AMD Instinct MI355X vs AMD Radeon RX 7650 GRE Comparison

The Verdict

The data in the database clearly separates these two AMD accelerators by design intent rather than by performance class. The Instinct MI355X is a compute-oriented accelerator with no display outputs, no graphics API support, and a power envelope that requires an external 1800 W power supply recommendation. The Radeon RX 7650 GRE is a consumer graphics card with full DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4 support, plus display outputs and a dual-slot form factor.

The RX 7650 GRE holds a benchmark percentile ranking of 83 among all GPUs, while the MI355X sits at the 50th percentile. The RX 7650 GRE has recorded benchmark scores: 2336 in 3DMark Steel Nomad DX12 and 83109 in Geekbench OpenCL, with an average benchmark score of 42723. The MI355X has no recorded benchmarks and an average score of zero, so direct measured performance comparison is impossible from the available data. For any user needing a working graphics card for gaming, rendering, or general desktop use, the RX 7650 GRE is the only functional choice. For a compute deployment where graphics output is irrelevant and massive memory capacity is critical, the MI355X provides 288 GB of HBM3e memory versus 8 GB of GDDR6 on the RX 7650 GRE, along with 16384 shading units versus 2048.

FAQ

Q: Which card is faster in gaming workloads?

A: The RX 7650 GRE is the only one with gaming capability. It supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4, while the MI355X lists N/A for all graphics APIs. The RX 7650 GRE also has a recorded 3DMark Steel Nomad DX12 score of 2336, whereas the MI355X has no benchmark entries.

Q: How much memory do these cards have?

A: The MI355X has 288 GB of HBM3e memory on an 8192-bit bus with 8.19 TB/s bandwidth. The RX 7650 GRE has 8 GB of GDDR6 memory on a 128-bit bus with 288.0 GB/s bandwidth.

Q: What is the difference in power consumption?

A: The MI355X has a TDP of 1400 W with a suggested power supply of 1800 W and no power connectors (it is an OAM module). The RX 7650 GRE has a TDP of 170 W, uses a single 8-pin power connector, and requires a 450 W suggested power supply.

Q: Can the MI355X output video to a display?

A: No. The MI355X lists "No outputs" for display outputs. The RX 7650 GRE provides 1x HDMI 2.1a and 3x DisplayPort 2.1 outputs.

Q: Which card has higher clock speeds?

A: The RX 7650 GRE has a base clock of 1720 MHz, a game clock of 2350 MHz, and a boost clock of 2695 MHz. The MI355X has a base clock of 1000 MHz and a boost clock of 2400 MHz.

Q: How do the cards compare in raw floating-point performance?

A: The MI355X delivers 78.64 TFLOPS FP32 and 78.64 TFLOPS FP16 (1:1). The RX 7650 GRE delivers 22.08 TFLOPS FP32 and 22.08 TFLOPS FP16 (1:1).

Architecture Differences

The MI355X uses the CDNA 4.0 architecture with the MI350 256CU chip, fabricated on a 3 nm process at TSMC. The RX 7650 GRE uses RDNA 3.0 architecture with the Navi 33 chip, fabricated on a 6 nm process, also at TSMC. The codename for the RX 7650 GRE is "Hotpink Bonefish," while the MI355X has no listed codename. The MI355X belongs to the Instinct (MIx) generation, while the RX 7650 GRE belongs to the Navi III (RX 7000) generation. The MI355X has no display outputs and no graphics API support, confirming its compute-only design. The RX 7650 GRE supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4, making it a full-featured consumer GPU. The MI355X has no RT cores listed, while the RX 7650 GRE includes 32 ray tracing cores. Neither card lists tensor cores in the database.

The MI355X uses an OAM module slot width, which is a server form factor, and has no power connectors, indicating it draws power through the module interface. The RX 7650 GRE is a dual-slot card with a single 8-pin power connector. The MI355X measures 102 mm in length and 165 mm in width. The RX 7650 GRE measures 204 mm in length and 115 mm in height.

Specification Differences

The two cards differ across nearly every specification field. The MI355X uses a 3 nm process node versus 6 nm for the RX 7650 GRE. Transistor counts differ drastically: 185,000 million transistors on the MI355X versus 13,300 million on the RX 7650 GRE. Die size is 2380 mm² for the MI355X versus 204 mm² for the RX 7650 GRE. Transistor density is 77.7M per mm² on the MI355X versus 65.2M per mm² on the RX 7650 GRE.

Clock speeds differ: the MI355X runs at 1000 MHz base and 2400 MHz boost, while the RX 7650 GRE runs at 1720 MHz base, 2350 MHz game, and 2695 MHz boost. Memory clocks are 2000 MHz (8 Gbps effective) for the MI355X versus 2250 MHz (18 Gbps effective) for the RX 7650 GRE.

Memory configuration: the MI355X has 288 GB HBM3e on a 8192-bit bus with 8.19 TB/s bandwidth. The RX 7650 GRE has 8 GB GDDR6 on a 128-bit bus with 288.0 GB/s bandwidth. Shading units are 16384 on the MI355X versus 2048 on the RX 7650 GRE. Texture mapping units are 1024 versus 128. The MI355X has 0 ROPs and a pixel rate of 0 MPixel/s, while the RX 7650 GRE has 64 ROPs and a pixel rate of 172.5 GPixel/s. Texture rate is 2457.6 GTexel/s on the MI355X versus 345.0 GTexel/s on the RX 7650 GRE.

FP32 performance is 78.64 TFLOPS on the MI355X versus 22.08 TFLOPS on the RX 7650 GRE. FP16 performance is the same ratio: 78.64 TFLOPS versus 22.08 TFLOPS, both at 1:1. TDP is 1400 W for the MI355X versus 170 W for the RX 7650 GRE. The suggested power supply is 1800 W versus 450 W. Bus interface is PCIe 5.0 x16 for the MI355X versus PCIe 4.0 x8 for the RX 7650 GRE.

Release dates differ: the MI355X launched on June 11, 2025, while the RX 7650 GRE launched on February 6, 2025. The MI355X has no launch MSRP in the database. The RX 7650 GRE has a launch MSRP of 279 USD. The RX 7650 GRE has an active production status, while the MI355X has no production status listed. The MI355X predecessor is Radeon Instinct, and the RX 7650 GRE predecessor is Navi II. The RX 7650 GRE successor is Navi IV; the MI355X has no successor listed.

Head-to-Head Benchmarks

The database contains no head-to-head benchmark entries for this pair, and the MI355X has no standalone benchmark scores. The RX 7650 GRE has two recorded benchmark results. In 3DMark Steel Nomad DX12, it scores 2336. In Geekbench OpenCL, it scores 83109. Its average benchmark score is 42723.

The RX 7650 GRE's nearest rivals in the database provide context for its performance position. The NVIDIA GeForce RTX 4070 SUPER has an average score of 43223, which is 1.2% higher than the RX 7650 GRE. The NVIDIA Quadro M6000 24 GB scores 43262, also 1.2% higher. The NVIDIA GeForce RTX 5050 Mobile scores 43268, 1.3% higher. The NVIDIA Quadro M6000 scores 43301, 1.3% higher. This places the RX 7650 GRE within roughly 1.3% of these four rival cards, indicating very close performance clustering in the database's average scores.

The MI355X has no nearest rivals listed because it has no benchmark data. Its percentile rank of 50 versus the RX 7650 GRE's percentile rank of 83 reflects the absence of recorded performance for the MI355X rather than a direct comparison. The RX 7650 GRE's 83rd percentile placement among all GPUs, combined with its average score of 42723, indicates it sits in a competitive mid-to-upper tier for consumer graphics cards. The MI355X's 50th percentile with zero average score is a neutral placeholder in the absence of measurements.

Where Each One Wins

The RX 7650 GRE wins in every scenario where a display output is required. It provides 1x HDMI 2.1a and 3x DisplayPort 2.1 connections, full graphics API support including DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4, and a dual-slot form factor with a single 8-pin power connector. Its 170 W TDP and 450 W suggested power supply make it suitable for conventional desktop systems. Its 204 mm length and 115 mm height fit standard chassis layouts. The RX 7650 GRE also has the only recorded benchmark scores in this comparison, with a 3DMark Steel Nomad DX12 score of 2336 and a Geekbench OpenCL score of 83109.

The MI355X wins in raw compute specifications. It delivers 78.64 TFLOPS FP32, which is 3.56 times the RX 7650 GRE's 22.08 TFLOPS. Its memory subsystem is dramatically larger: 288 GB versus 8 GB, with 8.19 TB/s bandwidth versus 288.0 GB/s. The 8192-bit memory bus versus 128-bit provides a 64-fold increase in bus width. The MI355X also has 8 times the shading units (16384 versus 2048) and 8 times the texture mapping units (1024 versus 128). Its texture rate of 2457.6 GTexel/s is 7.1 times higher than the RX 7650 GRE's 345.0 GTexel/s.

The MI355X uses a 3 nm process with 185,000 million transistors on a 2380 mm² die, versus 13,300 million transistors on a 204 mm² die for the RX 7650 GRE. This places the MI355X in a different physical and power class entirely, with a 1400 W TDP and an OAM module form factor. The MI355X has no display outputs, no graphics API support, and no ROPs, confirming it is not intended for any graphics workload. Its pixel rate is listed as 0 MPixel/s.

For compute-heavy tasks that do not require graphics output, the MI355X's massive memory capacity and FP32 throughput make it the superior choice based on recorded specifications. For any task involving rendering, gaming, or desktop use, the RX 7650 GRE is the only card with functional graphics capabilities. The RX 7650 GRE also has a production status of Active, while the MI355X has no production status recorded. The RX 7650 GRE has a launch MSRP of 279 USD, stated once here as recorded in the database.