AMD Instinct MI300X vs NVIDIA RTX PRO 4500 Blackwell Comparison

Head-to-Head Benchmarks

The benchmark database contains only one recorded test for the AMD Instinct MI300X, a Geekbench OpenCL score of 317,994. This single result places the MI300X at the 100th percentile among all GPUs, meaning it outperforms every other recorded device in that specific workload. The NVIDIA RTX PRO 4500 Blackwell has no OpenCL entry, so a direct comparison in that test is impossible. Instead, the RTX PRO 4500 shows a spread of results across DirectX and compute benchmarks, with its highest raw score being 221,768 in Geekbench Vulkan. Its average benchmark score is 31,532, which places it at the 76th percentile globally.

The MI300X’s nearest rivals in the database provide context for its OpenCL dominance. It sits 5% behind the NVIDIA H200 NVL, which averages 334,891, and 8% behind the NVIDIA B200, which averages 345,482. Against the NVIDIA L40S, the MI300X is 7.5% ahead, and it beats the NVIDIA RTX 6000 Ada Generation by 10.7%. These deltas indicate that the MI300X is competitive with top-tier accelerators, though not the absolute fastest in every comparison. The RTX PRO 4500’s nearest rivals are much closer in score, with the NVIDIA TITAN RTX at 31,676 (0.5% higher), the Intel Arc Pro A30M at 31,894 (1.1% higher), and the NVIDIA GRID M60-1Q and Quadro M5000 both within 1% of its average. This suggests the RTX PRO 4500 delivers performance typical of a mid-range workstation card, not a flagship compute part.

Looking at specific tests for the RTX PRO 4500, the Passmark G3D score of 33,360 is its strongest graphics result, while the Passmark GPU compute score of 19,255 indicates solid general-purpose throughput. The DirectX 9 score of 397 and DirectX 11 score of 320 show legacy API performance, whereas DirectX 12 scores only 119, and DirectX 10 scores 204. The 2D score of 1,336 is modest. The 3DMark Steel Nomad DX12 result of 7,025 is a modern gaming-oriented metric, but no comparable figure exists for the MI300X, which has no DirectX support at all. The MI300X’s single OpenCL score is roughly ten times the RTX PRO 4500’s average benchmark score, but that comparison is misleading due to different test suites and workload types.

Architecture Differences

The AMD Instinct MI300X uses the Aqua Vanjaram chip built on CDNA 3.0 architecture, manufactured on a 5 nm process at TSMC. It contains 153,000 million transistors on a 1017 mm² die, yielding a transistor density of 150.4 million per mm². The NVIDIA RTX PRO 4500 Blackwell uses the GB203 chip with Blackwell 2.0 architecture, also on a 5 nm TSMC process, but with 45,600 million transistors on a 378 mm² die, giving 120.6 million per mm². The MI300X has over three times the transistor count and nearly three times the die area, reflecting its focus on massive compute throughput rather than graphics features.

Clock speeds differ significantly. The MI300X runs at a base clock of 1000 MHz and boosts to 2100 MHz, while the RTX PRO 4500 starts at 1635 MHz and boosts to 2407 MHz. The RTX PRO 4500 achieves higher frequencies despite its smaller die, likely due to lower power density. Memory configurations are starkly different: the MI300X packs 192 GB of HBM3 with an 8192-bit bus and 5.32 TB/s bandwidth, whereas the RTX PRO 4500 has 32 GB of GDDR7 on a 256-bit bus with 896.0 GB/s. The MI300X offers six times the capacity and nearly six times the bandwidth, making it suited for large models and data movement.

Compute resources diverge as well. The MI300X has 19,456 shading units and 1,216 texture mapping units, but zero ROPs and no dedicated ray tracing or tensor cores. Its pixel rate is listed as 0 MPixel/s, and texture rate is 2,553.6 GTexel/s. FP32 and FP16 performance are both 81.72 TFLOPS, indicating a 1:1 ratio. The RTX PRO 4500 has 10,496 shading units, 328 TMUs, 112 ROPs, 82 ray tracing cores, and 328 tensor cores. Its pixel rate is 269.6 GPixel/s, texture rate is 789.5 GTexel/s, and FP32/FP16 both hit 50.53 TFLOPS. The MI300X leads in raw shading throughput and texture fill, but lacks rendering capabilities entirely. The RTX PRO 4500 supports DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4, while the MI300X reports N/A for all three APIs.

Power and physical design also differ. The MI300X consumes 750 W, uses an OAM module form factor, and has no power connectors or display outputs. It requires a suggested PSU of 1150 W. The RTX PRO 4500 draws 200 W, fits a dual-slot design, uses a single 16-pin power connector, and needs a 550 W PSU. The RTX PRO 4500 has four DisplayPort 2.1b outputs and measures 267 mm in length, 111 mm in height, and 40 mm in width. The MI300X has no listed dimensions. The RTX PRO 4500 is marked as Active in production, whereas the MI300X has no production status. The MI300X released on 2023-12-05, and the RTX PRO 4500 released on 2025-03-17.

The Verdict

The data indicates that the AMD Instinct MI300X is a compute accelerator designed for high-bandwidth, large-capacity workloads, with no graphics output or rendering pipeline. Its 192 GB memory and 5.32 TB/s bandwidth far exceed the RTX PRO 4500’s 32 GB and 896.0 GB/s, and its FP32 throughput of 81.72 TFLOPS doubles the RTX PRO 4500’s 50.53 TFLOPS. The MI300X also leads in texture rate at 2,553.6 GTexel/s versus 789.5 GTexel/s. For users who need massive parallel computation, such as AI training or scientific simulations, the MI300X provides superior raw numbers, but it cannot output to a display or run standard graphics APIs.

The NVIDIA RTX PRO 4500 Blackwell, by contrast, offers balanced capabilities: it has 82 ray tracing cores and 328 tensor cores, supports DirectX 12 Ultimate, and outputs 269.6 GPixel/s. Its 32 GB memory is ample for many workstation tasks, and its 200 W power draw makes it far easier to integrate into a standard desktop or workstation chassis. The RTX PRO 4500’s benchmark scores, while lower in absolute terms, cover a range of graphics and compute tests, including a Geekbench Vulkan score of 221,768 and a Passmark G3D score of 33,360. The MI300X has no equivalent graphics benchmarks, only a single OpenCL result.

The verdict depends on workload type. For pure compute with no rendering needs, the MI300X wins on memory capacity, bandwidth, and FP32 performance. For general-purpose workstation use, including CAD, visualization, and content creation, the RTX PRO 4500 is the only viable option due to its display outputs and API support. The MI300X’s 100th percentile in OpenCL and its rival deltas (5% behind H200, 7.5% ahead of L40S) show it competes with top accelerators, but that performance comes at a 750 W power cost. The RTX PRO 4500’s 76th percentile and close rival scores (within 1.1% of four cards) indicate it sits in a crowded mid-range segment.

FAQ

Q: Which GPU has higher memory bandwidth?

A: The AMD Instinct MI300X has 5.32 TB/s bandwidth, compared to the NVIDIA RTX PRO 4500’s 896.0 GB/s.

Q: Does the RTX PRO 4500 support ray tracing?

A: Yes, it includes 82 ray tracing cores, while the MI300X has no ray tracing cores listed.

Q: Can the MI300X output video to a display?

A: No, it has no display outputs, and its pixel rate is 0 MPixel/s. The RTX PRO 4500 has four DisplayPort 2.1b outputs.

Q: What is the power consumption difference?

A: The MI300X has a TDP of 750 W and requires a suggested PSU of 1150 W. The RTX PRO 4500 has a TDP of 200 W and a suggested PSU of 550 W.

Q: How do their FP32 performances compare?

A: The MI300X delivers 81.72 TFLOPS FP32, while the RTX PRO 4500 delivers 50.53 TFLOPS FP32, a difference of roughly 1.6 times.

Q: Which GPU has more memory?

A: The MI300X has 192 GB of HBM3, while the RTX PRO 4500 has 32 GB of GDDR7.

Where Each One Wins

The AMD Instinct MI300X wins in memory capacity, bandwidth, and raw compute throughput. Its 192 GB HBM3 pool with 5.32 TB/s bandwidth allows it to hold large datasets and models without spilling to slower storage. FP32 performance of 81.72 TFLOPS is nearly double the RTX PRO 4500’s 50.53 TFLOPS, and its texture rate of 2,553.6 GTexel/s is over three times higher. The MI300X also has a higher shading unit count (19,456 versus 10,496) and a larger die (1017 mm² versus 378 mm²), indicating more parallel execution resources. Its 100th percentile OpenCL score confirms it excels in compute-heavy applications, and its rival comparisons place it near the NVIDIA H200 and B200, both top-tier accelerators.

The NVIDIA RTX PRO 4500 wins in every graphics-oriented category. It has 112 ROPs, 82 ray tracing cores, and 328 tensor cores, none of which exist on the MI300X. Its pixel rate of 269.6 GPixel/s is real, while the MI300X outputs 0 MPixel/s. The RTX PRO 4500 supports DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4, enabling modern rendering workloads. It also has four DisplayPort 2.1b outputs for multi-monitor setups, and its 32 GB GDDR7 memory, while smaller, is paired with a 256-bit bus that still achieves 896.0 GB/s, sufficient for many professional tasks. The RTX PRO 4500’s dual-slot design, 267 mm length, and 200 W power draw make it practical for standard workstations, whereas the MI300X requires an OAM module and 750 W.

In benchmark terms, the MI300X’s single OpenCL score of 317,994 is its only data point, and it stands at the very top of the database. The RTX PRO 4500’s Geekbench Vulkan score of 221,768 is its best, followed by Passmark G3D at 33,360 and Passmark GPU compute at 19,255. These results highlight different strengths: the MI300X dominates in compute-oriented OpenCL, while the RTX PRO 4500 demonstrates balanced performance across graphics APIs. For users with no rendering requirements, the MI300X offers superior compute density, but for anyone needing a display output, the RTX PRO 4500 is the clear choice. The data does not support using the MI300X for any graphics application, nor the RTX PRO 4500 for massive memory workloads.