AMD Instinct MI350X vs AMD Radeon RX 7650 GRE Comparison

Where Each One Wins

The data splits these two AMD accelerators into entirely separate usage domains. The Instinct MI350X is a data center compute module with no display outputs, no graphics API support, and no ROPs. The Radeon RX 7650 GRE is a client graphics card with full DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4 support, plus 64 ROPs and 32 ray tracing cores. There is no head-to-head benchmark overlap in the database, so the wins are defined by capability rather than direct scores.

The RX 7650 GRE wins in every graphics-oriented category. It has a 172.5 GPixel/s pixel rate versus 0 MPixel/s for the MI350X. It delivers 345.0 GTexel/s texture rate, while the MI350X has 2,252.8 GTexel/s but zero pixel output. The MI350X cannot drive a display, cannot run DirectX, OpenGL, or Vulkan workloads, and has no ray tracing hardware. For any gaming, desktop, or workstation visualization task, the RX 7650 GRE is the only functional option.

The MI350X wins in raw compute throughput and memory capacity. Its FP32 performance is 72.09 TFLOPS, which is 3.27 times the RX 7650 GRE's 22.08 TFLOPS. FP16 performance is identical at 72.09 TFLOPS for the MI350X and 22.08 TFLOPS for the RX 7650 GRE, maintaining the same 3.27x ratio. The MI350X carries 288 GB of HBM3e memory with 8.19 TB/s of bandwidth, versus 8 GB of GDDR6 at 288.0 GB/s. That is 36 times the capacity and roughly 28.4 times the bandwidth. The MI350X also has 16,384 shading units compared to 2,048, an 8x difference.

Architecture Differences

The MI350X uses the CDNA 4.0 architecture on a 3 nm TSMC process, while the RX 7650 GRE uses RDNA 3.0 on a 6 nm TSMC process. The MI350X die is 2380 mm² with 185,000 million transistors, yielding a density of 77.7M transistors per mm². The RX 7650 GRE die is 204 mm² with 13,300 million transistors, giving 65.2M per mm². The MI350X is 11.7 times larger in die area and holds 13.9 times more transistors.

The MI350X chip is designated MI350 256CU, indicating 256 compute units. The RX 7650 GRE uses Navi 33, codenamed Hotpink Bonefish. The MI350X belongs to the Instinct (MIx) generation, while the RX 7650 GRE belongs to the Navi III (RX 7000) series. The RX 7650 GRE has a production status of Active; the MI350X has no recorded production status.

Clock behavior differs substantially. The MI350X base clock is 1000 MHz with a 2200 MHz boost. The RX 7650 GRE runs a 1720 MHz base, 2350 MHz game clock, and 2695 MHz boost. Despite the lower clock speeds, the MI350X achieves far higher throughput because of its massive shader count and memory subsystem. The MI350X memory runs at 2000 MHz with 8 Gbps effective, while the RX 7650 GRE memory runs at 2250 MHz with 18 Gbps effective.

The MI350X uses an OAM Module slot width with no power connectors and no display outputs. The RX 7650 GRE is a dual-slot card with one 8-pin connector and outputs of 1x HDMI 2.1a plus 3x DisplayPort 2.1. The MI350X uses PCIe 5.0 x16, while the RX 7650 GRE uses PCIe 4.0 x8. The MI350X measures 102 mm in length and 165 mm in width; the RX 7650 GRE measures 204 mm in length and 115 mm in height.

The MI350X has no API support for DirectX, OpenGL, or Vulkan, all listed as N/A. The RX 7650 GRE supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. The RX 7650 GRE has 32 RT cores; the MI350X has no RT core count recorded. Both have no tensor core counts listed.

FAQ

Q: Which card has higher FP32 compute performance?

A: The MI350X delivers 72.09 TFLOPS, which is 3.27 times the RX 7650 GRE's 22.08 TFLOPS.

Q: Does the MI350X support graphics APIs?

A: No. The database records DirectX, OpenGL, and Vulkan as N/A for the MI350X. The RX 7650 GRE supports DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4.

Q: How much memory does each card have?

A: The MI350X has 288 GB of HBM3e on an 8192-bit bus with 8.19 TB/s bandwidth. The RX 7650 GRE has 8 GB of GDDR6 on a 128-bit bus with 288.0 GB/s bandwidth.

Q: What are the power requirements?

A: The MI350X has a 1000 W TDP and a suggested PSU of 1400 W, with no power connectors because it is an OAM module. The RX 7650 GRE has a 170 W TDP and a suggested PSU of 450 W, using a single 8-pin connector.

Q: Which card can output video?

A: Only the RX 7650 GRE. It has 1x HDMI 2.1a and 3x DisplayPort 2.1. The MI350X has no display outputs.

Q: What are the release dates?

A: The MI350X was released on 2025-06-11. The RX 7650 GRE was released on 2025-02-06, roughly four months earlier.

Specification Differences

| Field | AMD Instinct MI350X | AMD Radeon RX 7650 GRE |

|---|---|---|

| Architecture | CDNA 4.0 | RDNA 3.0 |

| Process Node | 3 nm | 6 nm |

| Transistors | 185,000 million | 13,300 million |

| Die Size | 2380 mm² | 204 mm² |

| Transistor Density | 77.7M / mm² | 65.2M / mm² |

| Base Clock | 1000 MHz | 1720 MHz |

| Boost Clock | 2200 MHz | 2695 MHz |

| Game Clock | None | 2350 MHz |

| Memory Clock | 2000 MHz 8 Gbps effective | 2250 MHz 18 Gbps effective |

| Memory Size | 288 GB | 8 GB |

| Memory Type | HBM3e | GDDR6 |

| Memory Bus Width | 8192 bit | 128 bit |

| Memory Bandwidth | 8.19 TB/s | 288.0 GB/s |

| Shading Units | 16384 | 2048 |

| TMUs | 1024 | 128 |

| ROPs | 0 | 64 |

| RT Cores | None | 32 |

| Pixel Rate | 0 MPixel/s | 172.5 GPixel/s |

| Texture Rate | 2,252.8 GTexel/s | 345.0 GTexel/s |

| FP32 | 72.09 TFLOPS | 22.08 TFLOPS |

| FP16 | 72.09 TFLOPS (1:1) | 22.08 TFLOPS (1:1) |

| TDP | 1000 W | 170 W |

| Slot Width | OAM Module | Dual-slot |

| Power Connectors | None | 1x 8-pin |

| Suggested PSU | 1400 W | 450 W |

| Bus Interface | PCIe 5.0 x16 | PCIe 4.0 x8 |

| Display Outputs | No outputs | 1x HDMI 2.1a, 3x DisplayPort 2.1 |

| DirectX | N/A | 12 Ultimate (12_2) |

| OpenGL | N/A | 4.6 |

| Vulkan | N/A | 1.4 |

| Dimensions | 102 mm length, 165 mm width | 204 mm length, 115 mm height |

| Release Date | 2025-06-11 | 2025-02-06 |

Head-to-Head Benchmarks

The database contains no shared benchmark entries between the MI350X and the RX 7650 GRE. The MI350X has an empty benchmark array, an average benchmark score of 0, a percentile of 50, and no nearest rivals. The RX 7650 GRE has two recorded benchmark scores: 2336 in 3DMark Steel Nomad DX12 and 83109 in Geekbench OpenCL, giving an average of 42723 and a percentile of 83.

The RX 7650 GRE's average score places it within 1.3% of several NVIDIA parts. It trails the RTX 4070 SUPER by 1.2%, trails the Quadro M6000 24 GB by 1.2%, trails the RTX 5050 Mobile by 1.3%, and trails the Quadro M6000 by 1.3%. These deltas are small, meaning the RX 7650 GRE sits in a tight competitive cluster around the 42.7k to 43.3k range.

The MI350X cannot be compared numerically because no benchmark scores exist for it in the database. Its percentile of 50 is a default placement, not a measured result. The compute advantages are clear from the specification data: 72.09 TFLOPS FP32, 8.19 TB/s memory bandwidth, and 288 GB capacity. The RX 7650 GRE counters with 22.08 TFLOPS, 288.0 GB/s, and 8 GB, but also carries the only graphics pipeline.

Texture rate favors the MI350X at 2,252.8 GTexel/s versus 345.0 GTexel/s, a 6.5x advantage. Pixel rate favors the RX 7650 GRE at 172.5 GPixel/s versus 0 MPixel/s, an infinite ratio since the MI350X has no ROPs. The MI350X shader count of 16,384 is 8x the RX 7650 GRE's 2,048. The MI350X TMU count of 1024 is 8x the RX 7650 GRE's 128.

The RX 7650 GRE has higher clocks in every category: base 1720 MHz versus 1000 MHz, boost 2695 MHz versus 2200 MHz. It also has a dedicated game clock of 2350 MHz which the MI350X lacks. The RX 7650 GRE memory clock is 2250 MHz versus 2000 MHz, and its effective rate is 18 Gbps versus 8 Gbps. These clock advantages do not overcome the MI350X's massive parallel resources.

The Verdict

The MI350X is a compute accelerator for data center workloads. The data shows 72.09 TFLOPS FP32, 288 GB HBM3e, 8.19 TB/s bandwidth, and 16,384 shading units. It has no display outputs, no graphics APIs, and no ROPs. It requires a 1400 W suggested PSU and uses an OAM Module form factor with no power connectors. It was released on 2025-06-11 with no launch MSRP recorded.

The RX 7650 GRE is a client graphics card for gaming and workstation use. The data shows 22.08 TFLOPS FP32, 8 GB GDDR6, 288.0 GB/s bandwidth, 64 ROPs, 32 RT cores, and full DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4 support. It has a 170 W TDP, a 450 W suggested PSU, one 8-pin connector, and three display outputs plus HDMI. It was released on 2025-02-06 with a launch MSRP of 279 USD. Its average benchmark score of 42723 puts it at the 83rd percentile, within 1.3% of the RTX 4070 SUPER, Quadro M6000 24 GB, RTX 5050 Mobile, and Quadro M6000.

The MI350X should be selected for compute-only environments where graphics output is irrelevant. The RX 7650 GRE should be selected for any workload requiring a display, graphics API support, or ray tracing. The lack of overlapping benchmarks means the decision rests on capability boundaries, not comparative scores. The MI350X has no path to rendering; the RX 7650 GRE has no path to 288 GB memory or 8.19 TB/s bandwidth. Each card wins in its own domain by definition, and the other cannot substitute.