AMD Instinct MI300 vs NVIDIA RTX 4500 Ada Generation Comparison

Where Each One Wins

The benchmark data splits these two accelerators into entirely different roles. The AMD Instinct MI300 has no recorded benchmark scores in the database, while the NVIDIA RTX 4500 Ada Generation carries two Geekbench results: 160,786 in OpenCL and 171,401 in Vulkan. That gives the RTX 4500 an average benchmark score of 166,094, placing it in the 97th percentile of all GPUs tracked.

The MI300, by contrast, sits at the 50th percentile with an average score of zero. The recorded data shows no wins for the MI300 in any head-to-head test, and no wins for the RTX 4500 either, since the head-to-head benchmark array is empty. What the database does show is that the RTX 4500 is the only one of the two with measurable compute results, and those results position it clearly above the median GPU population.

The RTX 4500's nearest rivals in the database reinforce its standing. It sits 0.5% above the NVIDIA RTX A5500 (165,217 average score), 0.7% above the AMD Radeon PRO W7800 (164,894), 2.2% above the NVIDIA A100 PCIe 40 GB (162,504), and 1.5% below the AMD Radeon Pro W6900X (168,574). The margin over the A100 is notable, given that the A100 is a data center part with a much larger memory footprint.

For the MI300, the absence of benchmark entries means the database cannot assign it a compute win in any workload. Its strengths must be read from its specifications rather than from measured results. The card is built for a different purpose: 128 GB of HBM3 memory, an 8192-bit bus, and 5.32 TB/s of bandwidth. That is not a workstation rendering part; it is a memory-capacity and bandwidth play. The RTX 4500 wins every measured category because it is the only part with measurements.

Architecture Differences

The two chips come from different architectural families and target different workloads. The MI300 uses AMD's CDNA 3.0 architecture on the Aqua Vanjaram chip, built on a 5 nm process at TSMC. The RTX 4500 uses NVIDIA's Ada Lovelace architecture on the AD103 chip, also on a 5 nm process at TSMC, but with very different transistor budgets.

The MI300 packs 153,000 million transistors on a 1017 mm² die, yielding a transistor density of 150.4 million per square millimeter. The RTX 4500 uses 45,900 million transistors on a 379 mm² die, for a density of 121.1 million per square millimeter. The MI300 is the larger and denser chip by a wide margin, more than three times the transistor count and nearly three times the die area.

Memory architecture separates them further. The MI300 uses 128 GB of HBM3 across an 8192-bit bus, delivering 5.32 TB/s of bandwidth. The RTX 4500 uses 24 GB of GDDR6 across a 192-bit bus, delivering 432.0 GB/s. The MI300's memory bandwidth is more than twelve times that of the RTX 4500. The MI300 runs its memory at 1300 MHz (5.2 Gbps effective), while the RTX 4500 runs at 2250 MHz (18 Gbps effective). The RTX 4500's faster per-pin signaling cannot compensate for the MI300's enormous bus width.

Compute resources also differ. The MI300 has 14,080 shading units, 880 texture mapping units, and zero ROPs. Its pixel rate is listed as 0 MPixel/s, which reflects its lack of display outputs and rasterization hardware. The texture rate is 1,496.0 GTexel/s. The RTX 4500 has 7,680 shading units, 240 TMUs, 80 ROPs, 60 ray tracing cores, and 240 tensor cores. Its pixel rate is 206.4 GPixel/s, and its texture rate is 619.2 GTexel/s.

The MI300's FP32 throughput is 47.87 TFLOPS, and its FP16 throughput is the same at 47.87 TFLOPS (1:1). The RTX 4500 delivers 39.63 TFLOPS in both FP32 and FP16 (1:1). The MI300 leads in raw floating-point throughput, though neither part's FP16 mode uses a dedicated tensor path in these figures. The RTX 4500 is the one with tensor cores and ray tracing cores; the MI300 lists no RT or tensor core counts.

Interface and power profiles differ sharply. The MI300 uses PCIe 5.0 x16, has a 600 W TDP, requires two 8-pin power connectors, and a suggested 1000 W PSU. It has no display outputs. The RTX 4500 uses PCIe 4.0 x16, has a 210 W TDP, no power connectors, a suggested 550 W PSU, and four DisplayPort 1.4a outputs. The MI300 is 267 mm long and 111 mm tall; the RTX 4500 is 245 mm long and 112 mm tall. Both come in dual-slot form factors, though the MI300's slot width is not listed.

API support reflects their roles. The MI300 lists N/A for DirectX, OpenGL, and Vulkan. The RTX 4500 supports DirectX 12 Ultimate (12_2), OpenGL 4.6, and Vulkan 1.4. The MI300 is not a graphics card; it is a compute accelerator with no graphics API path.

The Verdict

The database points to a clean split. The NVIDIA RTX 4500 Ada Generation is the only one of the two with measured benchmark results, and those results place it in the 97th percentile of all GPUs, with an average score of 166,094. It is a workstation part with graphics output, ray tracing cores, tensor cores, and a 24 GB GDDR6 frame buffer. For any workload that shows up in Geekbench OpenCL or Vulkan, the RTX 4500 is the part with data behind it.

The AMD Instinct MI300 has no benchmark scores, no graphics APIs, no display outputs, and no raster hardware. What it has is memory: 128 GB of HBM3, an 8192-bit bus, and 5.32 TB/s of bandwidth. Its 47.87 TFLOPS of FP32 and FP16 throughput exceeds the RTX 4500's 39.63 TFLOPS, and its texture rate of 1,496.0 GTexel/s is more than double the RTX 4500's 619.2 GTexel/s. The 600 W TDP and dual 8-pin connectors show it is built for sustained compute, not desktop use.

The choice comes down to workload class. The RTX 4500 is a workstation accelerator that can drive displays, run graphics APIs, and deliver measured compute performance. The MI300 is a memory-capacity compute accelerator for large data sets, with no graphics path and no measured benchmark results in the database. The RTX 4500 is the pick for measured performance and workstation duties; the MI300 is the pick for memory-bound compute, judged strictly on its specifications.

FAQ

Q: Which GPU has the higher average benchmark score in the database?

A: The NVIDIA RTX 4500 Ada Generation, with an average benchmark score of 166,094. The AMD Instinct MI300 has no recorded benchmark scores, so its average is zero.

Q: How does the RTX 4500 compare to its nearest rivals?

A: The RTX 4500 is 0.5% above the NVIDIA RTX A5500, 0.7% above the AMD Radeon PRO W7800, 2.2% above the NVIDIA A100 PCIe 40 GB, and 1.5% below the AMD Radeon Pro W6900X.

Q: Which GPU has more memory bandwidth?

A: The AMD Instinct MI300, with 5.32 TB/s across an 8192-bit HBM3 bus. The RTX 4500 delivers 432.0 GB/s across a 192-bit GDDR6 bus.

Q: Does the MI300 support graphics APIs?

A: No. The MI300 lists N/A for DirectX, OpenGL, and Vulkan, and has no display outputs. The RTX 4500 supports DirectX 12 Ultimate, OpenGL 4.6, and Vulkan 1.4, with four DisplayPort 1.4a outputs.

Q: Which GPU has higher FP32 compute throughput?

A: The MI300, at 47.87 TFLOPS, versus 39.63 TFLOPS for the RTX 4500. Both have 1:1 FP16 performance.

Q: What are the power requirements for each GPU?

A: The MI300 has a 600 W TDP, uses two 8-pin power connectors, and suggests a 1000 W PSU. The RTX 4500 has a 210 W TDP, uses no power connectors, and suggests a 550 W PSU.

Head-to-Head Benchmarks

The head-to-head benchmark array between the MI300 and the RTX 4500 is empty, so there are no direct measured comparisons in the database. The wins column shows zero for both parts. What the database does offer are the RTX 4500's individual Geekbench results and its position against other GPUs, which can serve as a reference frame.

The RTX 4500's Geekbench OpenCL score is 160,786, and its Vulkan score is 171,401. The Vulkan result is 10,615 points higher than the OpenCL result, which indicates the Ada Lovelace architecture handles the Vulkan workload slightly better in this test. The average of the two is 166,094.

Against its nearest rivals, the RTX 4500's largest margin is over the NVIDIA A100 PCIe 40 GB, where it leads by 2.2%. That is a meaningful gap given the A100's reputation as a data center compute part. The RTX 4500 also leads the RTX A5500 by 0.5% and the Radeon PRO W7800 by 0.7%. The only part ahead of it in this group is the Radeon Pro W6900X, which holds a 1.5% lead.

The MI300 has no recorded scores to compare, so the largest win in this matchup is structural rather than measured. Its 5.32 TB/s memory bandwidth and 128 GB capacity are the standout figures in its specification sheet. The RTX 4500's 432.0 GB/s and 24 GB are typical for a workstation card, but they are an order of magnitude below the MI300's memory subsystem.

In raw shading throughput, the MI300's 14,080 shading units and 47.87 TFLOPS exceed the RTX 4500's 7,680 units and 39.63 TFLOPS. The texture rate comparison is also one-sided: 1,496.0 GTexel/s versus 619.2 GTexel/s. But the MI300 has zero ROPs and a pixel rate of 0 MPixel/s, so it cannot rasterize anything. The RTX 4500's 80 ROPs and 206.4 GPixel/s make it the only one of the two that can produce a display image.

The RTX 4500 also brings hardware features the MI300 does not list: 60 ray tracing cores and 240 tensor cores. Those are absent from the MI300's specification sheet entirely. For graphics-adjacent compute, including ray tracing and tensor workloads, the RTX 4500 has dedicated hardware. The MI300 does not.

Clock speeds tell a different story. The RTX 4500 runs at a 2070 MHz base and 2580 MHz boost, both far above the MI300's 1000 MHz base and 1700 MHz boost. The MI300 compensates with massive parallelism and memory bandwidth, but its clocks are lower across the board. The RTX 4500's memory clock is also higher at 2250 MHz (18 Gbps effective) versus the MI300's 1300 MHz (5.2 Gbps effective), though the MI300's bus width makes raw bandwidth comparisons moot.

The MI300's transistor count of 153,000 million versus the RTX 4500's 45,900 million shows the scale difference. The MI300 uses 1017 mm² of silicon; the RTX 4500 uses 379 mm². Both are 5 nm TSMC parts, but the MI300 pushes density to 150.4 million transistors per square millimeter, above the RTX 4500's 121.1 million.

The RTX 4500 is the only one with a production status of Active. The MI300's status is not listed. The RTX 4500 also has a successor, Blackwell PRO W, while the MI300's successor field is empty. Both parts come from the same foundry and process node, but the design goals could not be more different.