AMD Instinct MI350X vs NVIDIA GeForce RTX 4060 Comparison

Head-to-Head Benchmarks

The recorded database contains benchmark scores for the NVIDIA GeForce RTX 4060, while the AMD Instinct MI350X has no benchmark entries and an average score of zero. This makes a direct numerical comparison one-sided. The MI350X sits at the 50th percentile against all GPUs in the database, while the RTX 4060 ranks at the 61st percentile.

The RTX 4060 delivers measurable results across multiple test suites. In Geekbench OpenCL, it scores 95,057, and in Geekbench Vulkan it reaches 48,643. The Passmark G3D score is 19,545, with a Passmark GPU Compute score of 9,213. These numbers place the RTX 4060 in a competitive position among its nearest rivals in the database.

The closest rival to the RTX 4060 is the AMD Radeon HD 7790, which has an average score of 17,666 and a delta of -0.2 percent relative to the RTX 4060. That means the RTX 4060 trails the HD 7790 by a marginal 0.2 percent. The AMD Radeon 780M sits at 17,588, a 0.3 percent advantage for the RTX 4060. The AMD Radeon Pro 560 scores 17,551, putting the RTX 4060 ahead by 0.5 percent. The AMD Radeon Pro 460 scores 17,509, with the RTX 4060 leading by 0.7 percent.

The average benchmark score for the RTX 4060 is 17,639. This figure is nearly identical to the scores of its closest competitors, indicating that the RTX 4060 delivers performance that is tightly clustered around the 17,500 to 17,700 range in the database. The delta values are all under one percent, so the differences between the RTX 4060 and these four rivals are negligible in aggregate terms.

The MI350X, by contrast, has no recorded benchmark scores and an average score of zero. Its percentile ranking of 50 places it in the middle of the database distribution, but without actual test results, the head-to-head comparison cannot be quantified. The wins counter shows zero victories for the MI350X and zero for the RTX 4060, reflecting the absence of any head-to-head benchmark entries in the record.

Architecture Differences

The AMD Instinct MI350X and the NVIDIA GeForce RTX 4060 diverge fundamentally in architecture. The MI350X uses AMD's CDNA 4.0 architecture, built on a 3 nm process at TSMC. The RTX 4060 uses NVIDIA's Ada Lovelace architecture, fabricated on a 5 nm process, also at TSMC. The MI350X belongs to the Instinct (MIx) generation, while the RTX 4060 is part of the GeForce 40 series.

The chip differences are substantial. The MI350X carries the MI350 256CU chip, while the RTX 4060 uses the AD107 die. Transistor counts differ by an order of magnitude: the MI350X has 185,000 million transistors, compared to 18,900 million for the RTX 4060. The die size reflects this gap, with the MI350X measuring 2,380 mm² against 159 mm² for the RTX 4060. Transistor density tells a different story: the RTX 4060 packs 118.9 million transistors per square millimeter, while the MI350X has 77.7 million per square millimeter.

Memory architecture is another point of divergence. The MI350X uses 288 GB of HBM3e memory on an 8192-bit bus, delivering 8.19 TB/s of bandwidth. The RTX 4060 uses 8 GB of GDDR6 on a 128-bit bus, with 272.0 GB/s of bandwidth. The memory clock rates also differ: the MI350X runs at 2000 MHz with 8 Gbps effective, while the RTX 4060 runs at 2125 MHz with 17 Gbps effective.

The compute resources are heavily skewed toward the MI350X. It has 16,384 shading units and 1,024 texture mapping units, with zero ROPs. The RTX 4060 has 3,072 shading units, 96 TMUs, and 48 ROPs. The MI350X has no ray tracing cores or tensor cores listed, while the RTX 4060 includes 24 ray tracing cores and 96 tensor cores. Pixel rate for the MI350X is listed as 0 MPixel/s, while the RTX 4060 achieves 118.1 GPixel/s. Texture rate for the MI350X is 2,252.8 GTexel/s, far exceeding the RTX 4060's 236.2 GTexel/s.

FP32 throughput shows a similar imbalance. The MI350X delivers 72.09 TFLOPS, and the RTX 4060 delivers 15.11 TFLOPS. Both GPUs report FP16 at a 1:1 ratio with their FP32 figures. Clock speeds differ as well: the MI350X has a base clock of 1000 MHz and a boost of 2200 MHz, while the RTX 4060 has a base of 1830 MHz and a boost of 2460 MHz.

Where Each One Wins

The RTX 4060 wins in scenarios that require established graphics APIs and display output. It supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. The MI350X lists all three APIs as N/A. The RTX 4060 also provides display outputs with 1x HDMI 2.1 and 3x DisplayPort 1.4a, while the MI350X has no outputs. For desktop gaming and consumer graphics workloads, the RTX 4060 is the only option with functional API support and video connectivity.

The RTX 4060 also wins on power efficiency in terms of thermal design power. Its TDP is 115 W, compared to 1000 W for the MI350X. The suggested PSU for the RTX 4060 is 300 W, while the MI350X requires 1400 W. The RTX 4060 uses a single 12-pin power connector and fits in a dual-slot form factor. The MI350X is an OAM Module with no power connectors listed, indicating a different installation context.

The MI350X wins on raw compute scale. Its FP32 throughput of 72.09 TFLOPS is roughly 4.8 times the RTX 4060's 15.11 TFLOPS. Memory bandwidth of 8.19 TB/s dwarfs the RTX 4060's 272.0 GB/s by a factor of about 30. The 288 GB memory capacity is 36 times the RTX 4060's 8 GB. The MI350X also has a much higher texture rate at 2,252.8 GTexel/s, about 9.5 times the RTX 4060's 236.2 GTexel/s.

The MI350X uses a PCIe 5.0 x16 interface, while the RTX 4060 uses PCIe 4.0 x8. The MI350X was released on June 11, 2025, while the RTX 4060 was released on May 17, 2023. The RTX 4060 has a production status of End-of-life, while the MI350X has no production status listed. The RTX 4060's predecessor is the GeForce 30 series, and its successor is the GeForce 50 series. The MI350X's predecessor is Radeon Instinct.

FAQ

Q: Which GPU has higher FP32 performance?

A: The AMD Instinct MI350X delivers 72.09 TFLOPS, while the NVIDIA GeForce RTX 4060 delivers 15.11 TFLOPS.

Q: What memory configurations do these GPUs use?

A: The MI350X uses 288 GB of HBM3e on an 8192-bit bus with 8.19 TB/s bandwidth. The RTX 4060 uses 8 GB of GDDR6 on a 128-bit bus with 272.0 GB/s bandwidth.

Q: Does the RTX 4060 support modern graphics APIs?

A: Yes, the RTX 4060 supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. The MI350X lists all three APIs as N/A.

Q: What are the power requirements for each card?

A: The MI350X has a TDP of 1000 W and a suggested PSU of 1400 W. The RTX 4060 has a TDP of 115 W and a suggested PSU of 300 W.

Q: How does the RTX 4060 compare to its nearest rivals in benchmark scores?

A: The RTX 4060 has an average benchmark score of 17,639. The AMD Radeon HD 7790 scores 17,666, which is 0.2 percent higher. The AMD Radeon 780M scores 17,588, 0.3 percent lower. The AMD Radeon Pro 560 scores 17,551, 0.5 percent lower. The AMD Radeon Pro 460 scores 17,509, 0.7 percent lower.

Q: What process nodes are used for these GPUs?

A: The MI350X uses a 3 nm process at TSMC. The RTX 4060 uses a 5 nm process at TSMC.

Specification Differences

The two GPUs differ across nearly every recorded specification. The MI350X has 16,384 shading units, while the RTX 4060 has 3,072. Texture mapping units number 1,024 for the MI350X and 96 for the RTX 4060. The MI350X has 0 ROPs, while the RTX 4060 has 48. Ray tracing cores are absent from the MI350X, while the RTX 4060 has 24. Tensor cores are absent from the MI350X, while the RTX 4060 has 96.

Clock speeds differ as well. The MI350X has a base clock of 1000 MHz and a boost of 2200 MHz. The RTX 4060 has a base clock of 1830 MHz and a boost of 2460 MHz. Memory clocks are 2000 MHz with 8 Gbps effective for the MI350X, and 2125 MHz with 17 Gbps effective for the RTX 4060.

The MI350X has a transistor count of 185,000 million and a die size of 2380 mm². The RTX 4060 has 18,900 million transistors and a die size of 159 mm². Transistor density is 77.7 million per mm² for the MI350X and 118.9 million per mm² for the RTX 4060.

Power specifications show a wide gap. The MI350X has a TDP of 1000 W and a suggested PSU of 1400 W. The RTX 4060 has a TDP of 115 W and a suggested PSU of 300 W. Slot width is OAM Module for the MI350X and dual-slot for the RTX 4060. Power connectors are listed as none for the MI350X and 1x 12-pin for the RTX 4060.

Bus interfaces are PCIe 5.0 x16 for the MI350X and PCIe 4.0 x8 for the RTX 4060. Display outputs are absent on the MI350X, while the RTX 4060 includes 1x HDMI 2.1 and 3x DisplayPort 1.4a. Dimensions also differ: the MI350X measures 102 mm in length and 165 mm in width, while the RTX 4060 measures 240 mm in length, 111 mm in height, and 40 mm in width.

Release dates are June 11, 2025, for the MI350X and May 17, 2023, for the RTX 4060. The RTX 4060 has a launch MSRP of 299 USD. The MI350X has no launch MSRP listed. The production status is End-of-life for the RTX 4060, with no status for the MI350X.