AMD Radeon RX 6600S vs NVIDIA Quadro P4000 Comparison

The AMD Radeon RX 6600S and NVIDIA Quadro P4000 represent two distinct approaches to mobile and workstation graphics, separated by five years of architectural evolution. The RX 6600S, built on RDNA 2.0, is a modern, power-efficient mobile part, while the P4000 is a Pascal-era workstation card. Benchmark data shows the RX 6600S wins the majority of head-to-head tests, but the P4000 holds specific advantages that matter for certain workflows. This analysis breaks down the raw numbers, architectural differences, and practical implications of each GPU.

Head-to-Head Benchmarks

The most dramatic split in performance comes from compute-oriented workloads. In the Geekbench OpenCL test, the AMD Radeon RX 6600S scores 66,435, which is 83.5% higher than the Quadro P4000’s 36,212. This is the largest delta in the entire comparison, indicating a fundamental advantage in raw compute throughput for the AMD part. The RX 6600S also leads in the Passmark G3D test with 12,649 points against the P4000’s 11,466, a 10.3% victory that reflects better overall 3D rendering performance.

DirectX API performance further favors the AMD card. In Passmark DirectX 12, the RX 6600S scores 56 versus the P4000’s 40, a 40% advantage. The gap narrows in older APIs but remains positive: DirectX 11 shows 105 vs 86 (22.1% lead), and DirectX 10 shows 81 vs 66 (22.7% lead). This pattern suggests the RX 6600S has better driver optimization for modern graphics pipelines, while the P4000 holds its own in legacy scenarios.

The NVIDIA Quadro P4000 does secure three wins out of the eight head-to-head comparisons. Its most notable victory is in the Passmark G2D test, where it scores 786 against the RX 6600S’s 647, a 17.7% margin. This indicates superior 2D desktop and windowing performance, which is relevant for professional productivity tasks. The P4000 also edges out the AMD card in DirectX 9 (181 vs 176, a 2.8% lead) and in GPU compute (4,913 vs 4,879, a 0.7% lead), though the latter is essentially a statistical tie.

Looking at aggregate scores, the RX 6600S averages 10,629 across all benchmarks, placing it in the 49th percentile of all GPUs. The P4000 averages 9,665, sitting in the 47th percentile. The AMD card’s nearest rival is the Radeon R9 M275X at 10,582 (0.4% difference), while the P4000’s closest competitor is the Radeon Pro WX 2100 at 9,653 (0.1% difference). These figures show both cards are positioned in the mid-range segment, but the RX 6600S holds a roughly 10% aggregate performance edge.

Architecture Differences

The two GPUs come from different eras and process technologies. The AMD Radeon RX 6600S uses the Navi 23 chip built on a 7 nm process at TSMC, packing 11,060 million transistors into a 237 mm² die. The NVIDIA Quadro P4000 uses the GP104 chip on a 16 nm process, also from TSMC, with 7,200 million transistors spread across a larger 314 mm² die. The transistor density tells the story: the RX 6600S achieves 46.7 million transistors per mm², more than double the P4000’s 22.9 million per mm².

Memory configurations differ significantly. The RX 6600S comes with 4 GB of GDDR6 memory on a 128-bit bus, providing 224.0 GB/s of bandwidth. The P4000 offers 8 GB of GDDR5 on a 256-bit bus, with 243.3 GB/s of bandwidth. Despite having half the memory size, the RX 6600S benefits from faster GDDR6 technology, though the P4000 still maintains a slight bandwidth advantage due to its wider bus.

Clock speeds favor the AMD card substantially. The RX 6600S runs at a 1700 MHz base clock and 2000 MHz boost, with a game clock of 1881 MHz. The P4000 operates at 1202 MHz base and 1480 MHz boost. The RX 6600S also has faster effective memory at 14 Gbps versus the P4000’s 7.6 Gbps. This clock advantage translates directly into compute throughput: the RX 6600S delivers 7.168 TFLOPS FP32 performance, while the P4000 manages 5.304 TFLOPS.

Architectural features also diverge. The RX 6600S supports DirectX 12 Ultimate (12_2) and includes 28 ray tracing cores, a feature entirely absent from the P4000, which maxes out at DirectX 12 (12_1). The AMD card also supports FP16 at a 2:1 ratio (14.34 TFLOPS), while the P4000’s FP16 performance is severely limited at 82.88 GFLOPS (1:64 ratio). Both cards share 1792 shading units, 112 TMUs, and 64 ROPs, but the RX 6600S achieves higher pixel and texture rates: 128.0 GPixel/s and 224.0 GTexel/s versus the P4000’s 94.72 GPixel/s and 165.8 GTexel/s.

Power and physical design present a stark contrast. The RX 6600S has an 80 W TDP and is an integrated GPU (IGP) with no power connectors, designed for portable devices. The P4000 has a 105 W TDP, requires a single 6-pin power connector, and is a single-slot card measuring 241 mm in length and 111 mm in height. The P4000 also specifies a 300 W suggested PSU, while the RX 6600S has no such requirement. The bus interfaces differ too: the RX 6600S uses PCIe 4.0 x8, while the P4000 uses PCIe 3.0 x16.

Where Each One Wins

The AMD Radeon RX 6600S is the clear winner for modern gaming and compute-heavy applications. Its 83.5% lead in OpenCL performance makes it the better choice for GPU-accelerated workloads like video encoding, machine learning inference, and scientific computing that leverage OpenCL. The 40% advantage in DirectX 12 also positions it well for current-generation games and applications built on modern graphics APIs. The 10.3% edge in Passmark G3D further confirms its superiority in Direct3D rendering scenarios.

The RX 6600S also benefits from its architectural modernity. The inclusion of ray tracing cores provides hardware acceleration for ray-traced effects in supported games, a capability the P4000 simply cannot offer. The 2:1 FP16 ratio also makes it suitable for workloads that use half-precision arithmetic, where it delivers 14.34 TFLOPS against the P4000’s negligible 82.88 GFLOPS.

The NVIDIA Quadro P4000 wins in specific professional scenarios. Its 17.7% advantage in Passmark G2D indicates better performance for 2D CAD drafting, spreadsheet rendering, and multi-monitor desktop productivity. The DirectX 9 victory (181 vs 176) is marginal but suggests compatibility with legacy industrial software that still relies on older graphics APIs. The GPU compute score of 4,913 vs 4,879, while only 0.7% higher, shows the P4000 can hold its own in certain compute tasks despite its older architecture.

The P4000’s 8 GB of VRAM versus the RX 6600S’s 4 GB is a significant practical advantage for professional workloads. Larger textures, complex CAD models, and multi-layered compositing in video editing all benefit from the doubled memory capacity. The higher memory bandwidth (243.3 GB/s vs 224.0 GB/s) also helps in memory-bound scenarios, even if the AMD card’s faster clocks compensate in other areas.

FAQ

Q: Which GPU has better overall benchmark performance?

A: The AMD Radeon RX 6600S wins 5 out of 8 head-to-head tests, including an 83.5% lead in Geekbench OpenCL and a 40% lead in Passmark DirectX 12. Its average benchmark score is 10,629 compared to the P4000’s 9,665.

Q: Is the NVIDIA Quadro P4000 better for any specific tasks?

A: Yes, the P4000 wins in Passmark G2D by 17.7% (786 vs 647), indicating superior 2D desktop performance. It also has a slight edge in DirectX 9 (181 vs 176) and GPU compute (4,913 vs 4,879), plus double the VRAM at 8 GB.

Q: Does the RX 6600S support ray tracing?

A: Yes, the RX 6600S includes 28 ray tracing cores and supports DirectX 12 Ultimate (12_2). The Quadro P4000 has no ray tracing cores and only supports DirectX 12 (12_1).

Q: How do the power requirements compare?

A: The RX 6600S has an 80 W TDP and is an integrated GPU with no power connectors. The P4000 has a 105 W TDP, requires a single 6-pin power connector, and needs a 300 W suggested PSU.

Q: Which card has faster memory?

A: The RX 6600S uses GDDR6 at 14 Gbps effective, while the P4000 uses GDDR5 at 7.6 Gbps. However, the P4000 has a wider 256-bit bus, giving it 243.3 GB/s bandwidth versus the RX 6600S’s 224.0 GB/s.

Q: What are the process node differences?

A: The RX 6600S is built on a 7 nm process with 11,060 million transistors on a 237 mm² die. The P4000 uses a 16 nm process with 7,200 million transistors on a 314 mm² die.

Specification Differences

| Specification | AMD Radeon RX 6600S | NVIDIA Quadro P4000 |

|---|---|---|

| Architecture | RDNA 2.0 | Pascal |

| Process Node | 7 nm | 16 nm |

| Transistors | 11,060 million | 7,200 million |

| Die Size | 237 mm² | 314 mm² |

| Transistor Density | 46.7M / mm² | 22.9M / mm² |

| Base Clock | 1700 MHz | 1202 MHz |

| Boost Clock | 2000 MHz | 1480 MHz |

| Game Clock | 1881 MHz | — |

| Memory Clock | 1750 MHz / 14 Gbps effective | 1901 MHz / 7.6 Gbps effective |

| Memory Size | 4 GB | 8 GB |

| Memory Type | GDDR6 | GDDR5 |

| Memory Bus Width | 128 bit | 256 bit |

| Memory Bandwidth | 224.0 GB/s | 243.3 GB/s |

| RT Cores | 28 | — |

| Pixel Rate | 128.0 GPixel/s | 94.72 GPixel/s |

| Texture Rate | 224.0 GTexel/s | 165.8 GTexel/s |

| FP32 Performance | 7.168 TFLOPS | 5.304 TFLOPS |

| FP16 Performance | 14.34 TFLOPS (2:1) | 82.88 GFLOPS (1:64) |

| TDP | 80 W | 105 W |

| Slot Width | IGP | Single-slot |

| Power Connectors | None | 1x 6-pin |

| Suggested PSU | — | 300 W |

| Bus Interface | PCIe 4.0 x8 | PCIe 3.0 x16 |

| Display Outputs | Portable Device Dependent | 4x DisplayPort 1.4a |

| DirectX Support | 12 Ultimate (12_2) | 12 (12_1) |

| Dimensions | — | 241 mm / 9.5 inches length, 111 mm / 4.4 inches height |

| Release Date | 2022-01-03 | 2017-02-05 |

| Predecessor | Polaris Mobile | Quadro Maxwell |

| Successor | — | Quadro Volta |