AMD Instinct MI325X vs NVIDIA RTX 4500 Ada Generation Comparison

Head-to-Head Benchmarks

The recorded data for the AMD Instinct MI325X contains no benchmark entries, while the NVIDIA RTX 4500 Ada Generation has two published results. The RTX 4500 Ada Generation scores 160,786 in Geekbench OpenCL and 171,401 in Geekbench Vulkan. Its average benchmark score is 166,094, placing it at the 97th percentile among all GPUs in the database. The MI325X, by contrast, holds a 50th percentile ranking with an average benchmark score of zero, indicating that no comparable workload results have been recorded for it.

Because the MI325X lacks direct benchmark data, direct head-to-head comparisons in identical tests are not possible from the recorded measurements. The database shows the RTX 4500 Ada Generation outperforms several near rivals in its own percentile band. It sits 0.5% above the NVIDIA RTX A5500, which averages 165,217. It is 0.7% above the AMD Radeon PRO W7800, which averages 164,894. The RTX 4500 Ada Generation trails the AMD Radeon Pro W6900X by 1.5%, as that card averages 168,574. It leads the NVIDIA A100 PCIe 40 GB by 2.2%, which averages 162,504.

The MI325X does not appear in any head-to-head benchmark table, so no wins are recorded for either side in a direct matchup. The only measurable performance data in this comparison belongs to the RTX 4500 Ada Generation, and its two benchmark results are consistent with its 97th percentile standing. The OpenCL result of 160,786 and the Vulkan result of 171,401 show a spread of roughly 6.6% between the two API tests, with Vulkan delivering the higher score.

The MI325X has no published benchmark scores to interpret, so its relative standing cannot be quantified against the RTX 4500 Ada Generation or any other GPU. The database records zero wins for the AMD part and zero wins for the NVIDIA part in this pairing, which reflects the absence of parallel test data rather than a statement of equivalence.

The Verdict

The data supports a clear conclusion for the NVIDIA RTX 4500 Ada Generation: it is the only part in this pairing with recorded benchmark performance. Its average score of 166,094 and 97th percentile placement demonstrate that it competes closely with other high-end workstation and data center cards in the database. The MI325X, with a 50th percentile ranking and no benchmark entries, cannot be positioned relative to the RTX 4500 Ada Generation from the recorded measurements.

The RTX 4500 Ada Generation belongs to the GeForce 40-series and carries the Ada Lovelace architecture. It is an active production part with a dual-slot cooler, PCIe 4.0 x16 interface, and four DisplayPort 1.4a outputs. The MI325X is an OAM module with no display outputs, no power connectors, and a PCIe 5.0 x16 interface. These physical and interface differences are substantial. The RTX 4500 Ada Generation is designed for conventional workstation installations, while the MI325X targets a different form factor entirely.

From a pure performance standpoint, the RTX 4500 Ada Generation delivers 39.63 TFLOPS of FP32 and 39.63 TFLOPS of FP16 with a 1:1 ratio. The MI325X delivers 81.72 TFLOPS of FP32 and 81.72 TFLOPS of FP16, also at a 1:1 ratio. The AMD part has more than double the FP32 throughput on paper, but no benchmark data confirms how that translates into real workloads. The RTX 4500 Ada Generation has 60 ray tracing cores and 240 tensor cores, which the MI325X does not list. The MI325X has 19,456 shading units versus 7,680 for the RTX 4500 Ada Generation, and 1,216 texture mapping units versus 240.

The RTX 4500 Ada Generation is the only part with a production status of Active. Its predecessor is Workstation Ampere and its successor is Blackwell PRO W, so it sits within a clearly defined product lineage. The MI325X has no production status recorded and its predecessor is listed as Radeon Instinct. The RTX 4500 Ada Generation has a release date of August 8, 2023, while the MI325X was released on October 9, 2024. Neither part has a launch MSRP recorded.

For users who rely on recorded benchmark data, the RTX 4500 Ada Generation is the only option with measurable results. For users who need the highest raw FP32 or FP16 throughput, the MI325X specification sheet shows a large advantage. The RTX 4500 Ada Generation also has a much lower TDP of 210 W against 1000 W for the MI325X, and a suggested PSU of 550 W against 1400 W. The RTX 4500 Ada Generation is 245 mm long and 112 mm tall, while the MI325X has no recorded dimensions.

FAQ

Q: Which GPU has a higher average benchmark score?

A: The NVIDIA RTX 4500 Ada Generation has an average benchmark score of 166,094. The AMD Instinct MI325X has an average benchmark score of zero, as no benchmark results are recorded for it.

Q: How does the RTX 4500 Ada Generation compare to its nearest rivals?

A: The RTX 4500 Ada Generation is 0.5% above the NVIDIA RTX A5500 (165,217), 0.7% above the AMD Radeon PRO W7800 (164,894), and 2.2% above the NVIDIA A100 PCIe 40 GB (162,504). It is 1.5% below the AMD Radeon Pro W6900X (168,574).

Q: What are the FP32 performance figures for both cards?

A: The MI325X delivers 81.72 TFLOPS of FP32, and the RTX 4500 Ada Generation delivers 39.63 TFLOPS of FP32. Both cards provide FP16 performance at a 1:1 ratio with their FP32 figures.

Q: What memory configurations do the two cards use?

A: The MI325X has 256 GB of HBM3e memory on an 8192-bit bus with 6.14 TB/s of bandwidth. The RTX 4500 Ada Generation has 24 GB of GDDR6 memory on a 192-bit bus with 432.0 GB/s of bandwidth.

Q: Which card has ray tracing and tensor core support?

A: The RTX 4500 Ada Generation has 60 ray tracing cores and 240 tensor cores. The MI325X does not have ray tracing core or tensor core counts recorded in the database.

Q: What are the power requirements for each card?

A: The MI325X has a TDP of 1000 W with a suggested PSU of 1400 W. The RTX 4500 Ada Generation has a TDP of 210 W with a suggested PSU of 550 W.

Specification Differences

The two cards differ in nearly every recorded specification. The MI325X uses the Aqua Vanjaram chip with the CDNA 3.0 architecture, while the RTX 4500 Ada Generation uses the AD103 chip with the Ada Lovelace architecture. The MI325X belongs to the Instinct (MIx) generation, while the RTX 4500 Ada Generation belongs to the GeForce 40-series and the Workstation Ada generation. Both use a 5 nm process at TSMC.

Transistor counts differ substantially. The MI325X has 153,000 million transistors on a 1017 mm² die, giving a density of 150.4 million transistors per mm². The RTX 4500 Ada Generation has 45,900 million transistors on a 379 mm² die, giving a density of 121.1 million transistors per mm². The MI325X has more than three times the transistor count and nearly three times the die area.

Clock speeds are far apart. The MI325X has a base clock of 1000 MHz and a boost clock of 2100 MHz, with memory at 1500 MHz (6 Gbps effective). The RTX 4500 Ada Generation has a base clock of 2070 MHz and a boost clock of 2580 MHz, with memory at 2250 MHz (18 Gbps effective). The NVIDIA card runs at significantly higher clock speeds.

Memory specifications are also divergent. The MI325X uses 256 GB of HBM3e with an 8192-bit bus and 6.14 TB/s bandwidth. The RTX 4500 Ada Generation uses 24 GB of GDDR6 with a 192-bit bus and 432.0 GB/s bandwidth. The MI325X has a much wider memory bus and far higher bandwidth, while the NVIDIA card uses a smaller, faster-clocked memory pool.

Compute unit counts differ as well. The MI325X has 19,456 shading units, 1,216 TMUs, and 0 ROPs, with a pixel rate of 0 MPixel/s and a texture rate of 2,553.6 GTexel/s. The RTX 4500 Ada Generation has 7,680 shading units, 240 TMUs, and 80 ROPs, with a pixel rate of 206.4 GPixel/s and a texture rate of 619.2 GTexel/s. The MI325X has no ROPs recorded, which reflects its compute-oriented design.

The RTX 4500 Ada Generation supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. The MI325X has no API support recorded for DirectX, OpenGL, or Vulkan. The NVIDIA card has four DisplayPort 1.4a outputs, while the MI325X has no display outputs. The MI325X uses an OAM Module slot width with no power connectors, while the RTX 4500 Ada Generation is dual-slot with no power connectors listed. The MI325X uses a PCIe 5.0 x16 interface, and the RTX 4500 Ada Generation uses PCIe 4.0 x16.

Architecture Differences

The MI325X is built on the CDNA 3.0 architecture, which is AMD's compute-focused design lineage. The RTX 4500 Ada Generation uses the Ada Lovelace architecture, NVIDIA's workstation-oriented design. The MI325X has no ray tracing cores or tensor cores recorded, while the RTX 4500 Ada Generation includes 60 ray tracing cores and 240 tensor cores. This indicates a fundamental difference in feature focus: the MI325X specification sheet emphasizes raw compute throughput and memory capacity, while the RTX 4500 Ada Generation includes dedicated hardware for ray tracing and AI acceleration.

The MI325X uses HBM3e memory, which provides 6.14 TB/s of bandwidth across an 8192-bit bus. The RTX 4500 Ada Generation uses GDDR6 memory with 432.0 GB/s of bandwidth across a 192-bit bus. The memory technology choice reflects different design goals: the MI325X targets memory-bandwidth-bound workloads with massive capacity, while the RTX 4500 Ada Generation targets a more conventional workstation memory profile.

The MI325X has a transistor density of 150.4 million per mm², which is higher than the RTX 4500 Ada Generation's 121.1 million per mm². The MI325X also has a much larger die at 1017 mm² versus 379 mm². The RTX 4500 Ada Generation achieves higher clock speeds despite the smaller die, with a boost clock of 2580 MHz versus 2100 MHz for the MI325X.

The MI325X has no display outputs, no API support, and no ROPs, which indicates it is not designed for graphics rendering or display workloads. The RTX 4500 Ada Generation has four DisplayPort 1.4a outputs, full DirectX 12 Ultimate support, OpenGL 4.6, and Vulkan 1.4, along with 80 ROPs. This confirms the RTX 4500 Ada Generation is a full-featured workstation GPU, while the MI325X is an accelerator module without graphics output capabilities.

The MI325X belongs to the Instinct (MIx) generation and its predecessor is listed as Radeon Instinct. The RTX 4500 Ada Generation belongs to the GeForce 40-series and Workstation Ada generations, with its predecessor listed as Workstation Ampere and its successor as Blackwell PRO W. The MI325X has no successor recorded and no production status listed, while the RTX 4500 Ada Generation is marked as Active.