AMD Radeon R9 M375 vs AMD Radeon RX 6600S Comparison

The AMD Radeon RX 6600S and the AMD Radeon R9 M375 represent two distinct eras of mobile graphics, separated by process technology, architecture, and performance class. The data shows a decisive victory for the newer RX 6600S, but the comparison is still useful for understanding how far mobile GPUs have come. The RX 6600S, built on RDNA 2.0, is a modern part that targets high-end thin-and-light gaming, while the R9 M375 is an older GCN-based chip designed for basic multimedia and entry-level gaming. Benchmark results indicate the RX 6600S is in a completely different performance tier, yet the R9 M375’s legacy status and specific feature set provide context for its historical role.

Where Each One Wins

The performance split between these two is stark, with the RX 6600S winning the only shared benchmark by a massive margin. The data shows a single head-to-head test, Geekbench OpenCL, where the RX 6600S scored 66,435 against the R9 M375’s 10,457, a delta of 535.3%. This is not a close contest; the RX 6600S is categorically superior for any compute-oriented workload, including OpenCL-accelerated applications. Its wins extend to modern API support, with DirectX 12 Ultimate (12_2) and Vulkan 1.4, making it suitable for current-generation game titles that leverage ray tracing and mesh shaders. The R9 M375, conversely, offers no such advantages. Its only wins are in legacy contexts: it is an end-of-life product with a lower transistor count and a smaller die, which historically meant lower power draw and manufacturing cost. However, with no TDP listed for the R9 M375, the data cannot confirm an efficiency advantage. The R9 M375’s only measurable edge is its PCIe 3.0 x16 interface versus the RX 6600S’s PCIe 4.0 x8, which is a bandwidth advantage in theory but irrelevant given the R9 M375’s far lower compute throughput. In practical terms, the RX 6600S wins every meaningful performance scenario, while the R9 M375 wins only in the field of being a simpler, older part.

Architecture Differences

The architectural gap is fundamental. The RX 6600S is built on the RDNA 2.0 architecture, fabricated on a 7 nm process at TSMC, with 11,060 million transistors packed into a 237 mm² die, yielding a transistor density of 46.7M per mm². The R9 M375 uses the older GCN 1.0 architecture, on a 28 nm process, also at TSMC, with just 1,500 million transistors on a 123 mm² die, giving a density of 12.2M per mm². This process difference alone explains the RX 6600S’s ability to house far more hardware. The RX 6600S features 1,792 shading units, 112 texture mapping units, 64 ROPs, and 28 ray tracing cores, a hardware feature entirely absent from the R9 M375. The R9 M375 has 640 shading units, 40 TMUs, and 16 ROPs. Memory configurations also diverge sharply: the RX 6600S uses 4 GB of GDDR6 on a 128-bit bus, delivering 224.0 GB/s of bandwidth, while the R9 M375 uses 2 GB of DDR3 on a 128-bit bus, with a mere 28.80 GB/s of bandwidth. The RX 6600S’s memory clock is listed as 1750 MHz (14 Gbps effective), versus the R9 M375’s 900 MHz (1800 Mbps effective). The RX 6600S also supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4, while the R9 M375 is limited to DirectX 12 (11_1), OpenGL 4.6, and Vulkan 1.2.170. The RX 6600S is an IGP with no power connectors and a TDP of 80 W, whereas the R9 M375 has no TDP or slot width listed. The generation markers confirm the timeline: RX 6600S is "Navi Mobile (RX 6000M)" and the R9 M375 is "Gem System (R9 M300)".

Head-to-Head Benchmarks

The only direct benchmark comparison available is Geekbench OpenCL, and it is lopsided. The RX 6600S scores 66,435, which is 535.3% higher than the R9 M375’s 10,457. To put that in perspective, the RX 6600S’s average benchmark score across all tests is 10,629, while the R9 M375’s is 10,070. The RX 6600S’s OpenCL score is over six times its own average, indicating that it excels in compute-heavy tasks. The R9 M375’s OpenCL score of 10,457 is close to its average, suggesting it is a more balanced but far less capable part. The RX 6600S also has a Geekbench Vulkan score of 9,682 (from the R9 M375’s data), but the RX 6600S does not have a Vulkan score listed in its benchmarks, so no direct comparison is possible there. The RX 6600S’s other benchmark scores include Passmark DirectX 9 (176), DirectX 10 (81), DirectX 11 (105), DirectX 12 (56), G2D (647), G3D (12,649), and GPU Compute (4,879). These numbers indicate a strong DirectX 9 and G3D performance, but the lack of corresponding R9 M375 scores for those tests prevents further head-to-head analysis. The delta of 535.3% in OpenCL is the single most telling figure: it represents a generational leap, not an incremental improvement. The R9 M375’s nearest rivals include the NVIDIA Quadro K5100M (0.3% slower), AMD Radeon Pro 5300M (0.6% slower), and NVIDIA GeForce GTX 870M (1.1% slower), all within a narrow band of its average score. The RX 6600S’s nearest rivals are the AMD Radeon R9 M275X (0.4% slower), NVIDIA GeForce GTX 560 Ti (0.6% faster), and NVIDIA Quadro K2200 (1.2% faster), showing it sits in a higher performance bracket despite its own average being close to the R9 M375’s.

FAQ

Q: Which GPU is faster in OpenCL compute?

A: The AMD Radeon RX 6600S is decisively faster, scoring 66,435 in Geekbench OpenCL versus the R9 M375’s 10,457, a 535.3% advantage.

Q: Do these GPUs support the same DirectX version?

A: No. The RX 6600S supports DirectX 12 Ultimate (12_2), while the R9 M375 is limited to DirectX 12 (11_1). The RX 6600S also supports Vulkan 1.4, whereas the R9 M375 supports Vulkan 1.2.170.

Q: What are the memory specifications for each card?

A: The RX 6600S has 4 GB of GDDR6 on a 128-bit bus with 224.0 GB/s bandwidth. The R9 M375 has 2 GB of DDR3 on a 128-bit bus with 28.80 GB/s bandwidth.

Q: Is the R9 M375 a suitable replacement for the RX 6600S in modern games?

A: No. The RX 6600S includes 28 ray tracing cores and supports DirectX 12 Ultimate, while the R9 M375 has no ray tracing cores and only supports DirectX 12 (11_1), making it unsuitable for modern titles that rely on these features.

Q: How do their average benchmark scores compare?

A: The RX 6600S has an average benchmark score of 10,629, while the R9 M375 has an average of 10,070. The RX 6600S is about 5.5% higher on average, but its OpenCL score is dramatically higher.

Q: What are the process nodes for each GPU?

A: The RX 6600S is fabricated on a 7 nm process, while the R9 M375 uses a 28 nm process, both at TSMC.

Specification Differences

The following specifications differ between the two GPUs:

• Architecture: RDNA 2.0 (RX 6600S) vs GCN 1.0 (R9 M375)
• Process Node: 7 nm (RX 6600S) vs 28 nm (R9 M375)
• Transistors: 11,060 million (RX 6600S) vs 1,500 million (R9 M375)
• Die Size: 237 mm² (RX 6600S) vs 123 mm² (R9 M375)
• Transistor Density: 46.7M / mm² (RX 6600S) vs 12.2M / mm² (R9 M375)
• Base Clock: 1700 MHz (RX 6600S) vs 1000 MHz (R9 M375)
• Boost Clock: 2000 MHz (RX 6600S) vs 1015 MHz (R9 M375)
• Game Clock: 1881 MHz (RX 6600S) vs null (R9 M375)
• Memory Clock: 1750 MHz / 14 Gbps effective (RX 6600S) vs 900 MHz / 1800 Mbps effective (R9 M375)
• Memory Size: 4 GB (RX 6600S) vs 2 GB (R9 M375)
• Memory Type: GDDR6 (RX 6600S) vs DDR3 (R9 M375)
• Memory Bandwidth: 224.0 GB/s (RX 6600S) vs 28.80 GB/s (R9 M375)
• Shading Units: 1792 (RX 6600S) vs 640 (R9 M375)
• TMUs: 112 (RX 6600S) vs 40 (R9 M375)
• ROPs: 64 (RX 6600S) vs 16 (R9 M375)
• Ray Tracing Cores: 28 (RX 6600S) vs null (R9 M375)
• Pixel Rate: 128.0 GPixel/s (RX 6600S) vs 16.24 GPixel/s (R9 M375)
• Texture Rate: 224.0 GTexel/s (RX 6600S) vs 40.60 GTexel/s (R9 M375)
• FP32 Performance: 7.168 TFLOPS (RX 6600S) vs 1,299.2 GFLOPS (R9 M375)
• FP16 Performance: 14.34 TFLOPS (2:1) (RX 6600S) vs null (R9 M375)
• TDP: 80 W (RX 6600S) vs null (R9 M375)
• Slot Width: IGP (RX 6600S) vs null (R9 M375)
• Power Connectors: None (RX 6600S) vs null (R9 M375)
• Bus Interface: PCIe 4.0 x8 (RX 6600S) vs PCIe 3.0 x16 (R9 M375)
• Display Outputs: Portable Device Dependent (RX 6600S) vs null (R9 M375)
• DirectX Support: 12 Ultimate (12_2) (RX 6600S) vs 12 (11_1) (R9 M375)
• Vulkan Support: 1.4 (RX 6600S) vs 1.2.170 (R9 M375)
• Release Date: 2022-01-03 (RX 6600S) vs 2015-05-04 (R9 M375)
• Predecessor: Polaris Mobile (RX 6600S) vs Solar System (R9 M375)
• Successor: null (RX 6600S) vs Polaris Mobile (R9 M375)
• Generation: Navi Mobile (RX 6000M) (RX 6600S) vs Gem System (R9 M300) (R9 M375)