AMD Ryzen Threadripper PRO 9995WX vs Intel Xeon 6780E Comparison

Head-to-Head Benchmarks

The benchmark data records 16 head-to-head comparisons between the AMD Ryzen Threadripper PRO 9995WX and the Intel Xeon 6780E, and the results are remarkably one-sided. The AMD part wins all 16 tests, but the margin of victory varies dramatically by workload type.

The largest gaps appear in single-threaded and extended instruction workloads. In Cinebench R15 single-core, the AMD scores 2114 against Intel's 1049, a 101.5% advantage. That pattern repeats across the Cinebench suite: R20 single-core shows 8811 versus 4371 (101.6% ahead), and the PassMark single-thread test records 4542 versus 1923, a 136.2% delta. The PassMark extended instructions test shows the widest gap of all: 270647 versus 114008, putting AMD 137.4% ahead, which points to a substantial difference in SIMD and specialized instruction throughput.

Multi-threaded rendering tells a similar story, though the raw core count difference complicates interpretation. In Cinebench R23 multi-core, AMD posts 148601 against Intel's 73723, a 101.6% margin. The R15 and R20 multi-core tests each show the exact same 101.6% delta, with scores of 14978 versus 7431 and 62412 versus 30963 respectively. The PassMark multi-thread score is 171200 versus 86734, a 97.4% advantage. These are near-doubling results, not incremental gains.

Some workloads show smaller but still decisive wins. PassMark data encryption is the closest contest: AMD scores 206662 against Intel's 193004, only 7.1% ahead. Random string sorting is the second-closest at 28.1%, with AMD at 418973 versus 326954. Data compression sits at 45.6% (3723652 versus 2557582), and physics at 54% (16860 versus 10951). Integer math shows 87.5% (1203634 versus 641817), and floating-point math 67.1% (725066 versus 433862). Prime number finding lands at 108.5% (1476 versus 708).

The average benchmark score reinforces the overall picture: AMD's average is 412068, while Intel's is 280438. That difference places the Threadripper in the 100th percentile of all CPUs in the database, versus the 99th percentile for the Xeon. Interestingly, the AMD part's nearest rivals are all EPYC server chips, with the EPYC 9745 just 3.3% higher in average score, and the EPYC 9655P 3.6% lower. The Intel part's nearest rival is the Ryzen Threadripper 9970X, which scores only 0.2% different, suggesting the Xeon 6780E sits in a well-populated performance neighborhood.

The Verdict

The data is unambiguous: the AMD Ryzen Threadripper PRO 9995WX outperforms the Intel Xeon 6780E in every recorded benchmark. For workloads that depend on single-thread speed, the choice is clear, as AMD leads by more than double in some cases. For multi-threaded rendering, the AMD part also dominates, despite having 96 cores versus Intel's 144. The fact that AMD achieves these results with fewer cores and a higher TDP (350 watts versus 330) indicates a fundamentally different performance strategy.

Who should pick the Intel Xeon 6780E? The data shows it is competitive in specific narrow areas. Its data encryption score is within 7.1% of the AMD part, and random string sorting is within 28.1%. If a workload is heavily dependent on those specific operations, the Xeon is not catastrophically behind. However, the Xeon does not win a single recorded test. The database shows its nearest rivals are the Ryzen Threadripper 9970X and EPYC 9565, all within about 2.3%, which means it is a solid mid-pack performer in its own right, just not in this comparison.

Who should pick the AMD part? Anyone whose workload spans rendering, general compute, integer or floating-point math, or single-threaded applications. The 100th percentile ranking and the consistent doubling of scores across most tests make it the dominant choice in this head-to-head. The launch MSRP for the AMD part is $11700, while the Intel part launched at $11350, but the performance delta far exceeds the price delta in every category except encryption.

Architecture Differences

The two processors represent fundamentally different design philosophies. The AMD Ryzen Threadripper PRO 9995WX uses the Zen 5 architecture on a 4 nm TSMC process, with a codename of Shimada Peak. It packs 96 cores and 192 threads, with a base clock of 2.50 GHz and a boost clock of 5.40 GHz. The Intel Xeon 6780E uses the Sierra Forest architecture on a 5 nm Intel process, with 144 cores and 144 threads, a base clock of 2.20 GHz and a boost clock of 3.00 GHz. The clock speed difference is stark: AMD boosts nearly 2.4 GHz higher.

Cache organization differs substantially. AMD provides 64 KB of L1 per core and 1 MB of L2 per core, plus a large 384 MB L3 pool. Intel offers 96 KB of L1 per core but only 4 MB of L2 per module, with a shared 108 MB L3. The total cache footprint favors AMD dramatically, which likely explains much of the single-thread and integer math advantage. The transistor count for AMD is listed at 99,780 million, with a die composed of 12 chiplets at 70.6 mm² each. Intel's die is a monolithic 578 mm², with no transistor count recorded.

Memory support is identical on paper: both use DDR5 with an eight-channel bus and 409.6 GB/s of bandwidth, and both support ECC. PCIe connectivity differs: AMD provides Gen 5 with 128 lanes (CPU only), while Intel provides Gen 5 with 88 lanes. Neither has integrated graphics. AMD has an unlocked multiplier, Intel does not. The sockets are incompatible: AMD uses Socket sTR5, Intel uses Socket 4710.

FAQ

Q: Which processor has more cores?

A: The Intel Xeon 6780E has 144 cores, while the AMD Ryzen Threadripper PRO 9995WX has 96 cores. However, AMD has 192 threads versus Intel's 144, due to simultaneous multithreading.

Q: How much faster is the AMD part in single-threaded performance?

A: In Cinebench R15 single-core, AMD scores 2114 versus Intel's 1049, a 101.5% lead. The PassMark single-thread test shows 4542 versus 1923, a 136.2% lead.

Q: Is there any benchmark where the Intel Xeon wins?

A: No. The recorded data shows AMD winning all 16 head-to-head benchmarks, with the smallest margin being 7.1% in PassMark data encryption.

Q: What is the difference in average benchmark scores?

A: AMD's average benchmark score is 412068, placing it in the 100th percentile of all CPUs. Intel's average is 280438, placing it in the 99th percentile.

Q: Do both processors support the same memory?

A: Yes, both support DDR5 with an eight-channel memory bus and 409.6 GB/s bandwidth. Both also support ECC memory.

Q: What are the launch MSRP values?

A: The AMD Ryzen Threadripper PRO 9995WX has a launch MSRP of $11700, and the Intel Xeon 6780E has a launch MSRP of $11350.

Where Each One Wins

The AMD Ryzen Threadripper PRO 9995WX wins everywhere in the recorded data, but the magnitude of the win varies by workload type. The largest advantages are in extended instructions (137.4%) and single-thread performance (136.2%), which suggests AMD is the clear choice for applications that rely on vectorized math, encryption algorithms, or any latency-sensitive single-threaded code path. The Cinebench suite, which models real-world rendering, shows consistent 101.6% leads across all versions and thread counts, making AMD the obvious pick for 3D rendering, video encoding, and other creative workloads.

For integer math (87.5% ahead) and floating-point math (67.1% ahead), AMD similarly dominates. The prime number test, a pure integer workload, shows a 108.5% lead. Data compression is 45.6% ahead, and physics is 54% ahead. These results indicate that AMD's architecture scales better across general compute tasks, not just in niche benchmarks.

The Intel Xeon 6780E's best showing is in data encryption, where it trails by only 7.1%. This is a narrow enough margin that in a real-world system, other factors such as platform stability or memory configuration could close the gap. Random string sorting is the next closest at 28.1%, which is still a decisive loss but less catastrophic than the rendering or single-thread results. For workloads that are primarily encryption-heavy or involve large-scale string manipulation with minimal other compute demands, the Intel part is at least in the same performance class, even if it is still behind.

Specification Differences

The two processors differ in nearly every architectural specification. The AMD part uses 96 cores and 192 threads, while Intel uses 144 cores and 144 threads. AMD has a higher base clock (2.50 GHz versus 2.20 GHz) and a much higher boost clock (5.40 GHz versus 3.00 GHz). TDP is 350 watts for AMD and 330 watts for Intel. The socket is AMD Socket sTR5 versus Intel Socket 4710.

Cache configurations are fundamentally different: AMD offers 64 KB L1 per core and 1 MB L2 per core with 384 MB L3, while Intel offers 96 KB L1 per core and 4 MB L2 per module with 108 MB shared L3. The process node is 4 nm for AMD (TSMC) versus 5 nm for Intel (Intel foundry). AMD's die is composed of 12 chiplets at 70.6 mm² each, while Intel uses a single 578 mm² die. AMD has an unlocked multiplier; Intel does not. PCIe lanes are 128 for AMD versus 88 for Intel. The AMD part number is 100-000001361, and Intel's is SRPG3. The AMD part released on 2025-07-22, while Intel released on 2024-06-02. Both are active production parts with no integrated graphics.