AMD Radeon Pro 5300 vs NVIDIA GeForce RTX 4080 Comparison

The Verdict

The data presents a decisive separation between these two GPUs. The NVIDIA GeForce RTX 4080 is in a completely different performance tier, leading the AMD Radeon Pro 5300 by 454.2% in Geekbench OpenCL and by 637% in Geekbench Vulkan. If the workload demands maximum compute throughput, the RTX 4080 is the only choice from these two. The Radeon Pro 5300, with its much lower scores, is suited for lighter tasks where its drastically lower power draw and integrated form factor matter more. The RTX 4080 sits at the 86th percentile among all GPUs, while the Pro 5300 sits at the 82nd, but the raw score gap is enormous. For professional users needing raw compute, the RTX 4080 wins outright. For basic display or compute duties in a space-constrained system, the Pro 5300 is the pragmatic option.

Architecture Differences

The two cards come from different architectural generations and design philosophies. The RTX 4080 uses the AD103 chip built on Ada Lovelace architecture with a 5 nm process at TSMC. It packs 45,900 million transistors on a 379 mm² die, yielding a transistor density of 121.1 million per square millimeter. The Radeon Pro 5300 uses the Navi 14 chip on RDNA 1.0 architecture with a 7 nm process, also at TSMC. It has 6,400 million transistors on a 158 mm² die, with a density of 40.5 million per square millimeter.

The RTX 4080 carries 9,728 shading units, 304 texture mapping units, and 112 render output units. It also includes 76 dedicated ray tracing cores and 304 tensor cores, features entirely absent from the Pro 5300. The Pro 5300 has 1,280 shading units, 80 TMUs, and 32 ROPs. Clock speeds differ substantially: the RTX 4080 runs at a base of 2205 MHz and boosts to 2505 MHz, while the Pro 5300 operates at 1000 MHz base and 1650 MHz boost. The RTX 4080's FP32 throughput is 48.74 TFLOPS versus 4.224 TFLOPS for the Pro 5300. In FP16, the RTX 4080 maintains a 1:1 ratio at 48.74 TFLOPS, while the Pro 5300 achieves 8.448 TFLOPS with a 2:1 ratio.

Memory configurations are also divergent. The RTX 4080 has 16 GB of GDDR6X on a 256-bit bus, delivering 716.8 GB/s of bandwidth. The Pro 5300 has 4 GB of GDDR6 on a 128-bit bus, providing 224.0 GB/s. The interface differs as well: PCIe 4.0 x16 for the RTX 4080 versus PCIe 4.0 x8 for the Pro 5300. The RTX 4080 supports DirectX 12 Ultimate (12_2), while the Pro 5300 is limited to DirectX 12 (12_1). Both support OpenGL 4.6 and Vulkan 1.4.

Head-to-Head Benchmarks

The recorded data includes two direct comparisons. In Geekbench OpenCL, the RTX 4080 scores 214,739 against the Pro 5300's 38,747, a delta of 454.2%. This is not a marginal win but a multi-generational leap. The RTX 4080's compute advantage comes from its massive shading unit count, higher clocks, and larger memory bandwidth.

In Geekbench Vulkan, the gap widens further. The RTX 4080 scores 263,779 versus 35,793 for the Pro 5300, resulting in a 637% delta. Vulkan's low-level API exposes the hardware more directly, and the RTX 4080's architecture handles this workload far more efficiently. The Pro 5300's RDNA 1.0 design, with its lower transistor count and narrower memory bus, cannot keep pace.

The RTX 4080 also has additional benchmark results from the database that the Pro 5300 lacks. In 3DMark Steel Nomad DX12, it scores 6,567. In Passmark tests, it records 34,457 in G3D, 20,671 in GPU Compute, 1,239 in G2D, 370 in DirectX 9, 314 in DirectX 11, 204 in DirectX 10, and 132 in DirectX 12. The Pro 5300's only other recorded test is Geekbench Metal at 48,070, which the RTX 4080 does not have a matching entry for. For the tests both cards share, the RTX 4080 wins all of them.

FAQ

Q: Which GPU has the higher average benchmark score?

A: The RTX 4080 has an average benchmark score of 54,247, while the Radeon Pro 5300 has an average of 40,870.

Q: How much faster is the RTX 4080 in Geekbench Vulkan?

A: The RTX 4080 scores 263,779 compared to 35,793 for the Pro 5300, a 637% advantage.

Q: Does the Radeon Pro 5300 have ray tracing cores?

A: No, the Pro 5300 has no ray tracing cores, while the RTX 4080 has 76.

Q: What is the memory bandwidth difference?

A: The RTX 4080 provides 716.8 GB/s from 16 GB of GDDR6X on a 256-bit bus, while the Pro 5300 provides 224.0 GB/s from 4 GB of GDDR6 on a 128-bit bus.

Q: Which card has higher power consumption?

A: The RTX 4080 has a TDP of 320 W with a suggested PSU of 700 W, while the Pro 5300 has a TDP of 85 W with a suggested PSU of 250 W.

Q: What is the production status of both cards?

A: Both the RTX 4080 and the Radeon Pro 5300 are listed as end-of-life in the database.

Where Each One Wins

The RTX 4080 wins every shared benchmark by a wide margin. Its strengths are in compute-heavy workloads: OpenCL and Vulkan tasks benefit from its 9,728 shading units, 304 tensor cores, and high memory bandwidth. The 16 GB GDDR6X frame buffer allows large datasets to stay resident, and the 76 ray tracing cores enable hardware-accelerated ray tracing that the Pro 5300 cannot perform. The 1:1 FP16 ratio at 48.74 TFLOPS makes it suitable for mixed-precision work. Its pixel rate of 280.6 GPixel/s and texture rate of 761.5 GTexel/s indicate strong rasterization throughput as well.

The Radeon Pro 5300 wins in power efficiency and physical integration. Its 85 W TDP is a fraction of the RTX 4080's 320 W, and it requires no power connectors, with a suggested PSU of only 250 W. It is an integrated form factor (IGP) with no display outputs, meaning it is designed for embedded or Mac-based systems where space and power are limited. Its FP16 rate of 8.448 TFLOPS (2:1 ratio) offers some compute capability for lighter tasks. The 4 GB memory, while small, may suffice for basic workloads. The Pro 5300's 82nd percentile ranking shows it is not weak in absolute terms, but it operates in a different performance class.

Specification Differences

The two cards differ in nearly every measurable specification. The RTX 4080 uses a 5 nm process, the Pro 5300 uses 7 nm. Transistor counts are 45,900 million versus 6,400 million. Die size is 379 mm² versus 158 mm². Transistor density is 121.1M per mm² versus 40.5M per mm². Base clocks are 2205 MHz versus 1000 MHz, and boost clocks are 2505 MHz versus 1650 MHz. Memory speed is 22.4 Gbps effective versus 14 Gbps effective.

Memory size is 16 GB versus 4 GB, type is GDDR6X versus GDDR6, bus width is 256 bit versus 128 bit, and bandwidth is 716.8 GB/s versus 224.0 GB/s. Shading units are 9,728 versus 1,280, TMUs are 304 versus 80, and ROPs are 112 versus 32. The RTX 4080 has 76 RT cores and 304 tensor cores; the Pro 5300 has neither. Pixel rate is 280.6 GPixel/s versus 52.80 GPixel/s. Texture rate is 761.5 GTexel/s versus 132.0 GTexel/s. FP32 is 48.74 TFLOPS versus 4.224 TFLOPS. FP16 is 48.74 TFLOPS (1:1) versus 8.448 TFLOPS (2:1).

TDP is 320 W versus 85 W. Slot width is triple-slot versus IGP. Power connectors are 1x 16-pin versus none. Suggested PSU is 700 W versus 250 W. Bus interface is PCIe 4.0 x16 versus PCIe 4.0 x8. Display outputs are 1x HDMI 2.1 and 3x DisplayPort 1.4a versus no outputs. DirectX support is 12 Ultimate (12_2) versus 12 (12_1). The RTX 4080 has dimensions of 310 mm length, 140 mm height, and 61 mm width; the Pro 5300 has no recorded dimensions. Release dates are September 19, 2022 versus August 3, 2020. The RTX 4080 has a launch MSRP of 1,199 USD; the Pro 5300 has no recorded launch MSRP.