AMD Radeon Pro Duo vs NVIDIA RTX PRO 4500 Blackwell Comparison

Where Each One Wins

The AMD Radeon Pro Duo and NVIDIA RTX PRO 4500 Blackwell occupy entirely different positions in the database, and their benchmark coverage reflects that. The Radeon Pro Duo has a single recorded OpenCL score of 35,860, which places it at the 80th percentile of all GPUs in the database. That score is effectively a compute-oriented result, and it sits within 1.8% of its nearest rivals: the NVIDIA T1000 scores 36,289 (1.2% higher), the AMD Radeon RX 5300M scores 36,529 (1.8% higher), while the NVIDIA Quadro GV100 scores 35,520 (1% lower) and the GeForce RTX 5070 Ti Mobile scores 35,435 (1.2% lower). In raw OpenCL throughput, the Radeon Pro Duo is competitive with modern mid-range parts, but it is not dominant; it lands in the middle of a tight cluster.

The NVIDIA RTX PRO 4500 Blackwell, by contrast, has a much broader benchmark footprint. Its average benchmark score across all recorded tests is 31,532, which places it at the 76th percentile. Its strongest individual results are in Vulkan, where it posts 221,768 in Geekbench Vulkan, and in DirectX 12, where it scores 7,025 in 3DMark Steel Nomad. The PassMark suite shows a more mixed picture: 33,360 in G3D, 19,255 in GPU compute, 1,336 in G2D, and older DirectX tests ranging from 119 in DirectX 12 to 397 in DirectX 9. The RTX PRO 4500 wins in every category where both cards have data, but the comparison is complicated by the fact that the two cards share almost no common test results. The Radeon Pro Duo has no DirectX, Vulkan, or PassMark scores in the database, so any head-to-head judgment must rely on the single OpenCL point for the AMD part and the multiple scores for the NVIDIA part.

The practical takeaway is that the Radeon Pro Duo is a specialist compute card from the GCN era, while the RTX PRO 4500 is a general-purpose workstation GPU with strong performance across modern APIs. The database shows the NVIDIA card delivering over six times the Vulkan score of the AMD card's OpenCL score, but those are different tests, so direct numerical comparison is not meaningful. What is meaningful is that the RTX PRO 4500 has verifiable strength in DX12, Vulkan, and compute workloads, while the Radeon Pro Duo only proves itself in OpenCL.

Architecture Differences

The two cards are separated by nearly a decade of GPU design. The AMD Radeon Pro Duo uses the Capsaicin chip, built on GCN 3.0 architecture, fabricated on a 28 nm process at TSMC. It contains 8,900 million transistors on a 596 mm² die, giving a transistor density of 14.9 million per square millimeter. The NVIDIA RTX PRO 4500 Blackwell uses the GB203 chip, built on Blackwell 2.0 architecture, also at TSMC but on a 5 nm process. It packs 45,600 million transistors into a 378 mm² die, a density of 120.6 million per square millimeter. That is a massive difference in integration: the NVIDIA chip has over five times the transistor count on a smaller die.

The Radeon Pro Duo is a dual-GPU card in the sense of its product positioning, but its single recorded chip is GCN 3.0 with 4,096 shading units, 256 texture mapping units, and 64 raster output units. It has no dedicated ray tracing cores and no tensor cores. Its memory subsystem is 4 GB of HBM on a 4096-bit bus, delivering 512.0 GB/s of bandwidth. The memory clock is 500 MHz, or 1000 Mbps effective. The RTX PRO 4500, in contrast, has 10,496 shading units, 328 TMUs, 112 ROPs, 82 ray tracing cores, and 328 tensor cores. It uses 32 GB of GDDR7 on a 256-bit bus, with bandwidth of 896.0 GB/s. Its memory runs at 1750 MHz, or 28 Gbps effective. The NVIDIA card has more than double the shading units, more than double the ROPs, and nearly double the memory bandwidth, plus hardware ray tracing and tensor acceleration that the AMD card lacks entirely.

The feature set diverges sharply. The Radeon Pro Duo supports DirectX 12 (12_0), OpenGL 4.6, and Vulkan 1.2.170. The RTX PRO 4500 supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. The NVIDIA card also has a newer display output set: four DisplayPort 2.1b outputs versus the AMD card's single HDMI 1.4a and three DisplayPort 1.2. The bus interface differs too: PCIe 3.0 x16 on the AMD card versus PCIe 5.0 x16 on the NVIDIA card. The AMD card is a dual-slot design with three 8-pin power connectors and a 350 W TDP, while the RTX PRO 4500 is also dual-slot but uses a single 16-pin connector and a 200 W TDP. The suggested PSU drops from 750 W to 550 W. Physically, the AMD card is 277 mm long and 111 mm tall; the NVIDIA card is 267 mm long, 111 mm tall, and 40 mm wide. The AMD part is end-of-life, released April 2016, with a successor in Radeon Pro Polaris. The NVIDIA part is active, released March 2025, with a predecessor in Workstation Ada and no successor listed.

Head-to-Head Benchmarks

The database contains no direct head-to-head benchmark entries between these two cards, and the wins counters are zero for both. That means there is no single test where both cards ran the same workload and produced comparable scores. The only way to interpret the data is to look at each card's own recorded results and see where the strengths lie.

The Radeon Pro Duo's only score is 35,860 in Geekbench OpenCL. That result is within 1.2% of the NVIDIA T1000 and 1.8% of the AMD Radeon RX 5300M, and it edges out the NVIDIA Quadro GV100 by 1% and the GeForce RTX 5070 Ti Mobile by 1.2%. In other words, the AMD dual-GPU card from 2016 is still competitive with recent entry-level and mobile GPUs in OpenCL compute, but it does not exceed them by any meaningful margin. The tight clustering of its rivals, all within roughly 2% of its score, indicates that the Radeon Pro Duo is not an outlier in either direction; it is simply a competent OpenCL performer.

The RTX PRO 4500's results are more varied. Its PassMark G3D score of 33,360 is slightly below the Radeon Pro Duo's OpenCL score of 35,860, but these are different benchmarks. Its PassMark GPU compute score of 19,255 is significantly lower than its G3D score, which suggests that the card's compute performance in PassMark's specific test is not its strongest area. However, its Geekbench Vulkan score of 221,768 and 3DMark Steel Nomad DX12 score of 7,025 indicate strong modern API performance. The PassMark DirectX scores are odd: DirectX 9 at 397, DirectX 11 at 320, DirectX 10 at 204, and DirectX 12 at 119. The DirectX 12 score being the lowest of the four is counterintuitive, but the database records it as such. The G2D score of 1,336 shows the card handles 2D workloads well.

The nearest rivals for the RTX PRO 4500 are the NVIDIA TITAN RTX at 31,676 (0.5% higher), the NVIDIA GRID M60-1Q at 31,220 (1% lower), the NVIDIA Quadro M5000 at 31,206 (1% lower), and the Intel Arc Pro A30M at 31,894 (1.1% higher). This places the RTX PRO 4500 in a tight pack around the 31,200 to 31,900 range, with no rival more than 1.1% away. The average score of 31,532 is thus representative of a card that performs on par with a mix of older workstation cards and a current mobile Intel GPU.

Specification Differences

The differences between the two cards are stark across nearly every specification. The process node moves from 28 nm to 5 nm, transistor count from 8,900 million to 45,600 million, die size from 596 mm² to 378 mm², and transistor density from 14.9M per mm² to 120.6M per mm². Memory size jumps from 4 GB HBM to 32 GB GDDR7. Bus width drops from 4096 bit to 256 bit, but bandwidth rises from 512.0 GB/s to 896.0 GB/s thanks to the faster GDDR7. Memory clock goes from 500 MHz (1000 Mbps effective) to 1750 MHz (28 Gbps effective).

The compute resources differ massively: shading units go from 4,096 to 10,496, TMUs from 256 to 328, ROPs from 64 to 112. The NVIDIA card has 82 ray tracing cores and 328 tensor cores; the AMD card has none. Pixel rate rises from 64.00 GPixel/s to 269.6 GPixel/s. Texture rate rises from 256.0 GTexel/s to 789.5 GTexel/s. FP32 performance goes from 8.192 TFLOPS to 50.53 TFLOPS, and FP16 is 1:1 on both cards, so the NVIDIA card also delivers 50.53 TFLOPS FP16 versus 8.192 TFLOPS on the AMD card.

Power requirements go in the opposite direction: TDP drops from 350 W to 200 W, the power connector changes from three 8-pin to a single 16-pin, and the suggested PSU drops from 750 W to 550 W. The bus interface advances from PCIe 3.0 x16 to PCIe 5.0 x16. Display outputs change from 1x HDMI 1.4a and 3x DisplayPort 1.2 to 4x DisplayPort 2.1b. The API support advances from DirectX 12 (12_0) and Vulkan 1.2.170 to DirectX 12 Ultimate (12_2) and Vulkan 1.4. Physical dimensions are similar in length and height, but the NVIDIA card adds a width specification of 40 mm. The AMD card has a launch MSRP of 1,499 USD; the NVIDIA card has no recorded launch MSRP. Production status differs: end-of-life for the AMD card, active for the NVIDIA card.

FAQ

Q: Which card has more memory?

A: The NVIDIA RTX PRO 4500 Blackwell has 32 GB of GDDR7, while the AMD Radeon Pro Duo has 4 GB of HBM.

Q: Does the AMD Radeon Pro Duo support ray tracing?

A: No. The database lists no ray tracing cores for the AMD card, while the RTX PRO 4500 has 82 ray tracing cores.

Q: Which card has a higher FP32 throughput?

A: The RTX PRO 4500 delivers 50.53 TFLOPS FP32, compared to 8.192 TFLOPS for the Radeon Pro Duo.

Q: What is the power draw difference?

A: The Radeon Pro Duo has a 350 W TDP and requires a 750 W suggested PSU, while the RTX PRO 4500 has a 200 W TDP and a 550 W suggested PSU.

Q: Which card is newer?

A: The RTX PRO 4500 was released in March 2025 and is active, while the Radeon Pro Duo was released in April 2016 and is end-of-life.

Q: How do their OpenCL scores compare?

A: The Radeon Pro Duo scores 35,860 in Geekbench OpenCL. The RTX PRO 4500 has no recorded OpenCL score, so a direct comparison is not possible.

The Verdict

The data makes the choice straightforward for most buyers. The AMD Radeon Pro Duo is an end-of-life card from 2016 with a single OpenCL benchmark, 4 GB of HBM, no ray tracing or tensor cores, and a 350 W TDP. Its only strength is that its OpenCL score of 35,860 still sits near modern entry-level GPUs, but it is not ahead of them. It is competitive with the NVIDIA T1000 and AMD Radeon RX 5300M, but it does not beat them. The RTX PRO 4500 Blackwell, on the other hand, is an active product with 32 GB of GDDR7, 82 ray tracing cores, 328 tensor cores, 50.53 TFLOPS FP32, and support for DirectX 12 Ultimate and Vulkan 1.4. It uses less power, fits in a shorter length, and has a newer PCIe interface.

For a modern workstation workload that involves ray tracing, tensor operations, large datasets, or current API features, the RTX PRO 4500 is the only rational choice from this data. The Radeon Pro Duo cannot handle those tasks at all. For legacy OpenCL compute, the Radeon Pro Duo remains functional, but the tight clustering of its rivals shows it has no performance advantage even there. The RTX PRO 4500's average score of 31,532, while lower than the Radeon Pro Duo's single OpenCL score, comes from a wider range of tests and includes modern workloads that the AMD card never touches. The verdict is clear: the RTX PRO 4500 is the superior card for any current use case, and the Radeon Pro Duo is a historical artifact with narrow utility.