AMD Instinct MI350P vs AMD Radeon RX 6450M Comparison

Where Each One Wins

The AMD Instinct MI350P and AMD Radeon RX 6450M occupy entirely separate segments of the GPU landscape, and the recorded data confirms they have no overlapping benchmark wins. The MI350P is an accelerator built for compute workloads, while the RX 6450M is a mobile graphics processor. The head-to-head benchmark table is empty, indicating that no direct comparative tests exist in the database. Each product wins in its own domain by virtue of its design goals rather than through direct competition.

The Instinct MI350P targets server and data center environments where massive memory capacity and raw throughput matter. Its 144 GB of HBM3e memory and 8.19 TB/s bandwidth position it for large-scale compute tasks. The RX 6450M, by contrast, serves portable devices with a 50 W power envelope and integrated graphics form factor (IGP). The RX 6450M supports display outputs, while the MI350P has no outputs at all, making the former the only one of the two capable of driving a screen.

The percentile ranking for both products sits at 50 out of all GPUs, though each has an average benchmark score of 0 in the database. Neither product shows any nearest rivals, meaning there are no comparable entries to contextualize their standings. The wins are therefore defined by feature sets: the MI350P wins on memory size, bandwidth, compute throughput, and interface bandwidth, while the RX 6450M wins on power efficiency, display capability, and API support.

Architecture Differences

The MI350P uses the CDNA 4.0 architecture on a 3 nm process at TSMC. The RX 6450M uses RDNA 2.0 on a 6 nm process, also at TSMC. The process node difference is significant: 3 nm versus 6 nm represents a generational gap in transistor density. The MI350P packs 73,000 million transistors across a 1190 mm² die, yielding a density of 61.3 million transistors per square millimeter. The RX 6450M has 5,400 million transistors on a 107 mm² die, for a density of 50.5 million per square millimeter.

The MI350P chip is labeled "MI350 128CU," indicating 128 compute units. The RX 6450M uses the Navi 24 chip. The MI350P belongs to the Instinct (MIx) generation, while the RX 6450M belongs to the Radeon RX 6000 series under the Navi Mobile (RX 6000M) generation. The MI350P's predecessor is Radeon Instinct, while the RX 6450M's predecessor is Polaris Mobile.

The MI350P has 8,192 shading units, 512 texture mapping units, and no ROPs, resulting in a pixel rate of 0 MPixel/s. The RX 6450M has 768 shading units, 48 TMUs, and 32 ROPs, achieving a pixel rate of 78.72 GPixel/s. The MI350P has no ray tracing cores listed, while the RX 6450M has 12 RT cores. Neither product lists tensor cores.

Memory architecture diverges sharply. The MI350P uses HBM3e with a 8192-bit bus and 8.19 TB/s bandwidth. The RX 6450M uses GDDR6 with a 64-bit bus and 128.0 GB/s bandwidth. The MI350P's memory operates at 2000 MHz with 8 Gbps effective speed, while the RX 6450M's memory also runs at 2000 MHz but achieves 16 Gbps effective speed.

Head-to-Head Benchmarks

No head-to-head benchmark results exist in the database for these two products. The winsA and winsB fields are both zero, and the headToHeadBenchmarks array is empty. This absence reflects the products' different market positions rather than a lack of data quality. The MI350P is a dual-slot, 600 W accelerator with a 16-pin power connector and a suggested PSU of 1000 W. The RX 6450M is an IGP with no power connectors and no suggested PSU, consuming 50 W.

The MI350P's FP32 performance is 36.04 TFLOPS, and its FP16 performance is identical at 36.04 TFLOPS, indicating a 1:1 ratio. The RX 6450M delivers 3.779 TFLOPS FP32 and 7.557 TFLOPS FP16, with a 2:1 ratio. The MI350P is roughly 9.5 times faster in FP32 and about 4.8 times faster in FP16, based on the recorded figures. The texture rate difference is similarly stark: the MI350P reaches 1,126.4 GTexel/s, while the RX 6450M reaches 118.1 GTexel/s, a factor of about 9.5.

Clock speeds tell a different story. The MI350P has a base clock of 1000 MHz and a boost clock of 2200 MHz. The RX 6450M has a base clock of 2000 MHz, a boost clock of 2460 MHz, and a game clock of 2220 MHz. The RX 6450M runs at higher frequencies across the board, but the MI350P compensates with far more shading units and a wider memory bus.

Interface bandwidth also favors the MI350P. It uses PCIe 5.0 x16, while the RX 6450M uses PCIe 4.0 x4. The MI350P's physical dimensions are recorded: 267 mm in length, 111 mm in height, and 40 mm in width. The RX 6450M has no recorded dimensions, consistent with its mobile, integrated form factor.

Specification Differences

The following fields differ between the two products, based on the recorded data:

• Architecture: CDNA 4.0 versus RDNA 2.0
• Process node: 3 nm versus 6 nm
• Transistors: 73,000 million versus 5,400 million
• Die size: 1190 mm² versus 107 mm²
• Transistor density: 61.3M per mm² versus 50.5M per mm²
• Base clock: 1000 MHz versus 2000 MHz
• Boost clock: 2200 MHz versus 2460 MHz
• Game clock: not applicable versus 2220 MHz
• Memory speed: 8 Gbps effective versus 16 Gbps effective
• Memory size: 144 GB versus 4 GB
• Memory type: HBM3e versus GDDR6
• Memory bus width: 8192 bit versus 64 bit
• Memory bandwidth: 8.19 TB/s versus 128.0 GB/s
• Shading units: 8192 versus 768
• TMUs: 512 versus 48
• ROPs: 0 versus 32
• RT cores: not listed versus 12
• Pixel rate: 0 MPixel/s versus 78.72 GPixel/s
• Texture rate: 1,126.4 GTexel/s versus 118.1 GTexel/s
• FP32: 36.04 TFLOPS versus 3.779 TFLOPS
• FP16: 36.04 TFLOPS (1:1) versus 7.557 TFLOPS (2:1)
• TDP: 600 W versus 50 W
• Slot width: Dual-slot versus IGP
• Power connectors: 1x 16-pin versus none
• Suggested PSU: 1000 W versus not applicable
• Bus interface: PCIe 5.0 x16 versus PCIe 4.0 x4
• Display outputs: No outputs versus portable device dependent
• DirectX support: N/A versus 12 Ultimate (12_2)
• OpenGL support: N/A versus 4.6
• Vulkan support: N/A versus 1.4
• Dimensions: recorded for MI350P, absent for RX 6450M
• Production status: not recorded versus Active
• Release date: 2026-05-06 versus 2023-01-03
• Predecessor: Radeon Instinct versus Polaris Mobile

Both products share the same manufacturer, AMD, and neither lists a successor. Neither has a launch MSRP in the database. Both use TSMC as the foundry. The MI350P has a memory clock of 2000 MHz, and the RX 6450M also has a memory clock of 2000 MHz, but the effective speeds differ as noted. The MI350P's memory speed is listed as 8 Gbps effective, while the RX 6450M's is 16 Gbps effective.

FAQ

Q: Which product has more memory bandwidth?

A: The AMD Instinct MI350P has 8.19 TB/s of memory bandwidth, while the AMD Radeon RX 6450M has 128.0 GB/s. The MI350P's HBM3e memory with an 8192-bit bus provides substantially higher bandwidth than the RX 6450M's GDDR6 with a 64-bit bus.

Q: What are the FP32 performance figures for each GPU?

A: The MI350P delivers 36.04 TFLOPS FP32, and the RX 6450M delivers 3.779 TFLOPS FP32. The MI350P's FP32 output is approximately 9.5 times higher than the RX 6450M's.

Q: Does the RX 6450M support ray tracing?

A: Yes, the RX 6450M has 12 ray tracing cores. The MI350P does not list any ray tracing cores in the database.

Q: What is the power consumption difference?

A: The MI350P has a TDP of 600 W and requires a 1000 W suggested PSU with a 16-pin power connector. The RX 6450M has a TDP of 50 W and uses no power connectors, consistent with its IGP form factor.

Q: Which product supports display outputs?

A: The RX 6450M supports display outputs, listed as portable device dependent. The MI350P has no display outputs.

Q: What are the release dates for these products?

A: The MI350P has a release date of 2026-05-06, and the RX 6450M has a release date of 2023-01-03. The RX 6450M is marked as Active in production status, while the MI350P's production status is not recorded.