AMD Instinct MI300 vs NVIDIA RTX PRO 4500 Blackwell Comparison

FAQ

Q: What are the core architectural differences between the AMD Instinct MI300 and the NVIDIA RTX PRO 4500 Blackwell?

A: The MI300 uses AMD’s CDNA 3.0 architecture on the Aqua Vanjaram chip, while the RTX PRO 4500 uses NVIDIA’s Blackwell 2.0 architecture on the GB203 chip. Both are built on a 5 nm process at TSMC, but the MI300 is a compute-focused accelerator with no display outputs, whereas the RTX PRO 4500 is a workstation GPU with 4x DisplayPort 2.1b outputs.

Q: How do the memory subsystems compare between the two cards?

A: The MI300 has 128 GB of HBM3 memory on an 8192-bit bus, delivering 5.32 TB/s of bandwidth. The RTX PRO 4500 has 32 GB of GDDR7 memory on a 256-bit bus, delivering 896.0 GB/s. The MI300 offers 4 times the capacity and roughly 5.9 times the bandwidth.

Q: Which card has higher raw FP32 compute performance?

A: The RTX PRO 4500 delivers 50.53 TFLOPS of FP32, while the MI300 delivers 47.87 TFLOPS. The NVIDIA card is about 5.6% ahead in this metric, despite having fewer shading units (10,496 vs. 14,080).

Q: What is the power draw difference between the two?

A: The MI300 has a TDP of 600 W and requires a 1000 W suggested PSU with 2x 8-pin connectors. The RTX PRO 4500 has a TDP of 200 W, a 550 W suggested PSU, and uses a single 16-pin connector. The power consumption gap is substantial.

Q: Does the MI300 support any graphics APIs?

A: No. The MI300 lists DirectX, OpenGL, and Vulkan as N/A. The RTX PRO 4500 supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4, making it the only one of the two suitable for graphics workloads.

Q: How do the benchmark scores rank these GPUs?

A: The MI300 has no recorded benchmark scores and sits at the 50th percentile among all GPUs. The RTX PRO 4500 has an average benchmark score of 31,532, placing it at the 76th percentile, with its nearest rival being the NVIDIA TITAN RTX at nearly identical performance.

Architecture Differences

The AMD Instinct MI300 and NVIDIA RTX PRO 4500 Blackwell target fundamentally different workloads, and their architectures reflect that split. The MI300 uses AMD’s CDNA 3.0 design, which is optimized purely for compute and acceleration, not for rendering or display. Its chip, Aqua Vanjaram, is a massive 1017 mm² die with 153,000 million transistors, yielding a transistor density of 150.4M per mm². The RTX PRO 4500 uses NVIDIA’s Blackwell 2.0 architecture on the GB203 chip, a much smaller 378 mm² die with 45,600 million transistors, giving a density of 120.6M per mm².

The MI300 packs 14,080 shading units and 880 texture mapping units, but it has zero ROPs and no RT or tensor core entries. Its pixel rate is listed as 0 MPixel/s, confirming it is not designed to rasterize graphics. The RTX PRO 4500, by contrast, has 10,496 shading units, 328 TMUs, 112 ROPs, 82 RT cores, and 328 tensor cores. It delivers a pixel rate of 269.6 GPixel/s and a texture rate of 789.5 GTexel/s, compared to the MI300’s texture rate of 1,496.0 GTexel/s.

Memory architecture diverges sharply. The MI300 uses 128 GB of HBM3 on a 8192-bit bus, achieving 5.32 TB/s. The RTX PRO 4500 uses 32 GB of GDDR7 on a 256-bit bus, achieving 896.0 GB/s. Clock speeds also differ: the MI300 runs at 1000 MHz base and 1700 MHz boost, while the RTX PRO 4500 runs at 1635 MHz base and 2407 MHz boost. The MI300’s memory clock is 1300 MHz (5.2 Gbps effective), whereas the RTX PRO 4500’s memory clock is 1750 MHz (28 Gbps effective).

API support is another major architectural divider. The MI300 lists DirectX, OpenGL, and Vulkan as N/A, meaning it cannot run conventional graphics workloads. The RTX PRO 4500 supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. Both cards use PCIe 5.0 x16, but the MI300 has no display outputs, while the RTX PRO 4500 has 4x DisplayPort 2.1b. Physical dimensions are identical in length (267 mm) and height (111 mm), but the RTX PRO 4500 adds a width of 40 mm and is dual-slot, whereas the MI300’s slot width is not recorded.

The Verdict

The recorded data makes the choice straightforward based on workload. The AMD Instinct MI300 is a pure compute accelerator with no graphics capabilities, no API support, and no display outputs. It offers massive memory capacity (128 GB) and bandwidth (5.32 TB/s) but lacks any benchmark scores, leaving its real-world performance unquantified in the database. Its 600 W TDP and 1000 W suggested PSU make it a high-power, server-oriented part.

The NVIDIA RTX PRO 4500 Blackwell is a workstation GPU with full graphics support, including 4x DisplayPort 2.1b outputs and DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4 compatibility. It has an average benchmark score of 31,532 and sits at the 76th percentile among all GPUs, with its nearest rival being the NVIDIA TITAN RTX at only 0.5% lower performance. Its 200 W TDP and 550 W suggested PSU make it far more practical for desktop or workstation deployment.

For any task involving rendering, display output, or standard graphics APIs, the RTX PRO 4500 is the only viable option. For compute-only workloads requiring extreme memory capacity, the MI300’s 128 GB HBM3 pool is unmatched by the RTX PRO 4500’s 32 GB. However, the MI300’s lack of benchmark data means its compute advantage cannot be quantified from the database. The data supports the RTX PRO 4500 for general-purpose and graphics use, while the MI300 is a specialist accelerator for memory-bound compute tasks.

Specification Differences

The two cards differ across nearly every major specification category. The MI300 uses the Aqua Vanjaram chip with CDNA 3.0 architecture, while the RTX PRO 4500 uses the GB203 chip with Blackwell 2.0 architecture. Transistor counts are 153,000 million versus 45,600 million, and die sizes are 1017 mm² versus 378 mm². Transistor density is 150.4M per mm² versus 120.6M per mm².

Clock speeds differ significantly: the MI300 has a 1000 MHz base and 1700 MHz boost, while the RTX PRO 4500 has a 1635 MHz base and 2407 MHz boost. Memory clocks are 1300 MHz (5.2 Gbps effective) versus 1750 MHz (28 Gbps effective). Memory capacity is 128 GB of HBM3 versus 32 GB of GDDR7, with bus widths of 8192 bit versus 256 bit and bandwidths of 5.32 TB/s versus 896.0 GB/s.

Shader resources differ: the MI300 has 14,080 shading units and 880 TMUs, while the RTX PRO 4500 has 10,496 shading units and 328 TMUs. The MI300 has 0 ROPs, while the RTX PRO 4500 has 112. The MI300 has no RT or tensor core entries, while the RTX PRO 4500 has 82 RT cores and 328 tensor cores. Pixel rates are 0 MPixel/s versus 269.6 GPixel/s, and texture rates are 1,496.0 GTexel/s versus 789.5 GTexel/s.

FP32 performance is 47.87 TFLOPS on the MI300 versus 50.53 TFLOPS on the RTX PRO 4500, and FP16 performance is identical to FP32 on both (1:1 ratio). Power consumption is 600 W versus 200 W TDP, with suggested PSUs of 1000 W versus 550 W. Power connectors are 2x 8-pin versus 1x 16-pin. The MI300 has no display outputs, while the RTX PRO 4500 has 4x DisplayPort 2.1b. API support is N/A on the MI300, while the RTX PRO 4500 supports DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4.

The MI300 measures 267 mm by 111 mm, while the RTX PRO 4500 adds a 40 mm width dimension. The RTX PRO 4500 is dual-slot, while the MI300’s slot width is not recorded. The MI300 was released on January 3, 2023, and the RTX PRO 4500 on March 17, 2025. The RTX PRO 4500 has an active production status, while the MI300’s status is not recorded. The MI300’s predecessor is Radeon Instinct, and the RTX PRO 4500’s predecessor is Workstation Ada.

Head-to-Head Benchmarks

The database contains no head-to-head benchmark results between the AMD Instinct MI300 and the NVIDIA RTX PRO 4500 Blackwell. The MI300 has an empty benchmarks array and an average benchmark score of 0, placing it at the 50th percentile among all GPUs. The RTX PRO 4500, by contrast, has nine recorded benchmark scores and an average score of 31,532, placing it at the 76th percentile.

The RTX PRO 4500’s benchmark results show its strongest performance in Geekbench Vulkan with a score of 221,768. In Passmark tests, it scores 33,360 in G3D, 19,255 in GPU Compute, 1,336 in G2D, 397 in DirectX 9, 320 in DirectX 11, 204 in DirectX 10, and 119 in DirectX 12. In 3DMark Steel Nomad DX12, it scores 7,025.

The RTX PRO 4500’s nearest rivals in the database are all NVIDIA or Intel cards. The NVIDIA TITAN RTX has an average score of 31,676, which is 0.5% higher than the RTX PRO 4500. The NVIDIA GRID M60-1Q scores 31,220, which is 1% lower. The NVIDIA Quadro M5000 also scores 31,206, 1% lower. The Intel Arc Pro A30M scores 31,894, which is 1.1% higher.

Since the MI300 has no benchmark scores, no direct comparison of measured performance is possible. The only quantified performance differences come from specification-level metrics: the MI300 leads in texture rate (1,496.0 GTexel/s versus 789.5 GTexel/s) and memory bandwidth (5.32 TB/s versus 896.0 GB/s), while the RTX PRO 4500 leads in FP32 compute (50.53 TFLOPS versus 47.87 TFLOPS), pixel rate (269.6 GPixel/s versus 0), and clock speeds (2407 MHz boost versus 1700 MHz boost). The RTX PRO 4500’s benchmark presence and 76th percentile ranking indicate measured performance in real workloads, whereas the MI300’s 50th percentile ranking with zero scores reflects an absence of data rather than a performance verdict.