AMD Ryzen 7 PRO 4750GE vs Intel Xeon E-2378 Comparison

The Verdict

The recorded data shows a clear and consistent pattern: the AMD Ryzen 7 PRO 4750GE wins every single benchmark in the head-to-head comparison, taking all 6 contests against the Intel Xeon E-2378. The AMD part leads by 7.3% in Cinebench R20 and R23 multi-core and single-core tests, and by 7.2% to 7.3% in the R15 variants. For workloads that rely on Cinebench-style rendering, the AMD chip is the stronger choice. The Intel Xeon E-2378, however, is positioned for a different role entirely: it is a server and workstation part with a higher 65 TDP, a newer release date, and PCIe Gen 4 support, which matters for platform-level expansion rather than raw CPU throughput.

The database places the AMD Ryzen 7 PRO 4750GE at the 58th percentile among all CPUs, with an average benchmark score of 4411. The Intel Xeon E-2378 sits at the 57th percentile with an average score of 4232. That percentile gap is narrow, but the AMD part is 4.2% ahead in average score based on the recorded figures. The AMD processor also has a more favorable position relative to its nearest rivals: it is 0.9% ahead of the Intel Xeon E-2288G and 1.3% ahead of the AMD EPYC 7232P, while trailing the Intel Core i7-9800X by 1% and the AMD Ryzen 5 PRO 5650GE by 1.3%. The Intel Xeon E-2378, meanwhile, is 0.4% behind the Intel Core i7-1265U, 0.9% behind the Intel Xeon W-2140B, 0.4% ahead of the Intel Core i5-12500T, and 1.1% ahead of the Intel Core i5-11500H.

Who should pick which depends on the use case. If the priority is maximum multi-threaded rendering performance per benchmark score, the AMD Ryzen 7 PRO 4750GE is the data-supported winner. If the need is for a server platform with integrated graphics absent but PCIe Gen 4 connectivity present, the Intel Xeon E-2378 offers that expansion capability, though it sacrifices benchmark performance. The AMD part also carries integrated Radeon Vega 8 graphics, which the Intel Xeon lacks entirely.

Architecture Differences

The two processors come from fundamentally different design philosophies. The AMD Ryzen 7 PRO 4750GE is built on the Zen 2 architecture under the codename Renoir, part of the 4000 series, and manufactured on a 7 nm process at TSMC. It packs 9,800 million transistors into a 156 mm² die. The Intel Xeon E-2378 uses the Rocket Lake architecture, specifically Rocket Lake-E, from the Xeon E-2300 series, and is fabricated on Intel's 14 nm process with a 276 mm² die size.

Both CPUs have 8 cores and 16 threads, so thread counts match. The cache layouts differ notably. The AMD part has 64 KB of L1 cache per core, 512 KB of L2 per core, and 8 MB of L3 cache. The Intel part has a larger 80 KB L1 per core, the same 512 KB L2 per core, and a significantly larger 16 MB of shared L3 cache. That L3 advantage on the Intel side does not translate into benchmark wins, as the recorded scores show the AMD part ahead despite less L3.

Memory support is identical on paper: both support DDR4, both use dual-channel memory, and both have a memory bandwidth of 51.2 GB/s. Both also support ECC memory, which is a relevant feature for workstation and server deployments. The PCIe capabilities diverge sharply: the AMD Ryzen 7 PRO 4750GE offers PCIe Gen 3 with 16 lanes from the CPU, while the Intel Xeon E-2378 offers PCIe Gen 4 with 20 lanes. That Gen 4 support and higher lane count is the Intel part's main architectural advantage for storage and accelerator connectivity.

The AMD processor includes integrated Radeon Vega 8 graphics, while the Intel Xeon E-2378 has no integrated graphics at all. For systems that require a display output without a discrete GPU, the AMD part has a distinct advantage. The Intel part targets server and workstation environments where a dedicated GPU is assumed. Production status for both is Active, so neither is end-of-life.

Head-to-Head Benchmarks

The head-to-head results are uniform: the AMD Ryzen 7 PRO 4750GE wins every test. In Cinebench R15 multi-core, the AMD scores 1582 against Intel's 1474, a 7.3% lead. In R15 single-core, AMD scores 223 against 208, a 7.2% margin. The R20 tests show AMD at 6593 multi-core versus 6145 for Intel, again 7.3% ahead, and 930 single-core versus 867, also 7.3%. The R23 tests continue the pattern: AMD scores 15699 multi-core against Intel's 14633, a 7.3% edge, and 2216 single-core versus 2065, another 7.3% advantage.

These margins are remarkably consistent across all six tests, suggesting a stable performance differential that is not workload-sensitive within the Cinebench suite. The AMD part's higher base clock of 3.10 GHz versus Intel's 2.60 GHz likely contributes to the single-core wins, even though the Intel part has a higher boost clock of 4.80 GHz versus AMD's 4.30 GHz. The boost clock advantage does not overcome the AMD lead in these recorded runs.

The Geekbench results appear only for the AMD part: it scores 6430 multi-core and 1612 single-core. No comparable Geekbench scores are recorded for the Intel Xeon E-2378 in the database, so a direct comparison on that test is not possible. The Intel part's average benchmark score of 4232 is lower than AMD's 4411, which aligns with the head-to-head results.

Specification Differences

The two CPUs differ across several specification fields where the data is recorded. The AMD Ryzen 7 PRO 4750GE has a base clock of 3.10 GHz, while the Intel Xeon E-2378 has a base clock of 2.60 GHz. The boost clocks are reversed in favor of Intel: 4.80 GHz versus AMD's 4.30 GHz. The TDP is a major differentiator: AMD draws 35 watts, Intel draws 65 watts, so the AMD part is far more efficient on paper.

The process node differs: AMD uses 7 nm from TSMC, Intel uses 14 nm from its own foundry. The transistor count is recorded only for AMD at 9,800 million; no transistor count is listed for Intel. The die size is 156 mm² for AMD and 276 mm² for Intel, reflecting the density advantage of the smaller node. The L1 cache per core is 64 KB for AMD and 80 KB for Intel. The L3 cache is 8 MB for AMD and 16 MB for Intel.

The socket types are different: AMD uses Socket AM4, Intel uses Socket 1200. The PCIe generation and lane count differ: AMD has Gen 3 with 16 lanes, Intel has Gen 4 with 20 lanes. Integrated graphics are present on AMD as Radeon Vega 8, absent on Intel. The market segment is Desktop for AMD and Server/Workstation for Intel. The release dates differ: AMD launched on 2020-07-20, Intel on 2021-09-07. The Intel part has a launch MSRP of $362, which is the only recorded price. The AMD part has no launch MSRP in the database.

FAQ

Q: Which CPU has a higher base clock speed?

A: The AMD Ryzen 7 PRO 4750GE has a base clock of 3.10 GHz, which is higher than the Intel Xeon E-2378's base clock of 2.60 GHz.

Q: Does either CPU support ECC memory?

A: Yes, both the AMD Ryzen 7 PRO 4750GE and the Intel Xeon E-2378 support ECC memory, and both use dual-channel DDR4 with a recorded memory bandwidth of 51.2 GB/s.

Q: What is the performance difference in Cinebench R23 multi-core?

A: The AMD Ryzen 7 PRO 4750GE scores 15699 in Cinebench R23 multi-core, while the Intel Xeon E-2378 scores 14633. The AMD part is 7.3% ahead in that test.

Q: Which CPU has integrated graphics?

A: Only the AMD Ryzen 7 PRO 4750GE has integrated graphics, specifically Radeon Vega 8. The Intel Xeon E-2378 has no integrated graphics in the recorded data.

Q: How do the two CPUs compare in their nearest rival groups?

A: The AMD Ryzen 7 PRO 4750GE is 0.9% ahead of the Intel Xeon E-2288G and 1.3% ahead of the AMD EPYC 7232P, while trailing the Intel Core i7-9800X by 1% and the AMD Ryzen 5 PRO 5650GE by 1.3%. The Intel Xeon E-2378 is 0.4% behind the Intel Core i7-1265U and 0.9% behind the Intel Xeon W-2140B, while leading the Intel Core i5-12500T by 0.4% and the Intel Core i5-11500H by 1.1%.

Q: Which CPU has higher PCIe generation support?

A: The Intel Xeon E-2378 supports PCIe Gen 4 with 20 lanes from the CPU, while the AMD Ryzen 7 PRO 4750GE supports PCIe Gen 3 with 16 lanes. This gives the Intel part an advantage for newer expansion cards and storage devices.