AMD Instinct MI350P vs NVIDIA RTX 4000 Ada Generation Comparison

FAQ

Q: What are the two cards compared in this database entry?

A: The AMD Instinct MI350P, an accelerator based on CDNA 4.0 architecture, and the NVIDIA RTX 4000 Ada Generation, a workstation card based on Ada Lovelace architecture.

Q: Which card has the higher memory bandwidth?

A: The AMD Instinct MI350P delivers 8.19 TB/s of bandwidth from 144 GB of HBM3e memory, versus the NVIDIA RTX 4000 Ada Generation's 360.0 GB/s from 20 GB of GDDR6 memory.

Q: What is the transistor count difference between the two chips?

A: The AMD chip contains 73,000 million transistors on a 1190 mm² die, while the NVIDIA chip contains 35,800 million transistors on a 294 mm² die.

Q: Which card has a higher FP32 compute throughput?

A: The AMD Instinct MI350P reaches 36.04 TFLOPS, whereas the NVIDIA RTX 4000 Ada Generation reaches 26.73 TFLOPS.

Q: What is the thermal design power for each card?

A: The AMD Instinct MI350P has a 600 W TDP, while the NVIDIA RTX 4000 Ada Generation has a 130 W TDP.

Q: Which card supports display outputs?

A: The NVIDIA RTX 4000 Ada Generation provides 4x DisplayPort 1.4a outputs, while the AMD Instinct MI350P has no display outputs.

Architecture Differences

The AMD Instinct MI350P and NVIDIA RTX 4000 Ada Generation are built for entirely different workloads, and their architecture reflects that split. The MI350P uses CDNA 4.0, a compute-focused architecture that omits graphics-specific hardware entirely. Its chip, labeled MI350 128CU, contains 73,000 million transistors on a 1190 mm² die, fabricated on a 3 nm process by TSMC. The RTX 4000 Ada Generation uses Ada Lovelace, a workstation architecture derived from consumer GeForce designs, with 35,800 million transistors on a 294 mm² die, also from TSMC but on a 5 nm process.

The shading unit counts differ substantially. The MI350P has 8192 shading units with 512 texture mapping units, but its raster operations pipeline is zero, meaning it cannot perform pixel output. In contrast, the RTX 4000 Ada Generation has 6144 shading units, 192 TMUs, and 64 ROPs, allowing it to produce a pixel rate of 139.2 GPixel/s. The MI350P's texture rate is 1,126.4 GTexel/s, more than double the RTX 4000's 417.6 GTexel/s, but the NVIDIA card is the only one of the two with dedicated ray tracing cores (48) and tensor cores (192). The MI350P lists no RT cores and no tensor cores in the database.

The memory subsystems are also architecturally distinct. The MI350P uses HBM3e across an 8192-bit bus, yielding 8.19 TB/s bandwidth. The RTX 4000 uses GDDR6 across a 160-bit bus, yielding 360.0 GB/s. The MI350P's memory clock is 2000 MHz (8 Gbps effective), while the RTX 4000 runs at 2250 MHz (18 Gbps effective). The MI350P draws power through a single 16-pin connector and requires a 1000 W power supply, while the RTX 4000 also uses a single 16-pin connector but only needs a 300 W supply. The MI350P is dual-slot and has no display outputs; the RTX 4000 is single-slot and has four DisplayPort outputs.

The MI350P supports PCIe 5.0 x16, while the RTX 4000 supports PCIe 4.0 x16. The NVIDIA card exposes DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4 APIs, while the AMD card lists N/A for all three. The MI350P's release date is 2026-05-06, and its predecessor is Radeon Instinct. The RTX 4000's release date is 2023-08-08, its predecessor is Workstation Ampere, and its successor is Blackwell PRO W.

Head-to-Head Benchmarks

The database contains no direct head-to-head benchmark results between the AMD Instinct MI350P and the NVIDIA RTX 4000 Ada Generation. The wins counters are zero for both cards. However, the RTX 4000 has standalone benchmark scores: a Geekbench OpenCL score of 146,593 and a Geekbench Vulkan score of 123,842, for an average benchmark score of 135,218. The MI350P has no recorded benchmark scores and an average of zero.

The RTX 4000's percentile ranking versus all GPUs is 95, while the MI350P sits at the 50th percentile. This is a striking discrepancy given the MI350P's raw compute specifications. The RTX 4000's nearest rivals in the database are the NVIDIA A10M (avg score 135,230, delta 0%), the AMD Radeon PRO W6800 (avg score 135,396, delta -0.1%), the AMD Radeon Pro W6800X Duo (avg score 135,774, delta -0.4%), and the AMD Radeon PRO V620 (avg score 136,472, delta -0.9%). The RTX 4000 sits essentially at parity with these cards, trailing the A10M by 0% and the Radeon PRO V620 by 0.9%.

The FP32 throughput comparison favors the MI350P by a wide margin: 36.04 TFLOPS versus 26.73 TFLOPS, a 34.8% advantage. The texture rate comparison is even more lopsided: 1,126.4 GTexel/s versus 417.6 GTexel/s, a 169.7% advantage. Memory bandwidth is the largest gap, with the MI350P at 8.19 TB/s versus 360.0 GB/s, a 2,175% advantage. The pixel rate comparison reverses entirely, with the RTX 4000 at 139.2 GPixel/s and the MI350P at 0 MPixel/s.

Clock speeds also differ. The MI350P has a base clock of 1000 MHz and a boost clock of 2200 MHz. The RTX 4000 has a base clock of 1500 MHz and a boost clock of 2175 MHz. The NVIDIA card runs higher at both ends, but the AMD card's massive shading unit count and memory bus compensate in compute-bound tasks.

Specification Differences

The two cards differ across nearly every specification field in the database.

• Architecture: MI350P uses CDNA 4.0; RTX 4000 uses Ada Lovelace.
• Chip: MI350P uses MI350 128CU; RTX 4000 uses AD104.
• Process node: MI350P is 3 nm; RTX 4000 is 5 nm.
• Transistors: MI350P has 73,000 million; RTX 4000 has 35,800 million.
• Die size: MI350P is 1190 mm²; RTX 4000 is 294 mm².
• Transistor density: MI350P is 61.3M / mm²; RTX 4000 is 121.8M / mm².
• Base clock: MI350P is 1000 MHz; RTX 4000 is 1500 MHz.
• Boost clock: MI350P is 2200 MHz; RTX 4000 is 2175 MHz.
• Memory clock: MI350P is 2000 MHz (8 Gbps effective); RTX 4000 is 2250 MHz (18 Gbps effective).
• Memory size: MI350P is 144 GB; RTX 4000 is 20 GB.
• Memory type: MI350P uses HBM3e; RTX 4000 uses GDDR6.
• Memory bus width: MI350P is 8192 bit; RTX 4000 is 160 bit.
• Memory bandwidth: MI350P is 8.19 TB/s; RTX 4000 is 360.0 GB/s.
• Shading units: MI350P has 8192; RTX 4000 has 6144.
• Texture mapping units: MI350P has 512; RTX 4000 has 192.
• Raster operations units: MI350P has 0; RTX 4000 has 64.
• Ray tracing cores: MI350P has none; RTX 4000 has 48.
• Tensor cores: MI350P has none; RTX 4000 has 192.
• Pixel rate: MI350P is 0 MPixel/s; RTX 4000 is 139.2 GPixel/s.
• Texture rate: MI350P is 1,126.4 GTexel/s; RTX 4000 is 417.6 GTexel/s.
• FP32: MI350P is 36.04 TFLOPS; RTX 4000 is 26.73 TFLOPS.
• FP16: MI350P is 36.04 TFLOPS (1:1); RTX 4000 is 26.73 TFLOPS (1:1).
• TDP: MI350P is 600 W; RTX 4000 is 130 W.
• Slot width: MI350P is dual-slot; RTX 4000 is single-slot.
• Suggested PSU: MI350P is 1000 W; RTX 4000 is 300 W.
• Bus interface: MI350P is PCIe 5.0 x16; RTX 4000 is PCIe 4.0 x16.
• Display outputs: MI350P has none; RTX 4000 has 4x DisplayPort 1.4a.
• DirectX support: MI350P is N/A; RTX 4000 is 12 Ultimate (12_2).
• OpenGL support: MI350P is N/A; RTX 4000 is 4.6.
• Vulkan support: MI350P is N/A; RTX 4000 is 1.4.
• Dimensions: MI350P is 267 mm long, 111 mm high, 40 mm wide; RTX 4000 is 245 mm long, 112 mm high.
• Release date: MI350P is 2026-05-06; RTX 4000 is 2023-08-08.
• Production status: MI350P is null; RTX 4000 is active.

Where Each One Wins

The AMD Instinct MI350P wins decisively in raw compute throughput. Its FP32 output of 36.04 TFLOPS exceeds the RTX 4000's 26.73 TFLOPS by roughly 34.8%. Its FP16 output is identical to its FP32 at 36.04 TFLOPS, while the RTX 4000 also matches its FP32 at 26.73 TFLOPS, so the AMD card maintains the same advantage in half-precision workloads. The texture rate of 1,126.4 GTexel/s is more than double the RTX 4000's 417.6 GTexel/s, pointing to strong performance in shader-heavy or texture-fetch-bound compute kernels. The memory bandwidth advantage is overwhelming: 8.19 TB/s versus 360.0 GB/s, a factor of over 22. This makes the MI350P suited for large model loads, dense matrix operations, and data movement tasks that saturate memory channels. The 144 GB capacity also dwarfs the 20 GB on the RTX 4000, allowing far larger datasets to reside on the card without spilling to host memory.

The NVIDIA RTX 4000 Ada Generation wins in all graphics-related categories. It has 64 ROPs and a pixel rate of 139.2 GPixel/s, while the MI350P has zero ROPs and zero pixel output. It has 48 ray tracing cores and 192 tensor cores, while the MI350P has neither. It supports DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4, while the MI350P supports none of these APIs. It provides four DisplayPort outputs, making it a functional display adapter, whereas the MI350P cannot drive a monitor. The RTX 4000 also wins on efficiency: its 130 W TDP and 300 W suggested PSU compare favorably to the MI350P's 600 W TDP and 1000 W suggested PSU. Its clock speeds are higher at both base (1500 MHz vs 1000 MHz) and boost (2175 MHz vs 2200 MHz, nearly identical). The RTX 4000 is single-slot versus dual-slot, shorter in length (245 mm vs 267 mm), and has a higher transistor density (121.8M / mm² vs 61.3M / mm²), reflecting a more compact, integrated design.

The RTX 4000 also holds the only recorded benchmark scores in the database. Its Geekbench OpenCL score of 146,593 and Vulkan score of 123,842 place it at the 95th percentile of all GPUs, with an average score of 135,218. The MI350P has no recorded scores and sits at the 50th percentile. In the absence of head-to-head results, the RTX 4000 is the only card with measurable competitive standing, and its nearest rivals (NVIDIA A10M, AMD Radeon PRO W6800, W6800X Duo, Radeon PRO V620) all fall within a 0.9% delta of its average score.

The Verdict

The data separates these two cards cleanly. The AMD Instinct MI350P is a compute accelerator without any display or graphics capability. Its 36.04 TFLOPS FP32 throughput, 1,126.4 GTexel/s texture rate, and 8.19 TB/s memory bandwidth position it for dense compute, large memory footprints, and bandwidth-hungry workloads. Its 144 GB HBM3e memory and 8192-bit bus are unmatched in this comparison. The absence of ROPs, RT cores, tensor cores, and all graphics APIs confirms that this card is not intended for rendering or interactive workloads. Its 600 W TDP and 1000 W suggested PSU indicate a server or workstation chassis designed for sustained high-power compute.

The NVIDIA RTX 4000 Ada Generation is a conventional workstation card. It offers 139.2 GPixel/s pixel throughput, 48 RT cores, 192 tensor cores, and full DirectX, OpenGL, and Vulkan support. Its 26.73 TFLOPS FP32 output is lower than the MI350P, but it is the only card of the two that can render frames, drive displays, and run graphics APIs. Its 130 W TDP and single-slot form factor make it suitable for standard workstation builds. Its recorded benchmark scores and 95th percentile ranking give it a verified performance baseline, while the MI350P has no such data.

For a user whose workload is pure compute with no graphics output, the MI350P's specifications are superior across every compute metric in the database. For a user who needs rendering, display output, ray tracing, or API compatibility, the RTX 4000 is the only viable option. The MI350P is the compute winner by a wide margin in raw throughput and memory bandwidth, but the RTX 4000 is the only card with measured benchmark results, a 95th percentile standing, and any graphics functionality at all. The choice depends entirely on whether the task requires a display pipeline or not.