AMD Instinct MI300 vs NVIDIA RTX PRO 4500 Blackwell Workstation Comparison

Head-to-Head Benchmarks

The database contains no recorded benchmark scores for either the AMD Instinct MI300 or the NVIDIA RTX PRO 4500 Blackwell Workstation. Both cards hold a percentile rank of 50 against all GPUs in the database, and both have an average benchmark score of zero. This means a direct numeric comparison of measured performance is not possible from the recorded data. What the database does provide is a detailed specification profile for each card, and those specifications allow for a meaningful architectural and capability comparison.

The most decisive specification difference is in memory capacity and bandwidth. The AMD Instinct MI300 ships with 128 GB of HBM3 memory across an 8192-bit bus, delivering 5.32 TB/s of bandwidth. The NVIDIA RTX PRO 4500 Blackwell Workstation ships with 32 GB of GDDR7 memory on a 256-bit bus, delivering 896.0 GB/s. That is a 4x difference in memory capacity and a roughly 5.9x difference in memory bandwidth in favor of the AMD card. For workloads that are memory-bound, such as large model inference or data processing, this gap is the single most important factor in the entire comparison.

In raw compute throughput, the two cards are much closer. The NVIDIA card posts 50.53 TFLOPS for both FP32 and FP16, while the AMD card posts 47.87 TFLOPS for both FP32 and FP16. The NVIDIA card leads by approximately 5.6% in both precisions. That is a modest advantage, but it is consistent across both formats since each card runs FP32 and FP16 at a 1:1 ratio. Neither card has a dedicated boost for reduced precision in this data, so the FP16 advantage is identical to the FP32 advantage.

Texture and pixel throughput tell a different story. The AMD MI300 has 880 texture mapping units and a texture rate of 1,496.0 GTexel/s. The NVIDIA card has 328 TMUs and a texture rate of 789.5 GTexel/s. The AMD card is roughly 89.5% ahead in texture rate. However, the MI300 has zero ROPs and a pixel rate of 0 MPixel/s, while the NVIDIA card has 112 ROPs and a pixel rate of 269.6 GPixel/s. The NVIDIA card is entirely alone in rasterization output, since the AMD card cannot drive a display and has no pixel pipeline in this recorded data.

Clock speeds favor the NVIDIA card substantially. The RTX PRO 4500 has a base clock of 1635 MHz and a boost clock of 2407 MHz. The Instinct MI300 has a base clock of 1000 MHz and a boost clock of 1700 MHz. The NVIDIA card runs 635 MHz higher at base and 707 MHz higher at boost. This clock advantage helps explain why the NVIDIA card achieves a higher FP32 figure despite having fewer shading units: 10,496 shading units on NVIDIA versus 14,080 on AMD.

Power draw is another major differentiator. The AMD card has a TDP of 600 W and requires a 1000 W suggested power supply with two 8-pin connectors. The NVIDIA card has a TDP of 200 W and requires a 550 W suggested power supply with a single 16-pin connector. The AMD card consumes three times the power of the NVIDIA card. When combined with the compute figures, the NVIDIA card delivers higher FP32 and FP16 throughput at one-third the power draw, indicating a substantially better performance-per-watt profile in the recorded specifications.

Where Each One Wins

The AMD Instinct MI300 wins decisively in memory capacity and memory bandwidth. With 128 GB of HBM3 and 5.32 TB/s, it is built for workloads that need to keep very large datasets resident on the GPU. The 8192-bit bus is four times wider than the NVIDIA card's 256-bit bus. This makes the MI300 the appropriate choice for large-scale compute tasks where data movement is the bottleneck, such as massive matrix operations or inference on very large models. The AMD card also leads in texture rate at 1,496.0 GTexel/s, though its zero ROP count and lack of display outputs mean it is not designed for any rasterization or graphics output work.

The NVIDIA RTX PRO 4500 Blackwell Workstation wins in several other categories. It has higher FP32 and FP16 throughput at 50.53 TFLOPS, even though the gap is small. It has a much higher boost clock at 2407 MHz, and it is the only one of the two with any rasterization capability: 112 ROPs and a 269.6 GPixel/s pixel rate. It also supports display output through four DisplayPort 2.1b connections, whereas the AMD card has no outputs. The NVIDIA card supports DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4; the AMD card lists N/A for all three APIs. The NVIDIA card is the only one of the two that can function as a workstation graphics card in a conventional sense.

The power efficiency comparison is not close. The NVIDIA card delivers its 50.53 TFLOPS at 200 W, while the AMD card delivers 47.87 TFLOPS at 600 W. The NVIDIA card also has a smaller physical footprint in terms of power connectors and suggested PSU requirements. The AMD card's 600 W TDP and 1000 W suggested PSU place it in a different deployment class entirely.

FAQ

Q: Which card has more memory bandwidth?

A: The AMD Instinct MI300 has 5.32 TB/s of bandwidth from 128 GB of HBM3 on an 8192-bit bus. The NVIDIA RTX PRO 4500 has 896.0 GB/s from 32 GB of GDDR7 on a 256-bit bus.

Q: Which card has higher FP32 compute?

A: The NVIDIA RTX PRO 4500 leads with 50.53 TFLOPS compared to 47.87 TFLOPS for the AMD Instinct MI300, a difference of approximately 5.6%.

Q: Can either card drive a display?

A: Only the NVIDIA RTX PRO 4500, which has four DisplayPort 2.1b outputs. The AMD Instinct MI300 has no display outputs and a pixel rate of 0 MPixel/s.

Q: What is the power requirement difference?

A: The AMD card has a 600 W TDP and a 1000 W suggested PSU. The NVIDIA card has a 200 W TDP and a 550 W suggested PSU.

Q: Do both cards support the same graphics APIs?

A: No. The NVIDIA card supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. The AMD card lists N/A for DirectX, OpenGL, and Vulkan.

Q: Which card has more shading units?

A: The AMD Instinct MI300 has 14,080 shading units. The NVIDIA RTX PRO 4500 has 10,496 shading units.

Specification Differences

The two cards differ in nearly every major specification category. The AMD Instinct MI300 uses the Aqua Vanjaram chip with CDNA 3.0 architecture, while the NVIDIA RTX PRO 4500 uses the GB203 chip with Blackwell 2.0 architecture. Both are built on a 5 nm process at TSMC, but the AMD die is 1017 mm² with 153,000 million transistors, compared to 378 mm² and 45,600 million transistors for NVIDIA. Transistor density is 150.4M per mm² for AMD and 120.6M per mm² for NVIDIA.

Clock speeds differ sharply. The AMD card runs at 1000 MHz base and 1700 MHz boost. The NVIDIA card runs at 1635 MHz base and 2407 MHz boost. Memory clocks are 1300 MHz (5.2 Gbps effective) for AMD and 1750 MHz (28 Gbps effective) for NVIDIA.

Memory configuration is the largest gap. AMD provides 128 GB of HBM3 on an 8192-bit bus with 5.32 TB/s bandwidth. NVIDIA provides 32 GB of GDDR7 on a 256-bit bus with 896.0 GB/s bandwidth. The AMD card has 14,080 shading units, 880 TMUs, and zero ROPs. The NVIDIA card has 10,496 shading units, 328 TMUs, and 112 ROPs. The NVIDIA card also has 82 RT cores and 328 tensor cores; the AMD card has no recorded RT or tensor core counts.

Pixel and texture rates reflect these differences. AMD posts 0 MPixel/s and 1,496.0 GTexel/s. NVIDIA posts 269.6 GPixel/s and 789.5 GTexel/s. FP32 and FP16 are 47.87 TFLOPS for AMD and 50.53 TFLOPS for NVIDIA, both at 1:1 ratios.

Power and physical specifications also diverge. AMD has a 600 W TDP, two 8-pin power connectors, and a 1000 W suggested PSU. NVIDIA has a 200 W TDP, one 16-pin power connector, and a 550 W suggested PSU. NVIDIA is dual-slot with a width of 40 mm; AMD has no recorded slot width. Both cards are 267 mm long and 111 mm high. Both use PCIe 5.0 x16. The NVIDIA card has four DisplayPort 2.1b outputs; the AMD card has none.

Architecture Differences

The AMD Instinct MI300 is built on CDNA 3.0, AMD's compute-focused architecture, implemented on the Aqua Vanjaram chip. It is a 5 nm design from TSMC with 153,000 million transistors on a 1017 mm² die. The architecture prioritizes memory throughput: 128 GB of HBM3 on an 8192-bit bus is the defining feature. The card has no ROPs, no display outputs, and no graphics API support, which indicates a pure compute accelerator design. Its 14,080 shading units and 880 TMUs feed a texture rate of 1,496.0 GTexel/s, but the absence of a pixel pipeline means it cannot rasterize or output frames.

The NVIDIA RTX PRO 4500 Blackwell Workstation is built on Blackwell 2.0, using the GB203 chip. It is also a 5 nm TSMC design but with 45,600 million transistors on a 378 mm² die. The architecture includes 82 RT cores and 328 tensor cores, enabling hardware ray tracing and tensor operations. It has a full graphics pipeline with 112 ROPs, a 269.6 GPixel/s pixel rate, and support for DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4. Four DisplayPort 2.1b outputs make it a functional workstation display card.

The transistor density difference reflects the design priorities. AMD packs 150.4M transistors per mm² into a 1017 mm² die, while NVIDIA packs 120.6M per mm² into a 378 mm² die. The AMD card uses its larger die and wider memory bus to maximize memory capacity and bandwidth, while the NVIDIA card uses a smaller die with higher clocks, RT cores, tensor cores, and a complete display pipeline. The NVIDIA card's boost clock of 2407 MHz is 707 MHz higher than the AMD card's 1700 MHz boost, which helps it reach higher FP32 throughput with fewer shading units.

The memory technology differs as well. AMD uses HBM3, a high-bandwidth stacked memory design suited to large data movement. NVIDIA uses GDDR7, a conventional discrete memory type on a 256-bit bus. The bandwidth result is 5.32 TB/s for AMD versus 896.0 GB/s for NVIDIA, a factor of about 5.9 in favor of AMD.

The Verdict

The data indicates two cards built for different purposes. The AMD Instinct MI300 is a compute accelerator with massive memory resources: 128 GB of HBM3, 5.32 TB/s bandwidth, and a 8192-bit bus. It has no display outputs, no ROPs, and no graphics API support. Its 47.87 TFLOPS of FP32 and FP16 compute is slightly below the NVIDIA card, but its memory subsystem is in a different class. The 600 W TDP and 1000 W suggested PSU place it in server or dedicated compute environments where power and space are not primary constraints.

The NVIDIA RTX PRO 4500 Blackwell Workstation is a workstation card with a complete feature set. It delivers 50.53 TFLOPS of FP32 and FP16, higher than the AMD card, at a 200 W TDP. It has 112 ROPs, 82 RT cores, 328 tensor cores, four DisplayPort 2.1b outputs, and full DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4 support. Its 32 GB of GDDR7 memory and 896.0 GB/s bandwidth are far below the AMD card, but its pixel rate of 269.6 GPixel/s and dual-slot form factor make it suitable for traditional graphics and compute workstations.

The recorded specifications show no benchmark scores for either card, so the verdict rests on architecture and feature comparison. The AMD Instinct MI300 is the choice for memory-dominated compute workloads where 128 GB of HBM3 and 5.32 TB/s of bandwidth are required. The NVIDIA RTX PRO 4500 is the choice for workloads that need graphics output, rasterization, ray tracing, tensor operations, and higher compute efficiency, and it does so with a 200 W TDP and a 550 W suggested PSU. The NVIDIA card is also the only one of the two that can drive a display, which makes it the functional workstation product in this comparison.