AMD Instinct MI350X vs NVIDIA RTX PRO 4500 Blackwell Comparison

Head-to-Head Benchmarks

The database contains no overlapping benchmark results between the AMD Instinct MI350X and the NVIDIA RTX PRO 4500 Blackwell. The MI350X has no recorded benchmark entries, while the RTX PRO 4500 has nine recorded tests. Direct score comparisons are therefore impossible from the available data. What can be compared are the raw specification-derived performance ceilings and the measured results of the NVIDIA card against its own nearest rivals.

The RTX PRO 4500 Blackwell delivers a 3DMark Steel Nomad DX12 score of 7,025. Its Geekbench Vulkan result reaches 221,768 points, indicating strong compute throughput in API-accelerated workloads. Passmark results show a G3D score of 33,360, a GPU Compute score of 19,255, and DX11 performance of 320. These measured numbers place the RTX PRO 4500 at the 76th percentile among all GPUs in the database, with an average benchmark score of 31,532.

Relative to its nearest rivals, the RTX PRO 4500 sits within a tight band. It trails the NVIDIA TITAN RTX by 0.5% (TITAN RTX average score 31,676) and the Intel Arc Pro A30M by 1.1% (Arc Pro A30M average score 31,894). It leads the NVIDIA GRID M60-1Q by 1% (GRID M60-1Q average score 31,220) and the NVIDIA Quadro M5000 by 1% (Quadro M5000 average score 31,206). The data shows a clustered competitive field, with all four rivals within roughly two percentage points of the RTX PRO 4500.

The MI350X, by contrast, has a percentile rank of 50 and an average benchmark score of 0. This does not indicate zero capability; it reflects the absence of recorded benchmark submissions for this accelerator. The specification sheet shows FP32 throughput of 72.09 TFLOPS and FP16 throughput of 72.09 TFLOPS (1:1), both higher than the RTX PRO 4500's 50.53 TFLOPS in each precision. Texture rate for the MI350X reaches 2,252.8 GTexel/s versus 789.5 GTexel/s for the NVIDIA card. These figures suggest a large raw compute advantage for the AMD part, but no measured workload confirms it.

Where Each One Wins

The RTX PRO 4500 wins in any category where measured benchmarks exist. It has nine recorded tests spanning DirectX, Vulkan, and compute workloads, and it produces a 76th percentile ranking. Its nearest-rival comparisons show it is competitive with, and in two cases slightly ahead of, established workstation and prosumer cards. The NVIDIA part also wins on feature availability: it supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4, while the MI350X lists N/A for all three APIs. Display outputs are present on the RTX PRO 4500 (4x DisplayPort 2.1b), whereas the MI350X has no outputs.

The MI350X wins on raw specification targets. Its memory subsystem is substantially larger: 288 GB of HBM3e on an 8,192-bit bus delivers 8.19 TB/s of bandwidth, compared to 32 GB of GDDR7 on a 256-bit bus at 896.0 GB/s. Shading units number 16,384 versus 10,496, TMUs number 1,024 versus 328, and the FP32/FP16 throughput advantage is roughly 43% higher. The MI350X also uses a 3 nm process node versus 5 nm, and its transistor count of 185,000 million dwarfs the 45,600 million of the GB203 chip. These are the wins that would matter for large-scale compute, memory-bound workloads, or AI training, provided the software stack can use them.

The die size difference is stark: 2,380 mm² for the MI350X versus 378 mm² for the RTX PRO 4500. Transistor density favors NVIDIA at 120.6M per mm² versus 77.7M per mm², indicating the NVIDIA chip packs transistors more tightly despite the older node. The MI350X's pixel rate is listed as 0 MPixel/s with zero ROPs, meaning it is not designed for rasterization output. The RTX PRO 4500 has 112 ROPs and a pixel rate of 269.6 GPixel/s.

The Verdict

The data supports a clear split. For measured, validated performance in standard graphics and compute benchmarks, the RTX PRO 4500 Blackwell is the only option with evidence. Its 76th percentile standing, nine benchmark scores, and tight rival deltas (all within 1.1%) demonstrate a functional, competitive product. The MI350X has no benchmark data, no API support, no display outputs, and a 50th percentile rank based on zero recorded scores.

For peak theoretical throughput in FP32, FP16, texture rate, memory capacity, and memory bandwidth, the MI350X wins on paper. Its 72.09 TFLOPS in both FP32 and FP16, 2,252.8 GTexel/s texture rate, 288 GB HBM3e, and 8.19 TB/s bandwidth are all higher than the RTX PRO 4500's corresponding figures. However, the database contains no test that verifies these specifications translate into real-world results.

The RTX PRO 4500 is the choice for anyone needing a working GPU with driver-validated performance, API compatibility, and display output. The MI350X is the choice for anyone who requires extreme memory capacity and raw compute throughput and who can operate without graphics APIs or display connectivity. The absence of benchmarks for the MI350X means its performance class cannot be confirmed from recorded data.

FAQ

Q: Which GPU has a higher average benchmark score?

A: The RTX PRO 4500 has an average benchmark score of 31,532. The MI350X has an average benchmark score of 0, reflecting no recorded benchmark entries.

Q: How does the RTX PRO 4500 compare to its nearest rivals?

A: It trails the NVIDIA TITAN RTX by 0.5% and the Intel Arc Pro A30M by 1.1%. It leads the NVIDIA GRID M60-1Q by 1% and the NVIDIA Quadro M5000 by 1%.

Q: What is the memory configuration of each card?

A: The MI350X uses 288 GB of HBM3e with an 8,192-bit bus and 8.19 TB/s bandwidth. The RTX PRO 4500 uses 32 GB of GDDR7 with a 256-bit bus and 896.0 GB/s bandwidth.

Q: Which card supports DirectX and Vulkan?

A: The RTX PRO 4500 supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. The MI350X lists N/A for DirectX, OpenGL, and Vulkan.

Q: What are the FP32 throughput figures?

A: The MI350X delivers 72.09 TFLOPS FP32. The RTX PRO 4500 delivers 50.53 TFLOPS FP32.

Q: Does either card have display outputs?

A: The RTX PRO 4500 has 4x DisplayPort 2.1b outputs. The MI350X has no display outputs.

Architecture Differences

The MI350X uses the CDNA 4.0 architecture on a 3 nm TSMC process, with the MI350 256CU chip. The RTX PRO 4500 uses Blackwell 2.0 architecture on a 5 nm TSMC process, with the GB203 chip. The MI350X belongs to the Instinct (MIx) generation, while the RTX PRO 4500 belongs to the Blackwell PRO W (x000) generation.

The MI350X has 16,384 shading units and 1,024 TMUs, but zero ROPs, no RT cores, and no tensor cores listed. Its pixel rate is 0 MPixel/s, confirming no rasterization hardware. The RTX PRO 4500 has 10,496 shading units, 328 TMUs, 112 ROPs, 82 RT cores, and 328 tensor cores. Its pixel rate is 269.6 GPixel/s.

The MI350X is built on an OAM module form factor with no power connectors and no display outputs. The RTX PRO 4500 is a dual-slot card with a 1x 16-pin power connector and 4x DisplayPort 2.1b outputs. The MI350X supports no graphics APIs; the RTX PRO 4500 supports DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4.

Both cards use PCIe 5.0 x16 interfaces. The MI350X measures 102 mm in length and 165 mm in width, while the RTX PRO 4500 measures 267 mm in length, 111 mm in height, and 40 mm in width.

Specification Differences

The MI350X has a base clock of 1000 MHz and a boost clock of 2200 MHz, with memory clock at 2000 MHz (8 Gbps effective). The RTX PRO 4500 has a base clock of 1635 MHz and a boost clock of 2407 MHz, with memory clock at 1750 MHz (28 Gbps effective). The NVIDIA card runs at higher clocks across the board.

Transistor counts differ massively: 185,000 million for the MI350X versus 45,600 million for the RTX PRO 4500. Die size is 2,380 mm² versus 378 mm². Transistor density favors NVIDIA at 120.6M per mm² versus 77.7M per mm².

Power draw differs by a factor of five: 1000 W TDP for the MI350X versus 200 W for the RTX PRO 4500. The suggested power supply is 1400 W for the AMD card and 550 W for the NVIDIA card. The MI350X has no power connectors (OAM module), while the RTX PRO 4500 uses a single 16-pin connector.

Release dates differ: the MI350X launched on 2025-06-11, and the RTX PRO 4500 launched on 2025-03-17. The MI350X's predecessor is Radeon Instinct, and the RTX PRO 4500's predecessor is Workstation Ada. Neither card has a listed successor.

The RTX PRO 4500 has a production status of Active. The MI350X does not list a production status. Neither card has a launch MSRP in the database.