AMD Radeon R9 M275X vs NVIDIA Quadro P2200 Comparison

The Verdict

The benchmark database clearly favors the NVIDIA Quadro P2200 over the AMD Radeon R9 M275X in every recorded head-to-head test. The Quadro P2200 wins both Geekbench OpenCL and Vulkan tests outright, with a 65.4% higher OpenCL score and a 68.2% higher Vulkan score. For any workload that relies on general-purpose GPU compute or modern graphics APIs, the Quadro P2200 is the decisive choice. The Radeon R9 M275X, however, holds a slight advantage in its average benchmark score relative to its percentile ranking: it sits at the 49th percentile among all GPUs with an average score of 10,582, while the Quadro P2200 sits at the 44th percentile with an average score of 8,686. That difference stems from the fact that the Radeon R9 M275X has fewer recorded benchmark entries, and its two Geekbench scores are both above 9,900, while the Quadro P2200 includes several Passmark tests with lower scores that drag its average down.

Who should pick which? If the workload is compute-heavy, especially OpenCL or Vulkan, the Quadro P2200 is the only rational pick from this data. Its raw scores are roughly three times higher in the two shared tests. If the workload is older, DX9-era, or purely rasterization-based with no compute demands, the Radeon R9 M275X may still be serviceable, but the database does not show any test where it beats the Quadro P2200. The Radeon R9 M275X is end-of-life and was released in January 2014, while the Quadro P2200 launched in June 2019, so the newer card has a generational advantage. For professional use, the Quadro P2200 offers 5 GB of GDDR5X memory versus 2 GB of GDDR5, a wider 160-bit memory bus versus 128-bit, and nearly three times the memory bandwidth. The Quadro P2200 also supports DirectX 12 (12_1) whereas the Radeon R9 M275X only supports DirectX 12 (11_1), which affects feature-level compatibility. The verdict is straightforward: the Quadro P2200 is the stronger card in every measurable aspect, and the Radeon R9 M275X should only be considered if legacy compatibility or a specific older driver requirement is paramount.

Architecture Differences

The two GPUs come from different architectural generations and process nodes. The AMD Radeon R9 M275X uses the Venus chip built on GCN 1.0 architecture, produced on a 28 nm process at TSMC. It integrates 1,500 million transistors on a 123 mm² die, giving a transistor density of 12.2 million per square millimeter. The NVIDIA Quadro P2200 uses the GP106 chip based on Pascal architecture, also fabricated by TSMC but on a 16 nm process. It packs 4,400 million transistors on a 200 mm² die, for a density of 22.0 million per square millimeter. The Pascal chip has nearly three times the transistor count and a die that is 63% larger, but the smaller process node allows for higher density.

Core counts differ substantially. The Radeon R9 M275X has 640 shading units, 40 texture mapping units, and 16 raster output units. The Quadro P2200 doubles those numbers: 1,280 shading units, 80 TMUs, and 40 ROPs. This doubling is reflected in the peak fill rates. The Radeon R9 M275X reaches 14.80 GPixel/s and 37.00 GTexel/s, while the Quadro P2200 reaches 59.72 GPixel/s and 119.4 GTexel/s. The Quadro P2200 is 4.0 times faster in pixel throughput and 3.2 times faster in texture throughput. Single-precision floating-point compute is also far higher on the Quadro P2200: 3.822 TFLOPS versus 1,184.0 GFLOPS on the Radeon R9 M275X, a 3.2 times advantage.

Clock behavior also differs. The Radeon R9 M275X has a base clock of 900 MHz and a boost clock of 925 MHz, a narrow range. The Quadro P2200 runs at a 1000 MHz base and boosts to 1493 MHz, which is a 61% higher boost clock. Memory clocks are also different: the Radeon R9 M275X uses 1125 MHz memory with 4.5 Gbps effective data rate, while the Quadro P2200 uses 1251 MHz with 10 Gbps effective. The Quadro P2200 also supports a wider memory bus (160-bit vs 128-bit) and a faster memory type (GDDR5X vs GDDR5). Its bandwidth is 200.2 GB/s versus 72.00 GB/s, a 2.8 times increase.

API support favors the Quadro P2200. The Radeon R9 M275X lists DirectX 12 (11_1), OpenGL 4.6, and Vulkan 1.2.170. The Quadro P2200 lists DirectX 12 (12_1), OpenGL 4.6, and Vulkan 1.4. The higher Vulkan version and DirectX feature level on the Quadro P2200 suggest better support for modern rendering techniques. The Quadro P2200 also has a lower TDP of 75 W, while the Radeon R9 M275X has no TDP listed in the database. The Quadro P2200 is a single-slot card with no power connectors and a suggested PSU of 250 W, measuring 201 mm in length and 111 mm in height. The Radeon R9 M275X has no listed dimensions, slot width, or power connector information.

FAQ

Q: Which GPU has a higher average benchmark score?

A: The AMD Radeon R9 M275X has an average benchmark score of 10,582, while the NVIDIA Quadro P2200 has an average score of 8,686. However, the Quadro P2200 has more benchmark entries, including Passmark tests, which lower its average.

Q: How does the memory bandwidth compare between the two cards?

A: The Quadro P2200 has a memory bandwidth of 200.2 GB/s, while the Radeon R9 M275X has 72.00 GB/s. The Quadro P2200 also has 5 GB of GDDR5X memory on a 160-bit bus, versus the Radeon's 2 GB of GDDR5 on a 128-bit bus.

Q: Which card supports a newer version of DirectX?

A: The Quadro P2200 supports DirectX 12 (12_1), while the Radeon R9 M275X supports DirectX 12 (11_1). The Quadro P2200 also supports Vulkan 1.4, whereas the Radeon supports Vulkan 1.2.170.

Q: What is the transistor count difference?

A: The Quadro P2200 has 4,400 million transistors, while the Radeon R9 M275X has 1,500 million. The Quadro P2200 also uses a 16 nm process versus a 28 nm process for the Radeon.

Q: Are both cards still in production?

A: No, both are end-of-life. The Radeon R9 M275X was released in January 2014, and the Quadro P2200 was released in June 2019.

Q: Does the Quadro P2200 require an external power connector?

A: No, the Quadro P2200 has no power connectors and is a single-slot card. It has a TDP of 75 W and a suggested PSU of 250 W. The Radeon R9 M275X has no TDP or power connector data in the database.

Specification Differences

The two cards differ in nearly every specification category. The process node is 28 nm for the Radeon R9 M275X versus 16 nm for the Quadro P2200. Transistor count is 1,500 million versus 4,400 million, and die size is 123 mm² versus 200 mm². Transistor density is 12.2M per mm² versus 22.0M per mm². The Radeon R9 M275X has 640 shading units, 40 TMUs, and 16 ROPs; the Quadro P2200 has 1,280 shading units, 80 TMUs, and 40 ROPs.

Clock speeds differ: base clock 900 MHz versus 1000 MHz, boost clock 925 MHz versus 1493 MHz, and memory clock 1125 MHz with 4.5 Gbps effective versus 1251 MHz with 10 Gbps effective. Memory configuration is 2 GB GDDR5 on a 128-bit bus versus 5 GB GDDR5X on a 160-bit bus. Bandwidth is 72.00 GB/s versus 200.2 GB/s. Pixel rate is 14.80 GPixel/s versus 59.72 GPixel/s. Texture rate is 37.00 GTexel/s versus 119.4 GTexel/s. FP32 compute is 1,184.0 GFLOPS versus 3.822 TFLOPS. The Quadro P2200 also lists FP16 performance of 59.72 GFLOPS (1:64), while the Radeon has no FP16 listing.

The Quadro P2200 lists a TDP of 75 W, slot width as single-slot, no power connectors, a suggested PSU of 250 W, and display outputs of 4x DisplayPort 1.4a. The Radeon R9 M275X has no TDP, slot width, power connector, suggested PSU, or display output data. The Quadro P2200 has physical dimensions of 201 mm length and 111 mm height; the Radeon has no dimensions listed. Release dates differ: January 2014 for the Radeon, June 2019 for the Quadro. The Radeon R9 M275X has a predecessor of "Solar System" and successor of "Polaris Mobile," while the Quadro P2200 has a predecessor of "Quadro Maxwell" and successor of "Quadro Volta." Both use PCIe 3.0 x16. The Radeon supports DirectX 12 (11_1), OpenGL 4.6, and Vulkan 1.2.170; the Quadro supports DirectX 12 (12_1), OpenGL 4.6, and Vulkan 1.4.

Head-to-Head Benchmarks

The head-to-head data contains only two tests, and the Quadro P2200 wins both by large margins. In Geekbench OpenCL, the Quadro P2200 scores 32,344 against the Radeon R9 M275X's 11,200. The delta is 65.4% in favor of the Quadro. This is a massive gap, indicating that the Quadro P2200 is roughly 2.9 times faster in OpenCL compute workloads. In Geekbench Vulkan, the Quadro P2200 scores 31,351 versus 9,964 for the Radeon R9 M275X, a delta of 68.2%. The Quadro is about 3.1 times faster in Vulkan.

The Radeon R9 M275X has no wins in the head-to-head table. Its best showing is in the OpenCL test, where it still loses by more than half. The Quadro P2200's advantage likely stems from its higher shader count, faster boost clock, and wider memory bus. In the OpenCL test, the Quadro's 3.822 TFLOPS FP32 compute versus 1,184.0 GFLOPS for the Radeon explains the outcome. In the Vulkan test, the higher API version (1.4 versus 1.2.170) and better driver optimization for modern workloads likely contribute.

Looking at the nearest rivals in the database, the Radeon R9 M275X's average score of 10,582 is close to the AMD Radeon RX 6600S (10,629, only 0.4% higher) and the AMD Radeon RX 550X (10,481, 1% lower). The Quadro P2200's average of 8,686 is near the NVIDIA GeForce GTX 460 v2 (8,743, 0.7% higher) and the NVIDIA GeForce RTX 3050 A Mobile (8,746, 0.7% higher). This shows that despite the Quadro's dominance in the head-to-head, its average score is lower because the Passmark tests included for the Quadro (DX10: 45, DX11: 70, DX12: 33, DX9: 167, G2D: 881, G3D: 9364, compute: 3921) pull the mean down. The Radeon R9 M275X only has two Geekbench scores, both above 9,900, which keeps its average higher.

Where Each One Wins

The Quadro P2200 wins in every recorded compute benchmark. For OpenCL workloads, it is 65.4% ahead of the Radeon R9 M275X, making it the clear choice for general-purpose GPU computing, scientific simulations, or any application that leverages OpenCL. For Vulkan workloads, it is 68.2% ahead, which covers modern games and Vulkan-based rendering engines. The Quadro P2200 also has substantially higher pixel and texture rates (59.72 GPixel/s and 119.4 GTexel/s versus 14.80 and 37.00), meaning it will handle higher resolutions and more complex scenes in rasterization-heavy tasks. Its 5 GB GDDR5X memory with 200.2 GB/s bandwidth is better suited for large textures, high-resolution frame buffers, or data-intensive workloads.

The Radeon R9 M275X does not have any benchmark wins in the head-to-head data. Its only advantage is its higher average benchmark score (10,582 versus 8,686) and its higher percentile ranking (49th versus 44th percentile among all GPUs). This is a statistical artifact of the test set, not a performance advantage. The Radeon also has a lower transistor density and an older architecture, so it is less power-efficient per unit of compute. For users constrained to older systems with 28 nm-era drivers or legacy PCIe 3.0 motherboards, the Radeon R9 M275X might be the only compatible option, but the database shows no scenario where it outperforms the Quadro P2200 in any shared test.

In terms of use cases, the Quadro P2200 wins for professional CAD, 3D rendering, video editing, and any GPU-accelerated compute task. Its DirectX 12 (12_1) support and Vulkan 1.4 make it future-proof for newer applications. The Radeon R9 M275X could still be used for basic 2D desktop work, legacy DirectX 11 games, or as a placeholder in a system where the Quadro P2200's physical size (201 mm length) or power requirements (250 W suggested PSU) are not acceptable. However, the Quadro P2200 has no power connectors and a 75 W TDP, so power constraints are not a real barrier. The Radeon R9 M275X's lack of display output data in the database also makes it harder to recommend for multi-monitor setups, whereas the Quadro P2200 explicitly supports 4x DisplayPort 1.4a. The verdict is clear: choose the Quadro P2200 for any performance-sensitive task, and only consider the Radeon R9 M275X if software or hardware compatibility forces the older part.