AMD Radeon R9 M375X vs NVIDIA Quadro P2200 Comparison

The Verdict

The data presents a decisive outcome: the NVIDIA Quadro P2200 wins both head-to-head benchmark comparisons against the AMD Radeon R9 M375X, with no benchmark victories for the AMD part. The Quadro P2200 achieves a 291% advantage in Geekbench OpenCL and a 274.3% advantage in Geekbench Vulkan. These are not marginal differences; the NVIDIA card is operating in a different performance tier entirely.

The average benchmark score tells the same story. The Quadro P2200 sits at 8,686 points, while the Radeon R9 M375X averages 8,325 points. This places the Quadro in the 44th percentile of all GPUs, while the Radeon sits just one percentile lower at 43. Despite the massive head-to-head deltas, their overall percentile rankings are surprisingly close, suggesting that the AMD card holds its own in other workloads not captured in the head-to-head set.

For buyers, the choice depends on workload and context. If the task involves OpenCL or Vulkan compute—where the head-to-head data is available—the Quadro P2200 is the only rational selection. The Radeon R9 M375X, however, shows comparable average performance in its nearest-rival comparisons, meaning it may still be viable for legacy or non-compute tasks. The Quadro P2200 is a professional-grade Pascal part with modern API support; the Radeon is an older GCN 1.0 mobile-oriented chip. Users needing professional features, modern API coverage, and raw compute throughput should choose the Quadro. Users constrained to legacy systems or those where the Radeon is already installed may find it serviceable, but the data offers no scenario where the Radeon wins a direct comparison.

Architecture Differences

The architectural gap between these two GPUs is substantial and explains the benchmark results. The Quadro P2200 uses the GP106 chip built on TSMC's 16 nm process, packing 4,400 million transistors into a 200 mm² die. This yields a transistor density of 22.0 million per square millimeter. The Radeon R9 M375X uses the Tropo chip on TSMC's 28 nm process, with 1,500 million transistors on a 123 mm² die, for a density of 12.2 million per square millimeter. The Quadro's newer process node allows nearly three times the transistor count in a larger but more densely packed die.

Core configuration diverges sharply. The Quadro P2200 has 1,280 shading units, 80 texture mapping units, and 40 render output units. The Radeon R9 M375X has 640 shading units, 40 TMUs, and 16 ROPs. The Quadro has exactly double the shading units and TMUs, and 2.5 times the ROPs. Clock speeds also favor the Quadro: base clock of 1000 MHz versus 925 MHz, and boost clock of 1493 MHz versus 1015 MHz. The Quadro's boost advantage is 478 MHz, a significant margin.

Memory architecture is another major differentiator. The Quadro P2200 ships with 5 GB of GDDR5X memory on a 160-bit bus, delivering 200.2 GB/s of bandwidth. The Radeon R9 M375X has 2 GB of GDDR5 on a 128-bit bus, yielding 72.00 GB/s. The Quadro has 2.5 times the memory capacity and 2.78 times the bandwidth. Memory clock rates reinforce this: the Quadro runs at 1251 MHz with 10 Gbps effective, while the Radeon runs at 1125 MHz with 4.5 Gbps effective.

Compute rates follow the same pattern. The Quadro P2200 achieves 3.822 TFLOPS FP32, 59.72 GPixel/s pixel rate, and 119.4 GTexel/s texture rate. The Radeon R9 M375X delivers 1,299.2 GFLOPS FP32, 16.24 GPixel/s, and 40.60 GTexel/s. The Quadro is roughly 2.94 times faster in FP32, 3.68 times faster in pixel fill, and 2.94 times faster in texture fill. The Quadro also supports FP16 at 59.72 GFLOPS (1:64 ratio), while the Radeon has no FP16 data listed.

API support differs notably. The Quadro P2200 supports DirectX 12 (12_1), OpenGL 4.6, and Vulkan 1.4. The Radeon R9 M375X supports DirectX 12 (11_1), OpenGL 4.6, and Vulkan 1.2.170. Both are end-of-life products, but the Quadro's newer architecture provides a more recent DirectX feature level and a newer Vulkan version. The Quadro is a single-slot card with no power connectors, 75 W TDP, and a suggested 250 W PSU. The Radeon's TDP, slot width, and power connector data are not listed. The Quadro offers 4x DisplayPort 1.4a outputs; the Radeon's display outputs are not specified.

Head-to-Head Benchmarks

The Geekbench OpenCL test delivers the largest gap. The Quadro P2200 scores 32,344 points against the Radeon's 8,273 points, a 291% delta. This is nearly a four-fold difference in raw compute throughput. OpenCL workloads that stress FP32 compute, memory bandwidth, and shading units will heavily favor the Quadro. The Radeon's lower core count, slower clocks, and narrower memory bus all contribute to this result.

In Geekbench Vulkan, the gap narrows slightly but remains enormous. The Quadro scores 31,351 points versus the Radeon's 8,377 points, a 274.3% delta. Vulkan's lower-level API can sometimes reduce architectural overhead penalties, but here the raw hardware advantages of the Quadro still dominate. The Quadro's Vulkan 1.4 support versus the Radeon's Vulkan 1.2.170 may also play a role in driver efficiency and feature utilization.

The Radeon R9 M375X has no benchmark wins in the head-to-head data. Its only listed benchmarks are the two Geekbench tests, both of which it loses decisively. The Quadro P2200, by contrast, has a broader benchmark profile including Passmark tests across DirectX 9, 10, 11, 12, G2D, G3D, and GPU compute. The Quadro's Passmark G3D score is 9,364, and its GPU compute score is 3,921. These additional data points suggest the Quadro has wider workload coverage, though no direct Radeon comparison is available for those tests.

Nearest-rival data provides context for each card's standing. The Quadro P2200's closest rival is the NVIDIA GeForce GTX 460 v2 at 8,743 average score, a -0.7% delta, followed by the RTX 3050 A Mobile at 8,746 (-0.7%), the AMD FirePro W5170M at 8,595 (+1.1%), and the Intel Arc A380 at 8,558 (+1.5%). The Radeon R9 M375X's nearest rival is the NVIDIA Quadro K1200 at 8,265 (+0.7%), followed by the GTX 675MX at 8,427 (-1.2%), the AMD Radeon 880M at 8,436 (-1.3%), and the GeForce MX330 at 8,458 (-1.6%). Both cards sit in a crowded mid-low performance band among their peers.

FAQ

Q: Which GPU has more shading units?

A: The NVIDIA Quadro P2200 has 1,280 shading units, exactly double the 640 shading units of the AMD Radeon R9 M375X.

Q: What is the memory bandwidth difference?

A: The Quadro P2200 delivers 200.2 GB/s of bandwidth from 5 GB of GDDR5X on a 160-bit bus. The Radeon R9 M375X provides 72.00 GB/s from 2 GB of GDDR5 on a 128-bit bus. The Quadro's bandwidth is 2.78 times higher.

Q: Which card has a higher percentile ranking among all GPUs?

A: The Quadro P2200 ranks in the 44th percentile, while the Radeon R9 M375X ranks in the 43rd percentile. The difference is one percentile point.

Q: How do the FP32 compute figures compare?

A: The Quadro P2200 achieves 3.822 TFLOPS FP32, while the Radeon R9 M375X delivers 1,299.2 GFLOPS FP32. The Quadro is approximately 2.94 times faster.

Q: Which card supports a newer Vulkan version?

A: The Quadro P2200 supports Vulkan 1.4, while the Radeon R9 M375X supports Vulkan 1.2.170.

Q: What are the average benchmark scores for each card?

A: The Quadro P2200 has an average benchmark score of 8,686. The Radeon R9 M375X has an average benchmark score of 8,325.

Where Each One Wins

The NVIDIA Quadro P2200 wins in every category where direct head-to-head data exists. In Geekbench OpenCL, it is 291% ahead. In Geekbench Vulkan, it is 274.3% ahead. These are compute-oriented workloads, and the Quadro's superior core count, clock speeds, memory bandwidth, and FP32 throughput all contribute. The Quadro also wins on architecture fundamentals: newer 16 nm process, higher transistor density, double the shading units, double the TMUs, 2.5 times the ROPs, and nearly three times the FP32 compute. Its 5 GB GDDR5X memory with 200.2 GB/s bandwidth dwarfs the Radeon's 2 GB GDDR5 with 72.00 GB/s. For any professional or compute-heavy task, the Quadro P2200 is the clear winner.

The AMD Radeon R9 M375X has zero head-to-head wins, but the data shows it is not without merit. Its average benchmark score of 8,325 is only 4.2% below the Quadro's 8,686, and its 43rd percentile ranking is just one point lower. In its nearest-rival group, it performs competitively: it beats the Quadro K1200 by 0.7%, trades within 1.2-1.3% of the GTX 675MX and Radeon 880M, and trails the GeForce MX330 by only 1.6%. This suggests that in workloads not covered by the head-to-head tests—potentially older DirectX titles, 2D operations, or specific GCN-optimized applications—the Radeon may perform adequately relative to its peers. Its 28 nm process and lower transistor count mean it likely consumes less die area, though no TDP data is available to confirm power efficiency.

The use-case split is therefore stark. The Quadro P2200 wins for OpenCL and Vulkan compute, professional graphics workloads, modern API support, high memory capacity and bandwidth, and any task that leverages its 3.822 TFLOPS FP32. The Radeon R9 M375X wins for users already invested in GCN-era systems, those needing a smaller die (123 mm² versus 200 mm²), or those whose workloads align with its nearest-rival performance band. However, the data provides no benchmark where the Radeon outperforms the Quadro directly. The Quadro P2200 is the superior GPU by every measured metric.