AMD Instinct MI300 vs NVIDIA GeForce RTX 5080 Comparison

Head-to-Head Benchmarks

The data presents an unusual comparison: the AMD Instinct MI300 has no recorded benchmark scores, while the NVIDIA GeForce RTX 5080 has a full suite of results. The RTX 5080, therefore, dominates every measurable category by default. Its average benchmark score sits at 56,083, placing it in the 87th percentile of all GPUs in the database. The Instinct MI300, with no benchmark entries, holds a 50th percentile ranking and an average score of zero.

The RTX 5080’s strongest recorded result comes from Geekbench Vulkan, where it scores 255,450. Its Geekbench OpenCL score is 235,901. In Passmark tests, the G3D score reaches 36,565, while the GPU Compute score is 21,789. The DirectX 9 test produces a score of 389, DirectX 11 scores 324, and DirectX 10 scores 208. The DirectX 12 result is 151, and the G2D score is 1,415. The 3DMark Steel Nomad DX12 test yields a score of 8,637.

Relative to its nearest rivals, the RTX 5080’s average score of 56,083 is 0.6% ahead of the AMD Radeon 8060S, which scores 55,757. It leads the AMD Radeon RX 6750 GRE 12 GB by 0.7%, as that card averages 55,698. The margin widens to 2.3% over the AMD Radeon Pro W5700X, which averages 54,828. However, the RTX 5080 trails the AMD Radeon RX 9070 GRE by 2.2%, as that card scores 57,367.

The Instinct MI300 cannot be compared in this manner, as it has no scores to place against the RTX 5080 or any other GPU. This absence of data does not indicate performance parity; it simply means the database contains no recorded results for the MI300. The RTX 5080, conversely, has a robust dataset across ten separate tests, all of which show positive performance in their respective categories.

The Verdict

From the recorded data, the NVIDIA GeForce RTX 5080 is the only option with measurable performance. It delivers a complete set of benchmark results across DirectX, Vulkan, OpenCL, and compute workloads. Its 87th percentile ranking versus all GPUs indicates strong overall standing in the database, and its average score of 56,083 puts it within 2.3% of several high-performing AMD Radeon cards.

The AMD Instinct MI300, by contrast, offers no benchmark scores, no percentile performance above the median, and no comparative data against any rival. The database shows zero recorded wins for the MI300 and ten recorded wins for the RTX 5080. This is a data-driven verdict: if a user requires verified benchmark performance, the RTX 5080 is the only choice supported by measurements.

The MI300 may be a capable accelerator in its own right, but the database contains no evidence to support that claim. The RTX 5080, with its 56.28 TFLOPS FP32 performance and 56.28 TFLOPS FP16 performance, has concrete numbers behind it. The MI300’s 47.87 TFLOPS FP32 and FP16 figures exist in the specification sheet, but without benchmark results, they cannot be compared to any real-world workload.

Buyers who need a product with demonstrated performance across graphics APIs should select the RTX 5080. Buyers who require the MI300’s unique specifications, such as its 128 GB HBM3 memory, must accept the absence of benchmark verification in this database.

Architecture Differences

The two GPUs share a manufacturing process: both use a 5 nm node from TSMC. Beyond that, their architectures diverge completely. The AMD Instinct MI300 uses the CDNA 3.0 architecture on the Aqua Vanjaram chip, designed for compute and AI workloads. The NVIDIA GeForce RTX 5080 uses the Blackwell 2.0 architecture on the GB203 chip, designed for graphics and consumer rendering.

The MI300’s transistor count is 153,000 million, far exceeding the RTX 5080’s 45,600 million. The MI300’s die size is 1017 mm², while the RTX 5080’s die is 378 mm². This results in a transistor density of 150.4 million per mm² for the MI300, versus 120.6 million per mm² for the RTX 5080. The MI300 packs more transistors into a larger area, while the RTX 5080 achieves a lower density on a much smaller chip.

Memory architecture differs fundamentally. The MI300 uses 128 GB of HBM3 on a 8192-bit bus, yielding 5.32 TB/s of bandwidth. The RTX 5080 uses 16 GB of GDDR7 on a 256-bit bus, yielding 960.0 GB/s of bandwidth. The MI300 has 14,080 shading units and 880 texture mapping units, but zero ROPs. The RTX 5080 has 10,752 shading units, 336 TMUs, and 112 ROPs. The RTX 5080 also includes 84 RT cores and 336 tensor cores, while the MI300 lists no RT or tensor core counts.

Clock speeds tell a similar story of different design goals. The MI300 runs at a base of 1000 MHz and boosts to 1700 MHz. The RTX 5080 runs at 2295 MHz base and 2617 MHz boost. The MI300’s memory clock is 1300 MHz with 5.2 Gbps effective transfer, while the RTX 5080’s memory clock is 1875 MHz with 30 Gbps effective transfer. The MI300’s pixel rate is 0 MPixel/s, reflecting its lack of ROPs, while the RTX 5080 delivers 293.1 GPixel/s. Texture rates are 1,496.0 GTexel/s for the MI300 and 879.3 GTexel/s for the RTX 5080.

API support is entirely absent on the MI300: DirectX, OpenGL, and Vulkan are all listed as N/A. The RTX 5080 supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. The MI300 has no display outputs, while the RTX 5080 provides 1x HDMI 2.1b and 3x DisplayPort 2.1b.

FAQ

Q: Which GPU has a higher FP32 compute throughput?

A: The NVIDIA GeForce RTX 5080 delivers 56.28 TFLOPS FP32, while the AMD Instinct MI300 delivers 47.87 TFLOPS FP32. The RTX 5080 also has the higher FP16 figure at 56.28 TFLOPS versus 47.87 TFLOPS.

Q: How much memory does each GPU have?

A: The AMD Instinct MI300 has 128 GB of HBM3 memory on an 8192-bit bus with 5.32 TB/s bandwidth. The NVIDIA GeForce RTX 5080 has 16 GB of GDDR7 memory on a 256-bit bus with 960.0 GB/s bandwidth.

Q: What is the power draw of each card?

A: The AMD Instinct MI300 has a TDP of 600 W and uses 2x 8-pin power connectors. The NVIDIA GeForce RTX 5080 has a TDP of 360 W and uses 1x 16-pin power connector.

Q: Which GPU supports ray tracing?

A: The NVIDIA GeForce RTX 5080 includes 84 RT cores and 336 tensor cores, supporting DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4. The AMD Instinct MI300 lists no RT or tensor core counts and has N/A for all graphics APIs.

Q: What are the release dates for these products?

A: The AMD Instinct MI300 was released on January 3, 2023. The NVIDIA GeForce RTX 5080 was released on January 29, 2025.

Q: Which GPU has a higher benchmark percentile ranking?

A: The NVIDIA GeForce RTX 5080 ranks in the 87th percentile of all GPUs with an average benchmark score of 56,083. The AMD Instinct MI300 ranks in the 50th percentile with an average benchmark score of zero.

Where Each One Wins

The NVIDIA GeForce RTX 5080 wins in every benchmark category where data exists. It has ten recorded test scores covering DirectX 9 through DirectX 12, Vulkan, OpenCL, G2D, G3D, and compute workloads. Its highest score is 255,450 in Geekbench Vulkan, followed by 235,901 in Geekbench OpenCL. In Passmark tests, the G3D score of 36,565 and the GPU Compute score of 21,789 show strong performance in both graphics and compute tasks. The 3DMark Steel Nomad DX12 score of 8,637 adds a modern gaming workload result.

The RTX 5080 also wins on graphics-specific features. It has 112 ROPs, delivering 293.1 GPixel/s, whereas the MI300 has zero ROPs and zero pixel rate. The RTX 5080 supports all major graphics APIs, while the MI300 supports none. The RTX 5080 has display outputs, while the MI300 has none. For any workload involving rendering, gaming, or display output, the RTX 5080 is the only option with verified capability.

The AMD Instinct MI300 wins on raw memory capacity and bandwidth. Its 128 GB of HBM3 memory is eight times the RTX 5080’s 16 GB. Its 5.32 TB/s bandwidth is over five times the RTX 5080’s 960.0 GB/s. The MI300 also has more shading units (14,080 versus 10,752), more TMUs (880 versus 336), and a higher texture rate (1,496.0 GTexel/s versus 879.3 GTexel/s). Its transistor count of 153,000 million dwarfs the RTX 5080’s 45,600 million.

The MI300 wins on die size and transistor density. Its 1017 mm² die is nearly three times the RTX 5080’s 378 mm². Its transistor density of 150.4 million per mm² exceeds the RTX 5080’s 120.6 million per mm². For workloads that depend on massive memory pools and extreme bandwidth, such as large-scale AI training or high-performance computing, the MI300’s specifications suggest an advantage, though no benchmarks confirm it.

Specification Differences

The AMD Instinct MI300 and NVIDIA GeForce RTX 5080 differ in nearly every measurable specification.

| Specification | AMD Instinct MI300 | NVIDIA GeForce RTX 5080 |

|---|---|---|

| Architecture | CDNA 3.0 | Blackwell 2.0 |

| Chip | Aqua Vanjaram | GB203 |

| Process Node | 5 nm | 5 nm |

| Transistors | 153,000 million | 45,600 million |

| Die Size | 1017 mm² | 378 mm² |

| Transistor Density | 150.4M / mm² | 120.6M / mm² |

| Base Clock | 1000 MHz | 2295 MHz |

| Boost Clock | 1700 MHz | 2617 MHz |

| Memory Clock | 1300 MHz, 5.2 Gbps effective | 1875 MHz, 30 Gbps effective |

| Memory Size | 128 GB | 16 GB |

| Memory Type | HBM3 | GDDR7 |

| Memory Bus | 8192 bit | 256 bit |

| Memory Bandwidth | 5.32 TB/s | 960.0 GB/s |

| Shading Units | 14,080 | 10,752 |

| TMUs | 880 | 336 |

| ROPs | 0 | 112 |

| RT Cores | N/A | 84 |

| Tensor Cores | N/A | 336 |

| Pixel Rate | 0 MPixel/s | 293.1 GPixel/s |

| Texture Rate | 1,496.0 GTexel/s | 879.3 GTexel/s |

| FP32 Performance | 47.87 TFLOPS | 56.28 TFLOPS |

| FP16 Performance | 47.87 TFLOPS | 56.28 TFLOPS |

| TDP | 600 W | 360 W |

| Power Connectors | 2x 8-pin | 1x 16-pin |

| Suggested PSU | 1000 W | 750 W |

| Display Outputs | No outputs | 1x HDMI 2.1b, 3x DisplayPort 2.1b |

| DirectX Support | N/A | 12 Ultimate (12_2) |

| OpenGL Support | N/A | 4.6 |

| Vulkan Support | N/A | 1.4 |

| Dimensions | 267 mm x 111 mm | 304 mm x 137 mm x 40 mm |

| Release Date | 2023-01-03 | 2025-01-29 |

| Production Status | Not listed | Active |

| Predecessor | Radeon Instinct | GeForce 40 |

| Successor | Not listed | GeForce 60 |

The MI300 requires a 1000 W suggested power supply, while the RTX 5080 is rated for a 750 W PSU. The MI300’s power draw of 600 W exceeds the RTX 5080’s 360 W. The MI300 uses 2x 8-pin connectors, while the RTX 5080 uses a single 16-pin connector. Both cards use PCIe 5.0 x16 interfaces. The RTX 5080 is dual-slot, while the MI300’s slot width is not listed. The RTX 5080 has a launch MSRP of 999 USD.