AMD Radeon PRO W6800 vs AMD Radeon RX 6650M Comparison

The AMD Radeon PRO W6800 and AMD Radeon RX 6650M are both RDNA 2.0 parts built on TSMC's 7 nm process, but they occupy entirely different segments of the database. The PRO W6800 is a full-size workstation card based on the Navi 21 die, carrying 32 GB of GDDR6 and a 96th percentile standing among all recorded GPUs. The RX 6650M is a mobile-integrated part on the smaller Navi 23 die with 8 GB of memory and a 91st percentile standing. Across the two head-to-head benchmark results in the database, the PRO W6800 wins both, by margins of 85.1% in OpenCL and 41.5% in Vulkan.

The Verdict

The recorded data leaves little ambiguity about which card to pick for compute-heavy professional workloads. The PRO W6800's average benchmark score of 135396 sits nearly 89% above the RX 6650M's average of 71768, and the gap widens further in the Geekbench OpenCL result, where the workstation card scores 121808 against 65800. Anyone running GPU compute through OpenCL or Vulkan should choose the PRO W6800, full stop. Its 32 GB memory buffer and 512.0 GB/s of bandwidth also make it the only option of the two suitable for large datasets that exceed 8 GB.

The RX 6650M serves a different role. Its 120 W TDP and integrated form factor, listed as IGP with no power connectors, mean it lives inside portable systems where the PRO W6800's 250 W TDP, dual-slot width, and discrete power connectors are simply not options. Within its own competitive set, the data shows the RX 6650M performing in line with the NVIDIA TITAN X Pascal (72098 average, a 0.5% edge for the RX 6650M) and the AMD Radeon Pro Vega 64 (72379 average, 0.8% ahead of the mobile card), and clearly ahead of the AMD Radeon RX 6600 LE by 1.3%. That is respectable company for an integrated mobile part.

Both cards are flagged as end-of-life in the database, so neither represents a current-generation purchase path.

FAQ

Q: How much faster is the PRO W6800 than the RX 6650M in Geekbench OpenCL?

A: The PRO W6800 scores 121808 against the RX 6650M's 65800, an 85.1% advantage for the workstation card.

Q: Which card wins the Geekbench Vulkan test?

A: The PRO W6800, scoring 109961 versus 77735, a 41.5% margin. The RX 6650M closes the gap relative to OpenCL but still trails substantially.

Q: Does the PRO W6800 have any other recorded benchmark the RX 6650M lacks?

A: Yes. The database records a Geekbench Metal score of 174420 for the PRO W6800, with no corresponding RX 6650M result in that test.

Q: Which GPUs are the closest rivals to each card?

A: The PRO W6800's nearest rivals are the NVIDIA A10M (135230 average, 0.1% behind), the NVIDIA RTX 4000 Ada Generation (135218, 0.1% behind), the AMD Radeon Pro W6800X Duo (135774, 0.3% ahead), and the AMD Radeon PRO V620 (136472, 0.8% ahead). The RX 6650M's closest rivals are the TITAN X Pascal, the Radeon Pro Vega 64, the Radeon RX 6600 LE, and the Radeon Vega Frontier Edition, all within 2.2% of its 71768 average.

Q: How do their memory configurations compare?

A: The PRO W6800 has 32 GB of GDDR6 on a 256-bit bus with 512.0 GB/s of bandwidth. The RX 6650M has 8 GB of GDDR6 on a 128-bit bus with 224.0 GB/s of bandwidth. That is a fourfold capacity advantage and more than double the bandwidth for the workstation card.

Q: Are both cards still in production?

A: No. The database lists both as end-of-life. The PRO W6800 was released on 2021-06-07 and the RX 6650M on 2022-01-03.

Architecture Differences

Both GPUs share AMD's RDNA 2.0 architecture and are fabricated by TSMC on a 7 nm process, which makes the divergence in physical scale the central architectural story. The PRO W6800 uses the Navi 21 die, measuring 520 mm² and packing 26,800 million transistors at a density of 51.5M per mm². The RX 6650M uses the much smaller Navi 23 die at 237 mm² with 11,060 million transistors at 46.7M per mm². In other words, the workstation die is more than twice the area and holds roughly 2.4 times the transistor count of the mobile part.

That silicon investment translates directly into resources. The PRO W6800 carries 3840 shading units, 240 texture mapping units, 96 render output units, and 60 ray tracing cores. The RX 6650M carries 1792 shading units, 112 TMUs, 64 ROPs, and 28 RT cores. Neither card lists tensor cores. The throughput consequences are visible across the board: the PRO W6800 reaches 222.9 GPixel/s pixel rate, 557.3 GTexel/s texture rate, and 17.83 TFLOPS of FP32 (35.67 TFLOPS FP16 at a 2:1 ratio), while the RX 6650M reaches 154.6 GPixel/s, 270.6 GTexel/s, and 8.659 TFLOPS FP32 (17.32 TFLOPS FP16).

Both parts support the same software feature set: DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. There is no API-level differentiation here; the difference is purely in execution resources and memory subsystem.

Specification Differences

The two cards differ in nearly every practical specification:

• Chip and die: Navi 21, 520 mm², 26,800 million transistors (PRO W6800) versus Navi 23, 237 mm², 11,060 million transistors (RX 6650M).
• Clocks: The RX 6650M actually clocks higher, with a 2068 MHz base, 2222 MHz game clock, and 2416 MHz boost, against the PRO W6800's 1575 MHz base and 2322 MHz boost. Higher clocks cannot overcome the smaller die's resource deficit.
• Memory: 32 GB GDDR6, 256-bit bus, 512.0 GB/s at 16 Gbps effective (PRO W6800) versus 8 GB GDDR6, 128-bit bus, 224.0 GB/s at 14 Gbps effective (RX 6650M).
• Power: 250 W TDP with one 6-pin and one 8-pin connector and a 600 W suggested PSU (PRO W6800) versus 120 W TDP with no power connectors (RX 6650M).
• Bus interface: PCIe 4.0 x16 on the PRO W6800 versus PCIe 4.0 x8 on the RX 6650M, halving host bandwidth for the mobile part.
• Form factor: The PRO W6800 is a dual-slot card measuring 267 mm long, 120 mm high, and 50 mm wide, with six mini-DisplayPort 1.4a outputs. The RX 6650M is an IGP with device-dependent display outputs and no recorded dimensions.
• Series positioning: The PRO W6800 belongs to the Radeon Pro Navi generation and succeeds the Radeon Pro Vega. The RX 6650M belongs to the Radeon RX 6000 series' mobile Navi line and succeeds Polaris Mobile.
• Launch MSRP: The database records a launch MSRP of 2,249 USD for the PRO W6800; no launch MSRP is recorded for the RX 6650M.

Head-to-Head Benchmarks

Only two tests appear in the recorded head-to-head data, and the PRO W6800 takes both, for an overall record of two wins to zero.

The largest gap is in Geekbench OpenCL. The PRO W6800 scores 121808 while the RX 6650M manages 65800, an 85.1% advantage for the workstation card. This is the result the silicon disparity predicts: OpenCL compute workloads scale with shading resources and memory bandwidth, and the PRO W6800 holds more than double the shading units (3840 versus 1792) and more than double the bandwidth (512.0 GB/s versus 224.0 GB/s). A near-doubling of the score is consistent with that hardware advantage.

Geekbench Vulkan tells a more competitive story. The PRO W6800 scores 109961 against 77735, a 41.5% margin. The RX 6650M's relatively stronger showing here tracks with its higher clock speeds: its 2416 MHz boost exceeds the PRO W6800's 2322 MHz, and its 2222 MHz game clock indicates sustained frequencies that partially offset its smaller resource count in graphics-oriented APIs.

Context matters when reading these numbers. The PRO W6800's average benchmark score of 135396 places it in the 96th percentile of all GPUs in the database, in a cluster with the NVIDIA A10M (135230) and NVIDIA RTX 4000 Ada Generation (135218), both within 0.1%, and slightly behind the Radeon Pro W6800X Duo (135774, 0.3% ahead) and Radeon PRO V620 (136472, 0.8% ahead). The RX 6650M's average of 71768 places it in the 91st percentile, effectively tied with the TITAN X Pascal and Radeon Pro Vega 64 and ahead of the Radeon RX 6600 LE by 1.3%.

The summary judgment from the data is straightforward. The PRO W6800 is the decisively faster GPU in every recorded test, by 41.5% to 85.1% depending on the API, with a far larger memory subsystem behind it. The RX 6650M's case rests on integration: a 120 W, connector-free design that delivers 91st-percentile performance within the thermal and physical constraints of a portable system. Choose the PRO W6800 for workstation compute and memory-hungry workloads; choose the RX 6650M where the form factor demands it.