AMD Instinct MI300X vs AMD Radeon RX 6450M Comparison

Where Each One Wins

The AMD Instinct MI300X and the AMD Radeon RX 6450M occupy opposite ends of the AMD accelerator spectrum, and the recorded data reflects that split clearly. The MI300X is a data-center compute module built for massive parallel workloads, while the RX 6450M is a low-power mobile graphics processor for laptops. Their benchmark presence is asymmetrical: the MI300X has a recorded Geekbench OpenCL score of 317,994, placing it at the 100th percentile of all GPUs in the database, whereas the RX 6450M has no benchmark entries at all, sitting at the 50th percentile with a score of zero.

The MI300X wins in any workload that stresses raw compute throughput, memory bandwidth, or sheer shader count. It carries 19,456 shading units, 1,216 texture mapping units, and an FP32 throughput of 81.72 TFLOPS. Its HBM3 memory stack totals 192 GB across an 8192-bit bus, delivering 5.32 TB/s of bandwidth. These figures make it a clear choice for large-scale inference, scientific simulation, and any task where data sets exceed the capacity of typical accelerator memory.

The RX 6450M wins in the mobile and efficiency domain. It draws only 50 W, uses a 6 nm process, and integrates 768 shading units, 48 TMUs, and 32 ROPs. It supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4, making it a functional part of a portable gaming system. Its pixel rate of 78.72 GPixel/s and texture rate of 118.1 GTexel/s are modest but entirely appropriate for a 4 GB GDDR6 part with a 64-bit bus.

The key distinction is not which part is "better" in absolute terms; it is which workload each part is engineered to serve. The MI300X has no display outputs, no graphics API support (DirectX, OpenGL, and Vulkan are all listed as N/A), and a power draw of 750 W with a suggested PSU of 1150 W. The RX 6450M, by contrast, is an IGP-class chip with portable-device-dependent display outputs and a TDP of just 50 W. The MI300X is a compute accelerator, and the RX 6450M is a graphics processor. The data shows that each one wins in its own domain.

Architecture Differences

The two chips share a manufacturer but diverge at almost every architectural level. The MI300X uses the Aqua Vanjaram chip built on CDNA 3.0, fabricated by TSMC on a 5 nm process. It packs 153,000 million transistors onto a 1017 mm² die, yielding a transistor density of 150.4 million transistors per square millimeter. The RX 6450M uses the Navi 24 chip built on RDNA 2.0, also from TSMC but on a 6 nm process. It contains 5,400 million transistors on a 107 mm² die, for a density of 50.5 million transistors per square millimeter. The MI300X is roughly 283 times denser in absolute transistor count and about 3 times denser per square millimeter.

Memory architecture differs fundamentally. The MI300X uses HBM3 with 192 GB capacity, an 8192-bit bus, and 5.32 TB/s bandwidth. The RX 6450M uses GDDR6 with 4 GB capacity, a 64-bit bus, and 128.0 GB/s bandwidth. Clock behavior also differs: the MI300X runs at a 1000 MHz base and 2100 MHz boost, with memory at 1300 MHz (5.2 Gbps effective). The RX 6450M runs at 2000 MHz base, 2460 MHz boost, and a 2220 MHz game clock, with memory at 2000 MHz (16 Gbps effective). The RX 6450M has higher raw clock speeds, but the MI300X compensates with vastly wider memory and more compute units.

Compute feature sets diverge as well. The MI300X has no ROPs, no ray tracing cores, and no tensor core count listed; its pixel rate is recorded as 0 MPixel/s. It is purely a compute device. The RX 6450M has 32 ROPs, 12 ray tracing cores, and a pixel rate of 78.72 GPixel/s. The MI300X delivers FP16 at 81.72 TFLOPS in a 1:1 ratio with FP32, meaning both precisions run at the same rate. The RX 6450M delivers FP16 at 7.557 TFLOPS in a 2:1 ratio, half the rate of its FP32 throughput of 3.779 TFLOPS.

Interface and packaging also differ. The MI300X is an OAM module with PCIe 5.0 x16 connectivity and no power connectors listed. The RX 6450M is an IGP with PCIe 4.0 x4 connectivity. API support is another separator: the MI300X reports no API support, while the RX 6450M supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. Generation tags differ too: the MI300X belongs to the Instinct (MIx) generation with a 2023-12-05 release date, and the RX 6450M belongs to the Navi Mobile (RX 6000M) generation with a 2023-01-03 release date.

Head-to-Head Benchmarks

There are no direct head-to-head benchmark entries in the database for these two parts. The MI300X has one recorded Geekbench OpenCL score of 317,994. The RX 6450M has no recorded benchmark scores at all. The comparison must therefore be drawn from the MI300X's rival set and the architectural data of the RX 6450M.

The MI300X's score places it at the 100th percentile of all GPUs in the database. Its nearest rivals in the recorded data are all NVIDIA data-center parts. It trails the NVIDIA H200 NVL, which scores 334,891, by 5%. It also trails the NVIDIA B200, which scores 345,482, by 8%. Against the NVIDIA L40S, which scores 295,763, the MI300X leads by 7.5%. Against the NVIDIA RTX 6000 Ada Generation, which scores 287,237, it leads by 10.7%. These delta values show a competitive position in the top tier of compute accelerators: slightly behind the newest NVIDIA data-center parts, but ahead of the L40S and RTX 6000 Ada Generation.

For the RX 6450M, no comparable benchmark data exists in the database. Its 50th percentile placement is based on the absence of scores, not on measured performance. The data shows that its FP32 throughput of 3.779 TFLOPS and FP16 throughput of 7.557 TFLOPS are roughly 21.6 times lower and 10.8 times lower than the MI300X's respective figures, though such ratio calculations are not part of the database's rival framework.

The biggest wins in the MI300X's favor come from sheer scale: 192 GB of HBM3 memory versus 4 GB of GDDR6, 5.32 TB/s versus 128.0 GB/s bandwidth, 19,456 versus 768 shading units, and 81.72 versus 3.779 TFLOPS FP32. The RX 6450M's wins are in clock speed (2460 MHz boost versus 2100 MHz boost), pixel rate (78.72 GPixel/s versus 0 MPixel/s), and API support. The MI300X cannot render graphics at all, while the RX 6450M is a fully capable graphics processor with ray tracing cores.

The Verdict

The data indicates two entirely different products with no meaningful overlap in intended use. The MI300X is a compute accelerator that sits at the 100th percentile of all GPUs in the database, with a Geekbench OpenCL score of 317,994. It is 5% behind the NVIDIA H200 NVL and 8% behind the NVIDIA B200, but 7.5% ahead of the NVIDIA L40S and 10.7% ahead of the NVIDIA RTX 6000 Ada Generation. Any workload that needs 192 GB of HBM3 memory, 5.32 TB/s of bandwidth, or 81.72 TFLOPS of FP32 throughput should use this part. It has no graphics output and no API support, so it is not a display adapter.

The RX 6450M is a mobile graphics processor with a 50 W TDP, 4 GB of GDDR6 memory, and support for DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4. It has no recorded benchmark scores, so its database percentile of 50 reflects missing data rather than measured performance. Its role is clear from its specifications: a low-power part for portable devices that need graphics rendering, ray tracing, and standard API compatibility. It cannot approach the MI300X in compute throughput, but it does not need to, because it is built for a different task.

The choice between these two parts is strictly a function of workload. Compute-heavy data-center deployments align with the MI300X. Mobile graphics and rendering align with the RX 6450M. The database shows no scenario where their capabilities overlap.

FAQ

Q: What is the benchmark score of the AMD Instinct MI300X?

A: The MI300X records a Geekbench OpenCL score of 317,994, placing it at the 100th percentile of all GPUs in the database.

Q: Does the AMD Radeon RX 6450M have any recorded benchmark scores?

A: No. The RX 6450M has no benchmark entries in the database, and its 50th percentile placement reflects the absence of measured scores.

Q: How does the MI300X compare to its nearest rivals?

A: It trails the NVIDIA H200 NVL by 5% and the NVIDIA B200 by 8%, while leading the NVIDIA L40S by 7.5% and the NVIDIA RTX 6000 Ada Generation by 10.7%.

Q: What memory configurations do the two parts use?

A: The MI300X uses 192 GB of HBM3 with an 8192-bit bus and 5.32 TB/s bandwidth. The RX 6450M uses 4 GB of GDDR6 with a 64-bit bus and 128.0 GB/s bandwidth.

Q: What graphics API support does each part have?

A: The MI300X lists no API support, with DirectX, OpenGL, and Vulkan all recorded as N/A. The RX 6450M supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4.

Q: What are the power requirements of each part?

A: The MI300X has a TDP of 750 W and a suggested PSU of 1150 W. The RX 6450M has a TDP of 50 W and no suggested PSU listed.