AMD Instinct MI308X vs NVIDIA RTX PRO 4500 Blackwell Comparison

Head-to-Head Benchmarks

The recorded data for the AMD Instinct MI308X contains no benchmark entries, while the NVIDIA RTX PRO 4500 Blackwell has a full suite of nine benchmark results. This means direct head-to-head comparisons must be drawn from the RTX PRO 4500's recorded scores and the MI308X's architectural specifications.

The NVIDIA RTX PRO 4500 Blackwell delivers a 3DMark Steel Nomad DX12 score of 7,025. Its Geekbench Vulkan result reaches 221,768, which indicates a strong compute-oriented workload performance. Passmark results show a G3D score of 33,360, a GPU compute score of 19,255, and DirectX 11 score of 320. The DirectX 10 score is 204, DirectX 12 is 119, and DirectX 9 is 397. The G2D score of 1,336 completes the suite.

The RTX PRO 4500's average benchmark score sits at 31,532, placing it in the 76th percentile among all GPUs. Its nearest rivals cluster tightly around this figure. The NVIDIA TITAN RTX averages 31,676, a delta of -0.5 percent relative to the RTX PRO 4500. The Intel Arc Pro A30M averages 31,894, a delta of -1.1 percent. The NVIDIA GRID M60-1Q and Quadro M5000 both average 31,220 and 31,206 respectively, each showing a 1 percent delta.

The AMD Instinct MI308X, by contrast, has no recorded benchmark scores and sits at the 50th percentile with an average score of zero. The database shows zero wins for the MI308X and zero wins for the RTX PRO 4500 in head-to-head tests, since no shared benchmarks exist.

What the data does show is the MI308X's theoretical compute capacity. Its FP32 throughput is listed at 81.72 TFLOPS, which is 61.7 percent higher than the RTX PRO 4500's 50.53 TFLOPS. The texture rate for the MI308X is 2,553.6 GTexel/s versus 789.5 GTexel/s for the RTX PRO 4500, a 3.2x difference. Memory bandwidth likewise favors the AMD part: 5.32 TB/s from HBM3 across an 8192-bit bus, compared to 896.0 GB/s from GDDR7 across a 256-bit bus. That is a 5.9x bandwidth advantage.

The RTX PRO 4500 counters with capabilities the MI308X lacks entirely. It has 82 RT cores and 328 tensor cores, while the MI308X lists no RT core or tensor core counts. The RTX PRO 4500 also has 112 ROPs delivering 269.6 GPixel/s, whereas the MI308X lists 0 ROPs and 0 MPixel/s pixel rate. The NVIDIA card supports DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4. The MI308X lists N/A for all three APIs.

Where Each One Wins

The RTX PRO 4500 Blackwell wins in every measured benchmark category because it is the only one with recorded results. Its Passmark G3D score of 33,360 and average score of 31,532 put it slightly ahead of the TITAN RTX and clearly ahead of the GRID M60-1Q and Quadro M5000 in the database's rival set.

For rasterization and graphics workloads, the RTX PRO 4500's pixel rate of 269.6 GPixel/s and its DirectX 12 Ultimate support give it a clear functional edge. The MI308X has no pixel output capability listed, no display outputs, and no graphics API support. The RTX PRO 4500 provides four DisplayPort 2.1b outputs, making it usable for display-driven tasks.

The MI308X wins on raw compute throughput and memory capacity. Its 192 GB of HBM3 memory dwarfs the RTX PRO 4500's 32 GB of GDDR7. For workloads that fit within the RTX PRO 4500's memory envelope, the FP32 and FP16 figures of 50.53 TFLOPS are the only measured compute data available. The MI308X's 81.72 TFLOPS in both FP32 and FP16 (1:1 ratio) is a theoretical maximum rather than a measured result, but it indicates substantially higher raw arithmetic throughput.

The RTX PRO 4500 also wins on power efficiency in the recorded data. Its 200 W TDP with a suggested 550 W PSU contrasts with the MI308X's 750 W TDP and 1150 W suggested PSU. The NVIDIA card uses a single 16-pin connector and fits a dual-slot form factor at 267 mm length, 111 mm height, and 40 mm width. The MI308X is an OAM module with no power connectors listed, which means it requires a different physical integration path.

For ray tracing and tensor workloads, the RTX PRO 4500 is the only option with dedicated hardware. Its 82 RT cores and 328 tensor cores are recorded in the database. The MI308X has no such units listed.

The Verdict

The data presents two fundamentally different products. The NVIDIA RTX PRO 4500 Blackwell is a measured, benchmarked workstation GPU with a complete software stack. It supports DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4, and it has display outputs. Its average benchmark score of 31,532 and 76th percentile ranking are backed by nine individual test results.

The AMD Instinct MI308X is a compute-focused accelerator with no recorded benchmarks and no graphics APIs. Its 50th percentile ranking with an average score of zero reflects the absence of test data, not a performance verdict. The MI308X's advantages are architectural: 153,000 million transistors on a 1017 mm² die, 19,456 shading units, 192 GB of HBM3, and 5.32 TB/s of bandwidth. These are specifications for large-scale compute workloads, not for graphics or display tasks.

Users who need measured graphics performance, ray tracing, tensor operations, or a card that can drive displays should select the RTX PRO 4500. The data supports this through its benchmark scores, RT core and tensor core counts, and DisplayPort outputs. Users who need massive memory capacity and very high theoretical FP32 throughput for compute-only deployments would look at the MI308X, but the database contains no measured results to confirm its real-world performance.

The RTX PRO 4500's nearest rival data shows it is competitive with the TITAN RTX. A delta of -0.5 percent against the TITAN RTX means the two are effectively tied in average score. The Intel Arc Pro A30M leads by 1.1 percent, while the GRID M60-1Q and Quadro M5000 trail by 1 percent each. These deltas are all within a narrow band, indicating the RTX PRO 4500 performs at a consistent level relative to its recorded competition.

FAQ

Q: Which GPU has a higher average benchmark score?

A: The NVIDIA RTX PRO 4500 Blackwell has an average benchmark score of 31,532. The AMD Instinct MI308X has an average score of 0 because no benchmarks are recorded for it.

Q: How does the RTX PRO 4500 compare to its nearest rivals?

A: The RTX PRO 4500's average score of 31,532 is 0.5 percent lower than the NVIDIA TITAN RTX's 31,676, 1.1 percent lower than the Intel Arc Pro A30M's 31,894, and 1 percent higher than both the NVIDIA GRID M60-1Q (31,220) and NVIDIA Quadro M5000 (31,206).

Q: What is the memory configuration of each GPU?

A: The AMD Instinct MI308X has 192 GB of HBM3 memory on an 8192-bit bus with 5.32 TB/s bandwidth. The NVIDIA RTX PRO 4500 has 32 GB of GDDR7 memory on a 256-bit bus with 896.0 GB/s bandwidth.

Q: Does the MI308X support graphics APIs?

A: No. The database lists DirectX, OpenGL, and Vulkan support as N/A for the MI308X. The RTX PRO 4500 supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4.

Q: Which GPU has higher FP32 compute?

A: The AMD Instinct MI308X lists 81.72 TFLOPS FP32, compared to 50.53 TFLOPS for the NVIDIA RTX PRO 4500. Both GPUs have a 1:1 FP16 to FP32 ratio, meaning FP16 figures match their respective FP32 numbers.

Q: What are the physical and power specifications?

A: The MI308X is an OAM module with a 750 W TDP and 1150 W suggested PSU. The RTX PRO 4500 is a dual-slot card measuring 267 mm by 111 mm by 40 mm, with a 200 W TDP, 550 W suggested PSU, and a single 16-pin power connector.

Architecture Differences

The two GPUs use different architectures from different design lineages. The AMD Instinct MI308X uses CDNA 3.0 architecture on a chip called Aqua Vanjaram, part of the Instinct (MIx) generation. The NVIDIA RTX PRO 4500 uses Blackwell 2.0 architecture on the GB203 chip, part of the Blackwell PRO W (x000) generation.

Both are built on a 5 nm process at TSMC, but the similarities end there. The MI308X integrates 153,000 million transistors on a 1017 mm² die, yielding a transistor density of 150.4 million per mm². The RTX PRO 4500 has 45,600 million transistors on a 378 mm² die, with a density of 120.6 million per mm². The MI308X die is 2.7x larger and carries 3.4x more transistors.

Compute unit counts differ sharply. The MI308X has 19,456 shading units and 1,216 TMUs. The RTX PRO 4500 has 10,496 shading units, 328 TMUs, and 112 ROPs. The MI308X lists no ROPs and a 0 MPixel/s pixel rate, confirming it is not designed for rasterization output. The RTX PRO 4500's 82 RT cores and 328 tensor cores provide dedicated hardware for ray tracing and tensor operations, features absent from the MI308X's specification sheet.

Memory architecture reflects the different missions. The MI308X uses HBM3 with 192 GB capacity, an 8192-bit bus, and 5.32 TB/s bandwidth. The RTX PRO 4500 uses GDDR7 with 32 GB capacity, a 256-bit bus, and 896.0 GB/s bandwidth. The MI308X's memory bandwidth is nearly 6x higher, suited to data-intensive compute workloads. The RTX PRO 4500's smaller, faster-access memory pool suits graphics and workstation tasks.

Clock behavior also differs. The MI308X has a 1000 MHz base clock and 2100 MHz boost. The RTX PRO 4500 has a 1635 MHz base clock and 2407 MHz boost. The RTX PRO 4500 runs at higher clock speeds despite its lower TDP of 200 W versus 750 W.

Power and physical design diverge completely. The MI308X is an OAM module with no power connectors and no display outputs. The RTX PRO 4500 is a dual-slot PCIe card with one 16-pin connector, four DisplayPort 2.1b outputs, and a 267 mm length. The MI308X uses PCIe 5.0 x16, as does the RTX PRO 4500.

The release timeline shows the MI308X launched on December 5, 2023, with the Radeon Instinct as its predecessor. The RTX PRO 4500 launched on March 17, 2025, succeeding Workstation Ada, and is listed as Active in production status. The MI308X's production status is not recorded.

The RTX PRO 4500's API support includes DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. The MI308X lists N/A for all three, reinforcing its role as a compute accelerator without a graphics pipeline.