AMD Instinct MI350P vs NVIDIA RTX PRO 4500 Blackwell Comparison

The AMD Instinct MI350P and NVIDIA RTX PRO 4500 Blackwell represent two fundamentally different approaches to professional graphics hardware. The AMD part is a compute-focused accelerator with no display outputs, while the NVIDIA card is a full-featured workstation GPU. The recorded data shows that the MI350P has no benchmark entries, while the RTX PRO 4500 delivers a substantial set of scores. The MI350P is positioned with a 50th percentile ranking against all GPUs, whereas the RTX PRO 4500 sits at the 76th percentile. The NVIDIA card's average benchmark score is 31,532, placing it in a competitive range with several other professional cards.

Where Each One Wins

The RTX PRO 4500 Blackwell is the only one of the two with measurable benchmark results in the database. Its wins are comprehensive across every recorded test. In the 3DMark Steel Nomad DX12 test, it scores 7,025. The Geekbench Vulkan result is especially strong at 221,768, indicating robust compute and graphics performance under that API. The PassMark suite shows a G3D score of 33,360, a GPU Compute score of 19,255, and a G2D score of 1,336. The DirectX 9, 10, 11, and 12 tests return 397, 204, 320, and 119 respectively. Every one of these figures demonstrates that the NVIDIA card is active across a range of workloads.

The AMD MI350P has no recorded benchmarks and no wins in the head-to-head comparison. Its strengths appear only in its specifications. It can access 144 GB of HBM3e memory with a bandwidth of 8.19 TB/s, which far exceeds the NVIDIA card's 32 GB GDDR7 memory and 896.0 GB/s bandwidth. The AMD part also has a wider memory bus at 8192 bit versus 256 bit. These figures indicate that the MI350P is built for data-scale workloads where capacity and bandwidth matter more than rasterization. The RTX PRO 4500, by contrast, has actual performance data confirming its capability in both graphics and compute tests.

Architecture Differences

The two accelerators diverge sharply at every architectural level. The AMD Instinct MI350P uses the CDNA 4.0 architecture and is built on a 3 nm process at TSMC. It contains 73,000 million transistors on a die size of 1190 mm², giving it a transistor density of 61.3M per mm². The chip is designated as MI350 128CU. The NVIDIA RTX PRO 4500 Blackwell uses the Blackwell 2.0 architecture on a 5 nm TSMC process. It packs 45,600 million transistors into a 378 mm² die, achieving a transistor density of 120.6M per mm². The smaller process node of the AMD part allows for a much larger die despite the lower density.

The compute configurations differ in kind. The AMD MI350P has 8,192 shading units and 512 TMUs, but 0 ROPs, 0 pixel rate, and no RT cores or tensor cores listed. This is a pure compute design. The NVIDIA RTX PRO 4500 has 10,496 shading units, 328 TMUs, and 112 ROPs. It includes 82 RT cores and 328 tensor cores, enabling hardware ray tracing and AI acceleration. The pixel rate for the NVIDIA card is 269.6 GPixel/s, while the AMD part is listed at 0 MPixel/s. Texture rates are 1,126.4 GTexel/s for AMD and 789.5 GTexel/s for NVIDIA. The AMD FP32 throughput is 36.04 TFLOPS, and its FP16 is 36.04 TFLOPS at a 1:1 ratio. The NVIDIA card reaches 50.53 TFLOPS in both FP32 and FP16, also at a 1:1 ratio.

The API support is a decisive differentiator. The AMD MI350P lists N/A for DirectX, OpenGL, and Vulkan. The NVIDIA RTX PRO 4500 supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. The AMD card has no display outputs, while the NVIDIA card provides 4x DisplayPort 2.1b outputs. The NVIDIA part is marked as Active in production status, whereas the AMD part has no listed production status. These architectural choices confirm that the MI350P is for compute-only environments, while the RTX PRO 4500 is a complete workstation solution.

Head-to-Head Benchmarks

The head-to-head benchmark table is empty, and the win count is 0 for both cards. The only benchmark data available belongs to the NVIDIA RTX PRO 4500. The database records its 3DMark Steel Nomad DX12 score at 7,025. The Geekbench Vulkan score of 221,768 is the highest single test result recorded for either card. PassMark results break down by API generation: DirectX 9 at 397, DirectX 10 at 204, DirectX 11 at 320, and DirectX 12 at 119. The DirectX 12 score is notably lower than the DirectX 9 score, which may reflect the specific workload characteristics of the test.

The PassMark GPU Compute score of 19,255 is separate from the G3D score of 33,360. The G2D score of 1,336 is lower, as expected for a 2D-focused test. The NVIDIA card's average benchmark score is 31,532. Its nearest rivals in the database include the NVIDIA TITAN RTX with an average score of 31,676 and a delta of -0.5%, the NVIDIA GRID M60-1Q with 31,220 and a delta of 1%, the NVIDIA Quadro M5000 with 31,206 and a delta of 1%, and the Intel Arc Pro A30M with 31,894 and a delta of -1.1%. The RTX PRO 4500 sits within 1.1% of all four of these rivals, showing that its measured performance is tightly clustered with those cards despite the architectural generation gap.

The AMD MI350P has no scores to compare, so no direct performance delta can be calculated. The data shows that the RTX PRO 4500 is the only card in this pair with empirical benchmark evidence. Its percentile ranking of 76 places it well above the MI350P's 50th percentile, which is based on no recorded data. The absence of benchmarks for the AMD card means its actual performance relative to the NVIDIA card cannot be established from the database. The specification gap, however, is clear: the MI350P offers 144 GB of memory and 8.19 TB/s of bandwidth, while the RTX PRO 4500 offers 32 GB and 896.0 GB/s. The NVIDIA card still achieves higher FP32 and FP16 throughput at 50.53 TFLOPS compared to 36.04 TFLOPS for the AMD part.

The Verdict

The data indicates that the NVIDIA RTX PRO 4500 Blackwell is the only one of the two with confirmed performance. The database shows its 76th percentile ranking, its average score of 31,532, and its proximity to the NVIDIA TITAN RTX, GRID M60-1Q, Quadro M5000, and Intel Arc Pro A30M. For any workload that requires graphics, ray tracing, display output, or DirectX and Vulkan support, the RTX PRO 4500 is the only viable choice between the two. Its 112 ROPs, 82 RT cores, 328 tensor cores, and 4x DisplayPort 2.1b outputs support that role.

The AMD Instinct MI350P appears suited to a different category entirely. Its 144 GB of HBM3e memory, 8192 bit bus, and 8.19 TB/s bandwidth are specifications aimed at large-scale compute tasks. The lack of ROPs, pixel rate, display outputs, and API support confirms it is not a graphics card in the traditional sense. The 600 W TDP and 1000 W suggested PSU further distinguish it from the 200 W NVIDIA card with its 550 W suggested PSU. The MI350P has no benchmark scores, so its real-world performance is unverified in the database. The RTX PRO 4500 has a 76th percentile ranking, while the MI350P sits at the 50th percentile, a position that reflects no measured data.

For users who need display outputs, graphics APIs, or ray tracing, the choice is clear. For users who need massive memory capacity and bandwidth in a compute-only environment, the MI350P presents the relevant specifications. The two cards do not compete in the same market segment. The NVIDIA card is a complete workstation GPU with confirmed scores; the AMD card is a specialized accelerator whose performance data has not been recorded.

FAQ

Q: Which GPU has a higher benchmark score?

A: The NVIDIA RTX PRO 4500 Blackwell has an average benchmark score of 31,532. The AMD Instinct MI350P has no recorded benchmark scores in the database.

Q: What is the memory capacity difference?

A: The AMD Instinct MI350P has 144 GB of HBM3e memory, while the NVIDIA RTX PRO 4500 Blackwell has 32 GB of GDDR7 memory.

Q: Does either GPU support ray tracing?

A: The NVIDIA RTX PRO 4500 Blackwell includes 82 RT cores. The AMD Instinct MI350P lists no RT cores in the recorded data.

Q: What API support does each GPU have?

A: The NVIDIA RTX PRO 4500 supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. The AMD Instinct MI350P lists N/A for DirectX, OpenGL, and Vulkan.

Q: How do the power requirements compare?

A: The AMD Instinct MI350P has a TDP of 600 W and a suggested PSU of 1000 W. The NVIDIA RTX PRO 4500 has a TDP of 200 W and a suggested PSU of 550 W.

Q: Which GPU has display outputs?

A: The NVIDIA RTX PRO 4500 has 4x DisplayPort 2.1b outputs. The AMD Instinct MI350P has no display outputs.

Specification Differences

The two cards differ in nearly every specification field. The AMD Instinct MI350P uses a 3 nm process, while the NVIDIA RTX PRO 4500 uses a 5 nm process. The AMD chip is the MI350 128CU with CDNA 4.0 architecture, and the NVIDIA chip is GB203 with Blackwell 2.0 architecture. Transistor counts are 73,000 million for AMD and 45,600 million for NVIDIA. Die sizes are 1190 mm² for AMD and 378 mm² for NVIDIA, with transistor densities of 61.3M per mm² and 120.6M per mm² respectively.

Clock speeds show the NVIDIA card running higher. The AMD base clock is 1000 MHz and boost is 2200 MHz. The NVIDIA base clock is 1635 MHz and boost is 2407 MHz. Memory clocks are 2000 MHz (8 Gbps effective) for AMD and 1750 MHz (28 Gbps effective) for NVIDIA. Memory configurations are 144 GB HBM3e on an 8192 bit bus versus 32 GB GDDR7 on a 256 bit bus. Bandwidth is 8.19 TB/s for AMD and 896.0 GB/s for NVIDIA.

The compute units differ. AMD has 8,192 shading units, 512 TMUs, 0 ROPs, and no RT or tensor cores. NVIDIA has 10,496 shading units, 328 TMUs, 112 ROPs, 82 RT cores, and 328 tensor cores. Pixel rate is 0 MPixel/s for AMD and 269.6 GPixel/s for NVIDIA. Texture rates are 1,126.4 GTexel/s for AMD and 789.5 GTexel/s for NVIDIA. FP32 and FP16 are 36.04 TFLOPS for AMD and 50.53 TFLOPS for NVIDIA, both at a 1:1 ratio.

Power and physical specifications also diverge. The AMD TDP is 600 W with a 1000 W suggested PSU. The NVIDIA TDP is 200 W with a 550 W suggested PSU. Both are dual-slot with a 1x 16-pin power connector and PCIe 5.0 x16 interface. Both share the same dimensions: 267 mm length, 111 mm height, and 40 mm width. The NVIDIA card has 4x DisplayPort 2.1b outputs, while the AMD card has none. The NVIDIA card is listed as Active in production status, with a release date of 2025-03-17. The AMD card has no production status and a release date of 2026-05-06.