AMD Radeon PRO W6600 vs NVIDIA GeForce RTX 4090 D Comparison

Head-to-Head Benchmarks

The benchmark data in this comparison is starkly one-sided. Across the two shared tests recorded in the database, the NVIDIA GeForce RTX 4090 D wins both, and by margins that are not merely comfortable but overwhelming. In Geekbench OpenCL, the RTX 4090 D scores 278,621 against the AMD Radeon PRO W6600’s 73,514. That is a delta of 279%, meaning the NVIDIA card delivers nearly four times the raw compute throughput in this API. The Vulkan test tells a similar story: 246,941 for the RTX 4090 D versus 78,428 for the Radeon PRO W6600, a 214.9% advantage.

What makes these results particularly instructive is the context of where each card sits in the broader database. The RTX 4090 D ranks in the 98th percentile among all GPUs, with an average benchmark score of 178,050. The Radeon PRO W6600, by contrast, sits in the 92nd percentile with an average of 81,995. Both are well above the median, but the gap between them is roughly 2.17 times in average score. That is not a small step up the ladder; it is a chasm. The RTX 4090 D’s nearest rivals in the database are the NVIDIA RTX PRO 5000 Blackwell (182,109 average, 2.2% ahead), the NVIDIA A100 SXM4 80 GB (183,725, 3.1% ahead), the NVIDIA RTX 5000 Ada Generation (184,664, 3.6% ahead), and the NVIDIA A100 SXM4 40 GB (187,147, 4.9% ahead). Notably, all of these rivals are themselves NVIDIA data-center or workstation parts, and the RTX 4090 D trails them by only single-digit percentages. The Radeon PRO W6600’s nearest rivals, meanwhile, are a mixed bag: the AMD Radeon Pro Vega 64X (80,959, 1.3% behind), the NVIDIA GeForce RTX 5090 (79,842, 2.7% behind), and two Tesla P100 variants (79,605 and 79,396, 3% and 3.3% behind respectively). The W6600 beats all of its closest competitors, but none of those competitors are anywhere near the performance tier occupied by the RTX 4090 D.

The head-to-head results show no test where the AMD card comes out ahead. The database records winsA as 2 and winsB as 0. There is no single benchmark among the shared tests where the W6600 closes the gap to a competitive margin. Even in the Vulkan test, which often favors AMD’s driver stack in some workloads, the RTX 4090 D more than triples the AMD card’s score.

Architecture Differences

The architectural divide between these two GPUs is as large as the benchmark gap suggests. The RTX 4090 D is built on NVIDIA’s Ada Lovelace architecture, using the AD102 chip fabricated on a 5 nm process at TSMC. It packs 76,300 million transistors onto a 609 mm² die, yielding a transistor density of 125.3 million per square millimeter. The Radeon PRO W6600 uses AMD’s RDNA 2.0 architecture with the Navi 23 chip, also from TSMC but on a 7 nm process. It contains 11,060 million transistors on a 237 mm² die, with a density of 46.7 million per square millimeter. The difference in process node alone explains a substantial portion of the performance gulf: the 5 nm node allows nearly three times the transistor density, and the RTX 4090 D uses that density to deploy a far larger compute array.

The compute resources are not remotely comparable. The RTX 4090 D has 14,592 shading units, 456 texture mapping units, and 176 raster output units. It also carries 114 ray tracing cores and 456 tensor cores. The Radeon PRO W6600 has 1,792 shading units, 112 TMUs, and 64 ROPs, with 28 ray tracing cores and no tensor cores at all. In raw FP32 throughput, the RTX 4090 D delivers 73.54 TFLOPS, while the W6600 manages 9.247 TFLOPS. The FP16 numbers are interesting: the RTX 4090 D matches its FP32 rate at 73.54 TFLOPS (1:1 ratio), while the W6600 doubles its FP32 rate to 18.49 TFLOPS (2:1 ratio). Even with that doubling, the W6600 is at roughly one-quarter of the RTX 4090 D’s FP16 output.

Memory configuration reinforces the divide. The RTX 4090 D has 24 GB of GDDR6X on a 384-bit bus, delivering 1.01 TB/s of bandwidth. The W6600 has 8 GB of GDDR6 on a 128-bit bus, with 224.0 GB/s. That is a 4.5-fold difference in bandwidth and a 3-fold difference in capacity. Clock speeds are closer than one might expect: the RTX 4090 D runs at 2280 MHz base and 2520 MHz boost, while the W6600 runs at 2331 MHz base and 2580 MHz boost. The AMD card actually clocks slightly higher, but with so few compute units, the clock advantage is irrelevant to the final performance picture.

Other specifications diverge sharply. The RTX 4090 D has a 425 W TDP, requires a triple-slot cooler, a 16-pin power connector, and an 800 W suggested PSU. The W6600 sips power at 100 W, fits in a single slot, uses a 6-pin connector, and needs only a 300 W PSU. The RTX 4090 D is also physically larger: 304 mm long, 137 mm tall, and 61 mm wide, versus 241 mm long for the W6600. Both support PCIe 4.0, but the RTX 4090 D uses a full x16 link while the W6600 uses x8. Display outputs differ as well: the RTX 4090 D offers one HDMI 2.1 and three DisplayPort 1.4a ports, while the W6600 offers four DisplayPort 1.4a outputs. Both cards support DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4.

The Verdict

The database is unambiguous: the NVIDIA GeForce RTX 4090 D is in a completely different performance class from the AMD Radeon PRO W6600. Every shared benchmark, every compute metric, and every memory statistic points the same way. The RTX 4090 D is 279% ahead in OpenCL and 214.9% ahead in Vulkan. It has 8 times the FP32 throughput, 4.5 times the memory bandwidth, and 3 times the VRAM capacity. Its average benchmark score of 178,050 places it in the 98th percentile, while the W6600’s 81,995 places it in the 92nd percentile. The RTX 4090 D’s nearest rivals are all data-center or prosumer NVIDIA parts that beat it by less than 5%; the W6600’s nearest rivals are a mix of older pro cards and a gaming flagship that it beats by 1.3% to 3.3%.

That said, the W6600 is not a bad card in isolation. It outperforms the Radeon Pro Vega 64X, the GeForce RTX 5090, and both Tesla P100 variants in the database. It is also dramatically more efficient: 100 W TDP versus 425 W, single-slot versus triple-slot, and a 300 W PSU recommendation versus 800 W. For users who need a compact, low-power workstation card with four DisplayPort outputs, the W6600 has a clear niche. But for anyone who needs maximum compute performance, the choice is obvious. The RTX 4090 D is the faster card by every measurable benchmark metric, and the margin is so large that no workload in the shared test suite even approaches parity.

The release dates also tell a story: the RTX 4090 D launched on December 27, 2023, while the W6600 launched on June 7, 2021. The NVIDIA card is two and a half years newer, and it shows in both architecture and execution. Both are now end-of-life products, but the RTX 4090 D remains a top-tier performer in the database, while the W6600, though solid, sits far lower in absolute terms.

FAQ

Q: Which GPU has the higher average benchmark score?

A: The NVIDIA GeForce RTX 4090 D has an average benchmark score of 178,050, while the AMD Radeon PRO W6600 has an average of 81,995.

Q: How much faster is the RTX 4090 D in Geekbench OpenCL?

A: The RTX 4090 D scores 278,621 versus 73,514 for the W6600, a 279% advantage.

Q: Does the AMD Radeon PRO W6600 win any of the shared benchmarks?

A: No. The database records 2 wins for the RTX 4090 D and 0 wins for the W6600 across the head-to-head tests.

Q: What is the memory capacity difference between the two cards?

A: The RTX 4090 D has 24 GB of GDDR6X memory, while the W6600 has 8 GB of GDDR6.

Q: Which card has a lower power consumption?

A: The AMD Radeon PRO W6600 has a TDP of 100 W, compared to the RTX 4090 D’s 425 W.

Q: Are both cards still in production?

A: No, both are marked as end-of-life in the database.

Where Each One Wins

The RTX 4090 D wins in every compute-heavy scenario that the shared benchmarks represent. In OpenCL, which is widely used for general-purpose GPU compute across scientific, engineering, and rendering workloads, the 279% lead means tasks that take hours on the W6600 would finish in well under half the time on the RTX 4090 D. The Vulkan advantage of 214.9% similarly indicates that real-time graphics workloads, including those using ray tracing, will see massive frame rate or render time improvements. The 24 GB VRAM capacity and 1.01 TB/s bandwidth make the RTX 4090 D suitable for large datasets, high-resolution textures, and memory-intensive simulations that would simply exceed the W6600’s 8 GB frame buffer.

The W6600 wins in scenarios where power, space, and thermal constraints dominate. Its 100 W TDP means it can be powered by a 300 W PSU, and its single-slot design fits in dense workstation chassis where the RTX 4090 D’s triple-slot footprint would not. The four DisplayPort 1.4a outputs give the W6600 an edge in multi-monitor professional setups, as the RTX 4090 D offers only three DisplayPort plus one HDMI. For users running multiple displays at 4K or building a compact rendering node, the W6600 is the practical choice despite its lower compute performance. The 241 mm length also makes it easier to fit in smaller cases, and the 6-pin power connector is far more universally compatible than the 16-pin connector on the RTX 4090 D.

The performance percentile data reinforces this split. The RTX 4090 D at the 98th percentile is a top-tier compute card, competing with the likes of the RTX PRO 5000 Blackwell and A100 SXM4, which beat it by only 2.2% to 4.9%. The W6600 at the 92nd percentile is a capable mid-range professional card, beating the RTX 5090 by 2.7% and the Tesla P100 by 3% to 3.3%. Neither card is weak, but they serve different tiers of the market. The RTX 4090 D is for users who need maximum throughput, while the W6600 is for users who need efficient, compact, low-power compute with multiple display outputs.