AMD Instinct MI300X vs NVIDIA GeForce RTX 4080 SUPER Comparison

The AMD Instinct MI300X and the NVIDIA GeForce RTX 4080 SUPER represent two distinct branches of GPU design: one optimized for data-center compute, the other for client graphics. The database records a single direct benchmark comparison between them, yet the broader recorded specifications and rival comparisons reveal how differently each part is engineered. The MI300X is an OAM module with no display outputs, while the RTX 4080 SUPER is a triple-slot consumer card with a 16-pin connector. Their architectures could hardly be more divergent: CDNA 3.0 versus Ada Lovelace, 153,000 million transistors versus 45,900 million, and a 1017 mm² die versus a 379 mm² die.

Head-to-Head Benchmarks

The only shared benchmark test in the database is Geekbench OpenCL. Here the AMD Instinct MI300X records a score of 317994, while the NVIDIA GeForce RTX 4080 SUPER records 219065. The delta is 45.2% in favor of the AMD part, a decisive margin that reflects the MI300X’s compute-oriented design. The MI300X also holds the 100th percentile among all GPUs in the database, meaning it outperforms every other recorded GPU in aggregate benchmark score. Its average benchmark score is 317994, identical to its single OpenCL result, since no other tests are recorded for it.

The RTX 4080 SUPER, by contrast, holds the 86th percentile with an average benchmark score of 54209 across ten recorded tests. Its closest rival is the NVIDIA GeForce RTX 4080, which scores 54247, a delta of -0.1%. That places the SUPER essentially level with the non-SUPER model in the database’s aggregate scoring. The MI300X’s nearest rivals are all data-center or workstation parts: the NVIDIA B200 at 345482 (delta -8%), the NVIDIA H200 NVL at 334891 (delta -5%), the NVIDIA L40S at 295763 (delta 7.5%), and the NVIDIA RTX 6000 Ada Generation at 287237 (delta 10.7%). These deltas indicate that the MI300X sits in a performance tier far above the RTX 4080 SUPER, but also slightly below the top NVIDIA accelerators.

The OpenCL result is the sole head-to-head data point, so the 45.2% advantage is the only direct numerical comparison available. That advantage is consistent with other recorded facts: the MI300X delivers 81.72 TFLOPS FP32 and 81.72 TFLOPS FP16, while the RTX 4080 SUPER delivers 52.22 TFLOPS for both. The MI300X also has far higher texture rate, 2,553.6 GTexel/s versus 816.0 GTexel/s. The pixel rate tells a different story: the MI300X shows 0 MPixel/s, while the RTX 4080 SUPER shows 285.6 GPixel/s, reflecting the MI300X’s lack of rasterization hardware.

Where Each One Wins

The MI300X wins decisively in raw compute throughput and memory capacity. Its 192 GB of HBM3 memory with 8192-bit bus width and 5.32 TB/s bandwidth dwarfs the RTX 4080 SUPER’s 16 GB of GDDR6X on a 256-bit bus with 736.3 GB/s. For workloads that fit within OpenCL compute, the MI300X’s 45.2% lead in the shared test is the clearest indicator of its advantage. The MI300X also has more shading units (19456 versus 10240) and more TMUs (1216 versus 320), which supports its higher texture rate and FP32 throughput.

The RTX 4080 SUPER wins in areas the MI300X does not even attempt. It has 112 ROPs and a pixel rate of 285.6 GPixel/s, whereas the MI300X has 0 ROPs and 0 MPixel/s. It includes 80 RT cores and 320 tensor cores, features absent from the MI300X’s record. The RTX 4080 SUPER supports DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4, while the MI300X lists N/A for all three APIs. The RTX 4080 SUPER also has display outputs (1x HDMI 2.1, 3x DisplayPort 1.4a), while the MI300X has none. The MI300X is a compute accelerator; the RTX 4080 SUPER is a graphics card with compute capability.

The RTX 4080 SUPER’s recorded benchmarks show a wide spread across different test families. Its PassMark G3D score is 34245, its PassMark GPU compute score is 19822, and its 3DMark Steel Nomad DX12 score is 6600. It also has PassMark scores for older DirectX versions: 381 for DirectX 9, 301 for DirectX 11, 193 for DirectX 10, and 134 for DirectX 12. The Geekbench Vulkan score is 260075, and the Geekbench OpenCL score is 219065. These results show a part that is balanced across graphics and compute, but none of these tests are recorded for the MI300X, so no comparison is possible beyond the single OpenCL test.

The Verdict

The data indicates that the AMD Instinct MI300X is the stronger part for pure compute workloads. Its 45.2% OpenCL lead over the RTX 4080 SUPER, combined with its 100th percentile ranking, makes that clear. The MI300X also offers 12 times the memory capacity (192 GB versus 16 GB) and nearly 7.3 times the memory bandwidth (5.32 TB/s versus 736.3 GB/s). Its FP32 throughput is 56.5% higher (81.72 TFLOPS versus 52.22 TFLOPS). These are not marginal differences; they represent a different class of hardware.

The NVIDIA GeForce RTX 4080 SUPER is the only one of the two with any graphics capability. It has ROPs, RT cores, tensor cores, display outputs, and full graphics API support. The MI300X has none of these. The RTX 4080 SUPER’s 86th percentile ranking places it among high-end consumer GPUs, but its nearest rivals are all within a few percent: the RTX 4080 at -0.1%, the Radeon Pro W5700X at -1.1%, the Radeon RX 6750 GRE 12 GB at -2.7%, and the Radeon 8060S at -2.8%. That tight cluster suggests the RTX 4080 SUPER is competitively positioned within its own tier, but that tier is far below the MI300X’s.

Who should pick which depends entirely on the workload. The MI300X is for compute environments that need massive memory capacity and raw FP32/FP16 throughput, with no need for display output or graphics APIs. The RTX 4080 SUPER is for systems that need graphics rendering, ray tracing, and display connectivity, with compute capability secondary. The MI300X’s launch date is 2023-12-05, while the RTX 4080 SUPER’s is 2024-01-30. The RTX 4080 SUPER has a launch MSRP of 999 USD, and it is marked end-of-life with a successor in the GeForce 50 series. The MI300X’s predecessor is the Radeon Instinct, and no successor is recorded.

FAQ

Q: Which GPU has the higher Geekbench OpenCL score?

A: The AMD Instinct MI300X scores 317994, versus the NVIDIA GeForce RTX 4080 SUPER’s 219065, a 45.2% advantage for the MI300X.

Q: How does the MI300X compare to its nearest rivals?

A: The MI300X is 5% behind the NVIDIA H200 NVL (334891), 8% behind the NVIDIA B200 (345482), 7.5% ahead of the NVIDIA L40S (295763), and 10.7% ahead of the NVIDIA RTX 6000 Ada Generation (287237).

Q: What memory configurations do the two GPUs use?

A: The MI300X has 192 GB of HBM3 on an 8192-bit bus with 5.32 TB/s bandwidth. The RTX 4080 SUPER has 16 GB of GDDR6X on a 256-bit bus with 736.3 GB/s bandwidth.

Q: Does the MI300X support any graphics APIs?

A: No. The database lists DirectX, OpenGL, and Vulkan as N/A for the MI300X. The RTX 4080 SUPER supports DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4.

Q: What is the RTX 4080 SUPER’s percentile ranking?

A: It holds the 86th percentile among all GPUs, with an average benchmark score of 54209. Its closest rival, the RTX 4080, scores 54247, a delta of -0.1%.

Q: What are the physical differences between the two?

A: The MI300X is an OAM module with no power connectors and no display outputs. The RTX 4080 SUPER is a triple-slot card measuring 310 mm by 140 mm by 61 mm, with one 16-pin connector and 1x HDMI 2.1 plus 3x DisplayPort 1.4a outputs.

Architecture Differences

The MI300X uses the Aqua Vanjaram chip built on CDNA 3.0 architecture, while the RTX 4080 SUPER uses the AD103 chip built on Ada Lovelace. Both are manufactured on a 5 nm process at TSMC, but the die sizes diverged sharply: the MI300X is 1017 mm² with 153,000 million transistors, while the RTX 4080 SUPER is 379 mm² with 45,900 million transistors. Transistor density also differs: 150.4M per mm² for the MI300X versus 121.1M per mm² for the RTX 4080 SUPER.

The MI300X has 19456 shading units and 1216 TMUs but no ROPs, no RT cores, and no tensor cores recorded. The RTX 4080 SUPER has 10240 shading units, 320 TMUs, 112 ROPs, 80 RT cores, and 320 tensor cores. The MI300X’s pixel rate is 0 MPixel/s, confirming the absence of raster output hardware, while its texture rate is 2,553.6 GTexel/s. The RTX 4080 SUPER’s pixel rate is 285.6 GPixel/s and its texture rate is 816.0 GTexel/s.

Clock behavior differs as well. The MI300X runs at a base of 1000 MHz and boosts to 2100 MHz, with memory at 1300 MHz (5.2 Gbps effective). The RTX 4080 SUPER runs at a base of 2295 MHz and boosts to 2550 MHz, with memory at 1438 MHz (23 Gbps effective). The MI300X’s lower clocks but far larger chip produce higher FP32 throughput (81.72 TFLOPS versus 52.22 TFLOPS) and higher texture rate.

The MI300X uses HBM3 memory with an 8192-bit bus, yielding 5.32 TB/s bandwidth. The RTX 4080 SUPER uses GDDR6X with a 256-bit bus, yielding 736.3 GB/s. The MI300X’s memory bandwidth is more than seven times the RTX 4080 SUPER’s, and its capacity is twelve times greater. The MI300X has no display outputs, while the RTX 4080 SUPER has 1x HDMI 2.1 and 3x DisplayPort 1.4a.

Specification Differences

The MI300X and RTX 4080 SUPER differ in nearly every measured specification. The MI300X has a base clock of 1000 MHz and boost of 2100 MHz; the RTX 4080 SUPER has a base clock of 2295 MHz and boost of 2550 MHz. Memory clocks are 1300 MHz (5.2 Gbps effective) for the MI300X and 1438 MHz (23 Gbps effective) for the RTX 4080 SUPER.

Memory capacity: 192 GB HBM3 for the MI300X, 16 GB GDDR6X for the RTX 4080 SUPER. Bus width: 8192 bit versus 256 bit. Bandwidth: 5.32 TB/s versus 736.3 GB/s. Shading units: 19456 versus 10240. TMUs: 1216 versus 320. ROPs: 0 versus 112. RT cores: none recorded versus 80. Tensor cores: none recorded versus 320.

Pixel rate: 0 MPixel/s for the MI300X, 285.6 GPixel/s for the RTX 4080 SUPER. Texture rate: 2,553.6 GTexel/s versus 816.0 GTexel/s. FP32: 81.72 TFLOPS versus 52.22 TFLOPS. FP16: 81.72 TFLOPS (1:1) versus 52.22 TFLOPS (1:1).

TDP: 750 W for the MI300X, 320 W for the RTX 4080 SUPER. Suggested PSU: 1150 W versus 700 W. Slot width: OAM Module versus Triple-slot. Power connectors: none for the MI300X, 1x 16-pin for the RTX 4080 SUPER. Bus interface: PCIe 5.0 x16 for the MI300X, PCIe 4.0 x16 for the RTX 4080 SUPER.

Display outputs: none for the MI300X, 1x HDMI 2.1 plus 3x DisplayPort 1.4a for the RTX 4080 SUPER. APIs: N/A for the MI300X, DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4 for the RTX 4080 SUPER. The RTX 4080 SUPER has recorded dimensions of 310 mm by 140 mm by 61 mm; the MI300X has no recorded dimensions.

Release dates: the MI300X launched on 2023-12-05, the RTX 4080 SUPER on 2024-01-30. The MI300X has no launch MSRP recorded; the RTX 4080 SUPER has a launch MSRP of 999 USD. The RTX 4080 SUPER is marked end-of-life with a successor in the GeForce 50 series, while the MI300X’s production status is not recorded. The MI300X’s predecessor is the Radeon Instinct; the RTX 4080 SUPER’s predecessor is the GeForce 30 series.