AMD Radeon PRO W6400 vs NVIDIA RTX 5880 Ada Generation Comparison

Head-to-Head Benchmarks

The recorded data contains a single shared benchmark between the NVIDIA RTX 5880 Ada Generation and the AMD Radeon PRO W6400: the Geekbench OpenCL test. The result is decisively one-sided. The RTX 5880 Ada Generation scores 326,898 points, while the Radeon PRO W6400 scores 35,027 points. This produces a delta of 833.3%, meaning the NVIDIA card is roughly nine times faster in this compute workload. The win count reflects this dominance: the RTX 5880 Ada Generation takes the sole head-to-head win, with zero wins for the AMD board.

To contextualize the RTX 5880 Ada Generation's OpenCL result, the database places it in the 85th percentile among all GPUs. Its average benchmark score across all tests is 45,972. Its nearest rivals in the database include the NVIDIA RTX A2000 (average score 46,043, delta of -0.2%), the Intel Arc A730M (45,592, delta of +0.8%), the AMD Radeon Pro 5500 XT (45,384, delta of +1.3%), and the AMD Radeon RX 5600M (46,601, delta of -1.4%). These deltas are tiny, all within a 2.7 percentage point band. The data shows the RTX 5880 Ada Generation sits right in the middle of a tight cluster of mid-range workstation and mobile parts, despite its own OpenCL score being far higher than any of theirs. The average score is pulled down by the low PassMark scores recorded for this card: 167 in DirectX 10, 228 in DirectX 11, 70 in DirectX 12, and 335 in DirectX 9. The PassMark G3D score of 25,096 and the GPU compute score of 14,208 are more respectable, but the older DirectX tests skew the average.

The Radeon PRO W6400, by contrast, has a sparser benchmark footprint. The database only lists two results for it: the Geekbench OpenCL score of 35,027 and a Geekbench Vulkan score of 39,286. Its average benchmark score is 37,157, placing it in the 80th percentile of all GPUs. Its nearest rivals are the AMD Radeon RX Vega 56 (average score 37,507, delta of -0.9%), the NVIDIA Tesla P4 (37,628, delta of -1.3%), the NVIDIA GeForce RTX 4070 (37,648, delta of -1.3%), and the NVIDIA GeForce GTX TITAN X (36,530, delta of +1.7%). Again, the deltas are narrow, indicating the Radeon PRO W6400 performs in line with these older or lower-tier cards. The gap between the two cards is enormous: the RTX 5880 Ada Generation's average score of 45,972 is 23.7% above the Radeon's 37,157, but the raw OpenCL comparison shows a far larger chasm.

The Verdict

The data supports a clear choice for compute-heavy workloads: the NVIDIA RTX 5880 Ada Generation. Its Geekbench OpenCL score of 326,898 versus 35,027 for the AMD Radeon PRO W6400 is not a marginal lead; it is a landslide. The RTX 5880 Ada Generation also carries a higher average benchmark score (45,972 versus 37,157) and a higher percentile ranking (85th versus 80th). For anyone running OpenCL-based rendering, simulation, or data processing, the NVIDIA board is the only rational pick based on the recorded measurements.

The AMD Radeon PRO W6400 does have one practical advantage that is visible in the specification data: its power draw. The TDP is listed at 50 W, versus 285 W for the NVIDIA card. The AMD card also requires no power connectors and has a suggested PSU of 250 W, while the NVIDIA card needs a 16-pin connector and a 600 W power supply. For a low-power workstation, a compact single-slot system, or a deployment where heat and electricity are constrained, the Radeon PRO W6400 could be the appropriate choice despite its far lower performance. The data also shows the AMD card supports Vulkan, with a Geekbench Vulkan score of 39,286, which is higher than its OpenCL score. No Vulkan score is recorded for the NVIDIA card, so a direct comparison in that API is not possible from the database.

However, for raw throughput, the verdict is unambiguous. The RTX 5880 Ada Generation is in a different performance class, and the benchmark delta of 833.3% in OpenCL reflects that. The Radeon PRO W6400 is an end-of-life product, while the RTX 5880 Ada Generation is active in production. The NVIDIA card also has a successor listed (Blackwell PRO W), while the AMD card has none. The database suggests that anyone prioritizing compute performance should choose the RTX 5880 Ada Generation, while anyone prioritizing low power and physical footprint should consider the Radeon PRO W6400.

Architecture Differences

The two cards come from different architectural lineages. The NVIDIA RTX 5880 Ada Generation is built on the Ada Lovelace architecture, using the AD102 chip. It is manufactured on a 5 nm process at TSMC, with 76,300 million transistors packed into a 609 mm² die, giving a transistor density of 125.3 million per mm². The AMD Radeon PRO W6400 uses the RDNA 2.0 architecture with the Navi 24 chip. It is also made by TSMC, but on a 6 nm process, with 5,400 million transistors on a 107 mm² die, for a density of 50.5 million per mm². The NVIDIA chip is dramatically larger and denser, which aligns with its much higher performance.

The compute resources differ sharply. The RTX 5880 Ada Generation has 14,080 shading units, 440 texture mapping units, and 176 raster output units. It also features 110 ray tracing cores and 440 tensor cores. The Radeon PRO W6400 has 768 shading units, 48 TMUs, and 32 ROPs, along with 12 ray tracing cores and no tensor cores. The NVIDIA card's FP32 throughput is listed at 69.27 TFLOPS, while the AMD card manages 3.565 TFLOPS. For FP16, the NVIDIA card offers 69.27 TFLOPS with a 1:1 ratio, while the AMD card offers 7.130 TFLOPS with a 2:1 ratio. The pixel rate is 433.0 GPixel/s for the NVIDIA card versus 74.27 GPixel/s for the AMD card, and the texture rate is 1,082.4 GTexel/s versus 111.4 GTexel/s. These are not close comparisons; the NVIDIA part dominates every computational metric.

The memory subsystems also differ fundamentally. The RTX 5880 Ada Generation has 48 GB of GDDR6 memory on a 384-bit bus, yielding 864.0 GB/s of bandwidth. The Radeon PRO W6400 has 4 GB of GDDR6 on a 64-bit bus, yielding 128.0 GB/s. The NVIDIA card's memory clock is listed as 2250 MHz (18 Gbps effective), while the AMD card runs at 2000 MHz (16 Gbps effective). The base and boost clocks tell an interesting story: the AMD card has a higher base clock (2039 MHz versus 975 MHz) and a slightly higher boost clock (2321 MHz versus 2460 MHz, so the NVIDIA card boosts higher). The NVIDIA card compensates for its lower base clock with far more compute units, making the architectural comparison about scale rather than clock speed.

Specification Differences

The two cards diverge on nearly every physical and interface specification. The NVIDIA RTX 5880 Ada Generation is a dual-slot card measuring 267 mm in length and 112 mm in height, with a TDP of 285 W and a single 16-pin power connector. The AMD Radeon PRO W6400 is a single-slot card with no listed dimensions, a TDP of 50 W, and no power connectors at all. The suggested power supply is 600 W for the NVIDIA card and 250 W for the AMD card. The bus interface also differs: the NVIDIA card uses PCIe 4.0 x16, while the AMD card uses PCIe 4.0 x4. Display outputs are four DisplayPort 1.4a ports on the NVIDIA card versus two on the AMD card.

The memory configuration is a major differentiator. The RTX 5880 Ada Generation offers 48 GB of GDDR6 with a 384-bit bus and 864.0 GB/s bandwidth. The Radeon PRO W6400 offers 4 GB of GDDR6 with a 64-bit bus and 128.0 GB/s bandwidth. The release dates are also far apart: the NVIDIA card launched on January 4, 2024, while the AMD card launched on January 18, 2022. The production status is Active for the NVIDIA card and End-of-life for the AMD card. The predecessor and successor fields also differ: the NVIDIA card lists Workstation Ampere as its predecessor and Blackwell PRO W as its successor, while the AMD card lists Radeon Pro Vega as its predecessor and no successor. The API support is identical: both support DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4.

FAQ

Q: Which card has a higher Geekbench OpenCL score?

A: The NVIDIA RTX 5880 Ada Generation scores 326,898, which is 833.3% higher than the AMD Radeon PRO W6400's score of 35,027.

Q: Does the AMD Radeon PRO W6400 support any API that the NVIDIA card does not?

A: No. Both cards support DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. The AMD card has a recorded Geekbench Vulkan score of 39,286, but no Vulkan score is listed for the NVIDIA card.

Q: What is the power consumption difference?

A: The NVIDIA RTX 5880 Ada Generation has a TDP of 285 W and requires a 600 W power supply, while the AMD Radeon PRO W6400 has a TDP of 50 W and requires a 250 W power supply.

Q: Which card has more memory?

A: The NVIDIA RTX 5880 Ada Generation has 48 GB of GDDR6 on a 384-bit bus, while the AMD Radeon PRO W6400 has 4 GB of GDDR6 on a 64-bit bus.

Q: What are the production statuses?

A: The NVIDIA RTX 5880 Ada Generation is listed as Active, while the AMD Radeon PRO W6400 is listed as End-of-life.

Q: How do the average benchmark scores compare?

A: The NVIDIA card has an average benchmark score of 45,972, placing it in the 85th percentile, while the AMD card has an average score of 37,157, placing it in the 80th percentile.

Where Each One Wins

The NVIDIA RTX 5880 Ada Generation wins in every recorded performance benchmark. Its sole head-to-head result, Geekbench OpenCL, is a 833.3% victory. Its average benchmark score is higher, its percentile is higher, and its compute resources are vastly larger. For workloads involving OpenCL compute, large datasets (48 GB of memory versus 4 GB), or any task that benefits from high bandwidth (864.0 GB/s versus 128.0 GB/s), the NVIDIA card is the clear winner. The 14,080 shading units and 440 tensor cores also suggest strong performance in AI-adjacent tasks, though no tensor-specific benchmark is recorded in the database.

The AMD Radeon PRO W6400 wins in the areas of power efficiency and physical footprint. It draws 50 W versus 285 W, requires no power connector, and fits in a single slot. Its suggested power supply of 250 W is less than half of the NVIDIA card's 600 W requirement. For a workstation with limited cooling, a small form factor, or a need to minimize electricity usage, the AMD card is the sensible choice. Its Vulkan score of 39,286, while not directly comparable to the NVIDIA card (which has no Vulkan score in the database), shows it is capable in that API. The AMD card also has a higher base clock (2039 MHz versus 975 MHz), which could translate to better responsiveness in lightly threaded tasks, though no such benchmark exists in the data. The database ultimately shows a tradeoff: the RTX 5880 Ada Generation for performance, the Radeon PRO W6400 for efficiency.