AMD Radeon RX 6600 LE vs NVIDIA Quadro GP100 Comparison

The NVIDIA Quadro GP100 and AMD Radeon RX 6600 LE represent two very different approaches to GPU design, separated by seven years of architectural evolution. The Quadro GP100 is a 2016-era compute monster built on a massive 610 mm² die with HBM2 memory, while the RX 6600 LE is a 2023 mainstream gaming card on a compact 237 mm² die with GDDR6. Benchmark data shows the GP100 holds a decisive lead in raw OpenCL compute performance, but the RX 6600 LE counters with modern API support, higher clock speeds, and dramatically better transistor density.

Where Each One Wins

The NVIDIA Quadro GP100 is the clear winner in raw compute throughput. Its Geekbench OpenCL score of 87,445 sits 26.3% above the RX 6600 LE’s 69,229 in the same test. This advantage stems from its 3,584 shading units, 224 texture mapping units, and 96 ROPs—more than double the RX 6600 LE’s 1,792 shading units, 112 TMUs, and 64 ROPs. The GP100 also delivers 10.34 TFLOPS of FP32 performance versus 8.942 TFLOPS for the RX 6600 LE, and its FP16 output of 20.69 TFLOPS edges out the RX 6600 LE’s 17.88 TFLOPS. For compute-heavy workloads like scientific simulation or rendering, the GP100’s higher pixel rate (138.5 GPixel/s vs 159.7 GPixel/s) and texture rate (323.2 GTexel/s vs 279.4 GTexel/s) show it maintains strong output despite lower clocks.

The AMD Radeon RX 6600 LE wins in efficiency and modern feature support. Its 7 nm process node versus the GP100’s 16 nm node results in a transistor density of 46.7M per mm², nearly double the GP100’s 25.1M per mm². The RX 6600 LE’s TDP of 132 W is 103 W lower than the GP100’s 235 W, and its suggested PSU is 300 W versus 550 W. It also supports DirectX 12 Ultimate (12_2), while the GP100 is limited to DirectX 12 (12_1). The RX 6600 LE has 28 ray tracing cores, a feature entirely absent from the GP100. In Vulkan performance, the RX 6600 LE scores 72,428, though no comparable Vulkan score exists for the GP100 in the data.

Architecture Differences

The architectural divide is stark. The GP100 uses NVIDIA’s Pascal architecture, built on TSMC’s 16 nm process with 15,300 million transistors spread across a 610 mm² die. The RX 6600 LE uses AMD’s RDNA 2.0 architecture, also fabricated by TSMC but on a 7 nm node, packing 11,060 million transistors into a 237 mm² die. This makes the RX 6600 LE far more transistor-dense, achieving 46.7M transistors per mm² versus the GP100’s 25.1M.

Memory architecture differs fundamentally. The GP100 uses 16 GB of HBM2 on a 4096-bit bus, delivering 732.2 GB/s of bandwidth. The RX 6600 LE uses 8 GB of GDDR6 on a 128-bit bus, providing 224.0 GB/s. The GP100’s memory bandwidth is 3.3 times higher, which explains its compute dominance. Clock speeds tell the opposite story: the RX 6600 LE boosts to 2495 MHz with a base of 1626 MHz, while the GP100 runs at 1304 MHz base and 1443 MHz boost. The RX 6600 LE also has a game clock of 2045 MHz, a feature the GP100 lacks.

Feature sets diverge significantly. The RX 6600 LE includes 28 ray tracing cores and supports DirectX 12 Ultimate, Vulkan 1.4, and PCIe 4.0 x8. The GP100 supports DirectX 12 (12_1), Vulkan 1.3, and PCIe 3.0 x16. Both support OpenGL 4.6. The GP100 offers 1x DVI and 4x DisplayPort 1.4a outputs, while the RX 6600 LE provides 1x HDMI 2.1 and 3x DisplayPort 1.4a. The GP100 is end-of-life, released on September 30, 2016, while the RX 6600 LE is active, released on December 7, 2023.

FAQ

Q: Which card has higher raw compute performance?

A: The NVIDIA Quadro GP100 dominates with a Geekbench OpenCL score of 87,445, which is 26.3% higher than the AMD Radeon RX 6600 LE’s 69,229. The GP100 also leads in FP32 (10.34 TFLOPS vs 8.942 TFLOPS) and FP16 (20.69 TFLOPS vs 17.88 TFLOPS).

Q: Does the RX 6600 LE support ray tracing?

A: Yes, the RX 6600 LE includes 28 ray tracing cores. The Quadro GP100 has no ray tracing cores, making the RX 6600 LE the only option for hardware-accelerated ray tracing workloads.

Q: How do memory bandwidth and capacity compare?

A: The GP100 offers 16 GB of HBM2 on a 4096-bit bus with 732.2 GB/s bandwidth. The RX 6600 LE has 8 GB of GDDR6 on a 128-bit bus with 224.0 GB/s bandwidth. The GP100 provides over three times the bandwidth and double the capacity.

Q: Which card is more power-efficient?

A: The RX 6600 LE has a TDP of 132 W and suggests a 300 W PSU, while the GP100 has a TDP of 235 W and suggests a 550 W PSU. The RX 6600 LE’s 7 nm process contributes to this efficiency advantage.

Q: What are the API differences?

A: The RX 6600 LE supports DirectX 12 Ultimate (12_2) and Vulkan 1.4, while the GP100 supports DirectX 12 (12_1) and Vulkan 1.3. Both cards support OpenGL 4.6.

Q: How does the RX 6600 LE perform in Vulkan?

A: The RX 6600 LE scores 72,428 in Geekbench Vulkan. No Vulkan benchmark score is available for the GP100 in the provided data.

Specification Differences

| Specification | NVIDIA Quadro GP100 | AMD Radeon RX 6600 LE |

|---|---|---|

| Architecture | Pascal | RDNA 2.0 |

| Process Node | 16 nm | 7 nm |

| Transistors | 15,300 million | 11,060 million |

| Die Size | 610 mm² | 237 mm² |

| Transistor Density | 25.1M / mm² | 46.7M / mm² |

| Base Clock | 1304 MHz | 1626 MHz |

| Boost Clock | 1443 MHz | 2495 MHz |

| Game Clock | None | 2045 MHz |

| Memory Size | 16 GB | 8 GB |

| Memory Type | HBM2 | GDDR6 |

| Memory Bus Width | 4096 bit | 128 bit |

| Memory Bandwidth | 732.2 GB/s | 224.0 GB/s |

| Memory Clock | 715 MHz / 1430 Mbps | 1750 MHz / 14 Gbps |

| Shading Units | 3584 | 1792 |

| TMUs | 224 | 112 |

| ROPs | 96 | 64 |

| Ray Tracing Cores | None | 28 |

| Pixel Rate | 138.5 GPixel/s | 159.7 GPixel/s |

| Texture Rate | 323.2 GTexel/s | 279.4 GTexel/s |

| FP32 | 10.34 TFLOPS | 8.942 TFLOPS |

| FP16 | 20.69 TFLOPS (2:1) | 17.88 TFLOPS (2:1) |

| TDP | 235 W | 132 W |

| Suggested PSU | 550 W | 300 W |

| Bus Interface | PCIe 3.0 x16 | PCIe 4.0 x8 |

| Display Outputs | 1x DVI, 4x DisplayPort 1.4a | 1x HDMI 2.1, 3x DisplayPort 1.4a |

| DirectX | 12 (12_1) | 12 Ultimate (12_2) |

| Vulkan | 1.3 | 1.4 |

| Length | 267 mm (10.5 in) | 190 mm (7.5 in) |

| Height | 111 mm (4.4 in) | 110 mm (4.3 in) |

| Width | Not specified | 40 mm (1.6 in) |

| Production Status | End-of-life | Active |

| Release Date | September 30, 2016 | December 7, 2023 |

| Predecessor | Quadro Maxwell | Navi |

| Successor | Quadro Volta | Navi III |

Head-to-Head Benchmarks

The only direct benchmark comparison available is Geekbench OpenCL, where the NVIDIA Quadro GP100 scores 87,445 versus the AMD Radeon RX 6600 LE’s 69,229. This represents a 26.3% advantage for the GP100, a substantial margin that reflects its architectural focus on compute throughput. The GP100’s victory is driven by its 3,584 shading units—exactly twice the RX 6600 LE’s 1,792—and its 4096-bit memory bus that provides 732.2 GB/s of bandwidth compared to 224.0 GB/s.

The RX 6600 LE’s higher clocks (2495 MHz boost versus 1443 MHz) help it close the gap in some areas, but not enough. Its pixel rate of 159.7 GPixel/s actually exceeds the GP100’s 138.5 GPixel/s, and its texture rate of 279.4 GTexel/s trails only slightly behind the GP100’s 323.2 GTexel/s. However, the GP100’s superior FP32 and FP16 throughput—10.34 TFLOPS and 20.69 TFLOPS versus 8.942 TFLOPS and 17.88 TFLOPS—prove decisive in compute benchmarks.

Looking at the broader competitive landscape, the GP100 sits at the 93rd percentile of all GPUs, while the RX 6600 LE sits at the 91st percentile. The GP100’s nearest rival is the AMD Radeon PRO W7600 with an average score of 87,108, just 0.4% behind. The RX 6600 LE’s nearest rival is the NVIDIA RTX A3000 Mobile at 70,140, which the RX 6600 LE leads by 1%. The RX 6600 LE also surpasses the NVIDIA Quadro P6000 (69,986) by 1.2% and the AMD Radeon Pro WX 8200 (69,870) by 1.4%. Notably, the RX 6600 LE trails the AMD Radeon RX 6650M (71,768) by 1.3%.

The GP100’s average benchmark score of 87,445 places it ahead of the NVIDIA CMP 40HX (85,637) by 2.1% and the NVIDIA RTX A4500 Mobile (91,134) by 4%—though here the GP100 is the one behind. The data shows the GP100 holds its own against much newer workstation cards, while the RX 6600 LE competes primarily with mobile and older workstation parts. The RX 6600 LE’s Vulkan score of 72,428 has no direct GP100 comparison in the dataset, but it demonstrates the card’s capability in modern graphics APIs.