AMD Instinct MI350X vs NVIDIA GeForce RTX 4080 Mobile Comparison

Where Each One Wins

The AMD Instinct MI350X and the NVIDIA GeForce RTX 4080 Mobile occupy entirely different positions in the hardware landscape. The MI350X is a data center accelerator with no display outputs and no graphics API support. The RTX 4080 Mobile is a laptop GPU with full DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4 support. The recorded data shows a complete functional split: the MI350X does not participate in any of the benchmark tests that define the RTX 4080 Mobile's performance profile.

The NVIDIA part has nine benchmark entries in the database. Its PassMark G3D score of 24926 and Geekbench OpenCL score of 159575 indicate strong compute and rasterization performance for a mobile part. The MI350X has no benchmark scores recorded, placing it at the 50th percentile among all GPUs in the database, while the RTX 4080 Mobile sits at the 81st percentile. This percentile gap reflects availability of measured data rather than a direct performance comparison, since the MI350X has zero recorded benchmark results.

The use-case split is clear from the specification data. The MI350X delivers 72.09 TFLOPS of FP32 and 72.09 TFLOPS of FP16 (1:1), both figures far exceeding the RTX 4080 Mobile's 24.72 TFLOPS in each precision. The MI350X pairs this with 288 GB of HBM3e memory on an 8192-bit bus, producing 8.19 TB/s of bandwidth. The RTX 4080 Mobile offers 12 GB of GDDR6 on a 192-bit bus with 432.0 GB/s. These numbers indicate the MI350X targets memory-bound and throughput-bound workloads, while the RTX 4080 Mobile targets conventional graphics and general compute in portable systems.

The MI350X wins on raw throughput, memory capacity, and memory bandwidth. The RTX 4080 Mobile wins on feature completeness for graphics workloads, API support, and measured benchmark presence. The data does not support a single "winner" across all contexts; the victor depends entirely on whether the workload is a data center compute task or a mobile graphics task.

Architecture Differences

The two chips use different process nodes, different architectures, and different design philosophies. The MI350X uses a 3 nm process at TSMC, while the RTX 4080 Mobile uses a 5 nm process, also at TSMC. The MI350X integrates 185,000 million transistors on a 2380 mm² die, yielding a transistor density of 77.7M per mm². The RTX 4080 Mobile integrates 35,800 million transistors on a 294 mm² die, yielding a higher density of 121.8M per mm². The MI350X is the larger and more transistor-heavy chip, but the RTX 4080 Mobile packs transistors more densely.

The MI350X uses AMD's CDNA 4.0 architecture under the Instinct (MIx) generation label. It has 16,384 shading units and 1,024 texture mapping units, with zero ROPs and no ray tracing or tensor core counts listed. The RTX 4080 Mobile uses NVIDIA's Ada Lovelace architecture in the GeForce 40-series. It has 7,424 shading units, 232 TMUs, 80 ROPs, 58 ray tracing cores, and 232 tensor cores.

The MI350X has no display outputs and no DirectX, OpenGL, or Vulkan support. The RTX 4080 Mobile has portable-device-dependent display outputs and full API support: DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. The MI350X uses an OAM Module slot width with no power connectors and a 1000 W TDP, while the RTX 4080 Mobile is an IGP with no power connectors and a 110 W TDP. The MI350X connects via PCIe 5.0 x16; the RTX 4080 Mobile uses PCIe 4.0 x16.

The clock behavior also differs. The MI350X has a 1000 MHz base and 2200 MHz boost, with memory at 2000 MHz (8 Gbps effective). The RTX 4080 Mobile has a 1290 MHz base and 1665 MHz boost, with memory at 2250 MHz (18 Gbps effective). The MI350X boosts much higher despite a lower base clock, while the RTX 4080 Mobile runs a higher base but a lower boost. The MI350X's pixel rate is listed as 0 MPixel/s due to its lack of ROPs, while the RTX 4080 Mobile delivers 133.2 GPixel/s. Texture rates are 2,252.8 GTexel/s for the MI350X versus 386.3 GTexel/s for the RTX 4080 Mobile.

Head-to-Head Benchmarks

The database contains no head-to-head benchmark results between the MI350X and the RTX 4080 Mobile. The MI350X has zero recorded benchmark scores and zero wins in the head-to-head comparison. The RTX 4080 Mobile has nine recorded benchmark scores and also shows zero wins in the head-to-head field, because no direct comparison runs exist.

The RTX 4080 Mobile's benchmark suite provides context for its performance tier. Its Geekbench OpenCL score is 159575, and its Geekbench Vulkan score is 145807. PassMark results include 24926 in G3D, 11191 in GPU compute, 929 in G2D, 286 in DirectX 9, 244 in DirectX 11, 157 in DirectX 10, and 96 in DirectX 12. The average benchmark score across all entries is 38135.

The nearest rivals for the RTX 4080 Mobile in the database are all close in average score. The NVIDIA GeForce MX570 scores 38299, which is 0.4% higher than the RTX 4080 Mobile's average. The NVIDIA GeForce RTX 5080 Mobile scores 38349, 0.6% higher. The NVIDIA GeForce RTX 4070 scores 37648, which is 1.3% lower. The NVIDIA Tesla P4 scores 37628, also 1.3% lower. The RTX 4080 Mobile's average score of 38135 places it in a tightly packed group where the spread across all four rivals is only about 1.9% from the lowest to the highest.

The absence of MI350X benchmarks means no direct numerical comparison can be drawn. The specification data, however, suggests the MI350X would dominate in throughput-bound scenarios. Its 8.19 TB/s of memory bandwidth is roughly 19 times the RTX 4080 Mobile's 432.0 GB/s. Its FP32 throughput of 72.09 TFLOPS is about 2.9 times the RTX 4080 Mobile's 24.72 TFLOPS. These are extrapolations from specification fields, not measured benchmark results, so they carry less weight than actual scores.

Specification Differences

The two parts differ in nearly every recorded specification field. The MI350X uses a 3 nm process; the RTX 4080 Mobile uses 5 nm. The MI350X has 185,000 million transistors versus 35,800 million. Die size is 2380 mm² versus 294 mm². Transistor density is 77.7M per mm² versus 121.8M per mm².

Memory differences are substantial. The MI350X has 288 GB of HBM3e on an 8192-bit bus with 8.19 TB/s bandwidth. The RTX 4080 Mobile has 12 GB of GDDR6 on a 192-bit bus with 432.0 GB/s bandwidth. Memory clocks are 2000 MHz (8 Gbps effective) for the MI350X and 2250 MHz (18 Gbps effective) for the RTX 4080 Mobile.

Compute resources differ sharply. The MI350X has 16,384 shading units and 1,024 TMUs, with zero ROPs. The RTX 4080 Mobile has 7,424 shading units, 232 TMUs, and 80 ROPs. The MI350X lists no ray tracing cores or tensor cores; the RTX 4080 Mobile has 58 ray tracing cores and 232 tensor cores. FP32 and FP16 are both 72.09 TFLOPS for the MI350X and 24.72 TFLOPS for the RTX 4080 Mobile.

Clock speeds, power, and physical format all diverge. The MI350X runs 1000 MHz base and 2200 MHz boost; the RTX 4080 Mobile runs 1290 MHz base and 1665 MHz boost. TDP is 1000 W versus 110 W. The MI350X is an OAM Module measuring 102 mm by 165 mm, while the RTX 4080 Mobile is an IGP with no listed dimensions. The MI350X uses PCIe 5.0 x16; the RTX 4080 Mobile uses PCIe 4.0 x16. The MI350X has no display outputs; the RTX 4080 Mobile's outputs are portable device dependent. The MI350X has no API support; the RTX 4080 Mobile supports DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4.

Release timing also differs. The MI350X released on 2025-06-11, while the RTX 4080 Mobile released on 2023-01-02. The MI350X's predecessor is Radeon Instinct; the RTX 4080 Mobile's predecessor is GeForce 30 Mobile and its successor is GeForce 50 Mobile. The RTX 4080 Mobile has an active production status; the MI350X has no production status recorded.

FAQ

Q: Which GPU has higher FP32 compute throughput?

A: The AMD Instinct MI350X delivers 72.09 TFLOPS of FP32, which is 2.9 times the NVIDIA GeForce RTX 4080 Mobile's 24.72 TFLOPS.

Q: How do memory capacities compare?

A: The MI350X has 288 GB of HBM3e memory, while the RTX 4080 Mobile has 12 GB of GDDR6. Memory bandwidth is 8.19 TB/s versus 432.0 GB/s.

Q: Does the MI350X support DirectX or Vulkan?

A: No. The MI350X lists DirectX, OpenGL, and Vulkan as N/A. The RTX 4080 Mobile supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4.

Q: What is the TDP difference between the two?

A: The MI350X has a 1000 W TDP, while the RTX 4080 Mobile has a 110 W TDP. The MI350X also lists a 1400 W suggested PSU, while the RTX 4080 Mobile has no suggested PSU recorded.

Q: How does the RTX 4080 Mobile compare to its nearest rivals in average benchmark score?

A: The RTX 4080 Mobile averages 38135. The GeForce MX570 is 0.4% higher at 38299, the RTX 5080 Mobile is 0.6% higher at 38349, and both the RTX 4070 and Tesla P4 are 1.3% lower at 37648 and 37628 respectively.

Q: What process nodes do the two chips use?

A: The MI350X uses a 3 nm process at TSMC. The RTX 4080 Mobile uses a 5 nm process, also at TSMC. The MI350X has 185,000 million transistors on a 2380 mm² die, while the RTX 4080 Mobile has 35,800 million transistors on a 294 mm² die.