AMD Radeon Pro 450 vs AMD Radeon RX 6600S Comparison

AMD Radeon Pro 450 and AMD Radeon RX 6600S are both end-of-life mobile GPUs, but they serve entirely different performance tiers. The data is unequivocal: the RX 6600S is the far more powerful part, delivering a massive 86.4% advantage in the single overlapping benchmark, Geekbench OpenCL. The Pro 450, conversely, is a legacy low-power part whose only competitive edge is its 35 W TDP against the RX 6600S’s 80 W, making it suitable only for the lightest of legacy workloads. The RX 6600S is the pick for any task requiring modern compute or graphics throughput.

The Verdict

For any user comparing these two based on benchmark data, the choice is clear: the AMD Radeon RX 6600S wins on raw performance. Its Geekbench OpenCL score of 66,435 is over seven times higher than the Pro 450’s 9,002, representing a dominant 86.4% lead. While the Pro 450 edges out the RX 6600S in average benchmark score (10,804 vs. 10,629), this is misleading; the Pro 450’s average is pulled from its three Geekbench tests, whereas the RX 6600S’s average includes lower-severity legacy DirectX tests that drag its mean down. The Pro 450 belongs to a 2016-era GCN 4.0 design with 640 shading units, 2 GB GDDR5, and 81.28 GB/s bandwidth—adequate for basic 2D or very old 3D applications. The RX 6600S, a 2022 RDNA 2.0 part with 1,792 shading units, 4 GB GDDR6, and 224.0 GB/s bandwidth, is in a different league for gaming or compute. Choose the Pro 450 only if you require a 35 W MXM module for a specific legacy system; choose the RX 6600S for any modern workload.

Architecture Differences

The two GPUs come from entirely different architectural generations and foundries. The AMD Radeon Pro 450 uses the Baffin chip on a 14 nm GlobalFoundries process, with 3,000 million transistors on a 123 mm² die. Its GCN 4.0 architecture supports DirectX 12 (12_0), OpenGL 4.6, and Vulkan 1.3, but lacks hardware ray tracing. The AMD Radeon RX 6600S uses the Navi 23 chip built on a 7 nm TSMC process, packing 11,060 million transistors into a 237 mm² die—a transistor density of 46.7M per mm² versus the Pro 450’s 24.4M per mm². Its RDNA 2.0 architecture is far more modern, supporting DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. Crucially, the RX 6600S includes 28 ray tracing cores, which the Pro 450 completely lacks. Memory technology also diverges: the Pro 450 uses 2 GB of GDDR5 on a 128-bit bus (81.28 GB/s), while the RX 6600S uses 4 GB of GDDR6 on the same 128-bit bus but with nearly triple the bandwidth at 224.0 GB/s. The RX 6600S also has a faster memory clock at 1750 MHz (14 Gbps effective) versus the Pro 450’s 1270 MHz (5.1 Gbps effective).

Where Each One Wins

The benchmark data reveals a stark split: the RX 6600S wins the only direct head-to-head test (Geekbench OpenCL) with a blowout margin. Beyond that, the RX 6600S shows wins across various synthetic tests: it scores 12,649 in Passmark G3D, 4,879 in Passmark GPU Compute, and 647 in Passmark G2D. These numbers, while not compared directly to the Pro 450 (which lacks those tests), indicate a robust all-rounder. The Pro 450 wins in energy efficiency—its 35 W TDP is less than half the RX 6600S’s 80 W, making it suited for passively cooled or ultra-thin legacy notebooks. The Pro 450’s only benchmark wins are its Geekbench Metal score (12,893) and Geekbench Vulkan score (10,518), which the RX 6600S does not have listed. However, for any OpenCL compute task, the RX 6600S is overwhelmingly superior. For gaming or DirectX workloads, the RX 6600S’s higher pixel rate (128.0 GPixel/s vs. 12.80 GPixel/s) and texture rate (224.0 GTexel/s vs. 32.00 GTexel/s) make it the only viable option.

FAQ

Q: Which GPU has better raw compute performance?

A: The AMD Radeon RX 6600S is vastly superior, posting a Geekbench OpenCL score of 66,435 versus the Pro 450’s 9,002—a 86.4% difference in favor of the RX 6600S.

Q: Do both support the same DirectX version?

A: No. The Pro 450 supports DirectX 12 (12_0), while the RX 6600S supports DirectX 12 Ultimate (12_2), which includes features like hardware ray tracing via its 28 RT cores.

Q: What is the memory size and bandwidth difference?

A: The Pro 450 has 2 GB of GDDR5 with 81.28 GB/s bandwidth. The RX 6600S has 4 GB of GDDR6 with 224.0 GB/s bandwidth, offering over 2.75 times the bandwidth.

Q: Which GPU is more power-efficient?

A: The Pro 450 has a 35 W TDP, while the RX 6600S has an 80 W TDP. The Pro 450 consumes less than half the power, but this comes at a massive performance cost.

Q: Are these comparable in their average benchmark scores?

A: The Pro 450 has a slightly higher average benchmark score (10,804) than the RX 6600S (10,629). However, the RX 6600S’s average is dragged down by low DirectX 9, 10, and 12 scores (176, 81, and 56 respectively), which are not representative of its modern performance.

Q: What is the transistor density difference?

A: The RX 6600S has a transistor density of 46.7M per mm², nearly double the Pro 450’s 24.4M per mm², reflecting its more advanced 7 nm process versus 14 nm.

Head-to-Head Benchmarks

The only direct benchmark comparison in the data is Geekbench OpenCL, and it is a landslide. The RX 6600S scores 66,435 while the Pro 450 scores 9,002. This yields a delta of -86.4%, meaning the Pro 450 delivers less than 14% of the RX 6600S’s compute throughput. This single result is the most telling metric: for any OpenCL-accelerated application—be it video encoding, physics simulation, or machine learning inference—the RX 6600S is the only serious contender. The Pro 450’s nearest rivals (NVIDIA Quadro K2200, GeForce MX350, GTX 560 Ti) all sit within 1.1% of its average score, while the RX 6600S’s rivals (Radeon R9 M275X, GTX 560 Ti, Quadro K2200) are similarly clustered. This shows both GPUs are average performers in their respective eras, but the era gap is enormous. The Pro 450’s best scores come from Geekbench Metal (12,893) and Vulkan (10,518), but no RX 6600S comparison exists for those tests. The RX 6600S also shows strong Passmark results, with a G3D score of 12,649 and GPU Compute of 4,879, though the Pro 450 lacks those benchmark entries. In every measurable overlap, the RX 6600S wins decisively.

Specification Differences

| Specification | AMD Radeon Pro 450 | AMD Radeon RX 6600S |

|---|---|---|

| Chip | Baffin | Navi 23 |

| Architecture | GCN 4.0 | RDNA 2.0 |

| Process Node | 14 nm (GlobalFoundries) | 7 nm (TSMC) |

| Transistors | 3,000 million | 11,060 million |

| Die Size | 123 mm² | 237 mm² |

| Transistor Density | 24.4M / mm² | 46.7M / mm² |

| Base Clock | Not specified | 1700 MHz |

| Boost Clock | Not specified | 2000 MHz |

| Game Clock | Not specified | 1881 MHz |

| Memory Clock | 1270 MHz (5.1 Gbps effective) | 1750 MHz (14 Gbps effective) |

| Memory Size | 2 GB GDDR5 | 4 GB GDDR6 |

| Memory Bus | 128 bit | 128 bit |

| Bandwidth | 81.28 GB/s | 224.0 GB/s |

| Shading Units | 640 | 1,792 |

| TMUs | 40 | 112 |

| ROPs | 16 | 64 |

| Ray Tracing Cores | None | 28 |

| Pixel Rate | 12.80 GPixel/s | 128.0 GPixel/s |

| Texture Rate | 32.00 GTexel/s | 224.0 GTexel/s |

| FP32 Performance | 1,024.0 GFLOPS | 7.168 TFLOPS |

| FP16 Performance | 1,024.0 GFLOPS (1:1) | 14.34 TFLOPS (2:1) |

| TDP | 35 W | 80 W |

| Slot Width | MXM Module | IGP |

| Bus Interface | PCIe 3.0 x8 | PCIe 4.0 x8 |

| DirectX Support | 12 (12_0) | 12 Ultimate (12_2) |

| Vulkan Support | 1.3 | 1.4 |

| Release Date | 2016-10-29 | 2022-01-03 |

| Production Status | End-of-life | End-of-life |