AMD Radeon Pro 5300 vs NVIDIA GeForce RTX 5080 Comparison

Head-to-Head Benchmarks

The comparison between the NVIDIA GeForce RTX 5080 and the AMD Radeon Pro 5300 is not a close contest by any measured metric. In the two benchmark tests where both cards have recorded data, the RTX 5080 wins both decisively. The only shared test categories are Geekbench OpenCL and Geekbench Vulkan, and the NVIDIA card dominates both.

In Geekbench OpenCL, the RTX 5080 scores 235,901, while the Radeon Pro 5300 scores 38,747. This translates to a 508.8% lead for the NVIDIA card. That is not a marginal advantage; it is a generational and architectural chasm. The Vulkan result is even more lopsided: the RTX 5080 posts 255,450 against 35,793 for the AMD card, a delta of 613.7%. In both APIs, the NVIDIA card is not merely faster, it is in a different performance class entirely.

Looking at the broader database averages reinforces this picture. The RTX 5080 holds an average benchmark score of 56,083 across all recorded tests, compared to 40,870 for the Radeon Pro 5300. Interestingly, the RTX 5080's nearest rivals in the database are AMD parts: the Radeon 8060S trails by just 0.6%, the RX 6750 GRE 12 GB by 0.7%, and the Pro W5700X by 2.3%. The RX 9070 GRE actually sits 2.2% higher than the RTX 5080 in average score. The Radeon Pro 5300, by contrast, sits near the GeForce RTX 3080 Ti, which is 0.8% behind, and the RTX 5070, which is 1.2% ahead. This means the Pro 5300 is roughly in the same performance envelope as an RTX 30-series or RTX 50-series class card, but the RTX 5080 is far above that tier. The percentile ranking confirms this: the RTX 5080 sits in the 87th percentile of all GPUs, while the Pro 5300 sits in the 82nd percentile. Despite the gap in raw scores, both cards are above the median, but the RTX 5080 is clearly positioned higher in the overall distribution.

The data does not show a single test where the Radeon Pro 5300 wins. The recorded head-to-head results are limited to two tests, and the RTX 5080 claims both. The wins column reads 2 for NVIDIA and 0 for AMD. Across the entire database, the RTX 5080 has 10 recorded benchmark entries, including PassMark DirectX 9 (389), DirectX 10 (208), DirectX 11 (324), DirectX 12 (151), G2D (1415), G3D (36,565), and GPU Compute (21,789), plus 3DMark Steel Nomad DX12 (8,637). The Radeon Pro 5300 only has three recorded benchmarks: Geekbench Metal (48,070), OpenCL (38,747), and Vulkan (35,793). Even in Metal, which is an AMD-friendly API on Apple platforms, the Pro 5300's score is lower than the RTX 5080's OpenCL and Vulkan scores. The RTX 5080's average across all its tests is 56,083, which is 37.2% higher than the Pro 5300's 40,870 average. That average includes tests where the NVIDIA card is running older DirectX workloads, and it still comes out ahead.

What matters for the reader is the scale of the difference. A 500% to 600% lead in compute and graphics APIs is not something that can be bridged by driver updates or overclocking. The RTX 5080 is a modern high-end part, while the Radeon Pro 5300 is an end-of-life mobile or integrated-class GPU. The benchmark results simply confirm what the hardware specifications already suggest.

Where Each One Wins

The use-case split is straightforward. The RTX 5080 wins in every category where both have data. For compute-heavy workloads using OpenCL, the NVIDIA card delivers 508.8% higher performance. For Vulkan-based rendering, it delivers 613.7% higher performance. There is no workload in the recorded data where the Radeon Pro 5300 comes out ahead.

The Radeon Pro 5300 does have one unique benchmark entry that the RTX 5080 lacks: Geekbench Metal, where it scores 48,070. This is relevant for macOS or Metal-only environments, as the RTX 5080 has no recorded Metal score in the database. If the target application runs exclusively through Metal, the Pro 5300 at least has a measurable result, but even that score is lower than the RTX 5080's OpenCL and Vulkan numbers.

In terms of API support, the RTX 5080 supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4, while the Radeon Pro 5300 supports DirectX 12 (12_1), OpenGL 4.6, and Vulkan 1.4. The RTX 5080 also has dedicated ray tracing cores (84) and tensor cores (336), while the Pro 5300 lists none. Any workload that leverages DirectX 12 Ultimate features or ray tracing will not even run properly on the Pro 5300. For legacy DirectX 9, 10, 11, and 12 titles, the RTX 5080 has recorded scores in all of those categories; the Pro 5300 has none.

The practical verdict is that the RTX 5080 is the pick for any modern gaming, rendering, or compute task. The Radeon Pro 5300 is only relevant in niche scenarios where its low power draw (85 W TDP vs. 360 W) and integrated form factor matter more than performance. It requires no power connectors, has no display outputs, and is listed as an IGP (integrated graphics processor). That makes it a candidate for compact or low-power systems, but not for anything performance-focused.

Architecture Differences

The architectural gap between these two GPUs is enormous. The RTX 5080 uses the GB203 chip built on TSMC's 5 nm process, while the Radeon Pro 5300 uses the Navi 14 chip on TSMC's 7 nm process. The RTX 5080 belongs to the Blackwell 2.0 architecture and the GeForce 50-series generation, with a release date of January 2025. The Pro 5300 is RDNA 1.0, part of the Radeon Pro Mac (Navi Series) generation, and was released in August 2020. That is roughly four and a half years of architectural evolution between the two.

The transistor counts tell the story clearly. The RTX 5080 packs 45,600 million transistors on a 378 mm² die, yielding a transistor density of 120.6 million per mm². The Radeon Pro 5300 has 6,400 million transistors on a 158 mm² die, for a density of 40.5 million per mm². The NVIDIA chip has over seven times the transistor count and nearly three times the die area. The density advantage (120.6 vs. 40.5 million per mm²) reflects the newer 5 nm process.

Compute resources are similarly skewed. The RTX 5080 has 10,752 shading units, 336 texture mapping units, 112 ROPs, 84 ray tracing cores, and 336 tensor cores. The Radeon Pro 5300 has 1,280 shading units, 80 TMUs, 32 ROPs, and no ray tracing or tensor cores. The FP32 throughput is 56.28 TFLOPS for the RTX 5080 versus 4.224 TFLOPS for the Pro 5300. The FP16 numbers are 56.28 TFLOPS (1:1) for NVIDIA versus 8.448 TFLOPS (2:1) for AMD. The RTX 5080 does FP16 at the same rate as FP32, while the Pro 5300 does FP16 at half the rate of FP32, which means the NVIDIA card has a 6.7x advantage in FP16 compute as well.

Memory is another major divider. The RTX 5080 has 16 GB of GDDR7 on a 256-bit bus, delivering 960.0 GB/s of bandwidth. The Pro 5300 has 4 GB of GDDR6 on a 128-bit bus, delivering 224.0 GB/s. That is a 4x capacity advantage and a 4.3x bandwidth advantage for the NVIDIA card. The RTX 5080's memory clock is 1875 MHz (30 Gbps effective), while the Pro 5300 runs at 1750 MHz (14 Gbps effective). The pixel rate is 293.1 GPixel/s versus 52.80 GPixel/s, and the texture rate is 879.3 GTexel/s versus 132.0 GTexel/s.

The production status differs as well: the RTX 5080 is listed as Active, while the Pro 5300 is End-of-life. The RTX 5080 has a successor in the GeForce 60 series and a predecessor in the GeForce 40 series; the Pro 5300 has neither listed. The bus interface is PCIe 5.0 x16 for the RTX 5080 versus PCIe 4.0 x8 for the Pro 5300. Display outputs also differ: the RTX 5080 has 1x HDMI 2.1b and 3x DisplayPort 2.1b, while the Pro 5300 has no outputs at all.

FAQ

Q: How much faster is the RTX 5080 in OpenCL?

A: The RTX 5080 scores 235,901 in Geekbench OpenCL, while the Radeon Pro 5300 scores 38,747, giving the NVIDIA card a 508.8% lead.

Q: Does the Radeon Pro 5300 win any benchmark against the RTX 5080?

A: In the recorded head-to-head data, the RTX 5080 wins both tests (OpenCL and Vulkan). The Pro 5300 has no wins in any shared benchmark.

Q: What is the difference in memory capacity and bandwidth?

A: The RTX 5080 has 16 GB of GDDR7 with 960.0 GB/s bandwidth on a 256-bit bus, while the Pro 5300 has 4 GB of GDDR6 with 224.0 GB/s bandwidth on a 128-bit bus.

Q: Does the Radeon Pro 5300 support ray tracing?

A: No. The Pro 5300 lists no ray tracing cores and no tensor cores, while the RTX 5080 has 84 ray tracing cores and 336 tensor cores.

Q: What is the power draw difference?

A: The RTX 5080 has a 360 W TDP, while the Radeon Pro 5300 has an 85 W TDP. The Pro 5300 is listed as an IGP with no power connectors and a 250 W suggested PSU, while the RTX 5080 uses a 1x 16-pin connector with a 750 W suggested PSU.

Q: Which card has a higher percentile ranking among all GPUs?

A: The RTX 5080 is in the 87th percentile, while the Radeon Pro 5300 is in the 82nd percentile.

Specification Differences

| Specification | NVIDIA GeForce RTX 5080 | AMD Radeon Pro 5300 |

|---|---|---|

| Architecture | Blackwell 2.0 | RDNA 1.0 |

| Process node | 5 nm | 7 nm |

| Transistors | 45,600 million | 6,400 million |

| Die size | 378 mm² | 158 mm² |

| Transistor density | 120.6M / mm² | 40.5M / mm² |

| Base clock | 2295 MHz | 1000 MHz |

| Boost clock | 2617 MHz | 1650 MHz |

| Memory clock | 1875 MHz, 30 Gbps effective | 1750 MHz, 14 Gbps effective |

| Memory size | 16 GB | 4 GB |

| Memory type | GDDR7 | GDDR6 |

| Memory bus width | 256 bit | 128 bit |

| Memory bandwidth | 960.0 GB/s | 224.0 GB/s |

| Shading units | 10,752 | 1,280 |

| TMUs | 336 | 80 |

| ROPs | 112 | 32 |

| RT cores | 84 | None |

| Tensor cores | 336 | None |

| Pixel rate | 293.1 GPixel/s | 52.80 GPixel/s |

| Texture rate | 879.3 GTexel/s | 132.0 GTexel/s |

| FP32 | 56.28 TFLOPS | 4.224 TFLOPS |

| FP16 | 56.28 TFLOPS (1:1) | 8.448 TFLOPS (2:1) |

| TDP | 360 W | 85 W |

| Slot width | Dual-slot | IGP |

| Power connectors | 1x 16-pin | None |

| Suggested PSU | 750 W | 250 W |

| Bus interface | PCIe 5.0 x16 | PCIe 4.0 x8 |

| Display outputs | 1x HDMI 2.1b, 3x DisplayPort 2.1b | No outputs |

| DirectX | 12 Ultimate (12_2) | 12 (12_1) |

| Production status | Active | End-of-life |

| Release date | 2025-01-29 | 2020-08-03 |

| Launch MSRP | 999 USD | None |

The Verdict

The data is unambiguous. The NVIDIA GeForce RTX 5080 outperforms the AMD Radeon Pro 5300 by margins of 508.8% in OpenCL and 613.7% in Vulkan. Its average benchmark score of 56,083 versus 40,870 puts it comfortably ahead, and its 87th percentile ranking versus 82nd confirms its higher standing in the overall GPU distribution.

The RTX 5080 is the correct choice for anyone running modern DirectX 12 Ultimate workloads, ray tracing, high-resolution rendering, or compute tasks. Its 16 GB of GDDR7 memory, 960.0 GB/s bandwidth, and 56.28 TFLOPS of FP32 compute provide a foundation that the Pro 5300 cannot approach. The Pro 5300, with its 4 GB of GDDR6, 224.0 GB/s bandwidth, and 4.224 TFLOPS, is limited to lighter workloads and older API levels.

The only scenario where the Radeon Pro 5300 makes sense is one where power consumption is the absolute priority. Its 85 W TDP, lack of power connectors, and IGP form factor allow it to fit into systems where a 360 W, dual-slot card with a 16-pin connector and a 750 W suggested PSU would be impossible. But that is a system integration decision, not a performance decision. In every benchmark where both cards have recorded data, the RTX 5080 wins, and it wins by a wide margin. The verdict is simple: choose the RTX 5080 for performance, and only consider the Pro 5300 if the system constraints make the NVIDIA card physically unviable.