AMD Instinct MI355X vs NVIDIA RTX PRO 4500 Blackwell Server Comparison

Head-to-Head Benchmarks

The recorded database contains no direct head-to-head benchmark scores for the AMD Instinct MI355X versus the NVIDIA RTX PRO 4500 Blackwell Server. Both entries have an average benchmark score of 0, and the head-to-head benchmark array is empty. Consequently, the wins count for each product stands at zero. This absence of measured results means the comparison must be conducted through architectural and specification analysis rather than empirical performance data. The percentile ranking for both GPUs is identical at 50, placing them at the midpoint of all recorded GPUs, though this reflects the absence of benchmark submissions rather than equivalence in capability. The FP32 compute figures provide the most direct performance indicator: the AMD Instinct MI355X delivers 78.64 TFLOPS, while the NVIDIA RTX PRO 4500 Blackwell Server delivers 50.70 TFLOPS. This translates to the AMD part being approximately 55% ahead in raw FP32 throughput. In FP16, both cards maintain a 1:1 ratio with their FP32 numbers, meaning the AMD card again leads with 78.64 TFLOPS versus 50.70 TFLOPS for the NVIDIA part. Texture rate favors AMD at 2,457.6 GTexel/s compared to 792.1 GTexel/s, a margin of roughly 3.1x. However, the NVIDIA card dominates in pixel rate: 270.5 GPixel/s versus 0 MPixel/s for the AMD part, which records no pixel output capability whatsoever.

Where Each One Wins

The AMD Instinct MI355X is positioned for compute-heavy workloads that prioritize raw floating-point throughput and massive memory capacity. Its 288 GB of HBM3e memory with 8.19 TB/s bandwidth dwarfs the NVIDIA card's 32 GB of GDDR7 with 800.3 GB/s. This represents a 9x capacity advantage and over 10x bandwidth advantage. For large-scale inference, scientific simulation, or training scenarios where model weights exceed the smaller card's memory, the AMD part provides a decisive edge. The shading unit count of 16,384 versus 10,496, along with 1,024 TMUs versus 328, reinforces the compute-oriented design. The NVIDIA RTX PRO 4500 Blackwell Server wins in rasterization-related metrics. It has 112 ROPs while the AMD card has 0, and it produces 270.5 GPixel/s. The NVIDIA part also includes 82 RT cores and 328 tensor cores, features entirely absent from the AMD specifications. For workloads involving ray tracing, graphics rendering, or tensor-based acceleration such as DLSS-style operations, the NVIDIA card holds the functional advantage. The NVIDIA card also draws far less power: 165 W TDP versus 1,400 W TDP for the AMD part. The suggested PSU for the NVIDIA card is 450 W, while the AMD card requires an 1,800 W PSU. The AMD card is an OAM Module with no power connectors, indicating a server-only deployment, whereas the NVIDIA card is a single-slot PCIe card with a 1x 16-pin connector, allowing broader system integration.

Architecture Differences

The two accelerators are built on different process nodes from the same foundry. The AMD Instinct MI355X uses a 3 nm process at TSMC, while the NVIDIA RTX PRO 4500 Blackwell Server uses a 5 nm process, also at TSMC. The AMD chip, designated MI350 256CU, is based on the CDNA 4.0 architecture, while the NVIDIA chip, designated GB203, uses Blackwell 2.0. Transistor counts differ substantially: the AMD part integrates 185,000 million transistors on a die size of 2380 mm², yielding a transistor density of 77.7M per mm². The NVIDIA part contains 45,600 million transistors on a 378 mm² die, resulting in a higher density of 120.6M per mm². The AMD die is roughly 6.3x larger in area, but the NVIDIA design packs transistors more tightly. Memory technologies diverge completely: AMD uses HBM3e with an 8192-bit bus, while NVIDIA uses GDDR7 with a 256-bit bus. The AMD card has no display outputs, no pixel rate, and no ROPs, confirming its compute-only orientation. The NVIDIA card also has no display outputs, but it supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4, whereas the AMD card lists N/A for all three APIs. Clock speeds are similar at the boost level: 2400 MHz for AMD versus 2415 MHz for NVIDIA, with base clocks of 1000 MHz and 1215 MHz respectively. The AMD card measures 102 mm in length and 165 mm in width, while the NVIDIA card is 267 mm long, 111 mm high, and 40 mm wide. The AMD card's release date is 2025-06-11, and the NVIDIA card's release date is 2026-03-16. The AMD product's predecessor is Radeon Instinct, while the NVIDIA card's predecessor is Server Hopper, and its successor is Server Rubin. The NVIDIA card has an active production status, while the AMD card's production status is null.

The Verdict

The data indicates that the AMD Instinct MI355X is the superior choice for memory-bound compute workloads. Its 288 GB HBM3e pool and 8.19 TB/s bandwidth are unmatched by the NVIDIA part's 32 GB and 800.3 GB/s. For large language model inference, training datasets exceeding 32 GB, or scientific computing requiring massive in-memory data, the AMD card is the only viable option between the two. Its FP32 and FP16 throughput of 78.64 TFLOPS also exceeds the NVIDIA card's 50.70 TFLOPS, confirming a raw compute advantage. The NVIDIA RTX PRO 4500 Blackwell Server is the better pick for rasterization and graphics-adjacent tasks. It has ROPs, pixel rate, RT cores, and tensor cores, all of which the AMD card lacks. Its DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4 support means it can execute graphics APIs, while the AMD card cannot. The NVIDIA card also fits into standard single-slot PCIe systems with a 165 W TDP and a 450 W suggested PSU, whereas the AMD card requires an OAM Module form factor and an 1,800 W PSU, limiting deployment to specialized servers. For users with power or space constraints, the NVIDIA card is practical. For users prioritizing maximum compute and memory capacity, the AMD card wins decisively. The absence of benchmark scores means these conclusions rest on specification analysis alone, but the architectural gaps are substantial enough to guide selection.

FAQ

Q: Which GPU has more memory bandwidth?

A: The AMD Instinct MI355X has 8.19 TB/s of bandwidth from its HBM3e memory, compared to 800.3 GB/s for the NVIDIA RTX PRO 4500 Blackwell Server.

Q: Does the NVIDIA RTX PRO 4500 Blackwell Server support ray tracing?

A: Yes, it includes 82 RT cores, while the AMD Instinct MI355X has no RT cores listed.

Q: What is the power draw difference between the two cards?

A: The AMD Instinct MI355X has a TDP of 1,400 W and requires an 1,800 W suggested PSU. The NVIDIA RTX PRO 4500 Blackwell Server has a TDP of 165 W and requires a 450 W suggested PSU.

Q: Can either GPU output video to a display?

A: Neither card has display outputs. The AMD card records no pixel rate, and the NVIDIA card also lists no display outputs.

Q: Which GPU has more shading units?

A: The AMD Instinct MI355X has 16,384 shading units, while the NVIDIA RTX PRO 4500 Blackwell Server has 10,496.

Q: What memory types do the two GPUs use?

A: The AMD Instinct MI355X uses 288 GB of HBM3e with an 8192-bit bus. The NVIDIA RTX PRO 4500 Blackwell Server uses 32 GB of GDDR7 with a 256-bit bus.

Specification Differences

| Specification | AMD Instinct MI355X | NVIDIA RTX PRO 4500 Blackwell Server |

|----------------|---------------------|---------------------------------------|

| Process Node | 3 nm | 5 nm |

| Transistors | 185,000 million | 45,600 million |

| Die Size | 2380 mm² | 378 mm² |

| Transistor Density | 77.7M / mm² | 120.6M / mm² |

| Base Clock | 1000 MHz | 1215 MHz |

| Boost Clock | 2400 MHz | 2415 MHz |

| Memory Size | 288 GB | 32 GB |

| Memory Type | HBM3e | GDDR7 |

| Memory Bus Width | 8192 bit | 256 bit |

| Memory Bandwidth | 8.19 TB/s | 800.3 GB/s |

| Memory Clock | 2000 MHz 8 Gbps effective | 1563 MHz 25 Gbps effective |

| Shading Units | 16384 | 10496 |

| TMUs | 1024 | 328 |

| ROPs | 0 | 112 |

| RT Cores | None | 82 |

| Tensor Cores | None | 328 |

| Pixel Rate | 0 MPixel/s | 270.5 GPixel/s |

| Texture Rate | 2,457.6 GTexel/s | 792.1 GTexel/s |

| FP32 | 78.64 TFLOPS | 50.70 TFLOPS |

| FP16 | 78.64 TFLOPS (1:1) | 50.70 TFLOPS (1:1) |

| TDP | 1,400 W | 165 W |

| Slot Width | OAM Module | Single-slot |

| Power Connectors | None | 1x 16-pin |

| Suggested PSU | 1,800 W | 450 W |

| Bus Interface | PCIe 5.0 x16 | PCIe 5.0 x16 |

| Display Outputs | No outputs | No outputs |

| DirectX | N/A | 12 Ultimate (12_2) |

| OpenGL | N/A | 4.6 |

| Vulkan | N/A | 1.4 |

| Dimensions | 102 mm length, 165 mm width | 267 mm length, 111 mm height, 40 mm width |

| Production Status | Null | Active |

| Release Date | 2025-06-11 | 2026-03-16 |

| Predecessor | Radeon Instinct | Server Hopper |

| Successor | Null | Server Rubin |