AMD Radeon PRO W6400 vs NVIDIA GeForce RTX 4080 Mobile Comparison

# NVIDIA GeForce RTX 4080 Mobile vs AMD Radeon PRO W6400

The NVIDIA GeForce RTX 4080 Mobile and AMD Radeon PRO W6400 occupy vastly different segments of the mobile and workstation GPU market, respectively. The RTX 4080 Mobile is a high-end laptop part built on Ada Lovelace, while the Radeon PRO W6400 is a low-profile workstation card based on RDNA 2.0. Benchmark data shows the NVIDIA part dominates both shared tests, with a 355.6% lead in Geekbench OpenCL and a 271.1% lead in Geekbench Vulkan, yet the AMD card holds its own in the broader competitive landscape with an 80th percentile ranking versus the RTX 4080 Mobile's 81st. The two GPUs target different use cases, and the data underscores that raw benchmark superiority does not automatically translate to suitability for every workload.

Where Each One Wins

The NVIDIA GeForce RTX 4080 Mobile wins every head-to-head benchmark in the dataset, making it the clear choice for compute-heavy and graphics-intensive tasks. In Geekbench OpenCL, it scores 159,575 against the Radeon PRO W6400's 35,027, a 355.6% advantage that points to massive parallel compute throughput. Similarly, in Geekbench Vulkan, the RTX 4080 Mobile posts 145,807 versus 39,286, a 271.1% lead, indicating superior graphics API performance for modern gaming and rendering workloads. This GPU is designed for high-end laptops where maximum performance in 3D applications, content creation, and AI-accelerated tasks is the priority.

The AMD Radeon PRO W6400, by contrast, has no benchmark wins in this comparison, but its profile suggests a different strength: efficiency and compactness. With a 50 W TDP and single-slot design, it is optimized for workstation environments where power draw and physical footprint matter more than raw speed. Its 4 GB GDDR6 memory on a 64-bit bus is modest, yet its 80th percentile ranking among all GPUs indicates it outperforms a majority of graphics cards in the database, making it a viable option for professional 2D and light 3D workloads in small-form-factor systems. The data does not show it winning any compute race, but its lower power envelope and workstation-oriented feature set (like DisplayPort 1.4a outputs) make it a practical choice for multi-display office and CAD setups.

Architecture Differences

The architectural divide between these two GPUs is stark. The RTX 4080 Mobile uses the AD104 chip on NVIDIA's Ada Lovelace architecture, fabricated on a 5 nm process at TSMC with 35,800 million transistors on a 294 mm² die. This yields a transistor density of 121.8 million per mm², enabling 7,424 shading units, 232 texture mapping units, 80 ROPs, 58 RT cores, and 232 tensor cores. The inclusion of tensor cores and a 1:1 FP16/FP32 ratio (both 24.72 TFLOPS) makes it a compute beast, particularly for AI and machine learning workloads where tensor cores accelerate matrix operations.

The Radeon PRO W6400 uses the Navi 24 chip on AMD's RDNA 2.0 architecture, built on a 6 nm process at TSMC with 5,400 million transistors on a 107 mm² die, giving a density of 50.5 million per mm². It has 768 shading units, 48 TMUs, 32 ROPs, and 12 RT cores, but no tensor cores. Its FP32 throughput is 3.565 TFLOPS, while FP16 is 7.130 TFLOPS at a 2:1 ratio, reflecting a design that prioritizes gaming and general compute over AI-specific acceleration. The process node difference (5 nm vs 6 nm) and transistor count disparity (35.8 billion vs 5.4 billion) explain the massive performance gap, but they also highlight the W6400's efficiency: it achieves its performance at 50 W versus the RTX 4080 Mobile's 110 W.

Head-to-Head Benchmarks

The head-to-head data is limited to two tests, but the results are decisive. In Geekbench OpenCL, the RTX 4080 Mobile scores 159,575, which is 355.6% higher than the Radeon PRO W6400's 35,027. This benchmark exercises general-purpose compute using OpenCL, and the NVIDIA part's advantage stems from its 7,424 shading units and 24.72 TFLOPS FP32 performance, which dwarf the W6400's 768 shading units and 3.565 TFLOPS. The delta is so large that it is less a comparison and more a demonstration of different performance tiers.

In Geekbench Vulkan, the RTX 4080 Mobile records 145,807 against the AMD card's 39,286, a 271.1% lead. Vulkan tests graphics and compute in a low-overhead API, and the RTX 4080 Mobile's 58 RT cores and 232 tensor cores likely contribute to its strength in ray-traced and shader-heavy scenes. The Radeon PRO W6400's 12 RT cores are present but far fewer, and its 128.0 GB/s memory bandwidth (versus 432.0 GB/s) limits data throughput in memory-bound workloads. While these two benchmarks do not cover DirectX or Passmark tests (the W6400 lacks those scores), the pattern is unambiguous: the RTX 4080 Mobile is roughly 3-4 times faster in both measured scenarios.

Specification Differences

The specifications that differ between the two GPUs are extensive and reveal their distinct design philosophies. The RTX 4080 Mobile has 12 GB GDDR6 memory on a 192-bit bus with 432.0 GB/s bandwidth, while the Radeon PRO W6400 has 4 GB GDDR6 on a 64-bit bus with 128.0 GB/s bandwidth. This four-fold difference in memory capacity and 3.4x difference in bandwidth directly impacts high-resolution textures and large datasets. The NVIDIA part's base clock is 1290 MHz with a boost of 1665 MHz, whereas the AMD card runs at 2039 MHz base and 2321 MHz boost — the W6400's higher clocks partially compensate for its fewer cores but cannot close the compute gap.

Process node, die size, and transistor density all favor the RTX 4080 Mobile: 5 nm vs 6 nm, 294 mm² vs 107 mm², and 121.8M vs 50.5M transistors per mm². The RTX 4080 Mobile's power draw is 110 W versus 50 W, and it uses an IGP slot width with no power connectors, while the W6400 is single-slot with a 250 W suggested PSU. The bus interface differs too: PCIe 4.0 x16 for NVIDIA versus PCIe 4.0 x4 for AMD, which affects bandwidth to the host system. Display outputs also differ: the RTX 4080 Mobile is portable-device dependent, while the W6400 offers 2x DisplayPort 1.4a. Production status separates them as well — the RTX 4080 Mobile is Active, the W6400 is End-of-life.

FAQ

Q: Which GPU has higher memory bandwidth?

A: The NVIDIA GeForce RTX 4080 Mobile has 432.0 GB/s bandwidth, which is 3.4x higher than the AMD Radeon PRO W6400's 128.0 GB/s.

Q: What is the performance difference in Geekbench OpenCL?

A: The RTX 4080 Mobile scores 159,575 versus 35,027 for the W6400, giving the NVIDIA part a 355.6% lead.

Q: Does the AMD card have tensor cores?

A: No, the Radeon PRO W6400 has no tensor cores, while the RTX 4080 Mobile includes 232 tensor cores for AI acceleration.

Q: Which GPU is more power-efficient?

A: The AMD Radeon PRO W6400 has a 50 W TDP, less than half the RTX 4080 Mobile's 110 W, making it more power-efficient despite lower performance.

Q: Are both GPUs DirectX 12 Ultimate compatible?

A: Yes, both support DirectX 12 Ultimate (12_2), as well as OpenGL 4.6 and Vulkan 1.4.

Q: What is the production status of each GPU?

A: The RTX 4080 Mobile is Active, while the Radeon PRO W6400 is End-of-life, indicating the AMD part is no longer in production.