AMD Radeon PRO V620 vs NVIDIA Quadro RTX 6000 Comparison

AMD Radeon PRO V620 vs NVIDIA Quadro RTX 6000 is a matchup between two end-of-life workstation cards from different generations and design philosophies. The AMD card, built on Navi 21 with RDNA 2.0, targets raw compute throughput and large memory capacity, while the NVIDIA Quadro RTX 6000, based on TU102 with Turing, brings tensor cores and a wider memory bus. Benchmark data from Geekbench shows the AMD card winning both tested workloads, but the margin varies dramatically depending on the API. The V620's average benchmark score of 136,472 places it in the 96th percentile of all GPUs, while the RTX 6000's 101,872 average sits in the 94th percentile. This gap of roughly 34% in average score tells a clear story, but the specifics of each workload reveal where each card's architecture shines and where it falls behind.

Where Each One Wins

The AMD Radeon PRO V620 wins decisively in OpenCL compute, scoring 128,580 against the RTX 6000's 74,179 — a 73.3% advantage. This is the single largest performance gap in the comparison and indicates that the V620's RDNA 2.0 architecture with its 20.28 TFLOPS FP32 throughput is far better suited to raw, general-purpose compute workloads that scale with shading unit count and clock speed. The V620 also wins in Vulkan, but by a much narrower 11.4% margin, scoring 144,364 versus 129,564. Vulkan tends to favor architectures with efficient draw call handling and modern feature sets, so the V620's newer RDNA 2.0 design and PCIe 4.0 interface contribute to its edge there, though the RTX 6000's tensor cores and mature driver stack keep it competitive.

The NVIDIA Quadro RTX 6000 has no benchmark wins in this dataset, but its strengths are evident in its specification sheet. With 576 tensor cores and 72 RT cores, it offers hardware acceleration for AI inference and ray tracing that the AMD card's 72 RT cores cannot match in terms of dedicated tensor throughput. The RTX 6000's 672 GB/s memory bandwidth exceeds the V620's 512 GB/s, which benefits memory-bound workloads like large dataset processing or high-resolution texture streaming. For builders prioritizing CUDA-accelerated applications or TensorFlow-style workloads, the RTX 6000's feature set is the differentiator, even if the raw compute benchmarks favor AMD.

Architecture Differences

The two cards are built on fundamentally different process nodes and architectures. The AMD Radeon PRO V620 uses a 7 nm process at TSMC, packing 26,800 million transistors into a 520 mm² die. This yields a transistor density of 51.5 million per mm², a figure that reflects the modern RDNA 2.0 design. In contrast, the NVIDIA Quadro RTX 6000 uses a 12 nm process, also at TSMC, with 18,600 million transistors on a much larger 754 mm² die, giving a density of just 24.7 million per mm². The V620's smaller, denser chip allows for higher clock speeds — 1825 MHz base and 2200 MHz boost versus the RTX 6000's 1440 MHz base and 1770 MHz boost — which directly contributes to its compute advantage.

Memory configurations differ significantly. The V620 offers 32 GB of GDDR6 on a 256-bit bus, while the RTX 6000 provides 24 GB on a 384-bit bus. The wider bus gives the NVIDIA card higher bandwidth at 672 GB/s versus 512 GB/s, but the AMD card's larger capacity is a key advantage for workloads that exceed 24 GB, such as massive scene rendering or multi-model machine learning training. Both cards have 4608 shading units and 288 TMUs, but the V620 has 128 ROPs compared to the RTX 6000's 96, which helps its pixel rate of 281.6 GPixel/s versus 169.9 GPixel/s. The V620 also leads in texture rate at 633.6 GTexel/s versus 509.8 GTexel/s.

Feature-wise, the RTX 6000 includes 576 tensor cores, which the V620 lacks entirely. Both support DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4, but the RTX 6000 has display outputs (4x DisplayPort 1.4a and 1x USB Type-C) while the V620 has none, making it a compute-only card. The V620 uses PCIe 4.0 x16, while the RTX 6000 is limited to PCIe 3.0 x16. Power requirements differ too: the V620 draws 300 W with a 700 W suggested PSU and dual 8-pin connectors, while the RTX 6000 draws 260 W with a 600 W suggested PSU and a 6-pin plus 8-pin configuration.

Head-to-Head Benchmarks

The Geekbench OpenCL test delivers the most lopsided result. The AMD Radeon PRO V620 scores 128,580, while the NVIDIA Quadro RTX 6000 manages only 74,179. That is a 73.3% delta in favor of AMD. OpenCL workloads are heavily dependent on raw FP32 compute and memory throughput, and the V620's 20.28 TFLOPS FP32 rating, combined with its 2200 MHz boost clock, decimates the RTX 6000's 16.31 TFLOPS and 1770 MHz boost. The V620's higher ROP count also helps in compute kernels that involve pixel or fragment operations. This is not a marginal win; it is a generational leap in compute density.

The Vulkan test is closer but still favors AMD. The V620 scores 144,364 against 129,564 for the RTX 6000, a delta of 11.4%. Vulkan's lower overhead and better utilization of modern GPU features likely benefit the V620's RDNA 2.0 architecture, which was designed with contemporary graphics APIs in mind. The RTX 6000's Turing architecture, while capable, is older and less optimized for Vulkan's asynchronous compute and draw call batching. That said, the RTX 6000's tensor cores do not help in this particular Vulkan workload, which is purely graphics-based. The 11.4% gap suggests that in real-world Vulkan applications, the two cards are closer than the OpenCL result implies, but the AMD card still holds a clear edge.

Across both benchmarks, the V620 wins 2-0. Its average benchmark score of 136,472 is 34% higher than the RTX 6000's 101,872. For context, the V620's nearest rivals include the AMD Radeon Pro W6800X Duo (135,774, just 0.5% behind) and the NVIDIA A10M (135,230, 0.9% behind), showing that the V620 sits at the top of its class. The RTX 6000's nearest rivals include the AMD Radeon Pro Vega II Duo (106,750, which is 4.6% ahead of the RTX 6000) and the AMD Radeon RX 7900M (97,487, 4.5% behind), placing it in a mid-tier position relative to newer cards.

The Verdict

From the data, the AMD Radeon PRO V620 is the clear compute winner. It delivers 73.3% higher OpenCL performance and 11.4% higher Vulkan performance than the Quadro RTX 6000, with double the memory capacity (32 GB versus 24 GB) and a more modern 7 nm process. Anyone running OpenCL-heavy workloads, such as scientific simulations, rendering, or data processing that can utilize 32 GB of VRAM, should choose the V620 without hesitation. Its 96th percentile ranking and top-tier position among rivals like the W6800X Duo and A10M confirm its standing as a high-end compute card.

The NVIDIA Quadro RTX 6000 still has a role. Its 576 tensor cores are a unique feature that the V620 cannot match, making it the better choice for AI inference or any TensorFlow/PyTorch workload that leverages CUDA and cuDNN. The RTX 6000's 672 GB/s memory bandwidth also exceeds the V620's, which helps in bandwidth-bound tasks. Additionally, the RTX 6000 has display outputs, so it can drive monitors directly, while the V620 requires a separate GPU for display. For a mixed-use workstation that needs both compute and display capability, or for CUDA-specific applications, the RTX 6000 remains viable despite its lower raw benchmark scores.

Choose the V620 for maximum compute throughput and memory capacity. Choose the RTX 6000 for tensor core acceleration, CUDA compatibility, and integrated display outputs. The data does not support the RTX 6000 in pure performance terms, but its feature set addresses niches the V620 cannot.

FAQ

Q: Which card has a higher average benchmark score?

A: The AMD Radeon PRO V620 has an average benchmark score of 136,472, which is 34% higher than the NVIDIA Quadro RTX 6000's 101,872.

Q: How much faster is the V620 in OpenCL?

A: The V620 scores 128,580 in Geekbench OpenCL, while the RTX 6000 scores 74,179, giving the AMD card a 73.3% advantage.

Q: Does the RTX 6000 have any unique hardware features?

A: Yes, the RTX 6000 has 576 tensor cores and 72 RT cores, while the V620 has 72 RT cores but no tensor cores. The RTX 6000 also has display outputs, while the V620 has none.

Q: What is the memory capacity difference?

A: The V620 has 32 GB of GDDR6 memory on a 256-bit bus, while the RTX 6000 has 24 GB on a 384-bit bus. The RTX 6000 has higher bandwidth at 672 GB/s versus 512 GB/s.

Q: Which card requires more power?

A: The V620 has a 300 W TDP with a suggested 700 W PSU and dual 8-pin connectors, while the RTX 6000 has a 260 W TDP with a suggested 600 W PSU and a 6-pin plus 8-pin setup.

Q: How do their transistor densities compare?

A: The V620, built on 7 nm, has a density of 51.5 million transistors per mm² with 26,800 million total. The RTX 6000, on 12 nm, has 24.7 million per mm² with 18,600 million total.

Specification Differences

| Specification | AMD Radeon PRO V620 | NVIDIA Quadro RTX 6000 |

|----------------|---------------------|-------------------------|

| Process Node | 7 nm | 12 nm |

| Transistors | 26,800 million | 18,600 million |

| Die Size | 520 mm² | 754 mm² |

| Base Clock | 1825 MHz | 1440 MHz |

| Boost Clock | 2200 MHz | 1770 MHz |

| Memory Size | 32 GB | 24 GB |

| Memory Bus Width | 256 bit | 384 bit |

| Memory Bandwidth | 512.0 GB/s | 672.0 GB/s |

| ROPs | 128 | 96 |

| Tensor Cores | None | 576 |

| FP32 Performance | 20.28 TFLOPS | 16.31 TFLOPS |

| TDP | 300 W | 260 W |

| Power Connectors | 2x 8-pin | 1x 6-pin + 1x 8-pin |

| Suggested PSU | 700 W | 600 W |

| Bus Interface | PCIe 4.0 x16 | PCIe 3.0 x16 |

| Display Outputs | No outputs | 4x DisplayPort 1.4a, 1x USB Type-C |

| Release Date | 2021-11-03 | 2018-08-12 |