AMD Instinct MI350P vs NVIDIA RTX PRO 4500 Blackwell Server Comparison

Head-to-Head Benchmarks

The recorded data shows no head-to-head benchmark results for this pairing. Both the AMD Instinct MI350P and the NVIDIA RTX PRO 4500 Blackwell Server have empty benchmark arrays, zero average benchmark scores, and zero wins in direct comparisons. The database indicates both cards sit at the 50th percentile among all GPUs, which means the aggregate performance data does not differentiate between them at this time. With no measured scores, no deltas, and no nearest rivals listed, the quantitative comparison must rely entirely on the architectural specifications and computed throughput figures rather than observed workloads.

The raw compute numbers do separate the two. The MI350P delivers 36.04 TFLOPS for FP32 and the same 36.04 TFLOPS for FP16 with a 1:1 ratio. The RTX PRO 4500 delivers 50.70 TFLOPS for both FP32 and FP16, also at 1:1. That puts the NVIDIA part ahead by roughly 40.7% in raw floating-point throughput on paper. The texture rate favors AMD, with the MI350P producing 1,126.4 GTexel/s against 792.1 GTexel/s for the RTX PRO 4500, a 34.2% advantage. Pixel rate strongly favors NVIDIA, which posts 270.5 GPixel/s while the MI350P reports 0 MPixel/s, reflecting the absence of ROPs on the AMD accelerator.

Architecture Differences

The two cards come from different design philosophies. The AMD Instinct MI350P uses the MI350 128CU chip built on CDNA 4.0 architecture, fabricated on a 3 nm process at TSMC. The die contains 73,000 million transistors across 1190 mm², yielding a transistor density of 61.3M per mm². The NVIDIA RTX PRO 4500 Blackwell Server uses the GB203 chip on Blackwell 2.0 architecture, also from TSMC but on a 5 nm process. That die holds 45,600 million transistors across 378 mm², giving a density of 120.6M per mm². The AMD chip is physically much larger and packs more transistors, while the NVIDIA chip achieves a higher density on an older node.

Memory architecture diverges sharply. The MI350P carries 144 GB of HBM3e on an 8192-bit bus, producing 8.19 TB/s of bandwidth. The RTX PRO 4500 carries 32 GB of GDDR7 on a 256-bit bus, producing 800.3 GB/s. The AMD accelerator offers 4.5 times the memory capacity and roughly 10.2 times the memory bandwidth. Clock behavior differs as well. The MI350P runs a 1000 MHz base and 2200 MHz boost with memory at 2000 MHz, 8 Gbps effective. The RTX PRO 4500 runs a 1215 MHz base and 2415 MHz boost with memory at 1563 MHz, 25 Gbps effective. The NVIDIA card has a higher base clock by 21.5% and a higher boost clock by 9.8%, but the AMD card compensates with a far wider memory interface.

Compute resources also differ. The MI350P has 8192 shading units and 512 TMUs but no ROPs, no RT cores, and no tensor cores listed. The RTX PRO 4500 has 10496 shading units, 328 TMUs, 112 ROPs, 82 RT cores, and 328 tensor cores. The NVIDIA part supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4, while the AMD part reports N/A for all three APIs. Neither card has display outputs. Both use PCIe 5.0 x16 and a single 16-pin power connector, and both share identical dimensions of 267 mm length, 111 mm height, and 40 mm width. The power envelope differs enormously: the MI350P draws up to 600 W with a suggested 1000 W PSU, while the RTX PRO 4500 draws 165 W with a suggested 450 W PSU. The AMD card is dual-slot; the NVIDIA card is single-slot.

Where Each One Wins

The data indicates a clear split by workload type. The AMD Instinct MI350P wins on memory capacity and bandwidth, with 144 GB versus 32 GB and 8.19 TB/s versus 800.3 GB/s. That makes it the stronger candidate for large model residency, high-bandwidth data movement, and workloads that need to keep massive datasets close to the compute units. Its texture rate of 1,126.4 GTexel/s also exceeds the NVIDIA part, so texturing-heavy operations show an advantage on paper. The MI350P uses HBM3e, which provides a fundamentally different memory subsystem compared to GDDR7.

The NVIDIA RTX PRO 4500 Blackwell Server wins on raw FP32 and FP16 throughput, delivering 50.70 TFLOPS against 36.04 TFLOPS. It also has a higher pixel rate at 270.5 GPixel/s versus 0 MPixel/s, enabled by 112 ROPs that the AMD part lacks entirely. The NVIDIA card includes 82 RT cores and 328 tensor cores, which point to ray tracing and tensor acceleration capabilities not present in the AMD specifications. The API support on the NVIDIA side covers DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4, while the AMD side lists none, which limits the MI350P to compute-oriented deployments where graphics APIs are irrelevant. The power draw difference is substantial: 165 W versus 600 W means the NVIDIA card operates in a far lower power class, with a suggested PSU of 450 W compared to 1000 W. The NVIDIA part is also single-slot, while the AMD part requires dual-slot spacing.

FAQ

Q: Which card has more memory bandwidth?

A: The AMD Instinct MI350P has 8.19 TB/s of bandwidth from 144 GB of HBM3e on an 8192-bit bus, compared to the NVIDIA RTX PRO 4500's 800.3 GB/s from 32 GB of GDDR7 on a 256-bit bus.

Q: Which card has higher FP32 compute?

A: The NVIDIA RTX PRO 4500 Blackwell Server reaches 50.70 TFLOPS in FP32, while the AMD Instinct MI350P reaches 36.04 TFLOPS, a difference of roughly 40.7% in favor of NVIDIA.

Q: Does the AMD card support ray tracing?

A: The AMD Instinct MI350P lists no RT cores, no tensor cores, and no ROPs. The NVIDIA RTX PRO 4500 lists 82 RT cores, 328 tensor cores, and 112 ROPs.

Q: What are the power requirements for each card?

A: The AMD Instinct MI350P has a 600 W TDP and a suggested 1000 W PSU. The NVIDIA RTX PRO 4500 has a 165 W TDP and a suggested 450 W PSU.

Q: Do either of these cards have display outputs?

A: No. Both the AMD Instinct MI350P and the NVIDIA RTX PRO 4500 Blackwell Server report no display outputs.

Q: What API support does each card offer?

A: The NVIDIA RTX PRO 4500 supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. The AMD Instinct MI350P reports N/A for DirectX, OpenGL, and Vulkan.

Specification Differences

The two cards differ across nearly every major specification. The AMD Instinct MI350P uses a 3 nm process with 73,000 million transistors on a 1190 mm² die, while the NVIDIA RTX PRO 4500 uses a 5 nm process with 45,600 million transistors on a 378 mm² die. Transistor density is 61.3M per mm² for AMD and 120.6M per mm² for NVIDIA. Base clocks are 1000 MHz for AMD and 1215 MHz for NVIDIA; boost clocks are 2200 MHz for AMD and 2415 MHz for NVIDIA. Memory capacity is 144 GB of HBM3e versus 32 GB of GDDR7. The memory bus is 8192 bits versus 256 bits. Bandwidth is 8.19 TB/s versus 800.3 GB/s. Shading units are 8192 versus 10496. TMUs are 512 versus 328. ROPs are 0 versus 112. RT cores are not listed for AMD versus 82 for NVIDIA. Tensor cores are not listed for AMD versus 328 for NVIDIA. Pixel rate is 0 MPixel/s versus 270.5 GPixel/s. Texture rate is 1,126.4 GTexel/s versus 792.1 GTexel/s. FP32 and FP16 are 36.04 TFLOPS versus 50.70 TFLOPS. TDP is 600 W versus 165 W. Slot width is dual-slot versus single-slot. Suggested PSU is 1000 W versus 450 W. API support is N/A for AMD versus DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4 for NVIDIA. Both share PCIe 5.0 x16, a single 16-pin connector, no display outputs, and identical dimensions of 267 mm by 111 mm by 40 mm. The NVIDIA card is marked Active in production status, while the AMD card has no production status listed. Release dates differ as well, with the NVIDIA card dated 2026-03-16 and the AMD card dated 2026-05-06.

The Verdict

The data points to different deployment targets. The AMD Instinct MI350P is built around massive memory capacity and bandwidth: 144 GB of HBM3e at 8.19 TB/s, with a 8192-bit bus. The NVIDIA RTX PRO 4500 Blackwell Server is built around higher raw compute throughput: 50.70 TFLOPS in both FP32 and FP16, backed by 82 RT cores and 328 tensor cores. The NVIDIA card also operates at a fraction of the power draw, 165 W versus 600 W, and fits in a single slot.

For workloads that depend on holding very large models or datasets in memory, the MI350P's 144 GB and 8.19 TB/s are the dominant figures. For workloads that depend on FP32 or FP16 compute density, the RTX PRO 4500's 50.70 TFLOPS is the stronger number. The MI350P also leads texture rate at 1,126.4 GTexel/s, while the RTX PRO 4500 leads pixel rate at 270.5 GPixel/s and provides the only ray tracing and tensor core resources in this pairing. The absence of ROPs and graphics APIs on the AMD side confines it to compute-only roles, while the NVIDIA side carries full graphics API support. The production status shows the RTX PRO 4500 as Active, with the MI350P lacking a status field. Neither card has benchmark scores in the database, so the verdict rests on architecture and specification differences alone.