AMD Radeon PRO W6600 vs NVIDIA GeForce RTX 4080 SUPER Comparison

Head-to-Head Benchmarks

The recorded data shows a decisive result: the NVIDIA GeForce RTX 4080 SUPER wins both shared benchmark comparisons against the AMD Radeon PRO W6600. In the Geekbench OpenCL test, the RTX 4080 SUPER scores 219065, while the Radeon PRO W6600 scores 73514. That is a delta of 66.4% in favor of the NVIDIA card. In the Geekbench Vulkan test, the RTX 4080 SUPER posts 260075 against 78428 for the AMD card, a delta of 69.8%. The head-to-head win count stands at 2 for NVIDIA and 0 for AMD.

These are not small margins. The Vulkan gap, in particular, shows the RTX 4080 SUPER delivering more than three times the score of the Radeon PRO W6600. For OpenCL, the NVIDIA card is roughly three times faster as well. The percentile data places the Radeon PRO W6600 in the 92nd percentile among all GPUs, while the RTX 4080 SUPER sits in the 86th percentile. This is an unusual inversion: the older workstation card ranks higher in overall percentile despite losing head-to-head tests. The explanation lies in the average benchmark score. The Radeon PRO W6600 has an average score of 81995 across its three recorded tests (Geekbench Metal at 94042, OpenCL at 73514, Vulkan at 78428). The RTX 4080 SUPER has an average score of 54209 across ten tests, which includes lower DirectX and PassMark scores that drag down its average. So the percentile reflects the full test suite, not just the two shared comparisons.

Looking at the nearest rivals for each card clarifies the competitive context. The Radeon PRO W6600's closest rival is the AMD Radeon Pro Vega 64X with an average score of 80959, a delta of only 1.3%. The NVIDIA GeForce RTX 5090 is next at 79842, a 2.7% gap, followed by the Tesla P100 PCIe 16 GB at 79605 (3% delta) and the Tesla P100 PCIe 12 GB at 79396 (3.3% delta). The RTX 4080 SUPER's nearest rival is the RTX 4080 at 54247, a negligible delta of negative 0.1%. The AMD Radeon Pro W5700X follows at 54828 (negative 1.1%), then the RX 6750 GRE 12 GB at 55698 (negative 2.7%), and the AMD Radeon 8060S at 55757 (negative 2.8%). This shows the RTX 4080 SUPER is essentially tied with its non-SUPER predecessor in average score, while the Radeon PRO W6600 leads its closest rival by a small but real margin.

The head-to-head delta percentages are stark. A 66.4% deficit in OpenCL means the Radeon PRO W6600 achieves only about one-third of the RTX 4080 SUPER's raw compute output in that API. The Vulkan delta of 69.8% is even larger. These are not marginal differences; they represent a generational and architectural chasm in compute capability. The data does not show any single test where the AMD card wins. Every recorded shared benchmark goes to NVIDIA.

FAQ

Q: Which card wins the Geekbench OpenCL test, and by how much?

A: The NVIDIA GeForce RTX 4080 SUPER wins with a score of 219065 versus 73514 for the AMD Radeon PRO W6600. The delta is 66.4% in favor of NVIDIA.

Q: What is the average benchmark score for each card?

A: The AMD Radeon PRO W6600 has an average of 81995 across three tests (Geekbench Metal, OpenCL, and Vulkan). The NVIDIA GeForce RTX 4080 SUPER has an average of 54209 across ten tests, which includes PassMark and 3DMark results.

Q: How does the RTX 4080 SUPER compare to its closest rival, the RTX 4080?

A: The RTX 4080 SUPER's average score is 54209, while the RTX 4080 averages 54247. That is a delta of negative 0.1%, meaning the two are statistically tied in the database's measurements.

Q: What is the Radeon PRO W6600's closest rival in the database?

A: The closest rival is the AMD Radeon Pro Vega 64X with an average score of 80959, just 1.3% behind the W6600's 81995. The NVIDIA GeForce RTX 5090 is also close at 79842, a 2.7% delta.

Q: Does the Radeon PRO W6600 have any benchmark win over the RTX 4080 SUPER?

A: No. The head-to-head record shows 0 wins for the AMD card and 2 wins for the NVIDIA card across the two shared tests (Geekbench OpenCL and Vulkan).

Q: Which card has the higher percentile ranking among all GPUs?

A: The Radeon PRO W6600 ranks in the 92nd percentile, while the RTX 4080 SUPER ranks in the 86th percentile. This is due to the W6600's higher average score across its smaller test set.

Where Each One Wins

The Radeon PRO W6600 wins in the context of its own test suite. Its Geekbench Metal score of 94042 is the highest among its three recorded tests, indicating strong performance in Apple's Metal API, a workload the RTX 4080 SUPER has no recorded result for. The W6600 also leads its nearest rivals by small margins: 1.3% over the Pro Vega 64X, 2.7% over the RTX 5090, and 3.3% over the Tesla P100 12 GB. For users working in Metal-based applications or relying on the specific APIs the W6600 was tested with, the data shows a competitive, if not dominant, position.

The RTX 4080 SUPER wins in every shared comparison. Beyond the two Geekbench tests, its PassMark scores provide additional context. The PassMark G3D score is 34245, the GPU Compute score is 19822, and the DirectX tests range from 134 (DirectX 12) to 381 (DirectX 9). The 3DMark Steel Nomad DX12 score is 6600. These results, combined with the massive OpenCL and Vulkan leads, show the RTX 4080 SUPER as the clear choice for raw compute and modern API workloads. The Vulkan score of 260075 is particularly notable, as it exceeds the W6600's entire average benchmark score by a wide margin.

For professional workloads, the W6600's advantages are qualitative. It is a single-slot card with a 100 W TDP and a 6-pin power connector, requiring a 300 W suggested power supply. The RTX 4080 SUPER is a triple-slot card with a 320 W TDP, a 16-pin connector, and a 700 W suggested PSU. The W6600 also has four DisplayPort 1.4a outputs, while the RTX 4080 SUPER has one HDMI 2.1 and three DisplayPort 1.4a outputs. These differences favor the W6600 for multi-display setups and low-power environments, but the performance data overwhelmingly favors the RTX 4080 SUPER for compute.

Specification Differences

The two cards differ across nearly every core specification. The Radeon PRO W6600 has 1792 shading units, 112 TMUs, and 64 ROPs, while the RTX 4080 SUPER has 10240 shading units, 320 TMUs, and 112 ROPs. The NVIDIA card also has 80 RT cores and 320 tensor cores, whereas the AMD card has 28 RT cores and no tensor cores. In raw throughput, the RTX 4080 SUPER delivers 52.22 TFLOPS FP32 and 52.22 TFLOPS FP16 (1:1 ratio), compared to 9.247 TFLOPS FP32 and 18.49 TFLOPS FP16 (2:1 ratio) for the W6600. The pixel rate is 285.6 GPixel/s for NVIDIA versus 165.1 GPixel/s for AMD, and the texture rate is 816.0 GTexel/s versus 289.0 GTexel/s.

Memory is another significant differentiator. The W6600 has 8 GB of GDDR6 on a 128-bit bus, yielding 224.0 GB/s bandwidth. The RTX 4080 SUPER has 16 GB of GDDR6X on a 256-bit bus, yielding 736.3 GB/s bandwidth. That is more than three times the memory bandwidth. The clock speeds are similar: the W6600 boosts to 2580 MHz, while the RTX 4080 SUPER boosts to 2550 MHz. The base clocks are 2331 MHz and 2295 MHz, respectively. The memory clocks differ more substantially: 1750 MHz (14 Gbps effective) for AMD versus 1438 MHz (23 Gbps effective) for NVIDIA.

Physical dimensions diverge sharply. The W6600 is 241 mm long (9.5 inches) and single-slot. The RTX 4080 SUPER is 310 mm long (12.2 inches), 140 mm high (5.5 inches), and 61 mm wide (2.4 inches), occupying a triple-slot design. The bus interface also differs: PCIe 4.0 x8 for the W6600 versus PCIe 4.0 x16 for the RTX 4080 SUPER. The W6600 has a 100 W TDP and a 300 W suggested PSU, while the RTX 4080 SUPER has a 320 W TDP and a 700 W suggested PSU. The power connectors are 1x 6-pin versus 1x 16-pin.

Architecture Differences

The process nodes and chip designs are generations apart. The Radeon PRO W6600 uses the Navi 23 chip on TSMC's 7 nm process, built on RDNA 2.0 architecture. The RTX 4080 SUPER uses the AD103 chip on TSMC's 5 nm process, built on Ada Lovelace architecture. The transistor counts reflect this: 11,060 million for the W6600 versus 45,900 million for the RTX 4080 SUPER. The die sizes are 237 mm² for AMD and 379 mm² for NVIDIA. Transistor density is 46.7M per mm² for the W6600 and 121.1M per mm² for the RTX 4080 SUPER, showing the denser 5 nm process.

The W6600 is part of the Radeon Pro Navi (Navi II Series) generation, released on June 7, 2021, with a predecessor of Radeon Pro Vega. The RTX 4080 SUPER is part of the GeForce 40-series, released on January 30, 2024, with a predecessor of GeForce 30 and a successor of GeForce 50. Both cards support DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. The W6600's FP16 performance is listed as 18.49 TFLOPS with a 2:1 ratio, meaning it processes FP16 at half the rate of FP32. The RTX 4080 SUPER's FP16 is 52.22 TFLOPS with a 1:1 ratio, meaning it matches FP32 throughput. This is a key architectural difference: the NVIDIA card does not sacrifice FP16 performance.

The RT cores differ in count: 28 for the W6600 versus 80 for the RTX 4080 SUPER. Tensor cores are exclusive to NVIDIA, with 320 present on the RTX 4080 SUPER. The W6600 has no tensor core count listed. These architectural differences explain the benchmark gaps. The RTX 4080 SUPER's much larger shader count, combined with faster memory and a denser process node, produces the 66-70% deltas seen in shared tests.

The Verdict

The data is unambiguous: the NVIDIA GeForce RTX 4080 SUPER is the faster card in every shared benchmark. In OpenCL, it leads by 66.4%. In Vulkan, it leads by 69.8%. Its shading units (10240), memory bandwidth (736.3 GB/s), and FP32 throughput (52.22 TFLOPS) are all multiples of the AMD card's equivalents. For anyone prioritizing raw compute performance in OpenCL or Vulkan workloads, the RTX 4080 SUPER is the clear choice.

The Radeon PRO W6600 has its own niche. Its 92nd percentile ranking comes from a higher average score (81995) across its three tests, and its Geekbench Metal result of 94042 shows strength in that API. Its single-slot form factor, 100 W TDP, and 6-pin power requirement make it suitable for constrained systems. The four DisplayPort outputs support multi-monitor configurations that the RTX 4080 SUPER cannot match with its single HDMI and three DisplayPorts. The W6600 also launched with a 649 USD MSRP, while the RTX 4080 SUPER launched at 999 USD.

The verdict depends on the workload. For compute-heavy tasks using OpenCL or Vulkan, the RTX 4080 SUPER wins decisively. For Metal-specific workflows, multi-display setups, or power-constrained environments, the Radeon PRO W6600 offers advantages that the benchmark scores do not capture. The RTX 4080 SUPER's nearest rival is the RTX 4080 at a negative 0.1% delta, meaning the SUPER offers virtually no average-score improvement over its predecessor. The W6600, by contrast, leads its nearest rival by 1.3%, showing it is the stronger card in its own competitive tier.

Users should select the RTX 4080 SUPER for maximum performance in modern APIs and compute tasks. Users should select the Radeon PRO W6600 for its physical footprint, power efficiency, Metal performance, and multi-display capabilities. The recorded data supports both conclusions without contradiction.