AMD Instinct MI325X vs NVIDIA RTX PRO 4000 Blackwell Comparison

The Verdict

The AMD Instinct MI325X and NVIDIA RTX PRO 4000 Blackwell serve fundamentally different purposes. The MI325X is a massive, accelerator-focused compute module with no display outputs, designed for data center scale workloads where memory capacity and raw throughput dominate. The RTX PRO 4000 Blackwell is a single-slot workstation card with display outputs and full graphics API support, aimed at professional visualization and local compute tasks.

The data shows that the MI325X has no recorded benchmark scores in the database, while the RTX PRO 4000 Blackwell holds a 72nd percentile ranking across all GPUs, with an average benchmark score of 27,135. The MI325X sits at the 50th percentile with an average score of zero, meaning no measurable graphics or compute results exist for it in the database. This makes direct comparison challenging, but the specification differences are stark and informative.

For anyone needing a workstation card that renders, displays, and runs standard graphics workloads, the RTX PRO 4000 Blackwell is the clear choice from the recorded data. For anyone building a server node focused exclusively on massive memory capacity and FP32/FP16 compute throughput, the MI325X is the intended tool. The MI325X offers 256 GB of HBM3e memory versus 24 GB of GDDR7, and 81.72 TFLOPS FP32 versus 36.83 TFLOPS, but it lacks any video outputs and supports no graphics APIs. The RTX PRO 4000 Blackwell delivers DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4 support, making it a functional GPU in the traditional sense.

Head-to-Head Benchmarks

The database contains no head-to-head benchmark entries between these two cards. The MI325X has zero benchmark results recorded. The RTX PRO 4000 Blackwell has nine recorded benchmark scores, but none of these can be compared directly to the MI325X because the AMD card has no corresponding data.

What can be compared is the RTX PRO 4000 Blackwell's performance against its nearest rivals in the database. In the 3DMark Steel Nomad DX12 test, it scores 4,648. In Geekbench Vulkan, it scores 194,168. In Passmark tests, it records 28,427 for G3D, 14,805 for GPU Compute, 1,265 for G2D, 354 for DirectX 9, 276 for DirectX 11, 173 for DirectX 10, and 97 for DirectX 12.

The RTX PRO 4000 Blackwell's average benchmark score of 27,135 places it just 1.1% below the AMD Radeon RX 6700 XT (27,425) and 1.1% below the NVIDIA GeForce RTX 4070 Mobile (27,435). It sits 1.6% below the NVIDIA GeForce RTX 3090 (27,565) and 1.7% above the NVIDIA RTX A4000 (26,683). These delta percentages indicate that the RTX PRO 4000 Blackwell performs within a narrow band of these established GPUs, slightly behind the RTX 3090 but ahead of the RTX A4000.

For the MI325X, the absence of any benchmark scores means the database cannot confirm its real-world performance. Its theoretical FP32 output of 81.72 TFLOPS is more than double the RTX PRO 4000 Blackwell's 36.83 TFLOPS, and its texture rate of 2,553.6 GTexel/s is over four times the 575.4 GTexel/s of the NVIDIA card. However, these are specification-derived figures, not measured benchmark results.

Where Each One Wins

The MI325X wins decisively on memory capacity and bandwidth. It offers 256 GB of HBM3e across an 8192-bit bus, yielding 6.14 TB/s of bandwidth. The RTX PRO 4000 Blackwell provides 24 GB of GDDR7 on a 192-bit bus, with 672.0 GB/s. The AMD card's memory bandwidth is roughly nine times higher, and its capacity is over ten times larger. For workloads that load very large models or datasets into GPU memory, this is the deciding factor.

The MI325X also wins on raw compute throughput. Its FP32 and FP16 figures are both 81.72 TFLOPS, more than double the RTX PRO 4000 Blackwell's 36.83 TFLOPS for both precisions. Its texture rate of 2,553.6 GTexel/s dwarfs the 575.4 GTexel/s of the NVIDIA card. The AMD module uses a 1000 W TDP with a suggested PSU of 1400 W, whereas the NVIDIA card uses 140 W with a 300 W suggested PSU. The MI325X is an OAM module with no power connectors, indicating it draws power through the motherboard or backplane, not a user-installed PSU cable.

The RTX PRO 4000 Blackwell wins on functionality and efficiency. It has 96 ROPs producing 197.3 GPixel/s, while the MI325X has zero ROPs and zero pixel rate. The NVIDIA card includes 70 RT cores and 280 tensor cores, features entirely absent from the MI325X's specification sheet. It supports DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4, while the AMD module lists N/A for all graphics APIs. The RTX PRO 4000 Blackwell has four DisplayPort 2.1b outputs; the MI325X has no outputs at all. The NVIDIA card is single-slot, 241 mm long, 111 mm high, and 20 mm wide, with a standard 1x 16-pin power connector. The MI325X is an OAM module, which is a different physical form factor entirely.

The RTX PRO 4000 Blackwell also wins on transistor efficiency. It packs 45,600 million transistors on a 378 mm² die, yielding 120.6 million transistors per mm². The MI325X has 153,000 million transistors on a 1017 mm² die, yielding 150.4 million per mm². The AMD chip is denser, but the NVIDIA card delivers usable graphics features at a fraction of the power draw.

FAQ

Q: Which card has more memory, and what type?

A: The AMD Instinct MI325X has 256 GB of HBM3e memory, while the NVIDIA RTX PRO 4000 Blackwell has 24 GB of GDDR7 memory. The MI325X uses an 8192-bit bus, the NVIDIA card uses a 192-bit bus.

Q: Does either card support standard graphics APIs?

A: Only the NVIDIA RTX PRO 4000 Blackwell supports graphics APIs, with DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. The AMD Instinct MI325X lists N/A for DirectX, OpenGL, and Vulkan.

Q: What are the measured benchmark results for these cards?

A: The NVIDIA RTX PRO 4000 Blackwell has an average benchmark score of 27,135 and sits in the 72nd percentile of all GPUs. The AMD Instinct MI325X has no recorded benchmark scores and sits in the 50th percentile with an average score of zero.

Q: How does the RTX PRO 4000 Blackwell compare to its nearest rivals?

A: It is 1.1% slower than the AMD Radeon RX 6700 XT and the NVIDIA GeForce RTX 4070 Mobile, 1.6% slower than the NVIDIA GeForce RTX 3090, and 1.7% faster than the NVIDIA RTX A4000.

Q: What are the power requirements for each card?

A: The AMD Instinct MI325X has a 1000 W TDP and requires a 1400 W suggested PSU. The NVIDIA RTX PRO 4000 Blackwell has a 140 W TDP and requires a 300 W suggested PSU. The MI325X uses no power connectors, while the RTX PRO 4000 uses a single 16-pin connector.

Q: Do these cards have any display outputs?

A: No, the AMD Instinct MI325X has no display outputs. The NVIDIA RTX PRO 4000 Blackwell has four DisplayPort 2.1b outputs.

Architecture Differences

The AMD Instinct MI325X uses the Aqua Vanjaram chip built on CDNA 3.0 architecture, produced on TSMC's 5 nm process. It contains 153,000 million transistors on a 1017 mm² die, giving a transistor density of 150.4 million per mm². The NVIDIA RTX PRO 4000 Blackwell uses the GB203 chip on Blackwell 2.0 architecture, also on TSMC 5 nm, with 45,600 million transistors on a 378 mm² die, yielding 120.6 million per mm².

The MI325X has 19,456 shading units, 1,216 TMUs, and zero ROPs. It has no RT cores and no tensor cores listed. Its pixel rate is 0 MPixel/s, and its texture rate is 2,553.6 GTexel/s. The RTX PRO 4000 Blackwell has 8,960 shading units, 280 TMUs, and 96 ROPs. It includes 70 RT cores and 280 tensor cores. Its pixel rate is 197.3 GPixel/s, and its texture rate is 575.4 GTexel/s.

The MI325X's FP32 and FP16 performance are both 81.72 TFLOPS, with a 1:1 ratio. The RTX PRO 4000 Blackwell also has a 1:1 FP32 to FP16 ratio, but at 36.83 TFLOPS for both. The AMD card is built for compute density without any graphics pipeline elements, while the NVIDIA card includes the full rasterization, ray tracing, and tensor processing hardware.

The MI325X is an OAM module, meaning it is not a standard PCIe card with a cooling shroud and display ports. It has no power connectors because it draws power through the OAM socket. The RTX PRO 4000 Blackwell is a single-slot card with a 16-pin power connector, measuring 241 mm by 111 mm by 20 mm.

Specification Differences

The two cards differ across nearly every specification field. Process node and foundry are identical: 5 nm TSMC for both. Transistor counts differ greatly, at 153,000 million for the MI325X versus 45,600 million for the RTX PRO 4000 Blackwell. Die size is 1017 mm² for AMD versus 378 mm² for NVIDIA. Transistor density is 150.4M per mm² versus 120.6M per mm².

Clock speeds differ: the MI325X has a 1000 MHz base and 2100 MHz boost, while the RTX PRO 4000 Blackwell has a 1230 MHz base and 2055 MHz boost. Memory clock is 1500 MHz with 6 Gbps effective for AMD, versus 1750 MHz with 28 Gbps effective for NVIDIA.

Memory configuration is the largest differentiator. The MI325X has 256 GB of HBM3e on an 8192-bit bus with 6.14 TB/s bandwidth. The RTX PRO 4000 Blackwell has 24 GB of GDDR7 on a 192-bit bus with 672.0 GB/s bandwidth.

Compute resources differ substantially. The MI325X has 19,456 shading units, 1,216 TMUs, and zero ROPs. The RTX PRO 4000 Blackwell has 8,960 shading units, 280 TMUs, and 96 ROPs. Only the NVIDIA card has RT cores and tensor cores, at 70 and 280 respectively.

Pixel rate is 0 MPixel/s for AMD versus 197.3 GPixel/s for NVIDIA. Texture rate is 2,553.6 GTexel/s versus 575.4 GTexel/s. FP32 and FP16 are both 81.72 TFLOPS for AMD versus 36.83 TFLOPS for NVIDIA.

Power and physical specs diverge completely. The MI325X has a 1000 W TDP, no power connectors, a 1400 W suggested PSU, and an OAM Module slot width. The RTX PRO 4000 Blackwell has a 140 W TDP, one 16-pin connector, a 300 W suggested PSU, and a single-slot width. The NVIDIA card has dimensions of 241 mm length, 111 mm height, and 20 mm width; the AMD module has no recorded dimensions.

Display outputs and API support also differ. The MI325X has no outputs and N/A for all graphics APIs. The RTX PRO 4000 Blackwell has four DisplayPort 2.1b outputs and supports DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4. Release dates are October 9, 2024 for AMD and March 17, 2025 for NVIDIA. The AMD card is a Radeon Instinct successor, while the NVIDIA card succeeds Workstation Ada.