’s 35,793 by a substantial 29.7%. The NVIDIA card also offers 24 GB of memory versus 4 GB, which matters for large datasets, though the Radeon’s GDDR6 memory is newer. In short: choose NVIDIA for OpenCL/Vulkan and memory capacity; choose AMD for Metal-specific tasks.

FAQ

Q: Which GPU has the higher average benchmark score?

A: The NVIDIA Quadro M6000 24 GB has an average benchmark score of 43,262, compared to the AMD Radeon Pro 5300’s 40,870. That puts the NVIDIA card 2,392 points ahead, or roughly 5.9% higher.

Q: How do the two cards compare in the Geekbench Vulkan test?

A: The NVIDIA Quadro M6000 24 GB scores 46,425, while the AMD Radeon Pro 5300 scores 35,793. The NVIDIA card wins by 10,632 points, a 29.7% advantage.

Q: Does the AMD card win any benchmark against the NVIDIA card?

A: In the two head-to-head tests (OpenCL and Vulkan), the AMD card wins neither. However, the AMD card has a separate Geekbench Metal score of 48,070, which is its strongest result, but the NVIDIA card has no Metal score for comparison.

Q: What is the memory size difference between the two?

A: The NVIDIA Quadro M6000 24 GB comes with 24 GB of GDDR5 memory on a 384-bit bus, while the AMD Radeon Pro 5300 has 4 GB of GDDR6 memory on a 128-bit bus. The NVIDIA card has six times the memory capacity.

Q: Which GPU has a higher pixel rate?

A: The NVIDIA Quadro M6000 24 GB achieves a pixel rate of 106.9 GPixel/s, more than double the AMD Radeon Pro 5300’s 52.80 GPixel/s. This suggests NVIDIA has a significant edge in fill-rate-bound tasks.

Q: Are both cards still in production?

A: No. Both the NVIDIA Quadro M6000 24 GB and the AMD Radeon Pro 5300 are listed as end-of-life products. The NVIDIA card was released on March 4, 2016, and the AMD card on August 3, 2020.

Head-to-Head Benchmarks

The two cards share exactly two benchmark results: Geekbench OpenCL and Geekbench Vulkan. In both, the NVIDIA Quadro M6000 24 GB comes out ahead.

Starting with OpenCL, the NVIDIA card scores 40,098 against the AMD card’s 38,747. The 3.5% delta is modest but consistent, showing that the Maxwell-based Quadro holds a measurable lead in general-purpose compute. This margin is smaller than the difference in raw FP32 throughput — the NVIDIA card delivers 6.844 TFLOPS versus 4.224 TFLOPS for the AMD card — indicating that the Radeon’s newer architecture partially compensates for its lower theoretical peak.

The Vulkan test tells a more dramatic story. NVIDIA scores 46,425, which is 29.7% higher than AMD’s 35,793. This 10,632-point gap is far larger than the OpenCL difference, suggesting that NVIDIA’s Maxwell architecture handles Vulkan’s low-level draw call overhead and multi-threading more efficiently. The AMD card’s Vulkan score is also its lowest of the three benchmarks it runs, while the NVIDIA card’s Vulkan score is its highest.

Looking at the broader context, the NVIDIA card’s average score of 43,262 puts it within 0.1% of the NVIDIA Quadro M6000 (non-24GB version, 43,301) and within 0.9% of the GeForce RTX 4090 Mobile (43,667). The AMD card’s average of 40,870 is 0.8% behind the GeForce RTX 3080 Ti (41,187) and 1.2% ahead of the GeForce RTX 5070 (40,377). Neither card is a slouch, but the NVIDIA part consistently lands in higher-performance company.

Specification Differences

The two GPUs differ across nearly every major specification. The NVIDIA Quadro M6000 24 GB uses 3,072 shading units, 192 TMUs, and 96 ROPs, while the AMD Radeon Pro 5300 has 1,280 shading units, 80 TMUs, and 32 ROPs. The NVIDIA card also has a much wider 384-bit memory bus versus 128-bit, and its 24 GB memory dwarfs the AMD card’s 4 GB.

Clock speeds favor AMD. The Radeon Pro 5300 boosts to 1650 MHz, whereas the Quadro M6000 boosts to only 1114 MHz. Memory clocks show a similar pattern: AMD runs at 1750 MHz (14 Gbps effective) while NVIDIA runs at 1653 MHz (6.6 Gbps effective). Despite this, NVIDIA’s wider bus delivers higher bandwidth: 317.4 GB/s versus 224.0 GB/s.

Power and physical specs differ greatly. The NVIDIA card is a dual-slot, 250 W part requiring a single 8-pin power connector and a 600 W power supply. It measures 267 mm in length and 111 mm in height. The AMD card is an IGP (integrated graphics processor) with an 85 W TDP, no power connectors, and a suggested PSU of 250 W. It has no listed dimensions and no display outputs, unlike the NVIDIA card which offers 1x DVI and 4x DisplayPort 1.2 outputs. The bus interface also differs: NVIDIA uses PCIe 3.0 x16, AMD uses PCIe 4.0 x8.

Architecture Differences

The architectural gap is generational. The NVIDIA Quadro M6000 24 GB is built on the GM200 chip using Maxwell 2.0 architecture, fabricated on a 28 nm process at TSMC. The die is 601 mm² and contains 8,000 million transistors, yielding a transistor density of 13.3 million per mm². This is a large, power-hungry chip designed for maximum throughput.

In contrast, the AMD Radeon Pro 5300 uses the Navi 14 chip with RDNA 1.0 architecture, also fabricated at TSMC but on a 7 nm process. The die is just 158 mm² — less than a third the size — yet packs 6,400 million transistors, giving a density of 40.5 million per mm². This is a modern, dense design that achieves higher clocks (1650 MHz boost versus 1114 MHz) with far lower power (85 W versus 250 W).

Memory technology differs as well: NVIDIA uses GDDR5, AMD uses GDDR6. The AMD card supports FP16 at 8.448 TFLOPS (2:1 ratio), while the NVIDIA card lists no FP16 capability. Both cards support DirectX 12 (12_1), OpenGL 4.6, and Vulkan 1.4, and neither has ray tracing or tensor cores. The AMD card belongs to the "Radeon Pro Mac" generation, while NVIDIA’s is from the "Quadro Maxwell (Mx000)" generation, with a successor in Quadro Pascal.

The Verdict

The data points to a clear split based on workload and platform. For users running OpenCL or Vulkan applications, the NVIDIA Quadro M6000 24 GB is the superior choice. It wins both shared benchmarks, with a 3.5% lead in OpenCL and a commanding 29.7% lead in Vulkan. Its 24 GB of memory, 317.4 GB/s bandwidth, and higher pixel rate (106.9 GPixel/s) make it better suited for large textures, high-resolution rendering, and compute-heavy tasks. The 83rd percentile ranking reinforces its position as a high-performance part.

The AMD Radeon Pro 5300, however, is not without merit. Its Geekbench Metal score of 48,070 is its strongest result and exceeds the NVIDIA card’s best score (46,425 in Vulkan). This makes it the obvious pick for Mac-based workflows that rely on Metal, especially given its "Radeon Pro Mac" lineage. Its lower 85 W TDP and IGP form factor also mean it can fit into systems where the dual-slot, 250 W NVIDIA card simply cannot. The AMD card’s 7 nm process and GDDR6 memory are more modern, and its 82nd percentile is only one point behind NVIDIA.

Who should pick which? If the priority is raw cross-platform compute performance, memory capacity, and display outputs, the NVIDIA Quadro M6000 24 GB is the data-backed winner. If the target environment is macOS with Metal-based apps, or if power and space constraints rule out a large add-in card, the AMD Radeon Pro 5300 is the sensible alternative. The benchmark results do not support a single universal winner; they support two different winners for two different use cases.