AMD Instinct MI350P vs NVIDIA RTX 4500 Ada Generation Comparison

Head-to-Head Benchmarks

The recorded data for these two accelerators is asymmetrical. The AMD Instinct MI350P has no benchmark entries in the database, resulting in an average benchmark score of 0 and a percentile rank of 50 against all GPUs. The NVIDIA RTX 4500 Ada Generation, by contrast, has two recorded benchmark results and a percentile rank of 97.

The RTX 4500 Ada Generation delivers a Geekbench OpenCL score of 160,786 and a Geekbench Vulkan score of 171,401. Its average benchmark score across those entries is 166,094. The MI350P has no comparable scores, so a direct numerical head-to-head comparison of measured application performance is not possible from the database.

The RTX 4500 Ada Generation sits within a tight competitive cluster. Its average score of 166,094 places it 0.5% ahead of the NVIDIA RTX A5500, which averages 165,217. It also leads the AMD Radeon PRO W7800 (average 164,894) by 0.7%. The RTX 4500 trails the AMD Radeon Pro W6900X (average 168,574) by 1.5%. Against the NVIDIA A100 PCIe 40 GB, the RTX 4500 leads by 2.2%, with the A100 averaging 162,504. These margins are narrow, all within roughly two percentage points, indicating that the RTX 4500 Ada Generation performs in a well-established performance band for workstation accelerators.

The largest quantitative advantage for the RTX 4500 in the database is the 2.2% lead over the A100 PCIe 40 GB. The largest deficit is the 1.5% gap to the Radeon Pro W6900X. The MI350P has no wins recorded, as the winsA field is 0, and the RTX 4500 also has 0 recorded wins in the head-to-head array, which is empty. The database provides no cross-accelerator benchmark results between these two specific products.

Without measured scores for the MI350P, the FP32 compute figures from the specification data serve as the only common performance metric. The MI350P lists FP32 throughput of 36.04 TFLOPS, while the RTX 4500 Ada Generation lists 39.63 TFLOPS. That places the RTX 4500 approximately 10% higher in peak FP32 arithmetic throughput. The MI350P matches its FP32 number in FP16 at a 1:1 ratio, also 36.04 TFLOPS. The RTX 4500 also lists FP16 at 39.63 TFLOPS with a 1:1 ratio. Both parts therefore show equal FP16 and FP32 rates, which is typical of their respective architectures.

Texture and pixel throughput differ substantially. The MI350P has a texture rate of 1,126.4 GTexel/s, which is 81.9% higher than the RTX 4500's 619.2 GTexel/s. The MI350P lists a pixel rate of 0 MPixel/s, while the RTX 4500 outputs 206.4 GPixel/s. The MI350P has no ROPs, which explains the zero pixel rate. The RTX 4500 has 80 ROPs. Shader resources are close: the MI350P has 8,192 shading units, the RTX 4500 has 7,680. The MI350P has 512 TMUs, the RTX 4500 has 240.

Memory bandwidth is the largest specification gap. The MI350P uses 144 GB of HBM3e on an 8192-bit bus, delivering 8.19 TB/s. The RTX 4500 uses 24 GB of GDDR6 on a 192-bit bus, delivering 432.0 GB/s. The MI350P's bandwidth is roughly 19 times higher. Capacity is six times larger on the MI350P. These figures indicate entirely different workload targets despite similar FP32 peak rates.

The Verdict

The database contains no benchmark scores for the AMD Instinct MI350P, so any verdict must be drawn from specification data and the RTX 4500's measured results. The RTX 4500 Ada Generation has demonstrated performance in the 97th percentile of all GPUs, with an average score of 166,094. Its nearest rivals cluster within 1.5% of its average, confirming that it delivers competitive workstation compute for its class.

The MI350P targets a different segment. Its 144 GB memory capacity, 8.19 TB/s bandwidth, and 8192-bit memory interface indicate a design for large-model inference and training workloads where memory footprint and bandwidth dominate. The RTX 4500's 24 GB capacity and 432.0 GB/s bandwidth are far smaller, and its 192-bit bus reflects a conventional workstation memory subsystem. The MI350P's 600 W TDP, 1000 W suggested PSU, and 1x 16-pin power connector show a power-hungry accelerator, while the RTX 4500 runs at 210 W TDP with no power connectors listed and a 550 W suggested PSU.

The RTX 4500 has real output capabilities: 4x DisplayPort 1.4a, DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4 support. The MI350P lists no display outputs and N/A for DirectX, OpenGL, and Vulkan. The MI350P is not a graphics card in the conventional sense; it is a compute accelerator without a graphics API path.

For a user needing measured, verified performance data, the RTX 4500 Ada Generation is the only one of the two with benchmark results in the database. For a user needing massive memory capacity and bandwidth for large datasets, the MI350P's specifications point to a very different capability envelope. The data does not support a performance ranking between them, because no common measured benchmark exists.

Where Each One Wins

The RTX 4500 Ada Generation wins on measured performance evidence. It has two benchmark scores, an average of 166,094, and a 97th percentile ranking. It leads the RTX A5500 by 0.5%, the Radeon PRO W7800 by 0.7%, and the A100 PCIe 40 GB by 2.2% in average score. It trails the Radeon Pro W6900X by 1.5%. These results establish it as a solid mid-to-high workstation performer with graphics output and API support.

The MI350P wins on raw memory subsystem specifications. Its 144 GB capacity, 8.19 TB/s bandwidth, and 8192-bit bus are unmatched by the RTX 4500's 24 GB, 432.0 GB/s, and 192-bit bus. It also leads in texture rate at 1,126.4 GTexel/s versus 619.2 GTexel/s. FP32 peak is lower on the MI350P at 36.04 TFLOPS versus 39.63 TFLOPS, so the RTX 4500 wins on peak arithmetic throughput.

The MI350P uses HBM3e memory, a 3 nm process node, and a 73,000 million transistor count on a 1190 mm² die. The RTX 4500 uses GDDR6, a 5 nm node, 45,900 million transistors on a 379 mm² die. The MI350P has higher transistor density in absolute terms, but the RTX 4500 has higher density per area: 121.1M / mm² versus 61.3M / mm². The MI350P uses PCIe 5.0 x16; the RTX 4500 uses PCIe 4.0 x16.

The RTX 4500 wins on power efficiency from the specification sheet. At 210 W TDP versus 600 W, it delivers higher FP32 TFLOPS per watt. The MI350P's suggested PSU is 1000 W versus 550 W for the RTX 4500. Physical size is similar: the MI350P is 267 mm long, 111 mm high, and 40 mm wide; the RTX 4500 is 245 mm long and 112 mm high with no width listed. Both are dual-slot.

FAQ

Q: Which GPU has a higher measured benchmark score?

A: Only the NVIDIA RTX 4500 Ada Generation has benchmark scores in the database. Its average score is 166,094, with a Geekbench OpenCL score of 160,786 and a Geekbench Vulkan score of 171,401. The AMD Instinct MI350P has no recorded benchmark scores.

Q: How does the RTX 4500 Ada Generation compare to its nearest rivals?

A: The RTX 4500 averages 166,094, which is 0.5% ahead of the NVIDIA RTX A5500 (165,217), 0.7% ahead of the AMD Radeon PRO W7800 (164,894), and 2.2% ahead of the NVIDIA A100 PCIe 40 GB (162,504). It is 1.5% behind the AMD Radeon Pro W6900X (168,574).

Q: Which card has more memory and bandwidth?

A: The AMD Instinct MI350P has 144 GB of HBM3e on an 8192-bit bus with 8.19 TB/s bandwidth. The NVIDIA RTX 4500 Ada Generation has 24 GB of GDDR6 on a 192-bit bus with 432.0 GB/s bandwidth.

Q: Which card has higher FP32 compute?

A: The NVIDIA RTX 4500 Ada Generation lists 39.63 TFLOPS FP32, while the AMD Instinct MI350P lists 36.04 TFLOPS FP32. Both list FP16 at the same rate as FP32 (1:1 ratio).

Q: Does the MI350P support display outputs?

A: No. The AMD Instinct MI350P lists no display outputs and has N/A for DirectX, OpenGL, and Vulkan. The NVIDIA RTX 4500 Ada Generation has 4x DisplayPort 1.4a and supports DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4.

Q: What are the power requirements?

A: The AMD Instinct MI350P has a 600 W TDP, a 1x 16-pin power connector, and a suggested PSU of 1000 W. The NVIDIA RTX 4500 Ada Generation has a 210 W TDP, no power connectors listed, and a suggested PSU of 550 W.

Architecture Differences

The AMD Instinct MI350P uses the CDNA 4.0 architecture on a 3 nm TSMC process, with the MI350 128CU chip. The NVIDIA RTX 4500 Ada Generation uses the Ada Lovelace architecture on a 5 nm TSMC process, with the AD103 chip. Process node differences are clear: 3 nm versus 5 nm, both from TSMC.

Transistor counts differ substantially. The MI350P integrates 73,000 million transistors on a 1190 mm² die, yielding a density of 61.3M transistors per mm². The RTX 4500 integrates 45,900 million transistors on a 379 mm² die, yielding 121.1M transistors per mm². The RTX 4500 packs more than twice the transistor density per area, while the MI350P uses a much larger die overall.

The MI350P has 8,192 shading units, 512 TMUs, and no ROPs. The RTX 4500 has 7,680 shading units, 240 TMUs, and 80 ROPs. The MI350P's texture rate is 1,126.4 GTexel/s versus 619.2 GTexel/s on the RTX 4500. The MI350P's pixel rate is 0 MPixel/s, while the RTX 4500 reaches 206.4 GPixel/s.

The RTX 4500 includes 60 RT cores and 240 tensor cores. The MI350P lists no RT core count and no tensor core count in the database. This reflects the different feature sets: the RTX 4500 is built for graphics and ray-traced workloads with API support, while the MI350P is a compute-focused accelerator without graphics APIs.

Memory architecture is the defining difference. The MI350P uses HBM3e with 144 GB capacity, an 8192-bit bus, and 8.19 TB/s bandwidth at 2000 MHz (8 Gbps effective). The RTX 4500 uses GDDR6 with 24 GB capacity, a 192-bit bus, and 432.0 GB/s bandwidth at 2250 MHz (18 Gbps effective). The MI350P's memory bus width is 42.7 times wider, and its bandwidth is approximately 19 times higher.

The MI350P uses PCIe 5.0 x16, while the RTX 4500 uses PCIe 4.0 x16. The MI350P has no display outputs; the RTX 4500 has 4x DisplayPort 1.4a. The MI350P's API support is marked N/A for DirectX, OpenGL, and Vulkan. The RTX 4500 supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4.

Physical and power characteristics differ. The MI350P is 267 mm long, 111 mm high, and 40 mm wide, with a 600 W TDP, a 1x 16-pin power connector, and a 1000 W suggested PSU. The RTX 4500 is 245 mm long and 112 mm high, with no width listed, a 210 W TDP, no power connectors, and a 550 W suggested PSU. Both are dual-slot cards.

The release dates are far apart. The RTX 4500 Ada Generation was released on 2023-08-08 and is listed as Active in production status. The MI350P has a release date of 2026-05-06 and no production status listed. The RTX 4500's predecessor is Workstation Ampere, and its successor is Blackwell PRO W. The MI350P's predecessor is Radeon Instinct, with no successor listed. The RTX 4500 belongs to the GeForce 40-series family, while the MI350P belongs to the Instinct (MIx) generation.