AMD Radeon Pro Vega II Duo vs NVIDIA Quadro P6000 Comparison

Head-to-Head Benchmarks

The benchmark data is decisive. The AMD Radeon Pro Vega II Duo wins both recorded head-to-head comparisons, and it does so by substantial margins. In the Geekbench OpenCL test, the AMD card scores 98,432 against the NVIDIA Quadro P6000's 66,382. That is a 48.3% advantage. The gap is not a minor edge; it is a commanding lead that places the two cards in different performance tiers entirely.

The Vulkan results tell a similar story, though with a slightly narrower margin. The Radeon Pro Vega II Duo scores 99,296, while the Quadro P6000 manages 73,590. The delta here is 34.9%. While the percentage gap is smaller than in OpenCL, it remains a decisive victory. The AMD card retains its dominance across both API workloads.

Looking at the overall averages, the picture is consistent. The Radeon Pro Vega II Duo has an average benchmark score of 106,750, compared to 69,986 for the Quadro P6000. This puts the AMD card in the 94th percentile of all GPUs, while the NVIDIA card sits in the 90th percentile. The percentile difference may sound modest, but the raw score gap is roughly 52% in favor of the AMD card.

It is worth noting where each card sits among its nearest rivals. The Radeon Pro Vega II Duo is 4.8% ahead of the NVIDIA Quadro RTX 6000, which is a notable result given that the RTX 6000 is a newer architecture. It trails the AMD Radeon PRO W7900 by 3.6%, the AMD Radeon Pro Vega II by 2.6%, and the AMD Radeon Pro W6600X by just 0.6%. That last figure shows how tightly packed the upper mid-range of AMD's professional lineup is. The Quadro P6000, meanwhile, is nearly tied with the AMD Radeon Pro WX 8200, sitting just 0.2% above it, and is 1.4% above the NVIDIA CMP 90HX. It also trails the AMD Radeon RX 6600 LE by 1.2% and the NVIDIA RTX A3000 Mobile by 0.2%.

The head-to-head record is 2 wins for the AMD Radeon Pro Vega II Duo and 0 for the NVIDIA Quadro P6000. There are no benchmark categories where the NVIDIA card comes out ahead. The data is unambiguous.

Architecture Differences

The two cards represent fundamentally different design philosophies and eras. The AMD Radeon Pro Vega II Duo is built on the Vega 20 chip using the GCN 5.1 architecture, fabricated on a 7 nm process at TSMC. The NVIDIA Quadro P6000 uses the GP102 chip with the Pascal architecture, also from TSMC but on a much older 16 nm process node. The manufacturing difference is significant: the AMD card packs 13,230 million transistors into a 331 mm² die, yielding a transistor density of 40.0 million transistors per square millimeter. The NVIDIA card has fewer transistors overall, at 11,800 million, but spreads them across a much larger 471 mm² die, resulting in a density of just 25.1 million per square millimeter. The smaller, denser process gives AMD a clear manufacturing advantage.

The memory subsystems diverge completely. The Radeon Pro Vega II Duo uses 32 GB of HBM2 memory on a 4096-bit bus, delivering 1.02 TB/s of bandwidth. The Quadro P6000 uses 24 GB of GDDR5X on a 384-bit bus, with 432.8 GB/s of bandwidth. The AMD card offers more capacity and more than double the memory bandwidth. The bus width difference alone, 4096-bit versus 384-bit, explains much of the bandwidth gap.

Compute resources also differ in structure. The AMD card has 4,096 shading units, 256 texture mapping units, and 64 render output units. The NVIDIA card has 3,840 shading units, 240 TMUs, and 96 ROPs. AMD has more shaders and more texture units, but NVIDIA has more ROPs. The pixel rate reflects this: the Quadro P6000 achieves 157.9 GPixel/s, while the Radeon Pro Vega II Duo manages 110.1 GPixel/s. In texture rate, the AMD card pulls ahead at 440.3 GTexel/s versus 394.8 GTexel/s. Neither card has dedicated ray tracing cores or tensor cores.

The floating-point specifications show a strong divergence in compute philosophy. The AMD card delivers 14.09 TFLOPS of FP32 performance and 28.18 TFLOPS of FP16 performance at a 2:1 ratio. The NVIDIA card delivers 12.63 TFLOPS of FP32 but only 197.4 GFLOPS of FP16 at a 1:64 ratio. The FP16 difference is enormous, but it matters only for workloads that actually use half-precision arithmetic.

Power and physical design differ as well. The AMD card has a 475 W TDP and requires a quad-slot cooler, while the NVIDIA card has a 250 W TDP and fits in a dual-slot design. The AMD card uses an Apple MPX bus interface, while the NVIDIA card uses PCIe 3.0 x16. The NVIDIA card has a single 8-pin power connector, while the AMD card's connector configuration is not listed. The suggested power supply is 850 W for the AMD card and 600 W for the NVIDIA card. The Quadro P6000 is 267 mm long and 111 mm tall; the AMD card's dimensions are not recorded.

Where Each One Wins

The AMD Radeon Pro Vega II Duo wins in compute-heavy workloads, particularly those that leverage OpenCL and Vulkan. Its 48.3% OpenCL advantage over the Quadro P6000 indicates a major edge in general-purpose GPU compute. The 34.9% Vulkan lead reinforces this. For tasks that use FP16 arithmetic, the AMD card's 2:1 FP16 ratio versus the NVIDIA card's 1:64 ratio makes it categorically superior, even before considering the raw TFLOPS difference. The 32 GB HBM2 memory with 1.02 TB/s bandwidth also gives it a strong position for large datasets that need rapid memory access.

The NVIDIA Quadro P6000 has fewer recorded wins, but the data does reveal areas where it holds an advantage. Its pixel rate of 157.9 GPixel/s is substantially higher than the AMD card's 110.1 GPixel/s, which suggests better performance in fill-rate-bound scenarios such as heavy rasterization at high resolutions. The 96 ROPs versus 64 ROPs supports this. The NVIDIA card also has a higher base clock at 1506 MHz versus 1400 MHz, though the AMD card's boost clock of 1720 MHz exceeds the NVIDIA card's 1645 MHz. The NVIDIA card consumes considerably less power at 250 W versus 475 W, and its dual-slot design is more flexible for system integration than the AMD card's quad-slot requirement.

For software compatibility, the NVIDIA card supports Vulkan 1.4, while the AMD card supports Vulkan 1.3. Both support DirectX 12 (12_1) and OpenGL 4.6. The NVIDIA card is also physically smaller, at 267 mm in length, which matters for chassis compatibility.

Specification Differences

The two cards differ across nearly every major specification category. The AMD Radeon Pro Vega II Duo uses a 7 nm process; the NVIDIA Quadro P6000 uses 16 nm. The AMD card has 13,230 million transistors on a 331 mm² die; the NVIDIA card has 11,800 million on 471 mm². Transistor density is 40.0M per mm² for AMD versus 25.1M per mm² for NVIDIA.

Clock speeds: the AMD card has a 1400 MHz base and 1720 MHz boost, while the NVIDIA card has a 1506 MHz base and 1645 MHz boost. Memory differs entirely: the AMD card has 32 GB of HBM2 on a 4096-bit bus with 1.02 TB/s bandwidth; the NVIDIA card has 24 GB of GDDR5X on a 384-bit bus with 432.8 GB/s bandwidth.

Compute units: the AMD card has 4,096 shading units, 256 TMUs, and 64 ROPs. The NVIDIA card has 3,840 shading units, 240 TMUs, and 96 ROPs. Pixel rate favors NVIDIA at 157.9 GPixel/s versus 110.1 GPixel/s. Texture rate favors AMD at 440.3 GTexel/s versus 394.8 GTexel/s. FP32 favors AMD at 14.09 TFLOPS versus 12.63 TFLOPS. FP16 heavily favors AMD at 28.18 TFLOPS versus 197.4 GFLOPS.

Power and physical specs: the AMD card has a 475 W TDP, quad-slot width, and an Apple MPX bus interface. The NVIDIA card has a 250 W TDP, dual-slot width, PCIe 3.0 x16 interface, and a single 8-pin power connector. Suggested PSU is 850 W for AMD and 600 W for NVIDIA. Display outputs: the AMD card has 1x HDMI 2.0b and 4x Thunderbolt; the NVIDIA card has 1x DVI and 4x DisplayPort 1.4a.

Release dates: the AMD card launched on June 2, 2019; the NVIDIA card on September 30, 2016. Both are end-of-life. The NVIDIA card lists a predecessor (Quadro Maxwell) and successor (Quadro Volta); the AMD card lists neither. The AMD card's launch MSRP was 4,399 USD; the NVIDIA card's launch MSRP was 5,999 USD.

FAQ

Q: Which card has higher overall benchmark scores?

A: The AMD Radeon Pro Vega II Duo has an average benchmark score of 106,750, compared to 69,986 for the NVIDIA Quadro P6000.

Q: How large is the performance gap in OpenCL?

A: The AMD card scores 98,432 in Geekbench OpenCL, which is 48.3% higher than the NVIDIA card's 66,382.

Q: Does the NVIDIA card win any benchmark category?

A: No. The head-to-head record is 2 wins for the AMD card and 0 for the NVIDIA card across the recorded tests.

Q: Which card has more memory bandwidth?

A: The AMD Radeon Pro Vega II Duo has 1.02 TB/s of bandwidth from its HBM2 memory, while the NVIDIA Quadro P6000 has 432.8 GB/s from GDDR5X.

Q: Which card supports a newer Vulkan version?

A: The NVIDIA Quadro P6000 supports Vulkan 1.4, while the AMD Radeon Pro Vega II Duo supports Vulkan 1.3.

Q: What is the transistor count difference?

A: The AMD card has 13,230 million transistors, while the NVIDIA card has 11,800 million.

The Verdict

The AMD Radeon Pro Vega II Duo is the faster card by every recorded benchmark measurement. Its 48.3% OpenCL lead and 34.9% Vulkan lead over the Quadro P6000 are not marginal differences; they place the two cards in different performance classes. The average score of 106,750 versus 69,986 confirms this. For compute-intensive workloads, particularly those using OpenCL, Vulkan, or FP16 arithmetic, the AMD card is the clear choice. Its 32 GB HBM2 memory with 1.02 TB/s bandwidth also makes it better suited for large memory working sets.

The NVIDIA Quadro P6000 should be chosen only when its specific advantages matter more than raw compute throughput. Its 157.9 GPixel/s pixel rate exceeds the AMD card's 110.1 GPixel/s, so rasterization-heavy workloads may favor it. Its 250 W TDP and dual-slot design make it far easier to integrate into existing systems than the AMD card's 475 W, quad-slot footprint. The single 8-pin power connector and 600 W suggested PSU also reduce system power requirements significantly. Its Vulkan 1.4 support is newer than the AMD card's Vulkan 1.3.

The data does not support a scenario where the Quadro P6000 wins on performance. It wins on practicality: lower power, smaller size, and simpler integration. The AMD Radeon Pro Vega II Duo wins on every recorded performance metric. For users who need maximum compute performance and have the power and space budget, the AMD card is the answer. For users who need adequate performance with lower power draw and a more flexible physical footprint, the NVIDIA card remains a viable option despite its age.