AMD EPYC 7543 vs AMD EPYC 75F3 Comparison

Both the AMD EPYC 75F3 and the AMD EPYC 7543 are 32-core Zen 3 Milan server processors built for the same SP3 socket, but the benchmark data shows a clear, consistent performance hierarchy between them. The EPYC 75F3 wins every single Cinebench test in the head-to-head comparison, taking all six benchmark wins. That sweep is not a matter of a few points; the 75F3 maintains a uniform 2.5% advantage over the 7543 across both single-core and multi-core workloads. The 7543 is the lower-clocked sibling, and the results reflect that positioning. While both processors land in the same performance tier per their average scores, the 75F3 is the outright faster part for every measured workload.

Where Each One Wins

The win distribution is one-sided: the EPYC 75F3 takes all 6 benchmark wins in the head-to-head data. There is no workload category in the Cinebench suite where the EPYC 7543 comes out ahead. That means for any application that scales with Cinebench R15, R20, or R23 performance—whether single-threaded or multi-threaded—the 75F3 is the better choice. The 7543’s role is more about being the slightly more conservative configuration within the same family.

Looking at the raw scores, the 75F3’s advantage is most visible in the multi-core tests, where the gap in points is largest. In Cinebench R23 multi-core, the 75F3 scores 54829 against the 7543’s 53509, a difference of 1320 points. In single-core, the lead narrows to 186 points (7740 vs 7554). The pattern repeats across all three Cinebench versions: the multi-core delta in points is always roughly seven times larger than the single-core delta, even though the percentage gap stays pinned at 2.5%. For a server workload that is heavily threaded, that consistent multi-core edge is the deciding factor.

The 7543 does not lose by a wide margin, but the data shows no scenario where it wins. Its average benchmark score is 15477, compared to the 75F3’s 15859. The 75F3 sits in the 70th percentile of all CPUs, while the 7543 sits just below at the 69th percentile. If the choice is purely about benchmark performance, the 75F3 is the pick for every use case measured here.

Architecture Differences

Both processors share the same underlying design: Zen 3 architecture on the Milan codename, built on TSMC’s 7 nm process. The transistor count is identical at 33,200 million, and the die size is the same at 8x 81 mm². They are, architecturally, the same silicon with different clock configurations. The cache hierarchy is also identical: 64 KB of L1 per core, 512 KB of L2 per core, and 256 MB of shared L3. There is no difference in the memory subsystem either—both support DDR4 across an eight-channel bus with 204.8 GB/s of bandwidth and ECC memory.

The key architectural difference is in clock speeds. The EPYC 75F3 has a base clock of 2.95 GHz and a boost clock of 4.00 GHz. The EPYC 7543 runs lower, with a base clock of 2.80 GHz and a boost clock of 3.70 GHz. That 0.15 GHz difference at base and 0.30 GHz at boost is the entire source of the performance gap. The 75F3 is also rated for a higher TDP of 280 watts, against the 7543’s 225 watts. That 55-watt TDP difference is the trade-off for the higher clocks: the 75F3 draws more power to sustain its frequency advantage.

Both processors use the same AMD Socket SP3, provide the same PCIe Gen 4 with 128 lanes (CPU only), and have no integrated graphics. They were released on the same date, 2021-03-14, and are both actively in production. The part numbers differ (100-000000313100-100000313WOF for the 75F3, 100-000000345100-100000345WOF for the 7543), but that is a packaging distinction, not a functional one. The 7543 belongs to the broader EPYC 7003 series, while the 75F3 is a standalone listing, but the underlying silicon is the same Milan generation.

Head-to-Head Benchmarks

The head-to-head data lists six Cinebench tests, and the EPYC 75F3 wins all of them with a deltaPct of exactly 2.5% in every case. That uniformity is notable: the percentage lead does not grow or shrink with the workload, suggesting the clock advantage translates linearly across all thread counts and instruction mixes.

In Cinebench R15, the 75F3 scores 5526 multi-core and 780 single-core. The 7543 trails with 5393 multi-core and 761 single-core. The multi-core gap is 133 points, while the single-core gap is just 19 points. Moving to Cinebench R20, the 75F3 posts 23028 multi-core and 3250 single-core, against the 7543’s 22473 and 3172. The multi-core difference here is 555 points; the single-core difference is 78 points.

The largest absolute gaps appear in Cinebench R23. The 75F3 finishes with 54829 multi-core and 7740 single-core. The 7543 finishes with 53509 multi-core and 7554 single-core. That is a 1320-point multi-core lead and a 186-point single-core lead for the 75F3. Across all three Cinebench versions, the 75F3’s percentage advantage never wavers from 2.5%, which means the higher boost clock of 4.00 GHz over 3.70 GHz is delivering a consistent proportional uplift.

The 7543’s nearest rivals in the overall database include the Intel Core 5 211TE, which trails by 0.7%, and the AMD Ryzen 3 7440U, which is 1.3% ahead. The 75F3’s nearest rivals include the AMD Ryzen 5 40, which is essentially tied at -0.1%, and the AMD EPYC 9354P, which is 0.2% behind. These comparisons show that both Milan parts sit in a dense performance cluster, where a 2.5% internal gap is meaningful but does not move them into a different tier relative to the broader market.

Specification Differences

The specification sheets for the two processors are nearly identical, with only a handful of fields showing any divergence. The most significant difference is the clock speeds. The EPYC 75F3 runs at a 2.95 GHz base clock and a 4.00 GHz boost clock. The EPYC 7543 runs at a 2.80 GHz base clock and a 3.70 GHz boost clock. This is a 0.15 GHz difference at base and a 0.30 GHz difference at boost.

The TDP is the other major differentiator. The 75F3 is rated at 280 watts, while the 7543 is rated at 225 watts. That 55-watt gap is the cost of the higher clocks. The 7543 is listed as part of the EPYC 7003 series, while the 75F3 has a null series field, but that is a classification detail rather than a technical difference.

Every other specification is identical. Both have 32 cores and 64 threads, both use AMD Socket SP3, both are Zen 3 Milan on 7 nm TSMC, both have 33,200 million transistors and an 8x 81 mm² die size. The cache is the same: 64 KB L1 per core, 512 KB L2 per core, and 256 MB shared L3. Memory support is DDR4 with an eight-channel bus and 204.8 GB/s bandwidth, with ECC enabled. PCIe is Gen 4 with 128 lanes on both. Neither has integrated graphics, neither is multiplier unlocked, and both were released on 2021-03-14. The launch MSRP differs: the 75F3 is $4860, while the 7543 is $3761. Both are currently marked as active in production.

FAQ

Q: Which processor is faster in multi-core workloads?

A: The AMD EPYC 75F3 wins every multi-core test. In Cinebench R23 multi-core, it scores 54829 against the EPYC 7543’s 53509, a 2.5% lead that holds across R15 and R20 as well.

Q: Is there any benchmark where the EPYC 7543 comes out ahead?

A: No. The head-to-head data lists 6 Cinebench tests, and the EPYC 75F3 wins all 6. The 7543 has 0 wins in the comparison.

Q: What is the architectural difference between the two chips?

A: Both use the same Zen 3 architecture on the Milan codename, built on 7 nm TSMC with 33,200 million transistors and an 8x 81 mm² die size. The only functional difference is clock speed: the 75F3 has a 2.95 GHz base and 4.00 GHz boost, while the 7543 has a 2.80 GHz base and 3.70 GHz boost.

Q: How does the TDP compare between the two?

A: The EPYC 75F3 is rated at 280 watts TDP, while the EPYC 7543 is rated at 225 watts. The 75F3 consumes 55 watts more to support its higher clock speeds.

Q: Do they have the same cache and memory configuration?

A: Yes. Both have 64 KB L1 per core, 512 KB L2 per core, and 256 MB shared L3. Both support DDR4 memory over an eight-channel bus with 204.8 GB/s bandwidth and ECC.

Q: What is the performance gap in percentage terms?

A: The EPYC 75F3 leads by exactly 2.5% in all six Cinebench tests, both single-core and multi-core. The average benchmark score difference is 15859 for the 75F3 versus 15477 for the 7543.